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Items: 1 to 50 of 107

1.

Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis.

Pirkkanen J, Tharmalingam S, Morais IH, Lam-Sidun D, Thome C, Zarnke AM, Benjamin LV, Losch AC, Borgmann AJ, Sinex HC, Mendonca MS, Boreham DR.

Free Radic Biol Med. 2019 Dec;145:300-311. doi: 10.1016/j.freeradbiomed.2019.09.037. Epub 2019 Sep 30.

PMID:
31580949
2.

Acute pulmonary and splenic response in an in vivo model of whole-body low-dose X-radiation exposure.

Puukila S, Muise S, McEvoy J, Bouchier T, Hooker AM, Boreham DR, Khaper N, Dixon DL.

Int J Radiat Biol. 2019 Aug;95(8):1072-1084. doi: 10.1080/09553002.2019.1625459. Epub 2019 Jun 12.

PMID:
31140892
3.

Cardiovascular and growth outcomes of C57Bl/6J mice offspring exposed to maternal stress and ionizing radiation during pregnancy.

Sreetharan S, Stoa L, Cybulski ME, Jones DE, Lee AH, Kulesza AV, Tharmalingam S, Boreham DR, Tai TC, Wilson JY.

Int J Radiat Biol. 2019 Aug;95(8):1085-1093. doi: 10.1080/09553002.2019.1589025. Epub 2019 Apr 16.

PMID:
30831046
4.

BEIR VI radon: The rest of the story.

Zarnke AM, Tharmalingam S, Boreham DR, Brooks AL.

Chem Biol Interact. 2019 Mar 1;301:81-87. doi: 10.1016/j.cbi.2018.11.012. Epub 2019 Feb 11. Review.

5.

Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies.

Tharmalingam S, Sreetharan S, Brooks AL, Boreham DR.

Chem Biol Interact. 2019 Mar 1;301:54-67. doi: 10.1016/j.cbi.2018.11.013. Epub 2019 Feb 11. Review.

6.

Development and validation of probe-based multiplex real-time PCR assays for the rapid and accurate detection of freshwater fish species.

Hulley EN, Tharmalingam S, Zarnke A, Boreham DR.

PLoS One. 2019 Jan 30;14(1):e0210165. doi: 10.1371/journal.pone.0210165. eCollection 2019.

7.

The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer.

Puukila S, Thome C, Brooks AL, Woloschak G, Boreham DR.

Int J Radiat Biol. 2018 Nov;94(11):955-966. doi: 10.1080/09553002.2018.1511929. Epub 2018 Sep 26.

8.

Hormetic Effects of Early Juvenile Radiation Exposure on Adult Reproduction and Offspring Performance in the Cricket (Acheta domesticus).

Shephard AM, Aksenov V, Tran J, Nelson CJ, Boreham DR, Rollo CD.

Dose Response. 2018 Sep 6;16(3):1559325818797499. doi: 10.1177/1559325818797499. eCollection 2018 Jul-Sep.

9.

Daily, repeating fluctuations in embryonic incubation temperature alter metabolism and growth of Lake whitefish (Coregonus clupeaformis).

Eme J, Mueller CA, Lee AH, Melendez C, Manzon RG, Somers CM, Boreham DR, Wilson JY.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Dec;226:49-56. doi: 10.1016/j.cbpa.2018.07.027. Epub 2018 Aug 13.

PMID:
30114471
10.

Impacts of temperature, morpholine, and chronic radiation on the embryonic development of round whitefish (Prosopium cylindraceum).

Lim MY, Manzon RG, Somers CM, Boreham DR, Wilson JY.

Environ Toxicol Chem. 2018 Oct;37(10):2593-2608. doi: 10.1002/etc.4219. Epub 2018 Jul 30.

PMID:
29963715
11.

Early Intervention with a Multi-Ingredient Dietary Supplement Improves Mood and Spatial Memory in a Triple Transgenic Mouse Model of Alzheimer's Disease.

Hutton CP, Lemon JA, Sakic B, Rollo CD, Boreham DR, Fahnestock M, Wojtowicz JM, Becker S.

J Alzheimers Dis. 2018;64(3):835-857. doi: 10.3233/JAD-170921.

PMID:
29914019
12.

Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure: is There Evidence to Support a Reduction in Threshold Dose?

Thome C, Chambers DB, Hooker AM, Thompson JW, Boreham DR.

Health Phys. 2018 Mar;114(3):328-343. doi: 10.1097/HP.0000000000000810.

PMID:
29360710
13.

Micronuclei formation in rainbow trout cells exposed to multiple stressors: Morpholine, heat shock, and ionizing radiation.

