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Items: 1 to 50 of 210

1.

Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice.

Hatter JA, Kouche YM, Melchor SJ, Ng K, Bouley DM, Boothroyd JC, Ewald SE.

PLoS One. 2018 Oct 31;13(10):e0204895. doi: 10.1371/journal.pone.0204895. eCollection 2018.

2.

Erratum for Franco et al., "A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells".

Franco M, Panas MW, Marino ND, Lee MW, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC.

MBio. 2018 Oct 2;9(5). pii: e01869-18. doi: 10.1128/mBio.01869-18. No abstract available.

3.

Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids.

Pernas L, Bean C, Boothroyd JC, Scorrano L.

Cell Metab. 2018 Apr 3;27(4):886-897.e4. doi: 10.1016/j.cmet.2018.02.018.

PMID:
29617646
4.

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects.

Naor A, Panas MW, Marino N, Coffey MJ, Tonkin CJ, Boothroyd JC.

MBio. 2018 Apr 3;9(2). pii: e02401-17. doi: 10.1128/mBio.02401-17.

5.

A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.

Blank ML, Parker ML, Ramaswamy R, Powell CJ, English ED, Adomako-Ankomah Y, Pernas LF, Workman SD, Boothroyd JC, Boulanger MJ, Boyle JP.

Mol Microbiol. 2018 Jun;108(5):519-535. doi: 10.1111/mmi.13947. Epub 2018 Apr 11.

PMID:
29505111
6.

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii.

Marino ND, Panas MW, Franco M, Theisen TC, Naor A, Rastogi S, Buchholz KR, Lorenzi HA, Boothroyd JC.

PLoS Pathog. 2018 Jan 22;14(1):e1006828. doi: 10.1371/journal.ppat.1006828. eCollection 2018 Jan.

7.

mRNA pseudouridylation affects RNA metabolism in the parasite Toxoplasma gondii.

Nakamoto MA, Lovejoy AF, Cygan AM, Boothroyd JC.

RNA. 2017 Dec;23(12):1834-1849. doi: 10.1261/rna.062794.117. Epub 2017 Aug 29.

PMID:
28851751
8.

Plasmonic photothermal therapy of atherosclerosis with nanoparticles: long-term outcomes and safety in NANOM-FIM trial.

Kharlamov AN, Feinstein JA, Cramer JA, Boothroyd JA, Shishkina EV, Shur V.

Future Cardiol. 2017 Jul;13(4):345-363. doi: 10.2217/fca-2017-0009. Epub 2017 Jun 23.

PMID:
28644056
9.

WITHDRAWN: What exactly, regression of atherosclerosis or foreign body reaction with hyaline arteriosclerosis, drives transient scaffolding of coronary arteries? A pooled analysis of observational ABSORB studies with a serial multimodality imaging substudy of ABSORB cohort B1 trial.

Kharlamov AN, Feinstein JA, Cramer JA, Boothroyd JA.

Int J Cardiol. 2017 Jun 6. pii: S0167-5273(16)32984-9. doi: 10.1016/j.ijcard.2017.05.134. [Epub ahead of print] No abstract available.

PMID:
28629625
10.

Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association.

Kelly FD, Wei BM, Cygan AM, Parker ML, Boulanger MJ, Boothroyd JC.

mSphere. 2017 May 24;2(3). pii: e00183-17. doi: 10.1128/mSphere.00183-17. eCollection 2017 May-Jun.

11.

An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells.

Guiton PS, Sagawa JM, Fritz HM, Boothroyd JC.

PLoS One. 2017 Mar 31;12(3):e0173018. doi: 10.1371/journal.pone.0173018. eCollection 2017.

12.

Toxoplasma growth in vitro is dependent on exogenous tyrosine and is independent of AAH2 even in tyrosine-limiting conditions.

Marino ND, Boothroyd JC.

Exp Parasitol. 2017 May;176:52-58. doi: 10.1016/j.exppara.2017.02.018. Epub 2017 Feb 28.

13.

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M.

MBio. 2017 Feb 28;8(1). pii: e02189-16. doi: 10.1128/mBio.02189-16.

14.

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail.

Krishnamurthy S, Deng B, Del Rio R, Buchholz KR, Treeck M, Urban S, Boothroyd J, Lam YW, Ward GE.

MBio. 2016 Sep 13;7(5). pii: e00754-16. doi: 10.1128/mBio.00754-16.

15.

Editorial overview: Host-microbe interactions: parasites: How eukaryotic parasites meet the challenges of life in a host.

Burleigh BA, Boothroyd JC.

Curr Opin Microbiol. 2016 Aug;32:viii-xi. doi: 10.1016/j.mib.2016.06.004. Epub 2016 Jun 29. No abstract available.

