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Clinical features of sarcoidosis patients presenting with head and neck manifestations - a two-center retrospective study and proposal of a diagnostic algorithm for the otorhinolaryngologist.

Send T, Korsten P, Bertlich M, Braunwarth C, Bootz F, Skowasch D, Jakob M.

Acta Otolaryngol. 2019 Dec 11:1-5. doi: 10.1080/00016489.2019.1698767. [Epub ahead of print]


Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma.

Holderried TAW, de Vos L, Bawden EG, Vogt TJ, Dietrich J, Zarbl R, Bootz F, Kristiansen G, Brossart P, Landsberg J, Dietrich D.

Clin Epigenetics. 2019 Nov 20;11(1):161. doi: 10.1186/s13148-019-0752-8.


A matched-pair analysis on survival and response rates between German and non-German cancer patients treated at a Comprehensive Cancer Center.

Budde MK, Kuhn W, Keyver-Paik MD, Bootz F, Kalff JC, Müller SC, Bieber T, Brossart P, Vatter H, Herrlinger U, Wirtz DC, Schild HH, Kristiansen G, Pietsch T, Aretz S, Geiser F, Radbruch L, Reich RH, Strassburg CP, Skowasch D, Essler M, Ernstmann N, Landsberg J, Funke B, Schmidt-Wolf IGH.

BMC Cancer. 2019 Oct 30;19(1):1024. doi: 10.1186/s12885-019-6241-9.


DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon γ signature.

Sailer V, Sailer U, Bawden EG, Zarbl R, Wiek C, Vogt TJ, Dietrich J, Loick S, Grünwald I, Toma M, Golletz C, Gerstner A, Kristiansen G, Bootz F, Scheckenbach K, Landsberg J, Dietrich D.

EBioMedicine. 2019 Oct;48:341-352. doi: 10.1016/j.ebiom.2019.09.038. Epub 2019 Oct 15.


[Slowly progressive dysphonia].

Charpentier A, Thiesler T, Bartmann D, Send T, Pantelis A, Schade G, Bootz F, van Bremen T.

HNO. 2019 Dec;67(12):952-954. doi: 10.1007/s00106-019-0724-5. German. No abstract available.


Reconstruction of the skull base in spontaneous rhinoliquorrhea.

Jakob M, Bertlich M, Eichhorn KW, Thudium M, Bootz F, Send T.

GMS Interdiscip Plast Reconstr Surg DGPW. 2019 Jul 16;8:Doc11. doi: 10.3205/iprs000137. eCollection 2019.


Frequent detection of Saffold cardiovirus in adenoids.

Lindner K, Ludwig M, Bootz F, Reber U, Safavieh Z, Eis-Hübinger AM, Herberhold S.

PLoS One. 2019 Jul 3;14(7):e0218873. doi: 10.1371/journal.pone.0218873. eCollection 2019.


[Social reimbursement-the Spanish-German ENT Society's (SDGHNO) Latin America project].

Offergeld C, Zahnert T, Caro J, Prieto JA, Centeno J, Laszig R, Schwager K, Bockmühl U, Praetorius M, Baumann I, Bootz F, Schmidt T, Yepes A, Schipper J.

HNO. 2019 Jul;67(7):515-518. doi: 10.1007/s00106-019-0698-3. Review. German.


[Progressive hoarseness-surgical treatment of a benign tumor].

Koppen T, Schade G, Eichhorn K, Westermann S, Jakob M, Bootz F, Send T.

HNO. 2019 Aug;67(8):633-637. doi: 10.1007/s00106-019-0684-9. German. No abstract available.


Sarcoidosis of the paranasal sinuses.

Send T, Tuleta I, Koppen T, Thiesler T, Eichhorn KW, Bertlich M, Bootz F, Jakob M.

Eur Arch Otorhinolaryngol. 2019 Jul;276(7):1969-1974. doi: 10.1007/s00405-019-05388-7. Epub 2019 Mar 21.


Clinicopathological, immune and molecular correlates of PD-L2 methylation in gastric adenocarcinomas.

Lingohr P, Dohmen J, Semaan A, Branchi V, Dietrich J, Bootz F, Kalff JC, Matthaei H, Dietrich D.

Epigenomics. 2019 May;11(6):639-653. doi: 10.2217/epi-2018-0149. Epub 2019 Mar 1.


