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Microfluidic Model for Evaluation of Immune Checkpoint Inhibitors in Human Tumors.

Beckwith AL, Velásquez-García LF, Borenstein JT.

Adv Healthc Mater. 2019 Jun;8(11):e1900289. doi: 10.1002/adhm.201900289. Epub 2019 May 6.


Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition.

Ayoob AM, Peppi M, Tandon V, Langer R, Borenstein JT.

Eur J Pharm Sci. 2019 Jan 1;126:49-58. doi: 10.1016/j.ejps.2018.09.007. Epub 2018 Sep 7.


Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions.

Bale SS, Borenstein JT.

Drug Metab Dispos. 2018 Nov;46(11):1638-1646. doi: 10.1124/dmd.118.083055. Epub 2018 Aug 16. Review.


A multiplexed microfluidic system for evaluation of dynamics of immune-tumor interactions.

Moore N, Doty D, Zielstorff M, Kariv I, Moy LY, Gimbel A, Chevillet JR, Lowry N, Santos J, Mott V, Kratchman L, Lau T, Addona G, Chen H, Borenstein JT.

Lab Chip. 2018 Jun 26;18(13):1844-1858. doi: 10.1039/c8lc00256h.


A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery.

Ayoob AM, Peppi M, Tandon V, Langer R, Borenstein JT.

Hear Res. 2018 Oct;368:41-48. doi: 10.1016/j.heares.2018.03.026. Epub 2018 Apr 5.


Intracochlear drug delivery systems: a novel approach whose time has come.

Peppi M, Marie A, Belline C, Borenstein JT.

Expert Opin Drug Deliv. 2018 Apr;15(4):319-324. doi: 10.1080/17425247.2018.1444026. Epub 2018 Mar 9. No abstract available.


A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.

Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK.

Nat Commun. 2017 Mar 28;8:14584. doi: 10.1038/ncomms14584.


Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks.

Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG.

Adv Mater. 2017 May;29(19). doi: 10.1002/adma.201605947. Epub 2017 Mar 15.


A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control.

Coppeta JR, Mescher MJ, Isenberg BC, Spencer AJ, Kim ES, Lever AR, Mulhern TJ, Prantil-Baun R, Comolli JC, Borenstein JT.

Lab Chip. 2016 Dec 20;17(1):134-144.


A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury.

Hoganson DM, Finkelstein EB, Owens GE, Hsiao JC, Eng KY, Kulig KM, Kim ES, Kniazeva T, Pomerantseva I, Neville CM, Turk JR, Fermini B, Borenstein JT, Vacanti JP.

Biomicrofluidics. 2016 Oct 12;10(5):054116. eCollection 2016 Sep.


Development of a biomimetic microfluidic oxygen transfer device.

Gimbel AA, Flores E, Koo A, García-Cardeña G, Borenstein JT.

Lab Chip. 2016 Aug 16;16(17):3227-34. doi: 10.1039/c6lc00641h.


Organs-on-Chips: How Microsystems Technology Can Transform the Drug Development Process.

Borenstein JT.

IEEE Pulse. 2016 Mar-Apr;7(2):22-6. doi: 10.1109/MPUL.2015.2513722.


Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing.

Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, Sewell WF, Borenstein JT.

Lab Chip. 2016 Mar 7;16(5):829-46. doi: 10.1039/c5lc01396h.


Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model.

Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR.

Drug Metab Dispos. 2016 Feb;44(2):220-6. doi: 10.1124/dmd.115.066365. Epub 2015 Nov 19.


Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model.

Lever AR, Park H, Mulhern TJ, Jackson GR, Comolli JC, Borenstein JT, Hayden PJ, Prantil-Baun R.

Physiol Rep. 2015 Apr;3(4). pii: e12334. doi: 10.14814/phy2.12334.


Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform.

Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT.

Biomed Microdevices. 2015 Apr;17(2):37. doi: 10.1007/s10544-014-9923-8.


The role of intracochlear drug delivery devices in the management of inner ear disease.

Ayoob AM, Borenstein JT.

Expert Opin Drug Deliv. 2015 Mar;12(3):465-79. doi: 10.1517/17425247.2015.974548. Epub 2014 Oct 27. Review.


A microphysiological system model of therapy for liver micrometastases.

Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A.

Exp Biol Med (Maywood). 2014 Sep;239(9):1170-9. doi: 10.1177/1535370214532596. Epub 2014 May 12. Review.


Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT.

Drug Discov Today. 2014 Jun;19(6):754-62. doi: 10.1016/j.drudis.2014.04.017. Epub 2014 May 2. Review.


