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Items: 1 to 50 of 96

1.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

2.

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes".

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG.

ACS Cent Sci. 2017 Jun 28;3(6):673. doi: 10.1021/acscentsci.7b00185. Epub 2017 May 18.

3.

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease.

Kytidou K, Beenakker TJM, Westerhof LB, Hokke CH, Moolenaar GF, Goosen N, Mirzaian M, Ferraz MJ, de Geus M, Kallemeijn WW, Overkleeft HS, Boot RG, Schots A, Bosch D, Aerts JMFG.

Front Plant Sci. 2017 Jun 21;8:1026. doi: 10.3389/fpls.2017.01026. eCollection 2017.

4.

Stabilization of Glucocerebrosidase by Active Site Occupancy.

Ben Bdira F, Kallemeijn WW, Oussoren SV, Scheij S, Bleijlevens B, Florea BI, van Roomen CPAA, Ottenhoff R, van Kooten MJFM, Walvoort MTC, Witte MD, Boot RG, Ubbink M, Overkleeft HS, Aerts JMFG.

ACS Chem Biol. 2017 Jul 21;12(7):1830-1841. doi: 10.1021/acschembio.7b00276. Epub 2017 May 22.

5.

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes.

Kallemeijn WW, Scheij S, Hoogendoorn S, Witte MD, Herrera Moro Chao D, van Roomen CP, Ottenhoff R, Overkleeft HS, Boot RG, Aerts JM.

PLoS One. 2017 Feb 16;12(2):e0170268. doi: 10.1371/journal.pone.0170268. eCollection 2017.

6.

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

Marques AR, Willems LI, Herrera Moro D, Florea BI, Scheij S, Ottenhoff R, van Roomen CP, Verhoek M, Nelson JK, Kallemeijn WW, Biela-Banas A, Martin OR, Cachón-González MB, Kim NN, Cox TM, Boot RG, Overkleeft HS, Aerts JM.

Chembiochem. 2017 Feb 16;18(4):402-412. doi: 10.1002/cbic.201600561. Epub 2017 Jan 31.

PMID:
28000364
7.

Evolutionary heritage influences Amazon tree ecology.

Coelho de Souza F, Dexter KG, Phillips OL, Brienen RJ, Chave J, Galbraith DR, Lopez Gonzalez G, Monteagudo Mendoza A, Pennington RT, Poorter L, Alexiades M, Álvarez-Dávila E, Andrade A, Aragão LE, Araujo-Murakami A, Arets EJ, Aymard C GA, Baraloto C, Barroso JG, Bonal D, Boot RG, Camargo JL, Comiskey JA, Valverde FC, de Camargo PB, Di Fiore A, Elias F, Erwin TL, Feldpausch TR, Ferreira L, Fyllas NM, Gloor E, Herault B, Herrera R, Higuchi N, Honorio Coronado EN, Killeen TJ, Laurance WF, Laurance S, Lloyd J, Lovejoy TE, Malhi Y, Maracahipes L, Marimon BS, Marimon-Junior BH, Mendoza C, Morandi P, Neill DA, Vargas PN, Oliveira EA, Lenza E, Palacios WA, Peñuela-Mora MC, Pipoly JJ 3rd, Pitman NC, Prieto A, Quesada CA, Ramirez-Angulo H, Rudas A, Ruokolainen K, Salomão RP, Silveira M, Stropp J, Ter Steege H, Thomas-Caesar R, van der Hout P, van der Heijden GM, van der Meer PJ, Vasquez RV, Vieira SA, Vilanova E, Vos VA, Wang O, Young KR, Zagt RJ, Baker TR.

Proc Biol Sci. 2016 Dec 14;283(1844). pii: 20161587.

8.

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models.

Kramer G, Wegdam W, Donker-Koopman W, Ottenhoff R, Gaspar P, Verhoek M, Nelson J, Gabriel T, Kallemeijn W, Boot RG, Laman JD, Vissers JP, Cox T, Pavlova E, Moran MT, Aerts JM, van Eijk M.