In response to the letter to the editor regarding management and follow-up results of salivary fistulas treated with botulinum toxin.

Bertlich M, Jakob M, Send T, Eichhorn K, Bootz F.

Laryngoscope. 2019 May;129(5):E165. doi: 10.1002/lary.27681. Epub 2019 Feb 15. No abstract available.


Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study.

Jung M, Ellinger J, Gevensleben H, Syring I, Lüders C, de Vos L, Pützer S, Bootz F, Landsberg J, Kristiansen G, Dietrich D.

Clin Chem. 2019 Apr;65(4):559-568. doi: 10.1373/clinchem.2018.297549. Epub 2019 Jan 9.


Etiology, Management, and Outcome of Pediatric Epistaxis.

Send T, Bertlich M, Eichhorn KW, Ganschow R, Schafigh D, Horlbeck F, Bootz F, Jakob M.

Pediatr Emerg Care. 2019 Jan 7. doi: 10.1097/PEC.0000000000001698. [Epub ahead of print]


Amyloidosis of the Upper Aerodigestive Tract: Management of a Rare Disease and Review of the Literature.

Send T, Spiegel JL, Schade G, Pantelis A, Olthoff A, Bootz F, Canis M, Jakob M.

Dysphagia. 2019 Apr;34(2):179-191. doi: 10.1007/s00455-018-9956-x. Epub 2018 Oct 31. Review.


Management and outcome of epistaxis under direct oral anticoagulants: a comparison with warfarin.

Send T, Bertlich M, Horlbeck F, Schafigh D, Freytag S, Eichhorn KW, Gräff I, Bootz F, Jakob M.

Int Forum Allergy Rhinol. 2019 Jan;9(1):120-124. doi: 10.1002/alr.22210. Epub 2018 Oct 3.


Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5'-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients.

Vogt TJ, Gevensleben H, Dietrich J, Kristiansen G, Bootz F, Landsberg J, Goltz D, Dietrich D.

Oncoimmunology. 2018 Apr 18;7(8):e1452579. doi: 10.1080/2162402X.2018.1452579. eCollection 2018.


Management and Follow-up Results of Salivary Fistulas Treated With Botulinum Toxin.

Send T, Bertlich M, Eichhorn KW, Bootz F, Jakob M.

Laryngoscope. 2019 Feb;129(2):403-408. doi: 10.1002/lary.27416. Epub 2018 Aug 27.


CTLA4 methylation predicts response to anti-PD-1 and anti-CTLA-4 immunotherapy in melanoma patients.

Goltz D, Gevensleben H, Vogt TJ, Dietrich J, Golletz C, Bootz F, Kristiansen G, Landsberg J, Dietrich D.

JCI Insight. 2018 Jul 12;3(13). pii: 96793. doi: 10.1172/jci.insight.96793.


Potential of quantitative SEPT9 and SHOX2 methylation in plasmatic circulating cell-free DNA as auxiliary staging parameter in colorectal cancer: a prospective observational cohort study.

Bergheim J, Semaan A, Gevensleben H, Groening S, Knoblich A, Dietrich J, Weber J, Kalff JC, Bootz F, Kristiansen G, Dietrich D.

Br J Cancer. 2018 May;118(9):1217-1228. doi: 10.1038/s41416-018-0035-8. Epub 2018 Apr 3.


Significance of PITX2 Promoter Methylation in Colorectal Carcinoma Prognosis.

Semaan A, Uhl B, Branchi V, Lingohr P, Bootz F, Kristiansen G, Kalff JC, Matthaei H, Pantelis D, Dietrich D.

Clin Colorectal Cancer. 2018 Jun;17(2):e385-e393. doi: 10.1016/j.clcc.2018.02.008. Epub 2018 Feb 23.


Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomas.

Sailer V, Charpentier A, Dietrich J, Vogt TJ, Franzen A, Bootz F, Dietrich D, Schroeck A.

PLoS One. 2018 Feb 9;13(2):e0192742. doi: 10.1371/journal.pone.0192742. eCollection 2018.


PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas.

Franzen A, Vogt TJ, Müller T, Dietrich J, Schröck A, Golletz C, Brossart P, Bootz F, Landsberg J, Kristiansen G, Dietrich D.