All-human microphysical model of metastasis therapy.

Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C.

Stem Cell Res Ther. 2013;4 Suppl 1:S11. doi: 10.1186/scrt372. Epub 2013 Dec 20. Review.


A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control.

Kim ES, Gustenhoven E, Mescher MJ, Pararas EE, Smith KA, Spencer AJ, Tandon V, Borenstein JT, Fiering J.

Lab Chip. 2014 Feb 21;14(4):710-21. doi: 10.1039/c3lc51105g.


Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation.

Pereira MJ, Sundback CA, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao SL, McHugh K, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ, Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos PT.

Adv Healthc Mater. 2014 Apr;3(4):565-71. doi: 10.1002/adhm.201300264. Epub 2013 Sep 18.


Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers.

Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL.

Lab Chip. 2013 Jun 21;13(12):2311-9. doi: 10.1039/c3lc50199j. Epub 2013 May 2.


Fully biodegradable airway stents using amino alcohol-based poly(ester amide) elastomers.

Wang J, Boutin KG, Abdulhadi O, Personnat LD, Shazly T, Langer R, Channick CL, Borenstein JT.

Adv Healthc Mater. 2013 Oct;2(10):1329-36. doi: 10.1002/adhm.201200348. Epub 2013 Mar 25.


Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

Bellan LM, Kniazeva T, Kim ES, Epshteyn AA, Cropek DM, Langer R, Borenstein JT.

Adv Healthc Mater. 2012 Mar;1(2):164-7.


Membrane-integrated microfluidic device for high-resolution live cell imaging.

Epshteyn AA, Maher S, Taylor AJ, Holton AB, Borenstein JT, Cuiffi JD.

Biomicrofluidics. 2011 Dec;5(4):46501-465016. doi: 10.1063/1.3647824. Epub 2011 Oct 17.


Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device.

Kniazeva T, Epshteyn AA, Hsiao JC, Kim ES, Kolachalama VB, Charest JL, Borenstein JT.

Lab Chip. 2012 May 7;12(9):1686-95. doi: 10.1039/c2lc21156d. Epub 2012 Mar 14.


Microsystems technologies for drug delivery to the inner ear.

Pararas EE, Borkholder DA, Borenstein JT.

Adv Drug Deliv Rev. 2012 Nov;64(14):1650-60. doi: 10.1016/j.addr.2012.02.004. Epub 2012 Feb 21. Review.


A nanofiber membrane maintains the quiescent phenotype of hepatic stellate cells.

Eda H, Kulig KM, Steiner TA, Shimada H, Patel K, Park E, Kim ES, Borenstein JT, Neville CM, Keller BT.

Dig Dis Sci. 2012 May;57(5):1152-62. doi: 10.1007/s10620-012-2084-9. Epub 2012 Feb 23.


Evaluation of tissue interactions with mechanical elements of a transscleral drug delivery device.

Cohen SJ, Chan RV, Keegan M, Andreoli CM, Borenstein JT, Miller JW, Gragoudas ES.

Pharmaceutics. 2012 Mar 12;4(1):212-29. doi: 10.3390/pharmaceutics4010212.


Engineering tissue with BioMEMS.

Borenstein JT, Vunjak-Novakovic G.

IEEE Pulse. 2011 Nov;2(6):28-34. doi: 10.1109/MPUL.2011.942764.


Transport and shear in a microfluidic membrane bilayer device for cell culture.

Inamdar NK, Griffith LG, Borenstein JT.

Biomicrofluidics. 2011 Jun;5(2):22213. doi: 10.1063/1.3576925. Epub 2011 Jun 29.


Microfluidic cell culture models for tissue engineering.

Inamdar NK, Borenstein JT.

Curr Opin Biotechnol. 2011 Oct;22(5):681-9. doi: 10.1016/j.copbio.2011.05.512. Epub 2011 Jun 30. Review.


Intracochlear drug delivery systems.

Borenstein JT.

Expert Opin Drug Deliv. 2011 Sep;8(9):1161-74. doi: 10.1517/17425247.2011.588207. Epub 2011 May 26. Review.


Kinetics of reciprocating drug delivery to the inner ear.

Pararas EE, Chen Z, Fiering J, Mescher MJ, Kim ES, McKenna MJ, Kujawa SG, Borenstein JT, Sewell WF.

J Control Release. 2011 Jun 10;152(2):270-7. doi: 10.1016/j.jconrel.2011.02.021. Epub 2011 Mar 6.


Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers.

