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Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.

Preciado D, Nolan RM, Joshi R, Krakovsky GM, Zhang A, Pudik NA, Kumar NK, Shelton RL, Boppart SA, Bauman NM.

Otolaryngol Head Neck Surg. 2020 Jan 21:194599819900762. doi: 10.1177/0194599819900762. [Epub ahead of print]


Real-time intraoperative diagnosis by deep neural network driven multiphoton virtual histology.

You S, Sun Y, Yang L, Park J, Tu H, Marjanovic M, Sinha S, Boppart SA.

NPJ Precis Oncol. 2019 Dec 17;3:33. doi: 10.1038/s41698-019-0104-3. eCollection 2019.


Tracking metabolic dynamics of apoptosis with high-speed two-photon fluorescence lifetime imaging microscopy.

Bower AJ, Sorrells JE, Li J, Marjanovic M, Barkalifa R, Boppart SA.

Biomed Opt Express. 2019 Nov 21;10(12):6408-6421. doi: 10.1364/BOE.10.006408. eCollection 2019 Dec 1.


Label-free visualization and characterization of extracellular vesicles in breast cancer.

You S, Barkalifa R, Chaney EJ, Tu H, Park J, Sorrells JE, Sun Y, Liu YZ, Yang L, Chen DZ, Marjanovic M, Sinha S, Boppart SA.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24012-24018. doi: 10.1073/pnas.1909243116. Epub 2019 Nov 15.


Simultaneous label-free autofluorescence and multi-harmonic imaging reveals in vivo structural and metabolic changes in murine skin.

Lee JH, Rico-Jimenez JJ, Zhang C, Alex A, Chaney EJ, Barkalifa R, Spillman DR Jr, Marjanovic M, Arp Z, Hood SR, Boppart SA.

Biomed Opt Express. 2019 Oct 1;10(10):5431-5444. doi: 10.1364/BOE.10.005431. eCollection 2019 Oct 1.


Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography.

Won J, Monroy GL, Huang PC, Hill MC, Novak MA, Porter RG, Spillman DR, Chaney EJ, Barkalifa R, Boppart SA.

Ear Hear. 2019 Oct 18. doi: 10.1097/AUD.0000000000000796. [Epub ahead of print]


Detection of weak near-infrared optical imaging signals under ambient light by optical parametric amplification.

Sun Y, Tu H, You S, Zhang C, Liu YZ, Boppart SA.

Opt Lett. 2019 Sep 1;44(17):4391-4394. doi: 10.1364/OL.44.004391.


Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation.

Cocca CJ, Selmic LE, Samuelson J, Huang PC, Wang J, Boppart SA.

Vet Surg. 2019 Nov;48(8):1361-1371. doi: 10.1111/vsu.13305. Epub 2019 Aug 7.


Automated classification platform for the identification of otitis media using optical coherence tomography.

Monroy GL, Won J, Dsouza R, Pande P, Hill MC, Porter RG, Novak MA, Spillman DR, Boppart SA.

NPJ Digit Med. 2019 Mar 28;2:22. doi: 10.1038/s41746-019-0094-0. eCollection 2019.


Label-free molecular profiling for identification of biomarkers in carcinogenesis using multimodal multiphoton imaging.

Liu Y, Tu H, You S, Chaney EJ, Marjanovic M, Boppart SA.

Quant Imaging Med Surg. 2019 May;9(5):742-756. doi: 10.21037/qims.2019.04.16.


Complementary use of polarization-sensitive and standard OCT metrics for enhanced intraoperative differentiation of breast cancer.

Wang J, Xu Y, Mesa KJ, South FA, Chaney EJ, Spillman DR Jr, Barkalifa R, Marjanovic M, Carney PS, Higham AM, Liu ZG, Boppart SA.

Biomed Opt Express. 2018 Nov 28;9(12):6519-6528. doi: 10.1364/BOE.9.006519. eCollection 2018 Dec 1.


Automated sensorless single-shot closed-loop adaptive optics microscopy with feedback from computational adaptive optics.

Iyer RR, Liu YZ, Boppart SA.

Opt Express. 2019 Apr 29;27(9):12998-13014. doi: 10.1364/OE.27.012998.


