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Items: 1 to 50 of 72

1.

NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution.

Maszota-Zieleniak M, Jurczak P, Orlikowska M, Zhukov I, Borek D, Otwinowski Z, Skowron P, Pietralik Z, Kozak M, Szymańska A, Rodziewicz-Motowidło S.

FEBS J. 2019 Jul 22. doi: 10.1111/febs.15010. [Epub ahead of print]

PMID:
31330077
2.

Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody.

Amatya P, Wagner N, Chen G, Luthra P, Shi L, Borek D, Pavlenco A, Rohrs H, Basler CF, Sidhu SS, Gross ML, Leung DW.

ACS Infect Dis. 2019 Aug 9;5(8):1385-1396. doi: 10.1021/acsinfecdis.9b00091. Epub 2019 Jun 4.

PMID:
31120240
3.

Long-term persistence in patients with osteoporosis receiving denosumab in routine practice: 36-month non-interventional, observational study.

Borek DM, Smith RC, Gruber CN, Gruber BL.

Osteoporos Int. 2019 Jul;30(7):1455-1464. doi: 10.1007/s00198-019-04963-2. Epub 2019 Apr 22.

PMID:
31011760
4.

Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole.

Beraki T, Hu X, Broncel M, Young JC, O'Shaughnessy WJ, Borek D, Treeck M, Reese ML.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6361-6370. doi: 10.1073/pnas.1816161116. Epub 2019 Mar 8. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12111.

5.

Crystal structure of the human NK1 tachykinin receptor.

Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13264-13269. doi: 10.1073/pnas.1812717115. Epub 2018 Dec 11.

6.

The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots.

Cong Q, Li W, Borek D, Otwinowski Z, Grishin NV.

Mol Genet Genomics. 2019 Feb;294(1):211-226. doi: 10.1007/s00438-018-1494-6. Epub 2018 Oct 6.

PMID:
30293092
7.

Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli.

Valleau D, Little DJ, Borek D, Skarina T, Quaile AT, Di Leo R, Houliston S, Lemak A, Arrowsmith CH, Coombes BK, Savchenko A.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10004-10009. doi: 10.1073/pnas.1718350115. Epub 2018 Sep 14.

8.

Real-space analysis of radiation-induced specific changes with independent component analysis.

Borek D, Bromberg R, Hattne J, Otwinowski Z.

J Synchrotron Radiat. 2018 Mar 1;25(Pt 2):451-467. doi: 10.1107/S1600577517018148. Epub 2018 Feb 22.

9.

Complete Genome of Achalarus lyciades, The First Representative of the Eudaminae Subfamily of Skippers.

Shen J, Cong Q, Borek D, Otwinowski Z, Grishin NV.

Curr Genomics. 2017 Aug;18(4):366-374. doi: 10.2174/1389202918666170426113315.

10.

The first complete genomes of Metalmarks and the classification of butterfly families.

Cong Q, Shen J, Li W, Borek D, Otwinowski Z, Grishin NV.

Genomics. 2017 Oct;109(5-6):485-493. doi: 10.1016/j.ygeno.2017.07.006. Epub 2017 Jul 28.

11.

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW.

Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101.

12.

When COI barcodes deceive: complete genomes reveal introgression in hairstreaks.

Cong Q, Shen J, Borek D, Robbins RK, Opler PA, Otwinowski Z, Grishin NV.

Proc Biol Sci. 2017 Feb 8;284(1848). pii: 20161735. doi: 10.1098/rspb.2016.1735.

13.

Complete genome of Pieris rapae, a resilient alien, a cabbage pest, and a source of anti-cancer proteins.

Shen J, Cong Q, Kinch LN, Borek D, Otwinowski Z, Grishin NV.

F1000Res. 2016 Nov 3;5:2631. doi: 10.12688/f1000research.9765.1. eCollection 2016.

14.

Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.

Kikuchi S, Borek DM, Otwinowski Z, Tomchick DR, Yu H.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12444-12449. Epub 2016 Oct 18.

15.

Crystal structure of the human sterol transporter ABCG5/ABCG8.

Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM.

Nature. 2016 May 26;533(7604):561-4. doi: 10.1038/nature17666. Epub 2016 May 4.

16.

Complete genomes of Hairstreak butterflies, their speciation, and nucleo-mitochondrial incongruence.

Cong Q, Shen J, Borek D, Robbins RK, Otwinowski Z, Grishin NV.

Sci Rep. 2016 Apr 28;6:24863. doi: 10.1038/srep24863.

17.

Taking a look at the calibration of a CCD detector with a fiber-optic taper.

Alkire RW, Rotella FJ, Duke NE, Otwinowski Z, Borek D.

J Appl Crystallogr. 2016 Feb 16;49(Pt 2):415-425. eCollection 2016 Apr 1.

18.

Speciation in Cloudless Sulphurs Gleaned from Complete Genomes.

Cong Q, Shen J, Warren AD, Borek D, Otwinowski Z, Grishin NV.

Genome Biol Evol. 2016 Mar 30;8(3):915-31. doi: 10.1093/gbe/evw045.

19.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

20.

Skipper genome sheds light on unique phenotypic traits and phylogeny.

Cong Q, Borek D, Otwinowski Z, Grishin NV.

BMC Genomics. 2015 Aug 27;16:639. doi: 10.1186/s12864-015-1846-0.

21.

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L.

Mol Cell Biol. 2015 Jul;35(14):2425-35. doi: 10.1128/MCB.00392-15. Epub 2015 May 4.

22.

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK.

Cell Rep. 2015 Apr 21;11(3):376-89. doi: 10.1016/j.celrep.2015.03.034. Epub 2015 Apr 9.