FEBS Open Bio. 2016 Jul 30;6(9):902-13. doi: 10.1002/2211-5463.12078. eCollection 2016 Sep.

9.

Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem.

Herrera Moro Chao D, Argmann C, Van Eijk M, Boot RG, Ottenhoff R, Van Roomen C, Foppen E, Siljee JE, Unmehopa UA, Kalsbeek A, Aerts JM.

Sci Rep. 2016 Jul 8;6:29094. doi: 10.1038/srep29094.

10.

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

Kallemeijn WW, Scheij S, Voorn-Brouwer TM, Witte MD, Verhoek M, Overkleeft HS, Boot RG, Aerts JM.

Chembiochem. 2016 Sep 15;17(18):1698-704. doi: 10.1002/cbic.201600312. Epub 2016 Aug 4.

PMID:
27383447
11.

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JD, Boot RG, Davies GJ, Overkleeft HS, Aerts JM.

ACS Cent Sci. 2016 May 25;2(5):351-8. doi: 10.1021/acscentsci.6b00057. Epub 2016 Apr 26. Erratum in: ACS Cent Sci. 2017 Jun 28;3(6):673.

12.

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases.

Ferraz MJ, Marques AR, Appelman MD, Verhoek M, Strijland A, Mirzaian M, Scheij S, Ouairy CM, Lahav D, Wisse P, Overkleeft HS, Boot RG, Aerts JM.

FEBS Lett. 2016 Mar;590(6):716-25. doi: 10.1002/1873-3468.12104. Epub 2016 Mar 3.

13.

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases.

Marques AR, Mirzaian M, Akiyama H, Wisse P, Ferraz MJ, Gaspar P, Ghauharali-van der Vlugt K, Meijer R, Giraldo P, Alfonso P, Irún P, Dahl M, Karlsson S, Pavlova EV, Cox TM, Scheij S, Verhoek M, Ottenhoff R, van Roomen CP, Pannu NS, van Eijk M, Dekker N, Boot RG, Overkleeft HS, Blommaart E, Hirabayashi Y, Aerts JM.

J Lipid Res. 2016 Mar;57(3):451-63. doi: 10.1194/jlr.M064923. Epub 2016 Jan 2.

14.

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes.

Herrera Moro Chao D, Kallemeijn WW, Marques AR, Orre M, Ottenhoff R, van Roomen C, Foppen E, Renner MC, Moeton M, van Eijk M, Boot RG, Kamphuis W, Hol EM, Aten J, Overkleeft HS, Kalsbeek A, Aerts JM.

PLoS One. 2015 Sep 29;10(9):e0138107. doi: 10.1371/journal.pone.0138107. eCollection 2015.

15.

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.

James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC.

PMID:
26372680
16.

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice.

Marques AR, Aten J, Ottenhoff R, van Roomen CP, Herrera Moro D, Claessen N, Vinueza Veloz MF, Zhou K, Lin Z, Mirzaian M, Boot RG, De Zeeuw CI, Overkleeft HS, Yildiz Y, Aerts JM.

PLoS One. 2015 Aug 14;10(8):e0135889. doi: 10.1371/journal.pone.0135889. eCollection 2015.

17.

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

Jiang J, Kallemeijn WW, Wright DW, van den Nieuwendijk AMCH, Rohde VC, Folch EC, van den Elst H, Florea BI, Scheij S, Donker-Koopman WE, Verhoek M, Li N, Schürmann M, Mink D, Boot RG, Codée JDC, van der Marel GA, Davies GJ, Aerts JMFG, Overkleeft HS.

Chem Sci. 2015 May 1;6(5):2782-false. doi: 10.1039/c4sc03739a. Epub 2015 Feb 9.

18.

Hyperdominance in Amazonian forest carbon cycling.