High-speed imaging of transient metabolic dynamics using two-photon fluorescence lifetime imaging microscopy.

Bower AJ, Li J, Chaney EJ, Marjanovic M, Spillman DR Jr, Boppart SA.

Optica. 2018 Oct 20;5(10):1290-1296. doi: 10.1364/OPTICA.5.001290. Epub 2018 Oct 16.


Digital staining through the application of deep neural networks to multi-modal multi-photon microscopy.

Borhani N, Bower AJ, Boppart SA, Psaltis D.

Biomed Opt Express. 2019 Feb 19;10(3):1339-1350. doi: 10.1364/BOE.10.001339. eCollection 2019 Mar 1.


Characterization of Magnetic Nanoparticle-Seeded Microspheres for Magnetomotive and Multimodal Imaging.

Marjanovic M, Nguyen FT, Ahmad A, Huang PC, Suslick KS, Boppart SA.

IEEE J Sel Top Quantum Electron. 2019 Jan-Feb;25(1). pii: 7101314. doi: 10.1109/JSTQE.2018.2856582. Epub 2018 Jul 16.


Local wavefront mapping in tissue using computational adaptive optics OCT.

South FA, Liu YZ, Huang PC, Kohlfarber T, Boppart SA.

Opt Lett. 2019 Mar 1;44(5):1186-1189. doi: 10.1364/OL.44.001186.


Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography.

Huang PC, Chaney EJ, Iyer RR, Spillman DR Jr, Odintsov B, Sobh NA, Boppart SA.

Biomed Opt Express. 2019 Jan 14;10(2):539-551. doi: 10.1364/BOE.10.000539. eCollection 2019 Feb 1.


In vivo detection of endotracheal tube biofilms in intubated critical care patients using catheter-based optical coherence tomography.

Dsouza R, Spillman DR Jr, Barkalifa R, Monroy GL, Chaney EJ, White KC, Boppart SA.

J Biophotonics. 2019 May;12(5):e201800307. doi: 10.1002/jbio.201800307. Epub 2019 Jan 22.


Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging.

Sun Y, You S, Tu H, Spillman DR Jr, Chaney EJ, Marjanovic M, Li J, Barkalifa R, Wang J, Higham AM, Luckey NN, Cradock KA, George Liu Z, Boppart SA.

Sci Adv. 2018 Dec 19;4(12):eaau5603. doi: 10.1126/sciadv.aau5603. eCollection 2018 Dec.


Nonlinearity-tailored fiber laser technology for low-noise, ultra-wideband tunable femtosecond light generation.

Liu X, Laegsgaard J, Iegorov R, Svane AS, Ilday FÖ, Tu H, Boppart SA, Turchinovich D.

Photonics Res. 2017 Dec;5(6):750-761. doi: 10.1364/PRJ.5.000750. Epub 2017 Nov 27.


Slide-free virtual histochemistry (Part II): detection of field cancerization.

You S, Sun Y, Chaney EJ, Zhao Y, Chen J, Boppart SA, Tu H.

Biomed Opt Express. 2018 Oct 5;9(11):5253-5268. doi: 10.1364/BOE.9.005253. eCollection 2018 Nov 1.


Slide-free virtual histochemistry (Part I): development via nonlinear optics.

You S, Sun Y, Chaney EJ, Zhao Y, Chen J, Boppart SA, Tu H.

Biomed Opt Express. 2018 Oct 5;9(11):5240-5252. doi: 10.1364/BOE.9.005240. eCollection 2018 Nov 1.


Disintegration of simulated drinking water biofilms with arrays of microchannel plasma jets.

Sun PP, Araud EM, Huang C, Shen Y, Monroy GL, Zhong S, Tong Z, Boppart SA, Eden JG, Nguyen TH.

NPJ Biofilms Microbiomes. 2018 Oct 18;4:24. doi: 10.1038/s41522-018-0063-4. eCollection 2018.


Combined hardware and computational optical wavefront correction.

South FA, Kurokawa K, Liu Z, Liu YZ, Miller DT, Boppart SA.

Biomed Opt Express. 2018 May 8;9(6):2562-2574. doi: 10.1364/BOE.9.002562. eCollection 2018 Jun 1.


Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications.

Dsouza R, Won J, Monroy GL, Spillman DR, Boppart SA.

J Biomed Opt. 2018 Sep;23(9):1-11. doi: 10.1117/1.JBO.23.9.096003.


Intra-operative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography.

Selmic LE, Samuelson J, Reagan JK, Mesa KJ, Driskell E, Li J, Marjanovic M, Boppart SA.

Vet Comp Oncol. 2019 Mar;17(1):80-88. doi: 10.1111/vco.12448. Epub 2018 Nov 13.


Effect of divalent ions and a polyphosphate on composition, structure, and stiffness of simulated drinking water biofilms.

Shen Y, Huang PC, Huang C, Sun P, Monroy GL, Wu W, Lin J, Espinosa-Marzal RM, Boppart SA, Liu WT, Nguyen TH.

NPJ Biofilms Microbiomes. 2018 Jul 18;4:15. doi: 10.1038/s41522-018-0058-1. eCollection 2018.


Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception.

Huang PC, Chaney EJ, Shelton RL, Boppart SA.

IEEE Trans Biomed Eng. 2018 Dec;65(12):2837-2846. doi: 10.1109/TBME.2018.2819649. Epub 2018 Mar 26.


In situ biodistribution and residency of a topical anti-inflammatory using fluorescence lifetime imaging microscopy.

Alex A, Frey S, Angelene H, Neitzel CD, Li J, Bower AJ, Spillman DR Jr, Marjanovic M, Chaney EJ, Medler JL, Lee W, Vasist Johnson LS, Boppart SA, Arp Z.

Br J Dermatol. 2018 Dec;179(6):1342-1350. doi: 10.1111/bjd.16992. Epub 2018 Oct 8.


Coherent control of an opsin in living brain tissue.

Paul K, Sengupta P, Ark ED, Tu H, Zhao Y, Boppart SA.

Nat Phys. 2017 Nov;13(11):1111-1116. doi: 10.1038/NPHYS4257. Epub 2017 Sep 18.


In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media.

Dsouza R, Won J, Monroy GL, Hill MC, Porter RG, Novak MA, Boppart SA.

Sci Rep. 2018 Jun 8;8(1):8777. doi: 10.1038/s41598-018-26514-1.


Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy.

You S, Tu H, Chaney EJ, Sun Y, Zhao Y, Bower AJ, Liu YZ, Marjanovic M, Sinha S, Pu Y, Boppart SA.

Nat Commun. 2018 May 29;9(1):2125. doi: 10.1038/s41467-018-04470-8.


Direct Analysis of Pathogenic Structures Affixed to the Tympanic Membrane during Chronic Otitis Media.

Monroy GL, Hong W, Khampang P, Porter RG, Novak MA, Spillman DR, Barkalifa R, Chaney EJ, Kerschner JE, Boppart SA.

Otolaryngol Head Neck Surg. 2018 Jul;159(1):117-126. doi: 10.1177/0194599818766320. Epub 2018 Mar 27.


Pneumatic low-coherence interferometry otoscope to quantify tympanic membrane mobility and middle ear pressure.

Won J, Monroy GL, Huang PC, Dsouza R, Hill MC, Novak MA, Porter RG, Chaney E, Barkalifa R, Boppart SA.

Biomed Opt Express. 2018 Jan 3;9(2):397-409. doi: 10.1364/BOE.9.000397. eCollection 2018 Feb 1.


Wavefront measurement using computational adaptive optics.

South FA, Liu YZ, Bower AJ, Xu Y, Carney PS, Boppart SA.

J Opt Soc Am A Opt Image Sci Vis. 2018 Mar 1;35(3):466-473. doi: 10.1364/JOSAA.35.000466.


Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment.

Boppart SA, Brown JQ, Farah CS, Kho E, Marcu L, Saunders CM, Sterenborg HJCM.

J Biomed Opt. 2017 Dec;23(2):1-10. doi: 10.1117/1.JBO.23.2.021104. Review.


Intraoperative optical coherence tomography of the human thyroid: Feasibility for surgical assessment.

