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Items: 1 to 50 of 135


Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition.

Ayoob AM, Peppi M, Tandon V, Langer R, Borenstein JT.

Eur J Pharm Sci. 2018 Sep 7. pii: S0928-0987(18)30422-6. doi: 10.1016/j.ejps.2018.09.007. [Epub ahead of print]


Microfluidic cell culture platforms to capture hepatic physiology and complex cellular interactions.

Bale SS, Borenstein JT.

Drug Metab Dispos. 2018 Aug 16. pii: dmd.118.083055. doi: 10.1124/dmd.118.083055. [Epub ahead of print]


Promoting Wellness in Older Adults with Mental Illnesses and Substance Use Disorders: Call to Action to All Stakeholders.

Jeste DV, Peschin S, Buckwalter K, Blazer DG, McGuire MH, Moutier C, Doederlein A, Niederehe G, Altman B, Borenstein J, Saks E, Norquist G, Koob GF, Compton WM, Sperling A, Bain L, Glorioso D, Paul IH, Reynolds CF 3rd.

Am J Geriatr Psychiatry. 2018 Jun;26(6):617-630. doi: 10.1016/j.jagp.2018.03.011. Epub 2018 Apr 26. No abstract available.


A multiplexed microfluidic system for evaluation of dynamics of immune-tumor interactions.

Moore N, Doty D, Zielstorff M, Kariv I, Moy LY, Gimbel A, Chevillet JR, Lowry N, Santos J, Mott V, Kratchman L, Lau T, Addona G, Chen H, Borenstein JT.

Lab Chip. 2018 Jun 26;18(13):1844-1858. doi: 10.1039/c8lc00256h.


A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery.

Ayoob AM, Peppi M, Tandon V, Langer R, Borenstein JT.

Hear Res. 2018 Oct;368:41-48. doi: 10.1016/j.heares.2018.03.026. Epub 2018 Apr 5.


Intracochlear drug delivery systems: a novel approach whose time has come.

Peppi M, Marie A, Belline C, Borenstein JT.

Expert Opin Drug Deliv. 2018 Apr;15(4):319-324. doi: 10.1080/17425247.2018.1444026. Epub 2018 Mar 9. No abstract available.


Systems Addressing Frail Elder Care: Description of a Successful Model.

Ansryan LZ, Aronow HU, Borenstein JE, Mena V, Haus F, Palmer K, Chan E, Swanson JW, Mass S, Rosen B, Braunstein GD, Burnes Bolton L.

J Nurs Adm. 2018 Jan;48(1):11-17. doi: 10.1097/NNA.0000000000000564. Review.


Self-Driving Cars and Engineering Ethics: The Need for a System Level Analysis.

Borenstein J, Herkert JR, Miller KW.

Sci Eng Ethics. 2017 Nov 13. doi: 10.1007/s11948-017-0006-0. [Epub ahead of print]


The Ugly Truth About Ourselves and Our Robot Creations: The Problem of Bias and Social Inequity.

Howard A, Borenstein J.

Sci Eng Ethics. 2017 Sep 21. doi: 10.1007/s11948-017-9975-2. [Epub ahead of print]


A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.

Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK.

Nat Commun. 2017 Mar 28;8:14584. doi: 10.1038/ncomms14584.


Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks.

Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG.

Adv Mater. 2017 May;29(19). doi: 10.1002/adma.201605947. Epub 2017 Mar 15.


A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control.

Coppeta JR, Mescher MJ, Isenberg BC, Spencer AJ, Kim ES, Lever AR, Mulhern TJ, Prantil-Baun R, Comolli JC, Borenstein JT.

Lab Chip. 2016 Dec 20;17(1):134-144.


A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury.

Hoganson DM, Finkelstein EB, Owens GE, Hsiao JC, Eng KY, Kulig KM, Kim ES, Kniazeva T, Pomerantseva I, Neville CM, Turk JR, Fermini B, Borenstein JT, Vacanti JP.

Biomicrofluidics. 2016 Oct 12;10(5):054116. eCollection 2016 Sep.


Development of a biomimetic microfluidic oxygen transfer device.

Gimbel AA, Flores E, Koo A, García-Cardeña G, Borenstein JT.

Lab Chip. 2016 Aug 16;16(17):3227-34. doi: 10.1039/c6lc00641h.


Organs-on-Chips: How Microsystems Technology Can Transform the Drug Development Process.

Borenstein JT.

IEEE Pulse. 2016 Mar-Apr;7(2):22-6. doi: 10.1109/MPUL.2015.2513722.


Identification and team-based interprofessional management of hospitalized vulnerable older adults.