Sreetharan S, Thome C, Tsang KK, Somers CM, Manzon RG, Boreham DR, Wilson JY.

Toxicol In Vitro. 2018 Mar;47:38-47. doi: 10.1016/j.tiv.2017.10.026. Epub 2017 Oct 28.

PMID:
29111319
14.

Non-radioactive 2-deoxy-2-fluoro-D-glucose inhibits glucose uptake in xenograft tumours and sensitizes HeLa cells to doxorubicin in vitro.

Niccoli S, Boreham DR, Phenix CP, Lees SJ.

PLoS One. 2017 Nov 2;12(11):e0187584. doi: 10.1371/journal.pone.0187584. eCollection 2017.

15.

Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish (Coregonus clupeaformis) embryos.

Whitehouse LM, McDougall CS, Stefanovic DI, Boreham DR, Somers CM, Wilson JY, Manzon RG.

J Therm Biol. 2017 Oct;69:294-301. doi: 10.1016/j.jtherbio.2017.08.013. Epub 2017 Aug 30.

PMID:
29037397
16.

Nerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systems.

Kennedy AE, Laamanen CA, Ross MS, Vohra R, Boreham DR, Scott JA, Ross GM.

Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.339.

17.

Is There a Trade-Off between Radiation-Stimulated Growth and Metabolic Efficiency?

Mitz C, Thome C, Cybulski ME, Somers CM, Manzon RG, Wilson JY, Boreham DR.

Radiat Res. 2017 Oct;188(4.2):486-494. doi: 10.1667/RR14665.1. Epub 2017 Sep 6.

PMID:
28877005
18.

The CGL1 (HeLa × Normal Skin Fibroblast) Human Hybrid Cell Line: A History of Ionizing Radiation Induced Effects on Neoplastic Transformation and Novel Future Directions in SNOLAB.

Pirkkanen JS, Boreham DR, Mendonca MS.

Radiat Res. 2017 Oct;188(4.2):512-524. doi: 10.1667/RR14911.1. Epub 2017 Sep 5. Review.

PMID:
28873027
19.

Impact of Ionizing Radiation on the Cardiovascular System: A Review.

Puukila S, Lemon JA, Lees SJ, Tai TC, Boreham DR, Khaper N.

Radiat Res. 2017 Oct;188(4.2):539-546. doi: 10.1667/RR14864.1. Epub 2017 Sep 5. Review.

PMID:
28873026
20.

The effects of fluctuating temperature regimes on the embryonic development of lake whitefish (Coregonus clupeaformis).

Lim MY, Manzon RG, Somers CM, Boreham DR, Wilson JY.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Dec;214:19-29. doi: 10.1016/j.cbpa.2017.08.010. Epub 2017 Aug 30.

PMID:
28855119
21.

Low-Dose Ionizing Radiation Exposure, Oxidative Stress and Epigenetic Programing of Health and Disease.

Tharmalingam S, Sreetharan S, Kulesza AV, Boreham DR, Tai TC.

Radiat Res. 2017 Oct;188(4.2):525-538. doi: 10.1667/RR14587.1. Epub 2017 Jul 28. Review.

PMID:
28753061
22.

Single CT Scan Prolongs Survival by Extending Cancer Latency in Trp53 Heterozygous Mice.

Lemon JA, Phan N, Boreham DR.

Radiat Res. 2017 Oct;188(4.2):505-511. doi: 10.1667/RR14576.1. Epub 2017 Jul 25.

PMID:
28742468
23.

Multiple CT Scans Extend Lifespan by Delaying Cancer Progression in Cancer-Prone Mice.

Lemon JA, Phan N, Boreham DR.

Radiat Res. 2017 Oct;188(4.2):495-504. doi: 10.1667/RR14575.1. Epub 2017 Jul 25.

PMID:
28741984
24.

Initial Characterization of the Growth Stimulation and Heat-Shock-Induced Adaptive Response in Developing Lake Whitefish Embryos after Ionizing Radiation Exposure.

Thome C, Mitz C, Hulley EN, Somers CM, Manzon RG, Wilson JY, Boreham DR.

Radiat Res. 2017 Oct;188(4.2):475-485. doi: 10.1667/RR14574.1. Epub 2017 Jul 24.

PMID:
28737450
25.

The REPAIR Project: Examining the Biological Impacts of Sub-Background Radiation Exposure within SNOLAB, a Deep Underground Laboratory.

Thome C, Tharmalingam S, Pirkkanen J, Zarnke A, Laframboise T, Boreham DR.

Radiat Res. 2017 Oct;188(4.2):470-474. doi: 10.1667/RR14654.1. Epub 2017 Jul 19.