Oncotarget. 2017 Dec 7;9(1):641-650. doi: 10.18632/oncotarget.23080. eCollection 2018 Jan 2.


PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations.

Röver LK, Gevensleben H, Dietrich J, Bootz F, Landsberg J, Goltz D, Dietrich D.

EBioMedicine. 2018 Feb;28:97-104. doi: 10.1016/j.ebiom.2018.01.016. Epub 2018 Jan 31.


[Rare cause of a supraclavicular swelling].

Bartmann D, Koppen T, Pieper CC, Bootz F, Send T.

HNO. 2018 Jun;66(6):485-488. doi: 10.1007/s00106-018-0472-y. German. No abstract available.


Comparison of quantification algorithms for circulating cell-free DNA methylation biomarkers in blood plasma from cancer patients.

de Vos L, Gevensleben H, Schröck A, Franzen A, Kristiansen G, Bootz F, Dietrich D.

Clin Epigenetics. 2017 Dec 1;9:125. doi: 10.1186/s13148-017-0425-4. eCollection 2017.


PD-L1: a novel prognostic biomarker in head and neck squamous cell carcinoma.

Müller T, Braun M, Dietrich D, Aktekin S, Höft S, Kristiansen G, Göke F, Schröck A, Brägelmann J, Held SAE, Bootz F, Brossart P.

Oncotarget. 2017 May 2;8(32):52889-52900. doi: 10.18632/oncotarget.17547. eCollection 2017 Aug 8.


RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.


[Rare cervical soft tissue tumor].

Send T, Isselstein LJ, Eichhorn KW, Greschus S, Bootz F, van Bremen T.

HNO. 2017 Dec;65(12):1018-1022. doi: 10.1007/s00106-017-0374-4. German. No abstract available.


Clinical performance validation of PITX2 DNA methylation as prognostic biomarker in patients with head and neck squamous cell carcinoma.

Sailer V, Gevensleben H, Dietrich J, Goltz D, Kristiansen G, Bootz F, Dietrich D.

PLoS One. 2017 Jun 15;12(6):e0179412. doi: 10.1371/journal.pone.0179412. eCollection 2017.


Robot-assisted endoscope guidance versus manual endoscope guidance in functional endonasal sinus surgery (FESS).

Eichhorn KW, Westphal R, Rilk M, Last C, Bootz F, Wahl F, Jakob M, Send T.

Acta Otolaryngol. 2017 Oct;137(10):1090-1095. doi: 10.1080/00016489.2017.1336284. Epub 2017 Jun 9.


Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study.

Schröck A, Leisse A, de Vos L, Gevensleben H, Dröge F, Franzen A, Wachendörfer M, Schröck F, Ellinger J, Teschke M, Wilhelm-Buchstab T, Landsberg J, Holdenrieder S, Hartmann G, Field JK, Bootz F, Kristiansen G, Dietrich D.

Clin Chem. 2017 Jul;63(7):1288-1296. doi: 10.1373/clinchem.2016.270207. Epub 2017 May 17.


PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients.

Goltz D, Gevensleben H, Dietrich J, Schroeck F, de Vos L, Droege F, Kristiansen G, Schroeck A, Landsberg J, Bootz F, Dietrich D.

Oncotarget. 2017 Jun 20;8(25):41011-41020. doi: 10.18632/oncotarget.17354.


[PET-CT in head and neck cancer].

Send T, Kreppel B, Gaertner FC, Bundschuh RA, Strunk H, Bootz F, Essler M.

HNO. 2017 Jun;65(6):504-513. doi: 10.1007/s00106-017-0355-7. Review. German.


[Interventional radiology in the head and neck region].

Mayer C, Hattingen E, Schild H, Bootz F, Schröck A.

HNO. 2017 Jun;65(6):482-489. doi: 10.1007/s00106-017-0354-8. Review. German.


[Imaging in otorhinolaryngology].

Bootz F.

HNO. 2017 Jun;65(6):460-461. doi: 10.1007/s00106-017-0356-6. German. No abstract available.


[Imaging for surgical planning : Tumor surgery including reconstructive procedures].

Bootz F, Greschus S.

HNO. 2017 Jun;65(6):472-481. doi: 10.1007/s00106-017-0343-y. Review. German.


PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma.

Sailer V, Holmes EE, Gevensleben H, Goltz D, Dröge F, Franzen A, Dietrich J, Kristiansen G, Bootz F, Schröck A, Dietrich D.