Wang J, Bettinger CJ, Langer RS, Borenstein JT.

Organogenesis. 2010 Oct-Dec;6(4):212-6. doi: 10.4161/org.6.4.12909.


A microfluidic respiratory assist device with high gas permeance for artificial lung applications.

Kniazeva T, Hsiao JC, Charest JL, Borenstein JT.

Biomed Microdevices. 2011 Apr;13(2):315-23. doi: 10.1007/s10544-010-9495-1.


Advanced material strategies for tissue engineering scaffolds.

Freed LE, Engelmayr GC Jr, Borenstein JT, Moutos FT, Guilak F.

Adv Mater. 2009 Sep 4;21(32-33):3410-8. doi: 10.1002/adma.200900303. No abstract available.


Liver-assist device with a microfluidics-based vascular bed in an animal model.

Hsu WM, Carraro A, Kulig KM, Miller ML, Kaazempur-Mofrad M, Weinberg E, Entabi F, Albadawi H, Watkins MT, Borenstein JT, Vacanti JP, Neville C.

Ann Surg. 2010 Aug;252(2):351-7. doi: 10.1097/SLA.0b013e3181e982ba.


Branched vascular network architecture: a new approach to lung assist device technology.

Hoganson DM, Anderson JL, Weinberg EF, Swart E, Orrick BK, Borenstein JT, Vacanti JP.

J Thorac Cardiovasc Surg. 2010 Nov;140(5):990-5. doi: 10.1016/j.jtcvs.2010.02.062. Epub 2010 Jun 29. Erratum in: J Thorac Cardiovasc Surg. 2014 Oct;148(4):1773. Swart, Eric J [Corrected to Swart, Eric].


Drug delivery for treatment of inner ear disease: current state of knowledge.

McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ.

Ear Hear. 2010 Apr;31(2):156-65. doi: 10.1097/AUD.0b013e3181c351f2. Review.


Pulmonary tissue engineering using dual-compartment polymer scaffolds with integrated vascular tree.

Fritsche CS, Simsch O, Weinberg EJ, Orrick B, Stamm C, Kaazempur-Mofrad MR, Borenstein JT, Hetzer R, Vacanti JP.

Int J Artif Organs. 2009 Oct;32(10):701-10.


Development of a microfluidics-based intracochlear drug delivery device.

Sewell WF, Borenstein JT, Chen Z, Fiering J, Handzel O, Holmboe M, Kim ES, Kujawa SG, McKenna MJ, Mescher MM, Murphy B, Swan EE, Peppi M, Tao S.

Audiol Neurootol. 2009;14(6):411-22. doi: 10.1159/000241898. Epub 2009 Nov 16.


Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate.

Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, García-Cardeña G.

Biomed Microdevices. 2010 Feb;12(1):71-9. doi: 10.1007/s10544-009-9361-1.


Engineering substrate topography at the micro- and nanoscale to control cell function.

Bettinger CJ, Langer R, Borenstein JT.

Angew Chem Int Ed Engl. 2009;48(30):5406-15. doi: 10.1002/anie.200805179. Review.


Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System.

Mescher MJ, Swan EE, Fiering J, Holmboe ME, Sewell WF, Kujawa SG, McKenna MJ, Borenstein JT.

J Microelectromech Syst. 2009 Jun 1;18(3):501-510.


Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices.

Handzel O, Wang H, Fiering J, Borenstein JT, Mescher MJ, Swan EE, Murphy BA, Chen Z, Peppi M, Sewell WF, Kujawa SG, McKenna MJ.

Audiol Neurootol. 2009;14(5):308-14. doi: 10.1159/000212110. Epub 2009 Apr 15.


Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering.

Bettinger CJ, Bruggeman JP, Misra A, Borenstein JT, Langer R.

Biomaterials. 2009 Jun;30(17):3050-7. doi: 10.1016/j.biomaterials.2009.02.018. Epub 2009 Mar 14.


Rapid generation of spatially and temporally controllable long-range concentration gradients in a microfluidic device.

Du Y, Shim J, Vidula M, Hancock MJ, Lo E, Chung BG, Borenstein JT, Khabiry M, Cropek DM, Khademhosseini A.

Lab Chip. 2009 Mar 21;9(6):761-7. doi: 10.1039/b815990d. Epub 2008 Dec 10.


In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers.

Bettinger CJ, Bruggeman JP, Borenstein JT, Langer R.

J Biomed Mater Res A. 2009 Dec 15;91(4):1077-88. doi: 10.1002/jbm.a.32306.


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