Fauset S, Johnson MO, Gloor M, Baker TR, Monteagudo M A, Brienen RJ, Feldpausch TR, Lopez-Gonzalez G, Malhi Y, ter Steege H, Pitman NC, Baraloto C, Engel J, Pétronelli P, Andrade A, Camargo JL, Laurance SG, Laurance WF, Chave J, Allie E, Vargas PN, Terborgh JW, Ruokolainen K, Silveira M, Aymard C GA, Arroyo L, Bonal D, Ramirez-Angulo H, Araujo-Murakami A, Neill D, Hérault B, Dourdain A, Torres-Lezama A, Marimon BS, Salomão RP, Comiskey JA, Réjou-Méchain M, Toledo M, Licona JC, Alarcón A, Prieto A, Rudas A, van der Meer PJ, Killeen TJ, Marimon Junior BH, Poorter L, Boot RG, Stergios B, Torre EV, Costa FR, Levis C, Schietti J, Souza P, Groot N, Arets E, Moscoso VC, Castro W, Coronado EN, Peña-Claros M, Stahl C, Barroso J, Talbot J, Vieira IC, van der Heijden G, Thomas R, Vos VA, Almeida EC, Davila EÁ, Aragão LE, Erwin TL, Morandi PS, de Oliveira EA, Valadão MB, Zagt RJ, van der Hout P, Loayza PA, Pipoly JJ, Wang O, Alexiades M, Cerón CE, Huamantupa-Chuquimaco I, Di Fiore A, Peacock J, Camacho NC, Umetsu RK, de Camargo PB, Burnham RJ, Herrera R, Quesada CA, Stropp J, Vieira SA, Steininger M, Rodríguez CR, Restrepo Z, Muelbert AE, Lewis SL, Pickavance GC, Phillips OL.

Nat Commun. 2015 Apr 28;6:6857. doi: 10.1038/ncomms7857.

19.

Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard.

Mirzaian M, Wisse P, Ferraz MJ, Gold H, Donker-Koopman WE, Verhoek M, Overkleeft HS, Boot RG, Kramer G, Dekker N, Aerts JM.

Blood Cells Mol Dis. 2015 Apr;54(4):307-14. doi: 10.1016/j.bcmd.2015.01.006. Epub 2015 Jan 17.

PMID:
25842368
20.

Long-term decline of the Amazon carbon sink.

Brienen RJ, Phillips OL, Feldpausch TR, Gloor E, Baker TR, Lloyd J, Lopez-Gonzalez G, Monteagudo-Mendoza A, Malhi Y, Lewis SL, Vásquez Martinez R, Alexiades M, Álvarez Dávila E, Alvarez-Loayza P, Andrade A, Aragão LE, Araujo-Murakami A, Arets EJ, Arroyo L, Aymard C GA, Bánki OS, Baraloto C, Barroso J, Bonal D, Boot RG, Camargo JL, Castilho CV, Chama V, Chao KJ, Chave J, Comiskey JA, Cornejo Valverde F, da Costa L, de Oliveira EA, Di Fiore A, Erwin TL, Fauset S, Forsthofer M, Galbraith DR, Grahame ES, Groot N, Hérault B, Higuchi N, Honorio Coronado EN, Keeling H, Killeen TJ, Laurance WF, Laurance S, Licona J, Magnussen WE, Marimon BS, Marimon-Junior BH, Mendoza C, Neill DA, Nogueira EM, Núñez P, Pallqui Camacho NC, Parada A, Pardo-Molina G, Peacock J, Peña-Claros M, Pickavance GC, Pitman NC, Poorter L, Prieto A, Quesada CA, Ramírez F, Ramírez-Angulo H, Restrepo Z, Roopsind A, Rudas A, Salomão RP, Schwarz M, Silva N, Silva-Espejo JE, Silveira M, Stropp J, Talbot J, ter Steege H, Teran-Aguilar J, Terborgh J, Thomas-Caesar R, Toledo M, Torello-Raventos M, Umetsu RK, van der Heijden GM, van der Hout P, Guimarães Vieira IC, Vieira SA, Vilanova E, Vos VA, Zagt RJ.

