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Items: 47

1.

CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth.

Casagrande N, Borghese C, Visser L, Mongiat M, Colombatti A, Aldinucci D.

Haematologica. 2019 Mar;104(3):564-575. doi: 10.3324/haematol.2018.196725. Epub 2018 Oct 11.

2.

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

Tarvin RD, Borghese CM, Sachs W, Santos JC, Lu Y, O'Connell LA, Cannatella DC, Harris RA, Zakon HH.

Science. 2017 Sep 22;357(6357):1261-1266. doi: 10.1126/science.aan5061.

3.

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.

Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B.

Sci Rep. 2017 Jul 24;7(1):6230. doi: 10.1038/s41598-017-05966-x.

4.

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.

Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA.

Neuropharmacology. 2017 Sep 1;123:201-209. doi: 10.1016/j.neuropharm.2017.06.013. Epub 2017 Jun 13.

5.

Self-assembling nanoparticles encapsulating zoledronic acid inhibit mesenchymal stromal cells differentiation, migration and secretion of proangiogenic factors and their interactions with prostate cancer cells.

Borghese C, Casagrande N, Pivetta E, Colombatti A, Boccellino M, Amler E, Normanno N, Caraglia M, De Rosa G, Aldinucci D.

Oncotarget. 2017 Jun 27;8(26):42926-42938. doi: 10.18632/oncotarget.17216.

6.

New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status.

Altaf M, Monim-Ul-Mehboob M, Kawde AN, Corona G, Larcher R, Ogasawara M, Casagrande N, Celegato M, Borghese C, Siddik ZH, Aldinucci D, Isab AA.

Oncotarget. 2017 Jan 3;8(1):490-505. doi: 10.18632/oncotarget.13448.

7.

Clinical-grade quality platelet-rich plasma releasate (PRP-R/SRGF) from CaCl2 -activated platelet concentrates promoted expansion of mesenchymal stromal cells.

Borghese C, Agostini F, Durante C, Colombatti A, Mazzucato M, Aldinucci D.

Vox Sang. 2016 Aug;111(2):197-205. doi: 10.1111/vox.12405. Epub 2016 Apr 14.

PMID:
27077937
8.

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.

Borghese CM, Ruiz CI, Lee US, Cullins MA, Bertaccini EJ, Trudell JR, Harris RA.

ACS Chem Neurosci. 2016 Jan 20;7(1):100-8. doi: 10.1021/acschemneuro.5b00246. Epub 2015 Nov 25.

9.

Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma.

Celegato M, Borghese C, Casagrande N, Mongiat M, Kahle XU, Paulitti A, Spina M, Colombatti A, Aldinucci D.

Blood. 2015 Sep 10;126(11):1394-7. doi: 10.1182/blood-2015-07-660365. Epub 2015 Jul 30. No abstract available.

10.

The molecular pharmacology of volatile anesthetics.

Borghese CM.

Int Anesthesiol Clin. 2015 Spring;53(2):28-39. doi: 10.1097/AIA.0000000000000060. Review. No abstract available.

11.

Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer.

Casagrande N, Celegato M, Borghese C, Mongiat M, Colombatti A, Aldinucci D.

Clin Cancer Res. 2014 Nov 1;20(21):5496-506. doi: 10.1158/1078-0432.CCR-14-0713. Epub 2014 Sep 17.

12.

Preclinical activity of multiple-target gold(III)-dithiocarbamato peptidomimetics in prostate cancer cells and xenografts.

Celegato M, Fregona D, Mongiat M, Ronconi L, Borghese C, Canzonieri V, Casagrande N, Nardon C, Colombatti A, Aldinucci D.

Future Med Chem. 2014 Jul;6(11):1249-63. doi: 10.4155/fmc.14.81.

PMID:
25162999
13.

The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.

Celegato M, Borghese C, Umezawa K, Casagrande N, Colombatti A, Carbone A, Aldinucci D.

Cancer Lett. 2014 Jul 10;349(1):26-34. doi: 10.1016/j.canlet.2014.03.030. Epub 2014 Apr 2.

PMID:
24704296
14.

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, Hanrahan JR, Johnston GA, Chebib M, Harris RA.

PLoS One. 2014 Jan 16;9(1):e85525. doi: 10.1371/journal.pone.0085525. eCollection 2014.

15.

GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.

Borghese CM, Hicks JA, Lapid DJ, Trudell JR, Harris RA.

J Neurochem. 2014 Feb;128(3):363-75. doi: 10.1111/jnc.12476. Epub 2013 Oct 28.

16.

Preclinical evaluation of a new liposomal formulation of cisplatin, lipoplatin, to treat cisplatin-resistant cervical cancer.

Casagrande N, De Paoli M, Celegato M, Borghese C, Mongiat M, Colombatti A, Aldinucci D.

Gynecol Oncol. 2013 Dec;131(3):744-52. doi: 10.1016/j.ygyno.2013.08.041. Epub 2013 Sep 10.

PMID:
24029417
17.

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA.

Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15.

18.

Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts.

Celegato M, Borghese C, Casagrande N, Carbone A, Colombatti A, Aldinucci D.

Leuk Lymphoma. 2014 Jan;55(1):149-59. doi: 10.3109/10428194.2013.800196. Epub 2013 Jun 12.

PMID:
23647062
19.

Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity.

Borghese C, Cattaruzza L, Pivetta E, Normanno N, De Luca A, Mazzucato M, Celegato M, Colombatti A, Aldinucci D.

J Cell Biochem. 2013 May;114(5):1135-44. doi: 10.1002/jcb.24456.

PMID:
23192362
20.
21.

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA.

Anesthesiology. 2012 Oct;117(4):765-71.

