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Items: 9


Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.

Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka AH, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma'ayan A, Greally JM, Frenette PS.

Nat Cell Biol. 2019 May;21(5):560-567. doi: 10.1038/s41556-019-0308-3. Epub 2019 Apr 15.


Induced pluripotent stem cell models of lysosomal storage disorders.

Borger DK, McMahon B, Roshan Lal T, Serra-Vinardell J, Aflaki E, Sidransky E.

Dis Model Mech. 2017 Jun 1;10(6):691-704. doi: 10.1242/dmm.029009. Review.


Efferocytosis is impaired in Gaucher macrophages.

Aflaki E, Borger DK, Grey RJ, Kirby M, Anderson S, Lopez G, Sidransky E.

Haematologica. 2017 Apr;102(4):656-665. doi: 10.3324/haematol.2016.155093. Epub 2016 Dec 23.


A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.

Aflaki E, Borger DK, Moaven N, Stubblefield BK, Rogers SA, Patnaik S, Schoenen FJ, Westbroek W, Zheng W, Sullivan P, Fujiwara H, Sidhu R, Khaliq ZM, Lopez GJ, Goldstein DS, Ory DS, Marugan J, Sidransky E.

J Neurosci. 2016 Jul 13;36(28):7441-52. doi: 10.1523/JNEUROSCI.0636-16.2016.


Once again, rare diseases provide a spotlight.

Lal TR, Borger DK, Sidransky E.

Mol Genet Metab. 2016 May;118(1):1-2. doi: 10.1016/j.ymgme.2016.03.002. Epub 2016 Mar 5. No abstract available.


Varied autopsy findings in five treated patients with Gaucher disease and parkinsonism include the absence of Gaucher cells.

Monestime G, Borger DK, Kim J, Lopez G, Allgaeuer M, Jain D, Vortmeyer A, Wang HW, Sidransky E.

Mol Genet Metab. 2016 May;118(1):55-9. doi: 10.1016/j.ymgme.2016.02.008. Epub 2016 Feb 28.


Applications of iPSC-derived models of Gaucher disease.

Borger DK, Aflaki E, Sidransky E.

Ann Transl Med. 2015 Nov;3(19):295. doi: 10.3978/j.issn.2305-5839.2015.10.41. No abstract available.


Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.

Aflaki E, Moaven N, Borger DK, Lopez G, Westbroek W, Chae JJ, Marugan J, Patnaik S, Maniwang E, Gonzalez AN, Sidransky E.

Aging Cell. 2016 Feb;15(1):77-88. doi: 10.1111/acel.12409. Epub 2015 Oct 21.


New macrophage models of Gaucher disease offer new tools for drug development.

Borger DK, Sidransky E, Aflaki E.

Macrophage (Houst). 2015;2(1):e712.

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