Borenstein JE, Aronow HU, Bolton LB, Dimalanta MI, Chan E, Palmer K, Zhang X, Rosen B, Braunstein GD.

Nurs Outlook. 2016 Mar-Apr;64(2):137-145. doi: 10.1016/j.outlook.2015.11.014. Epub 2015 Nov 22.


Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing.

Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, Sewell WF, Borenstein JT.

Lab Chip. 2016 Mar 7;16(5):829-46. doi: 10.1039/c5lc01396h.


Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model.

Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR.

Drug Metab Dispos. 2016 Feb;44(2):220-6. doi: 10.1124/dmd.115.066365. Epub 2015 Nov 19.


Rethinking authorship in the era of collaborative research.

Borenstein J, Shamoo AE.

Account Res. 2015;22(5):267-83. doi: 10.1080/08989621.2014.968277.


Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model.

Lever AR, Park H, Mulhern TJ, Jackson GR, Comolli JC, Borenstein JT, Hayden PJ, Prantil-Baun R.

Physiol Rep. 2015 Apr;3(4). pii: e12334. doi: 10.14814/phy2.12334.


Robotic Nudges: The Ethics of Engineering a More Socially Just Human Being.

Borenstein J, Arkin R.

Sci Eng Ethics. 2016 Feb;22(1):31-46. doi: 10.1007/s11948-015-9636-2. Epub 2015 Mar 4.


Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform.

Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT.

Biomed Microdevices. 2015 Apr;17(2):37. doi: 10.1007/s10544-014-9923-8.


The role of intracochlear drug delivery devices in the management of inner ear disease.

Ayoob AM, Borenstein JT.

Expert Opin Drug Deliv. 2015 Mar;12(3):465-79. doi: 10.1517/17425247.2015.974548. Epub 2014 Oct 27. Review.


Validating SPICES as a Screening Tool for Frailty Risks among Hospitalized Older Adults.

Aronow HU, Borenstein J, Haus F, Braunstein GD, Bolton LB.

Nurs Res Pract. 2014;2014:846759. doi: 10.1155/2014/846759. Epub 2014 Apr 27.


A microphysiological system model of therapy for liver micrometastases.

Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A.

Exp Biol Med (Maywood). 2014 Sep;239(9):1170-9. doi: 10.1177/1535370214532596. Epub 2014 May 12. Review.


Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT.

Drug Discov Today. 2014 Jun;19(6):754-62. doi: 10.1016/j.drudis.2014.04.017. Epub 2014 May 2. Review.


All-human microphysical model of metastasis therapy.

Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C.

Stem Cell Res Ther. 2013;4 Suppl 1:S11. doi: 10.1186/scrt372. Epub 2013 Dec 20. Review.


A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control.

Kim ES, Gustenhoven E, Mescher MJ, Pararas EE, Smith KA, Spencer AJ, Tandon V, Borenstein JT, Fiering J.

Lab Chip. 2014 Feb 21;14(4):710-21. doi: 10.1039/c3lc51105g.


Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation.

Pereira MJ, Sundback CA, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao SL, McHugh K, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ, Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos PT.

Adv Healthc Mater. 2014 Apr;3(4):565-71. doi: 10.1002/adhm.201300264. Epub 2013 Sep 18.


Early recognition of risk factors for adverse outcomes during hospitalization among Medicare patients: a prospective cohort study.

Borenstein J, Aronow HU, Bolton LB, Choi J, Bresee C, Braunstein GD.

BMC Geriatr. 2013 Jul 8;13:72. doi: 10.1186/1471-2318-13-72.


Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers.

Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL.

Lab Chip. 2013 Jun 21;13(12):2311-9. doi: 10.1039/c3lc50199j. Epub 2013 May 2.


Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood.

Zhang Z, Borenstein J, Guiney L, Miller R, Sukavaneshvar S, Loose C.

Lab Chip. 2013 May 21;13(10):1963-8. doi: 10.1039/c3lc50302j. Epub 2013 Apr 5.


Fully biodegradable airway stents using amino alcohol-based poly(ester amide) elastomers.

Wang J, Boutin KG, Abdulhadi O, Personnat LD, Shazly T, Langer R, Channick CL, Borenstein JT.

Adv Healthc Mater. 2013 Oct;2(10):1329-36. doi: 10.1002/adhm.201200348. Epub 2013 Mar 25.


Understanding ill-structured engineering ethics problems through a collaborative learning and argument visualization approach.

Hoffmann M, Borenstein J.

Sci Eng Ethics. 2014 Mar;20(1):261-76. doi: 10.1007/s11948-013-9430-y. Epub 2013 Feb 19.


Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

Bellan LM, Kniazeva T, Kim ES, Epshteyn AA, Cropek DM, Langer R, Borenstein JT.

Adv Healthc Mater. 2012 Mar;1(2):164-7.


Membrane-integrated microfluidic device for high-resolution live cell imaging.

Epshteyn AA, Maher S, Taylor AJ, Holton AB, Borenstein JT, Cuiffi JD.

Biomicrofluidics. 2011 Dec;5(4):46501-465016. doi: 10.1063/1.3647824. Epub 2011 Oct 17.


Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device.

Kniazeva T, Epshteyn AA, Hsiao JC, Kim ES, Kolachalama VB, Charest JL, Borenstein JT.

Lab Chip. 2012 May 7;12(9):1686-95. doi: 10.1039/c2lc21156d. Epub 2012 Mar 14.


Contentious problems in bioscience and biotechnology: a pilot study of an approach to ethics education.

Berry RM, Borenstein J, Butera RJ.

Sci Eng Ethics. 2013 Jun;19(2):653-68. doi: 10.1007/s11948-012-9359-6. Epub 2012 Mar 3.


Microsystems technologies for drug delivery to the inner ear.

Pararas EE, Borkholder DA, Borenstein JT.

Adv Drug Deliv Rev. 2012 Nov;64(14):1650-60. doi: 10.1016/j.addr.2012.02.004. Epub 2012 Feb 21. Review.


A nanofiber membrane maintains the quiescent phenotype of hepatic stellate cells.

Eda H, Kulig KM, Steiner TA, Shimada H, Patel K, Park E, Kim ES, Borenstein JT, Neville CM, Keller BT.

Dig Dis Sci. 2012 May;57(5):1152-62. doi: 10.1007/s10620-012-2084-9. Epub 2012 Feb 23.


Evaluation of tissue interactions with mechanical elements of a transscleral drug delivery device.

Cohen SJ, Chan RV, Keegan M, Andreoli CM, Borenstein JT, Miller JW, Gragoudas ES.

Pharmaceutics. 2012 Mar 12;4(1):212-29. doi: 10.3390/pharmaceutics4010212.


Development, reliability, and validity of a new Preference and Satisfaction Questionnaire.

Gold DT, Horne R, Coon CD, Price MA, Borenstein J, Varon SF, Satram-Hoang S, Macarios D.

Value Health. 2011 Dec;14(8):1109-16. doi: 10.1016/j.jval.2011.06.010. Epub 2011 Oct 1.


Engineering tissue with BioMEMS.

Borenstein JT, Vunjak-Novakovic G.

IEEE Pulse. 2011 Nov;2(6):28-34. doi: 10.1109/MPUL.2011.942764.


Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women.

Freemantle N, Satram-Hoang S, Tang ET, Kaur P, Macarios D, Siddhanti S, Borenstein J, Kendler DL; DAPS Investigators.

Osteoporos Int. 2012 Jan;23(1):317-26. doi: 10.1007/s00198-011-1780-1. Epub 2011 Sep 17.


The intervention of robot caregivers and the cultivation of children's capability to play.

Pearson Y, Borenstein J.

Sci Eng Ethics. 2013 Mar;19(1):123-37. doi: 10.1007/s11948-011-9309-8. Epub 2011 Sep 15.


Transport and shear in a microfluidic membrane bilayer device for cell culture.

Inamdar NK, Griffith LG, Borenstein JT.

Biomicrofluidics. 2011 Jun;5(2):22213. doi: 10.1063/1.3576925. Epub 2011 Jun 29.


Microfluidic cell culture models for tissue engineering.

Inamdar NK, Borenstein JT.

Curr Opin Biotechnol. 2011 Oct;22(5):681-9. doi: 10.1016/j.copbio.2011.05.512. Epub 2011 Jun 30. Review.


Intracochlear drug delivery systems.

Borenstein JT.

Expert Opin Drug Deliv. 2011 Sep;8(9):1161-74. doi: 10.1517/17425247.2011.588207. Epub 2011 May 26. Review.


Responsible authorship in engineering fields: an overview of current ethical challenges.

Borenstein J.

Sci Eng Ethics. 2011 Jun;17(2):355-64. doi: 10.1007/s11948-011-9272-4. Epub 2011 Apr 22. Review.


Kinetics of reciprocating drug delivery to the inner ear.

Pararas EE, Chen Z, Fiering J, Mescher MJ, Kim ES, McKenna MJ, Kujawa SG, Borenstein JT, Sewell WF.

J Control Release. 2011 Jun 10;152(2):270-7. doi: 10.1016/j.jconrel.2011.02.021. Epub 2011 Mar 6.

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