Nature. 2015 Mar 19;519(7543):344-8. doi: 10.1038/nature14283.

PMID:
25788097
21.

Development of an acid ceramidase activity-based probe.

Ouairy CM, Ferraz MJ, Boot RG, Baggelaar MP, van der Stelt M, Appelman M, van der Marel GA, Florea BI, Aerts JM, Overkleeft HS.

Chem Commun (Camb). 2015 Apr 11;51(28):6161-3. doi: 10.1039/c5cc00356c.

PMID:
25748248
22.

Increased glucocerebrosidase expression and activity in preeclamptic placenta.

Jebbink JM, Boot RG, Keijser R, Moerland PD, Aten J, Veenboer GJ, van Wely M, Buimer M, Ver Loren van Themaat E, Aerts JM, van der Post JA, Afink GB, Ris-Stalpers C.

Placenta. 2015 Feb;36(2):160-9. doi: 10.1016/j.placenta.2014.12.001. Epub 2014 Dec 13.

PMID:
25552189
23.

A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.

Kallemeijn WW, Witte MD, Voorn-Brouwer TM, Walvoort MT, Li KY, Codée JD, van der Marel GA, Boot RG, Overkleeft HS, Aerts JM.

J Biol Chem. 2014 Dec 19;289(51):35351-62. doi: 10.1074/jbc.M114.593376. Epub 2014 Oct 24.

24.

Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors.

Li KY, Jiang J, Witte MD, Kallemeijn WW, Donker-Koopman WE, Boot RG, Aerts JM, Codée JD, van der Marel GA, Overkleeft HS.

Org Biomol Chem. 2014 Oct 21;12(39):7786-91. doi: 10.1039/c4ob01611d. Epub 2014 Aug 26.

PMID:
25156485
25.

Potent and selective activity-based probes for GH27 human retaining α-galactosidases.

Willems LI, Beenakker TJ, Murray B, Scheij S, Kallemeijn WW, Boot RG, Verhoek M, Donker-Koopman WE, Ferraz MJ, van Rijssel ER, Florea BI, Codée JD, van der Marel GA, Aerts JM, Overkleeft HS.

J Am Chem Soc. 2014 Aug 20;136(33):11622-5. doi: 10.1021/ja507040n. Epub 2014 Aug 11.

PMID:
25105979
26.

Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.

Duivenvoorden BA, Ghauharali K, Scheij S, Boot RG, Aerts JM, van der Marel GA, Overkleeft HS, Codée JD.

Carbohydr Res. 2014 Nov 18;399:26-37. doi: 10.1016/j.carres.2014.07.007. Epub 2014 Jul 18.

PMID:
25104395
27.

Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.

van Dussen L, Hendriks EJ, Groener JE, Boot RG, Hollak CE, Aerts JM.

J Inherit Metab Dis. 2014 Nov;37(6):991-1001. doi: 10.1007/s10545-014-9711-x. Epub 2014 May 16.

PMID:
24831585
28.

Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses.

Ferraz MJ, Kallemeijn WW, Mirzaian M, Herrera Moro D, Marques A, Wisse P, Boot RG, Willems LI, Overkleeft HS, Aerts JM.

Biochim Biophys Acta. 2014 May;1841(5):811-25. doi: 10.1016/j.bbalip.2013.11.004. Epub 2013 Nov 13. Review.

PMID:
24239767
29.

The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma.

Konradsen JR, James A, Nordlund B, Reinius LE, Söderhäll C, Melén E, Wheelock AM, Lödrup Carlsen KC, Lidegran M, Verhoek M, Boot RG, Dahlén B, Dahlén SE, Hedlin G.

J Allergy Clin Immunol. 2013 Aug;132(2):328-35.e5. doi: 10.1016/j.jaci.2013.03.003. Epub 2013 Apr 26. Erratum in: J Allergy Clin Immunol. 2013 Nov;132(5):1259. Wheelock, Asa [corrected to Wheelock, Asa M].