22.

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.

23.

Pitfalling in nanomedical targeting of melanoma: a 'clinical' case of misdelivered RNAi.

Perris R, Borghese C, Magro G.

Pigment Cell Melanoma Res. 2011 Oct;24(5):980-2; author reply 983-5. doi: 10.1111/j.1755-148X.2011.00888.x. No abstract available.

PMID:
21762469
24.

IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion.

Aldinucci D, Celegato M, Borghese C, Colombatti A, Carbone A.

Br J Haematol. 2011 Jan;152(2):182-90. doi: 10.1111/j.1365-2141.2010.08497.x. Epub 2010 Nov 28.

PMID:
21114485
25.

Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2011 Jan;336(1):145-54. doi: 10.1124/jpet.110.171645. Epub 2010 Sep 27.

26.

A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.

McCracken ML, Borghese CM, Trudell JR, Harris RA.

J Pharmacol Exp Ther. 2010 Dec;335(3):600-6. doi: 10.1124/jpet.110.170472. Epub 2010 Sep 8.

27.

Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.

Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI 2nd, Harrison NL, Harris RA, Homanics GE.

J Pharmacol Exp Ther. 2011 Jan;336(1):134-44. doi: 10.1124/jpet.110.170431. Epub 2010 Aug 31.

28.

Anti-brain antibodies in adult patients with obsessive-compulsive disorder.

Maina G, Albert U, Bogetto F, Borghese C, Berro AC, Mutani R, Rossi F, Vigliani MC.

J Affect Disord. 2009 Aug;116(3):192-200. doi: 10.1016/j.jad.2008.11.019. Epub 2009 Jan 12.

29.

Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes.

Reilly MT, Lobo IA, McCracken LM, Borghese CM, Gong D, Horishita T, Harris RA.

Alcohol Clin Exp Res. 2008 Feb;32(2):188-96. doi: 10.1111/j.1530-0277.2007.00569.x.

30.
31.

An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.

Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL 2nd, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL.

J Pharmacol Exp Ther. 2006 Oct;319(1):208-18. Epub 2006 Jun 28.

PMID:
16807363
32.

Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol.

Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE.

J Pharmacol Exp Ther. 2006 Oct;319(1):219-27. Epub 2006 Jun 19.

PMID:
16785315
33.

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA.

J Pharmacol Exp Ther. 2006 Mar;316(3):1360-8. Epub 2005 Nov 4.

PMID:
16272217
34.

Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI 2nd.

Anesth Analg. 2005 Aug;101(2):412-8, table of contents.

PMID:
16037154
35.

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

Borghese CM, Henderson LA, Bleck V, Trudell JR, Harris RA.

J Pharmacol Exp Ther. 2003 Oct;307(1):42-52. Erratum in: J Pharmacol Exp Ther. 2004 Apr;309(1):439.

PMID:
14500778
36.

Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action.

Borghese CM, Wang L, Bleck V, Harris RA.

Addict Biol. 2003 Sep;8(3):313-8.

PMID:
13129833
37.

Differential expression of mucins 1-6 in papillary thyroid carcinoma: evidence for transformation-dependent post-translational modifications of MUC1 in situ.

Magro G, Schiappacassi M, Perissinotto D, Corsaro A, Borghese C, Belfiore A, Colombatti A, Grasso S, Botti C, Bombardieri E, Perris R.

J Pathol. 2003 Jul;200(3):357-69.

PMID:
12845632
38.

Inhaled drugs of abuse enhance serotonin-3 receptor function.

Lopreato GF, Phelan R, Borghese CM, Beckstead MJ, Mihic SJ.

Drug Alcohol Depend. 2003 May 1;70(1):11-5.

PMID:
12681521
39.

Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.

Borghese CM, Ali DN, Bleck V, Harris RA.

Alcohol Clin Exp Res. 2002 Dec;26(12):1764-72.

PMID:
12500099
40.

Anesthetic-induced immobility: neuronal nicotinic acetylcholine receptors are no longer in the picture.

Borghese CM, Harris RA.

Anesth Analg. 2002 Sep;95(3):509-11. No abstract available.

PMID:
12198026
41.

Does acetaldehyde mediate ethanol action in the central nervous system?

Mascia MP, Maiya R, Borghese CM, Lobo IA, Hara K, Yamakura T, Gong DH, Beckstead MJ.

Alcohol Clin Exp Res. 2001 Nov;25(11):1570-5.

PMID:
11707631
42.
43.

Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats.

Borghese CM, Córdoba NE, Laino CH, Orsingher OA, Rubio MC, Niselman V.

Brain Res Bull. 1998 Jun;46(3):237-44.

PMID:
9667818
44.

Chronic Diazepam Administration Failed to Induce Tolerance and Withdrawal Syndrome in Perinatally Undernourished Female Rats as Measured in the Open Field Drink Test.

Borghese CM, Córdoba NE, Arolfo MP, Orsingher OA.

Nutr Neurosci. 1998;1(6):427-37. doi: 10.1080/1028415X.1998.11747253.

PMID:
27406550
45.

Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats.

Cordoba NE, Borghese CM, Arolfo MP, Orsingher OA.

Pharmacol Biochem Behav. 1997 Aug;57(4):659-63.

PMID:
9258991
46.

Phosphatidylserine increases hippocampal synaptic efficacy.

Borghese CM, Gómez RA, Ramírez OA.

Brain Res Bull. 1993;31(6):697-700.

PMID:
8100181
47.

The learning capacity of high or low performance rats is related to the hippocampus NMDA receptors.

Keller EA, Borghese CM, Carrer HF, Ramirez OA.

Brain Res. 1992 Mar 27;576(1):162-4.

PMID:
1355386

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