Clin Epigenetics. 2017 Feb 2;9:12. doi: 10.1186/s13148-017-0317-7. eCollection 2017.


MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy.

Laban S, Giebel G, Klümper N, Schröck A, Doescher J, Spagnoli G, Thierauf J, Theodoraki MN, Remark R, Gnjatic S, Krupar R, Sikora AG, Litjens G, Grabe N, Kristiansen G, Bootz F, Schuler PJ, Brunner C, Brägelmann J, Hoffmann TK, Perner S.

Oncotarget. 2017 Feb 28;8(9):14719-14735. doi: 10.18632/oncotarget.14830.


Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression.

von Mässenhausen A, Brägelmann J, Billig H, Thewes B, Queisser A, Vogel W, Kristiansen G, Schröck A, Bootz F, Brossart P, Kirfel J, Perner S.

Int J Mol Sci. 2016 Dec 22;18(1). pii: E7. doi: 10.3390/ijms18010007.


The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis.

Fugmann T, Sofron A, Ritz D, Bootz F, Neri D.

J Immunol. 2017 Feb 1;198(3):1357-1364. doi: 10.4049/jimmunol.1601157. Epub 2016 Dec 23.


Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients.

Meller S, VAN Ellen A, Gevensleben H, Bicker A, Hankeln T, Gorr TA, Sailer V, Dröge F, Schröck F, Bootz F, Schröck A, Perner S, Dietrich D, Kristiansen G.

Anticancer Res. 2016 Dec;36(12):6235-6241.


[Diagnosis and treatment of parapharyngeal space tumors].

Bootz F, Greschus S, van Bremen T.

HNO. 2016 Nov;64(11):815-821. Review. German.


[Dysphonia and Dysphagia Caused by a Pedunculated Polyp of the Hypopharynx].

Schwarte B, Bootz F, Zhou H, Schade G.

Laryngorhinootologie. 2016 Oct;95(10):702-703. doi: 10.1055/s-0042-109614. Epub 2016 Jul 14. German. No abstract available.


PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma.

Sailer V, Holmes EE, Gevensleben H, Goltz D, Dröge F, de Vos L, Franzen A, Schröck F, Bootz F, Kristiansen G, Schröck A, Dietrich D.

Oncotarget. 2016 Nov 15;7(46):75827-75838. doi: 10.18632/oncotarget.12417.


Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12.

Bootz F, Venetz D, Ziffels B, Neri D.

Protein Eng Des Sel. 2016 Oct;29(10):445-455. doi: 10.1093/protein/gzw038. Epub 2016 Aug 11.


Antibody-Based Targeted Delivery of Interleukin-22 Promotes Rapid Clinical Recovery in Mice With DSS-Induced Colitis.

Bootz F, Ziffels B, Neri D.

Inflamm Bowel Dis. 2016 Sep;22(9):2098-105. doi: 10.1097/MIB.0000000000000851.


Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib.

von Mässenhausen A, Sanders C, Brägelmann J, Konantz M, Queisser A, Vogel W, Kristiansen G, Duensing S, Schröck A, Bootz F, Brossart P, Kirfel J, Lengerke C, Perner S.

Int J Cancer. 2016 Nov 15;139(10):2359-69. doi: 10.1002/ijc.30279. Epub 2016 Jul 30.


Interdisziplinäre Versorgung von Kindern nach Fremdkörper aspiration und Fremdkörperingestion.

Eich C, Nicolai T, Hammer J, Deitmer T, Schmittenbecher P, Schubert KP, Laschat M, Sittel C, Claßen M, Becke K, Bootz F, Höhne C, Jungehülsing M, Windfuhr J.

Laryngorhinootologie. 2016 May;95(5):321-31. doi: 10.1055/s-0042-102614. Epub 2016 May 2. Review. German. No abstract available.


MERTK as a novel therapeutic target in head and neck cancer.

von Mässenhausen A, Sanders C, Thewes B, Deng M, Queisser A, Vogel W, Kristiansen G, Duensing S, Schröck A, Bootz F, Brossart P, Kirfel J, Heasley L, Brägelmann J, Perner S.

Oncotarget. 2016 May 31;7(22):32678-94. doi: 10.18632/oncotarget.8724.

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