PMID:
23628340
30.

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

Kallemeijn WW, Li KY, Witte MD, Marques AR, Aten J, Scheij S, Jiang J, Willems LI, Voorn-Brouwer TM, van Roomen CP, Ottenhoff R, Boot RG, van den Elst H, Walvoort MT, Florea BI, Codée JD, van der Marel GA, Aerts JM, Overkleeft HS.

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12529-33. doi: 10.1002/anie.201207771. Epub 2012 Nov 8.

PMID:
23139194
31.

Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts.

Aureli M, Bassi R, Loberto N, Regis S, Prinetti A, Chigorno V, Aerts JM, Boot RG, Filocamo M, Sonnino S.

J Inherit Metab Dis. 2012 Nov;35(6):1081-91. doi: 10.1007/s10545-012-9478-x. Epub 2012 Apr 19.

PMID:
22526844
32.

Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis.

Lo SM, Choi M, Liu J, Jain D, Boot RG, Kallemeijn WW, Aerts JM, Pashankar F, Kupfer GM, Mane S, Lifton RP, Mistry PK.

Blood. 2012 May 17;119(20):4731-40. doi: 10.1182/blood-2011-10-386862. Epub 2012 Apr 4. Erratum in: Blood. 2014 Oct 9;124(15):2469.

33.

Glycosphingolipids and insulin resistance.

Aerts JM, Boot RG, van Eijk M, Groener J, Bijl N, Lombardo E, Bietrix FM, Dekker N, Groen AK, Ottenhoff R, van Roomen C, Aten J, Serlie M, Langeveld M, Wennekes T, Overkleeft HS.

Adv Exp Med Biol. 2011;721:99-119. doi: 10.1007/978-1-4614-0650-1_7. Review.

PMID:
21910085
34.

Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response.

Dekker N, van Dussen L, Hollak CE, Overkleeft H, Scheij S, Ghauharali K, van Breemen MJ, Ferraz MJ, Groener JE, Maas M, Wijburg FA, Speijer D, Tylki-Szymanska A, Mistry PK, Boot RG, Aerts JM.

Blood. 2011 Oct 20;118(16):e118-27. doi: 10.1182/blood-2011-05-352971. Epub 2011 Aug 25.

35.

Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.

van den Berg RJ, Wennekes T, Ghisaidoobe A, Donker-Koopman WE, Strijland A, Boot RG, van der Marel GA, Aerts JM, Overkleeft HS.

ACS Med Chem Lett. 2011 Apr 7;2(7):519-22. doi: 10.1021/ml200050s. eCollection 2011 Jul 14.

36.

Activity-based profiling of retaining β-glucosidases: a comparative study.

Witte MD, Walvoort MT, Li KY, Kallemeijn WW, Donker-Koopman WE, Boot RG, Aerts JM, Codée JD, van der Marel GA, Overkleeft HS.

Chembiochem. 2011 May 16;12(8):1263-9. doi: 10.1002/cbic.201000773. Epub 2011 Apr 28.

PMID:
21538758
37.

Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies.

Aerts JM, Kallemeijn WW, Wegdam W, Joao Ferraz M, van Breemen MJ, Dekker N, Kramer G, Poorthuis BJ, Groener JE, Cox-Brinkman J, Rombach SM, Hollak CE, Linthorst GE, Witte MD, Gold H, van der Marel GA, Overkleeft HS, Boot RG.

J Inherit Metab Dis. 2011 Jun;34(3):605-19. doi: 10.1007/s10545-011-9308-6. Epub 2011 Mar 29. Review.

38.

Ultrasensitive in situ visualization of active glucocerebrosidase molecules.