23.

Tiger Swallowtail Genome Reveals Mechanisms for Speciation and Caterpillar Chemical Defense.

Cong Q, Borek D, Otwinowski Z, Grishin NV.

Cell Rep. 2015 Feb 17;10(6):910-919. doi: 10.1016/j.celrep.2015.01.026. Epub 2015 Feb 13.

24.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK.

Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008.

25.

Crystal structure of active site mutant of antileukemic L-asparaginase reveals conserved zinc-binding site.

Borek D, Kozak M, Pei J, Jaskolski M.

FEBS J. 2014 Sep;281(18):4097-111. doi: 10.1111/febs.12906. Epub 2014 Jul 28.

26.

Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys.

Semeiks J, Borek D, Otwinowski Z, Grishin NV.

BMC Genomics. 2014 Jul 12;15:590. doi: 10.1186/1471-2164-15-590.

27.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK.

J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1.

28.

Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.

Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC.

Cell. 2014 Jan 30;156(3):482-94. doi: 10.1016/j.cell.2014.01.004.

29.

Development of RNA aptamers targeting Ebola virus VP35.

Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK.

Biochemistry. 2013 Nov 26;52(47):8406-19. doi: 10.1021/bi400704d. Epub 2013 Nov 14.

30.

Structure of the human cohesin inhibitor Wapl.

Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11355-60. doi: 10.1073/pnas.1304594110. Epub 2013 Jun 17.

31.

Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein.

Orlikowska M, Szymańska A, Borek D, Otwinowski Z, Skowron P, Jankowska E.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):577-86. doi: 10.1107/S0907444912051657. Epub 2013 Mar 14.

32.

Identification of patterns in diffraction intensities affected by radiation exposure.

Borek D, Dauter Z, Otwinowski Z.

J Synchrotron Radiat. 2013 Jan;20(Pt 1):37-48. doi: 10.1107/S0909049512048807. Epub 2012 Dec 6.

33.

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.

Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20661-6. doi: 10.1073/pnas.1213559109. Epub 2012 Nov 26.

34.

Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU.

Halavaty AS, Borek D, Tyson GH, Veesenmeyer JL, Shuvalova L, Minasov G, Otwinowski Z, Hauser AR, Anderson WF.

PLoS One. 2012;7(11):e49388. doi: 10.1371/journal.pone.0049388. Epub 2012 Nov 14.

35.

Crystallization and preliminary X-ray diffraction analysis of Val57 mutants of the amyloidogenic protein human cystatin C.

Orlikowska M, Jankowska E, Borek D, Otwinowski Z, Skowron P, Szymańska A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1608-11. doi: 10.1107/S1744309111039741. Epub 2011 Nov 26.

36.

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.

Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M.

J Mol Biol. 2011 Oct 28;413(3):699-711. doi: 10.1016/j.jmb.2011.08.049. Epub 2011 Sep 6.

37.

Structure and control of the actin regulatory WAVE complex.

Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK.

Nature. 2010 Nov 25;468(7323):533-8. doi: 10.1038/nature09623.

38.

To automate or not to automate: this is the question.

Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W.

J Struct Funct Genomics. 2010 Sep;11(3):211-21. doi: 10.1007/s10969-010-9092-9. Epub 2010 Jun 6.

39.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27.

40.

Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain.

Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK.

J Mol Biol. 2010 Jun 11;399(3):347-57. doi: 10.1016/j.jmb.2010.04.022. Epub 2010 Apr 24.

41.

Diffraction data analysis in the presence of radiation damage.

Borek D, Cymborowski M, Machius M, Minor W, Otwinowski Z.

Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):426-36. doi: 10.1107/S0907444909040177. Epub 2010 Mar 24.

42.

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.

Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK.

Nat Struct Mol Biol. 2010 Feb;17(2):165-72. doi: 10.1038/nsmb.1765. Epub 2010 Jan 17.

43.

Structure and mechanism of a eukaryotic FMN adenylyltransferase.

Huerta C, Borek D, Machius M, Grishin NV, Zhang H.

J Mol Biol. 2009 Jun 5;389(2):388-400. doi: 10.1016/j.jmb.2009.04.022. Epub 2009 Apr 16.

44.

X-ray diffraction experiment--the last experiment in the structure elucidation process.

Chruszcz M, Borek D, Domagalski M, Otwinowski Z, Minor W.

Adv Protein Chem Struct Biol. 2009;77:23-40. doi: 10.1016/S1876-1623(09)77002-6. Epub 2009 Nov 28. Review.

45.

Crystal packing of plant-type L-asparaginase from Escherichia coli.

Michalska K, Borek D, Hernández-Santoyo A, Jaskolski M.

Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):309-20. doi: 10.1107/S0907444907068072. Epub 2008 Feb 20.

PMID:
18323626
46.

The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly.

Rezácová P, Krejciríková V, Borek D, Moy SF, Joachimiak A, Otwinowski Z.

Proteins. 2007 Nov 15;69(3):679-82. No abstract available.

47.

Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus.

Rezácová P, Borek D, Moy SF, Joachimiak A, Otwinowski Z.

Proteins. 2008 Feb 1;70(2):311-9.

48.

The many faces of radiation-induced changes.

Borek D, Ginell SL, Cymborowski M, Minor W, Otwinowski Z.

J Synchrotron Radiat. 2007 Jan;14(Pt 1):24-33. Epub 2006 Dec 15.

PMID:
17211069
49.

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H.

Mol Cell. 2006 Aug 4;23(3):377-87.

50.

Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.

Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J.

Science. 2006 Mar 24;311(5768):1761-4.

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