PMID:
27372032
16.

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells.

Franco M, Panas MW, Marino ND, Lee MC, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC.

MBio. 2016 Feb 2;7(1):e02231-15. doi: 10.1128/mBio.02231-15. Erratum in: MBio. 2018 Oct 2;9(5):.

17.

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.

Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD.

Nat Commun. 2016 Jan 7;7:10147. doi: 10.1038/ncomms10147.

18.

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.

Coffey MJ, Sleebs BE, Uboldi AD, Garnham A, Franco M, Marino ND, Panas MW, Ferguson DJ, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ.

Elife. 2015 Nov 18;4. pii: e10809. doi: 10.7554/eLife.10809.

19.

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.

Han SJ, Melichar HJ, Coombes JL, Chan SW, Koshy AA, Boothroyd JC, Barton GM, Robey EA.

Immunol Cell Biol. 2014 Nov;92(10):872-81. doi: 10.1038/icb.2014.70. Epub 2014 Aug 26.

20.

The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.

Reese ML, Shah N, Boothroyd JC.

J Biol Chem. 2014 Oct 3;289(40):27849-58. doi: 10.1074/jbc.M114.567057. Epub 2014 Aug 12.

21.

Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.

Christian DA, Koshy AA, Reuter MA, Betts MR, Boothroyd JC, Hunter CA.

Infect Immun. 2014 Oct;82(10):4056-67. doi: 10.1128/IAI.01643-14. Epub 2014 Jul 14.

22.

The calcium-dependent protein kinase 3 of toxoplasma influences basal calcium levels and functions beyond egress as revealed by quantitative phosphoproteome analysis.

Treeck M, Sanders JL, Gaji RY, LaFavers KA, Child MA, Arrizabalaga G, Elias JE, Boothroyd JC.

PLoS Pathog. 2014 Jun 19;10(6):e1004197. doi: 10.1371/journal.ppat.1004197. eCollection 2014 Jun.

23.

Impact of regulated secretion on antiparasitic CD8 T cell responses.

Grover HS, Chu HH, Kelly FD, Yang SJ, Reese ML, Blanchard N, Gonzalez F, Chan SW, Boothroyd JC, Shastri N, Robey EA.

Cell Rep. 2014 Jun 12;7(5):1716-1728. doi: 10.1016/j.celrep.2014.04.031. Epub 2014 May 22.

24.

Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.

Pernas L, Adomako-Ankomah Y, Shastri AJ, Ewald SE, Treeck M, Boyle JP, Boothroyd JC.

PLoS Biol. 2014 Apr 29;12(4):e1001845. doi: 10.1371/journal.pbio.1001845. eCollection 2014 Apr.

25.

GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response.

Shastri AJ, Marino ND, Franco M, Lodoen MB, Boothroyd JC.

Infect Immun. 2014 Jun;82(6):2595-605. doi: 10.1128/IAI.01339-13. Epub 2014 Apr 7.

26.

Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines.

Pernas L, Ramirez R, Holmes TH, Montoya JG, Boothroyd JC.

J Infect Dis. 2014 Sep 15;210(6):923-31. doi: 10.1093/infdis/jiu189. Epub 2014 Mar 23.

27.

Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulates.

Franco M, Shastri AJ, Boothroyd JC.

Eukaryot Cell. 2014 Apr;13(4):483-93. doi: 10.1128/EC.00316-13. Epub 2014 Feb 14.

28.

NLRP1 is an inflammasome sensor for Toxoplasma gondii.

Ewald SE, Chavarria-Smith J, Boothroyd JC.

Infect Immun. 2014 Jan;82(1):460-8. doi: 10.1128/IAI.01170-13. Epub 2013 Nov 11.

29.

Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1.

Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC.

PLoS One. 2013 Aug 5;8(8):e70637. doi: 10.1371/journal.pone.0070637. Print 2013.

30.

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.

Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M.

Nat Chem Biol. 2013 Oct;9(10):651-6. doi: 10.1038/nchembio.1315. Epub 2013 Aug 11.

31.

A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.

Caffaro CE, Koshy AA, Liu L, Zeiner GM, Hirschberg CB, Boothroyd JC.

PLoS Pathog. 2013;9(5):e1003331. doi: 10.1371/journal.ppat.1003331. Epub 2013 May 2.

32.

Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses.

Boothroyd JC.

PLoS Pathog. 2013;9(4):e1003296. doi: 10.1371/journal.ppat.1003296. Epub 2013 Apr 25. No abstract available.

33.

Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.

Buchholz KR, Bowyer PW, Boothroyd JC.

Eukaryot Cell. 2013 Mar;12(3):399-410. doi: 10.1128/EC.00343-12. Epub 2013 Jan 4.