Witte MD, Kallemeijn WW, Aten J, Li KY, Strijland A, Donker-Koopman WE, van den Nieuwendijk AM, Bleijlevens B, Kramer G, Florea BI, Hooibrink B, Hollak CE, Ottenhoff R, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Nat Chem Biol. 2010 Dec;6(12):907-13. doi: 10.1038/nchembio.466. Epub 2010 Oct 31.

PMID:
21079602
39.

Pharmacological small molecules for the treatment of lysosomal storage disorders.

Smid BE, Aerts JM, Boot RG, Linthorst GE, Hollak CE.

Expert Opin Investig Drugs. 2010 Nov;19(11):1367-79. doi: 10.1517/13543784.2010.524205. Epub 2010 Oct 13. Review. Erratum in: Expert Opin Investig Drugs. 2011 Feb;20(2):309.

PMID:
20942596
40.

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation.

Dekker N, Voorn-Brouwer T, Verhoek M, Wennekes T, Narayan RS, Speijer D, Hollak CE, Overkleeft HS, Boot RG, Aerts JM.

Blood Cells Mol Dis. 2011 Jan 15;46(1):19-26. doi: 10.1016/j.bcmd.2010.07.009. Epub 2010 Aug 21.

PMID:
20728381
41.

Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.

van den Nieuwendijk AM, Ruben M, Engelsma SE, Risseeuw MD, van den Berg RJ, Boot RG, Aerts JM, Brussee J, van der Marel GA, Overkleeft HS.

Org Lett. 2010 Sep 3;12(17):3957-9. doi: 10.1021/ol101556k.

PMID:
20690611
42.

Curdlan-mediated regulation of human phagocyte-specific chitotriosidase.

van Eijk M, Voorn-Brouwer T, Scheij SS, Verhoeven AJ, Boot RG, Aerts JM.

FEBS Lett. 2010 Jul 16;584(14):3165-9. doi: 10.1016/j.febslet.2010.06.001. Epub 2010 Jun 10.

43.

Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.

van Eijk M, Aust G, Brouwer MS, van Meurs M, Voerman JS, Dijke IE, Pouwels W, Sändig I, Wandel E, Aerts JM, Boot RG, Laman JD, Hamann J.

Immunol Lett. 2010 Apr 8;129(2):64-71. doi: 10.1016/j.imlet.2010.02.004. Epub 2010 Feb 16.

PMID:
20167235
44.

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.

Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM.

J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m.

PMID:
20000679
45.

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Angew Chem Int Ed Engl. 2009;48(47):8848-69. doi: 10.1002/anie.200902620. Review.

PMID:
19862781
46.

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis.

Boot RG, Hollak CE, Verhoek M, Alberts C, Jonkers RE, Aerts JM.

Clin Chim Acta. 2010 Jan;411(1-2):31-6. doi: 10.1016/j.cca.2009.09.034. Epub 2009 Oct 4.

PMID:
19808030
47.

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

Bijl N, Sokolović M, Vrins C, Langeveld M, Moerland PD, Ottenhoff R, van Roomen CP, Claessen N, Boot RG, Aten J, Groen AK, Aerts JM, van Eijk M.

Hepatology. 2009 Nov;50(5):1431-41. doi: 10.1002/hep.23175.

PMID:
19731235
48.

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

Bussink AP, Verhoek M, Vreede J, Ghauharali-van der Vlugt K, Donker-Koopman WE, Sprenger RR, Hollak CE, Aerts JM, Boot RG.

FEBS J. 2009 Oct;276(19):5678-88. doi: 10.1111/j.1742-4658.2009.07259.x. Epub 2009 Sep 2.

49.

Gaucher disease: a model disorder for biomarker discovery.

Boot RG, van Breemen MJ, Wegdam W, Sprenger RR, de Jong S, Speijer D, Hollak CE, van Dussen L, Hoefsloot HC, Smilde AK, de Koster CG, Vissers JP, Aerts JM.

Expert Rev Proteomics. 2009 Aug;6(4):411-9. doi: 10.1586/epr.09.54. Review.

PMID:
19681676
50.

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.

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