Erickson-Bhatt SJ, Mesa KJ, Marjanovic M, Chaney EJ, Ahmad A, Huang PC, Liu ZG, Cunningham K, Boppart SA.

Transl Res. 2018 May;195:13-24. doi: 10.1016/j.trsl.2017.12.001. Epub 2017 Dec 8.


Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention.

Monroy GL, Pande P, Nolan RM, Shelton RL, Porter RG, Novak MA, Spillman DR, Chaney EJ, McCormick DT, Boppart SA.

J Biomed Opt. 2017 Dec;22(12):1-11. doi: 10.1117/1.JBO.22.12.121614.


Biophotonics: the big picture.

Marcu L, Boppart SA, Hutchinson MR, Popp J, Wilson BC.

J Biomed Opt. 2017 Dec;23(2):1-7. doi: 10.1117/1.JBO.23.2.021103.


Review of optical coherence tomography in oncology.

Wang J, Xu Y, Boppart SA.

J Biomed Opt. 2017 Dec;22(12):1-23. doi: 10.1117/1.JBO.22.12.121711. Review.


Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.

Monroy GL, Won J, Spillman DR, Dsouza R, Boppart SA.

J Biomed Opt. 2017 Dec;22(12):1-30. doi: 10.1117/1.JBO.22.12.121715.


Optical assessment of the in vivo tympanic membrane status using a handheld optical coherence tomography-based otoscope.

Park K, Cho NH, Jeon M, Lee SH, Jang JH, Boppart SA, Jung W, Kim J.

Acta Otolaryngol. 2018 Apr;138(4):367-374. doi: 10.1080/00016489.2017.1395515. Epub 2017 Nov 10.


Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy.

Li J, Bower AJ, Arp Z, Olson EJ, Holland C, Chaney EJ, Marjanovic M, Pande P, Alex A, Boppart SA.

J Biophotonics. 2018 Mar;11(3). doi: 10.1002/jbio.201700195. Epub 2017 Nov 8.


Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy.

You S, Liu Y, Arp Z, Zhao Y, Chaney EJ, Marjanovic M, Boppart SA.

J Biomed Opt. 2017 Jul 1;22(7):70502. doi: 10.1117/1.JBO.22.7.070502.


Computational optical coherence tomography [Invited].

Liu YZ, South FA, Xu Y, Carney PS, Boppart SA.

Biomed Opt Express. 2017 Feb 16;8(3):1549-1574. doi: 10.1364/BOE.8.001549. eCollection 2017 Mar 1.


Quantitative Pneumatic Otoscopy Using a Light-Based Ranging Technique.

Shelton RL, Nolan RM, Monroy GL, Pande P, Novak MA, Porter RG, Boppart SA.

J Assoc Res Otolaryngol. 2017 Aug;18(4):555-568. doi: 10.1007/s10162-017-0629-5. Epub 2017 Jun 26.


Ratiometric analysis of optical coherence tomography-measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy.

Bhaduri B, Shelton RL, Nolan RM, Hendren L, Almasov A, Labriola LT, Boppart SA.

J Biophotonics. 2017 Nov;10(11):1430-1441. doi: 10.1002/jbio.201600282. Epub 2017 Jun 21.


In Vivo Assessment of Engineered Skin Cell Delivery with Multimodal Optical Microscopy.

Bower AJ, Mahmassani Z, Zhao Y, Chaney EJ, Marjanovic M, Lee MK, Graf BW, De Lisio M, Kong H, Boppart MD, Boppart SA.

Tissue Eng Part C Methods. 2017 Jul;23(7):434-442. doi: 10.1089/ten.TEC.2017.0185.


In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe.

Park K, Cho NH, Jang JH, Lee SH, Kim P, Jeon M, Boppart SA, Kim J, Jung W.

Appl Opt. 2017 Mar 20;56(9):D115-D119. doi: 10.1364/AO.56.00D115.


Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification.

Mesa KJ, Selmic LE, Pande P, Monroy GL, Reagan J, Samuelson J, Driskell E, Li J, Marjanovic M, Chaney EJ, Boppart SA.

Lasers Surg Med. 2017 Mar;49(3):240-248. doi: 10.1002/lsm.22633. Epub 2017 Mar 20.

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