PMID:
28723273
26.

The Role of Radiation Induced Injury on Lung Cancer.

Puukila S, Thome C, Brooks AL, Woloschak G, Boreham DR.

Cancers (Basel). 2017 Jul 12;9(7). pii: E89. doi: 10.3390/cancers9070089.

27.

Ionizing Radiation Exposure During Pregnancy: Effects on Postnatal Development and Life.

Sreetharan S, Thome C, Tharmalingam S, Jones DE, Kulesza AV, Khaper N, Lees SJ, Wilson JY, Boreham DR, Tai TC.

Radiat Res. 2017 Jun;187(6):647-658. doi: 10.1667/RR14657.1. Epub 2017 Apr 18. Review.

PMID:
28418814
28.

A method to transform a variable thermal regime to a physiologically equivalent effective temperature.

Mitz C, Thome C, Thompson J, Manzon RG, Wilson JY, Boreham DR.

J Therm Biol. 2017 Apr;65:21-25. doi: 10.1016/j.jtherbio.2016.12.011. Epub 2017 Jan 26.

PMID:
28343571
29.

Developmental effects of the industrial cooling water additives morpholine and sodium hypochlorite on lake whitefish (Coregonus clupeaformis).

Thome C, Mitz C, Sreetharan S, Mitz C, Somers CM, Manzon RG, Boreham DR, Wilson JY.

Environ Toxicol Chem. 2017 Jul;36(7):1955-1965. doi: 10.1002/etc.3727. Epub 2017 Jan 31.

PMID:
28036109
30.

Lipid content and fatty acid profile during lake whitefish embryonic development at different incubation temperatures.

Mueller CA, Doyle L, Eme J, Manzon RG, Somers CM, Boreham DR, Wilson JY.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Jan;203:201-209. doi: 10.1016/j.cbpa.2016.09.018. Epub 2016 Sep 28.

PMID:
27686607
31.

A multi-ingredient dietary supplement abolishes large-scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice.

Lemon JA, Aksenov V, Samigullina R, Aksenov S, Rodgers WH, Rollo CD, Boreham DR.

Environ Mol Mutagen. 2016 Jun;57(5):382-404. doi: 10.1002/em.22019. Epub 2016 May 20.

PMID:
27199101
32.

The effects of increased constant incubation temperature and cumulative acute heat shock exposures on morphology and survival of Lake Whitefish (Coregonus clupeaformis) embryos.

Lee AH, Eme J, Mueller CA, Manzon RG, Somers CM, Boreham DR, Wilson JY.

J Therm Biol. 2016 Apr;57:11-20. doi: 10.1016/j.jtherbio.2016.01.010. Epub 2016 Feb 27.

PMID:
27033035
33.

Fine-Scale Ecological and Genetic Population Structure of Two Whitefish (Coregoninae) Species in the Vicinity of Industrial Thermal Emissions.

Graham CF, Eberts RL, Morgan TD, Boreham DR, Lance SL, Manzon RG, Martino JA, Rogers SM, Wilson JY, Somers CM.

PLoS One. 2016 Jan 25;11(1):e0146656. doi: 10.1371/journal.pone.0146656. eCollection 2016.

34.

Chromosome Damage Caused by Accidental Chronic Whole-Body Gamma Radiation Exposure in Thailand.

Ulsh BA, Dolling J, Lavoie J, Mitchel RE, Boreham DR.

Dose Response. 2015 Nov 12;13(4):1559325815614302. doi: 10.1177/1559325815614302. eCollection 2015 Oct-Dec.

35.

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans.

Schnarr K, Carter TF, Gillis D, Webber C, Lemon JA, Dayes I, Dolling JA, Gulenchyn K, Boreham DR.

Dose Response. 2015 Nov 19;13(4):1559325815611904. doi: 10.1177/1559325815611904. eCollection 2015 Oct-Dec.

36.

Thermal stress and the heat shock response in embryonic and young of the year juvenile lake whitefish.

Stefanovic DI, Manzon LA, McDougall CS, Boreham DR, Somers CM, Wilson JY, Manzon RG.

Comp Biochem Physiol A Mol Integr Physiol. 2016 Mar;193:1-10. doi: 10.1016/j.cbpa.2015.12.001. Epub 2015 Dec 3.

PMID:
26658267
37.

Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice.

Hutton CP, Déry N, Rosa E, Lemon JA, Rollo CD, Boreham DR, Fahnestock M, deCatanzaro D, Wojtowicz JM, Becker S.

Neuroscience. 2015 Nov 12;308:180-93. doi: 10.1016/j.neuroscience.2015.09.005. Epub 2015 Sep 7.