34.

A forward genetic screen reveals that calcium-dependent protein kinase 3 regulates egress in Toxoplasma.

Garrison E, Treeck M, Ehret E, Butz H, Garbuz T, Oswald BP, Settles M, Boothroyd J, Arrizabalaga G.

PLoS Pathog. 2012;8(11):e1003049. doi: 10.1371/journal.ppat.1003049. Epub 2012 Nov 29.

35.

Toxoplasma co-opts host cells it does not invade.

Koshy AA, Dietrich HK, Christian DA, Melehani JH, Shastri AJ, Hunter CA, Boothroyd JC.

PLoS Pathog. 2012;8(7):e1002825. doi: 10.1371/journal.ppat.1002825. Epub 2012 Jul 26.

36.

A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

Fleckenstein MC, Reese ML, Könen-Waisman S, Boothroyd JC, Howard JC, Steinfeldt T.

PLoS Biol. 2012;10(7):e1001358. doi: 10.1371/journal.pbio.1001358. Epub 2012 Jul 10.

37.

Infected dendritic cells facilitate systemic dissemination and transplacental passage of the obligate intracellular parasite Neospora caninum in mice.

Collantes-Fernandez E, Arrighi RB, Alvarez-García G, Weidner JM, Regidor-Cerrillo J, Boothroyd JC, Ortega-Mora LM, Barragan A.

PLoS One. 2012;7(3):e32123. doi: 10.1371/journal.pone.0032123. Epub 2012 Mar 5.

38.

Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Fritz HM, Buchholz KR, Chen X, Durbin-Johnson B, Rocke DM, Conrad PA, Boothroyd JC.

PLoS One. 2012;7(2):e29998. doi: 10.1371/journal.pone.0029998. Epub 2012 Feb 13.

39.

Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance.

Fritz HM, Bowyer PW, Bogyo M, Conrad PA, Boothroyd JC.

PLoS One. 2012;7(1):e29955. doi: 10.1371/journal.pone.0029955. Epub 2012 Jan 18.

40.

Tissue barriers of the human placenta to infection with Toxoplasma gondii.

Robbins JR, Zeldovich VB, Poukchanski A, Boothroyd JC, Bakardjiev AI.

Infect Immun. 2012 Jan;80(1):418-28. doi: 10.1128/IAI.05899-11. Epub 2011 Nov 14.

41.

Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hosts.

Ong YC, Boyle JP, Boothroyd JC.

PLoS One. 2011;6(10):e26369. doi: 10.1371/journal.pone.0026369. Epub 2011 Oct 13.

42.

Identification of tissue cyst wall components by transcriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoites.

Buchholz KR, Fritz HM, Chen X, Durbin-Johnson B, Rocke DM, Ferguson DJ, Conrad PA, Boothroyd JC.

Eukaryot Cell. 2011 Dec;10(12):1637-47. doi: 10.1128/EC.05182-11. Epub 2011 Oct 21.

43.

The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.

Treeck M, Sanders JL, Elias JE, Boothroyd JC.

Cell Host Microbe. 2011 Oct 20;10(4):410-9. doi: 10.1016/j.chom.2011.09.004.

44.

Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.

Morgado P, Ong YC, Boothroyd JC, Lodoen MB.

Infect Immun. 2011 Nov;79(11):4401-12. doi: 10.1128/IAI.05562-11. Epub 2011 Sep 12.

45.

Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.

Srinivasan P, Beatty WL, Diouf A, Herrera R, Ambroggio X, Moch JK, Tyler JS, Narum DL, Pierce SK, Boothroyd JC, Haynes JD, Miller LH.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13275-80. doi: 10.1073/pnas.1110303108. Epub 2011 Jul 25.

46.

A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence.

Reese ML, Boothroyd JC.

J Biol Chem. 2011 Aug 19;286(33):29366-75. doi: 10.1074/jbc.M111.253435. Epub 2011 Jun 27.

47.

Evidence for host cells as the major contributor of lipids in the intravacuolar network of Toxoplasma-infected cells.

Caffaro CE, Boothroyd JC.

Eukaryot Cell. 2011 Aug;10(8):1095-9. doi: 10.1128/EC.00002-11. Epub 2011 Jun 17.

48.

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.

Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10568-73. doi: 10.1073/pnas.1105622108. Epub 2011 Jun 13.

49.

Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.

Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP.

Cell Host Microbe. 2011 Jun 16;9(6):472-83. doi: 10.1016/j.chom.2011.04.015.

50.

Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.

Tyler JS, Treeck M, Boothroyd JC.

Trends Parasitol. 2011 Sep;27(9):410-20. doi: 10.1016/j.pt.2011.04.002. Epub 2011 Jun 12. Review.

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