PMID:
26358368
38.

Embryonic development of lake whitefish Coregonus clupeaformis: a staging series, analysis of growth and effects of fixation.

Sreetharan S, Thome C, Mitz C, Eme J, Mueller CA, Hulley EN, Manzon RG, Somers CM, Boreham DR, Wilson JY.

J Fish Biol. 2015 Sep;87(3):539-58. doi: 10.1111/jfb.12725. Epub 2015 Jul 17.

PMID:
26184490
39.

Impacts of degraded DNA on restriction enzyme associated DNA sequencing (RADSeq).

Graham CF, Glenn TC, McArthur AG, Boreham DR, Kieran T, Lance S, Manzon RG, Martino JA, Pierson T, Rogers SM, Wilson JY, Somers CM.

Mol Ecol Resour. 2015 Nov;15(6):1304-15. doi: 10.1111/1755-0998.12404. Epub 2015 Apr 1.

PMID:
25783180
40.

Quantifying murine bone marrow and blood radiation dose response following (18)F-FDG PET with DNA damage biomarkers.

Manning G, Taylor K, Finnon P, Lemon JA, Boreham DR, Badie C.

Mutat Res. 2014 Dec;770:29-36. doi: 10.1016/j.mrfmmm.2014.09.002. Epub 2014 Sep 16.

PMID:
25771867
41.

Embryonic critical windows: changes in incubation temperature alter survival, hatchling phenotype, and cost of development in lake whitefish (Coregonus clupeaformis).

Mueller CA, Eme J, Manzon RG, Somers CM, Boreham DR, Wilson JY.

J Comp Physiol B. 2015 Apr;185(3):315-31. doi: 10.1007/s00360-015-0886-8. Epub 2015 Jan 14.

PMID:
25585944
42.

The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line.

Mills CE, Thome C, Koff D, Andrews DW, Boreham DR.

Radiat Res. 2015 Jan;183(1):42-51. doi: 10.1667/RR13821.1. Epub 2014 Dec 23.

PMID:
25536231
43.

The influence of Trp53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells.

Lemon JA, Taylor K, Verdecchia K, Phan N, Boreham DR.

Dose Response. 2014 Apr 22;12(3):365-85. doi: 10.2203/dose-response.14-008.Lemon. eCollection 2014 Jul.

44.

Critical windows in embryonic development: Shifting incubation temperatures alter heart rate and oxygen consumption of Lake Whitefish (Coregonus clupeaformis) embryos and hatchlings.

Eme J, Mueller CA, Manzon RG, Somers CM, Boreham DR, Wilson JY.

Comp Biochem Physiol A Mol Integr Physiol. 2015 Jan;179:71-80. doi: 10.1016/j.cbpa.2014.09.005. Epub 2014 Sep 16.

PMID:
25236178
45.

Low-dose radiation from 18F-FDG PET does not increase cancer frequency or shorten latency but reduces kidney disease in cancer-prone Trp53+/- mice.

Taylor K, Lemon JA, Phan N, Boreham DR.

Mutagenesis. 2014 Jul;29(4):289-94. doi: 10.1093/mutage/geu017. Epub 2014 May 28.

PMID:
24870563
46.

Radiation-induced DNA damage and the relative biological effectiveness of 18F-FDG in wild-type mice.

Taylor K, Lemon JA, Boreham DR.

Mutagenesis. 2014 Jul;29(4):279-87. doi: 10.1093/mutage/geu016. Epub 2014 May 28.

PMID:
24870562
47.

Biological effects and adaptive response from single and repeated computed tomography scans in reticulocytes and bone marrow of C57BL/6 mice.

Phan N, De Lisio M, Parise G, Boreham DR.

Radiat Res. 2012 Feb;177(2):164-75. Epub 2011 Nov 7.

PMID:
22059980
48.

Health effects from low dose occupational and medical radiation exposure and the role of adaptive response.

Phan N, Boreham DR.

Health Phys. 2011 Mar;100(3):286-7. No abstract available.

PMID:
21595071
49.

Human Health and the Biological Effects of Tritium in Drinking Water: Prudent Policy Through Science - Addressing the ODWAC New Recommendation.

Dingwall S, Mills CE, Phan N, Taylor K, Boreham DR.

Dose Response. 2011 Feb 22;9(1):6-31. doi: 10.2203/dose-response.10-048.Boreham.

50.

Exercise-induced protection of bone marrow cells following exposure to radiation.

De Lisio M, Phan N, Boreham DR, Parise G.

Appl Physiol Nutr Metab. 2011 Feb;36(1):80-7. doi: 10.1139/H10-087.

PMID:
21326381

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