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Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.

Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.

PLoS Comput Biol. 2018 Oct 30;14(10):e1006532. doi: 10.1371/journal.pcbi.1006532. eCollection 2018 Oct.


Comparison of Different Remission and Low Disease Definitions in Psoriatic Arthritis and Evaluation of Their Prognostic Value.

Coates LC, Gottlieb AB, Merola JF, Boone C, Szumski A, Chhabra A.

J Rheumatol. 2018 Oct 15. pii: jrheum.180249. doi: 10.3899/jrheum.180249. [Epub ahead of print]


The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment.

Goodwin CR, Ahmed AK, Boone C, Abu-Bonsrah N, Xu R, Germscheid N, Fourney DR, Clarke M, Laufer I, Fisher CG, Bettegowda C, Sciubba DM.

Global Spine J. 2018 Aug;8(5):517-526. doi: 10.1177/2192568217737777. Epub 2017 Nov 20. Review.


Resistance training does not induce uniform adaptations to quadriceps.

Mangine GT, Redd MJ, Gonzalez AM, Townsend JR, Wells AJ, Jajtner AR, Beyer KS, Boone CH, La Monica MB, Stout JR, Fukuda DH, Ratamess NA, Hoffman JR.

PLoS One. 2018 Aug 30;13(8):e0198304. doi: 10.1371/journal.pone.0198304. eCollection 2018.


Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis.

Corcoles-Saez I, Dong K, Johnson AL, Waskiewicz E, Costanzo M, Boone C, Cha RS.

Dev Cell. 2018 Aug 20;46(4):495-503.e2. doi: 10.1016/j.devcel.2018.07.011.


Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell.

VanderSluis B, Costanzo M, Billmann M, Ward HN, Myers CL, Andrews BJ, Boone C.

Curr Opin Microbiol. 2018 Jul 27;45:170-179. doi: 10.1016/j.mib.2018.06.004. [Epub ahead of print] Review.


A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A.

Ciftci-Yilmaz S, Au WC, Mishra PK, Eisenstatt JR, Chang J, Dawson AR, Zhu I, Rahman M, Bilke S, Costanzo M, Baryshnikova A, Myers CL, Meltzer PS, Landsman D, Baker RE, Boone C, Basrai MA.

Genetics. 2018 Sep;210(1):203-218. doi: 10.1534/genetics.118.301305. Epub 2018 Jul 16.


Selection of the sex-linked inhibitor of apoptosis in mountain pine beetle (Dendroctonus ponderosae) driven by enhanced expression during early overwintering.

Horianopoulos LC, Boone CK, Samarasekera GDNG, Kandola GK, Murray BW.

Ecol Evol. 2018 May 24;8(12):6253-6264. doi: 10.1002/ece3.4164. eCollection 2018 Jun.


Relationship between beliefs about medicines, adherence to treatment, and disease activity in patients with rheumatoid arthritis under subcutaneous anti-TNFα therapy.

Horne R, Albert A, Boone C.

Patient Prefer Adherence. 2018 Jun 22;12:1099-1111. doi: 10.2147/PPA.S166451. eCollection 2018.


Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.

Hou J, van Leeuwen J, Andrews BJ, Boone C.

Trends Genet. 2018 Aug;34(8):578-586. doi: 10.1016/j.tig.2018.05.006. Epub 2018 Jun 11. Review.


The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.

Sing TL, Hung MP, Ohnuki S, Suzuki G, San Luis BJ, McClain M, Unruh JR, Yu Z, Ou J, Marshall-Sheppard J, Huh WK, Costanzo M, Boone C, Ohya Y, Jaspersen SL, Brown GW.

J Cell Biol. 2018 Jul 2;217(7):2445-2462. doi: 10.1083/jcb.201709009. Epub 2018 Jun 6.


MR-Guided Functional Neurosurgery: Laser Ablation and Deep Brain Stimulation.

Boone CE, Wojtasiewicz T, Moukheiber E, Butala A, Jordao L, Mills KA, Sair H, Anderson WS.

Top Magn Reson Imaging. 2018 Jun;27(3):171-177. doi: 10.1097/RMR.0000000000000152. Review.


Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome.

Boone CE, Davoudi H, Harrold JB, Foster DJ.

Neuroscience. 2018 Aug 1;384:275-289. doi: 10.1016/j.neuroscience.2018.05.012. Epub 2018 May 22.


Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.

Mount HO, Revie NM, Todd RT, Anstett K, Collins C, Costanzo M, Boone C, Robbins N, Selmecki A, Cowen LE.

PLoS Genet. 2018 Apr 27;14(4):e1007319. doi: 10.1371/journal.pgen.1007319. eCollection 2018 Apr.


Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.


Effects of biologic disease-modifying anti-rheumatic drugs on the radiographic progression of rheumatoid arthritis: a systematic literature review.

Combe B, Lula S, Boone C, Durez P.

Clin Exp Rheumatol. 2018 Jul-Aug;36(4):658-667. Epub 2018 Mar 20. Review.


Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M; AMP T2D-GENES Consortium, Myers CL, Boone C, Florez JC, Lindquist S.

Cell. 2018 Mar 22;173(1):62-73.e9. doi: 10.1016/j.cell.2018.02.026. Epub 2018 Mar 8.


Allostery revealed within lipid binding events to membrane proteins.

Patrick JW, Boone CD, Liu W, Conover GM, Liu Y, Cong X, Laganowsky A.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2976-2981. doi: 10.1073/pnas.1719813115. Epub 2018 Mar 5.


Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.

Shin M, van Leeuwen J, Boone C, Bretscher A.

Mol Biol Cell. 2018 Apr 15;29(8):923-936. doi: 10.1091/mbc.E17-10-0592. Epub 2018 Mar 30.


Pain and Opioid use Outcomes Following Minimally Invasive Sacroiliac Joint Fusion with Decortication and Bone Grafting: The Evolusion Clinical Trial.

Araghi A, Woodruff R, Colle K, Boone C, Ingham L, Tomeh A, Fielding LC.

Open Orthop J. 2017 Dec 27;11:1440-1448. doi: 10.2174/1874325001711011440. eCollection 2017.


Contextual factors influence work outcomes in employed patients with ankylosing spondylitis starting etanercept: 2-year results from AS@Work.

Boonen A, Boone C, Albert A, Mielants H.

Rheumatology (Oxford). 2018 May 1;57(5):791-797. doi: 10.1093/rheumatology/kex476.


The Role of Sulfur Dioxide in Stratospheric Aerosol Formation Evaluated Using In-Situ Measurements in the Tropical Lower Stratosphere.

Rollins AW, Thornberry TD, Watts LA, Yu P, Rosenlof KH, Mills M, Baumann E, Giorgetta FR, Bui TV, Höpfner M, Walker KA, Boone C, Bernath PF, Colarco PR, Newman PA, Fahey DW, Gao RS.

Geophys Res Lett. 2017 May 16;44(9):4280-4286. doi: 10.1002/2017GL072754. Epub 2017 May 3.


MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action.

Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.

Bioinformatics. 2018 Apr 1;34(7):1251-1252. doi: 10.1093/bioinformatics/btx732.


Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286a.


Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286b.


Pathway-based discovery of genetic interactions in breast cancer.

Wang W, Xu ZZ, Costanzo M, Boone C, Lange CA, Myers CL.

PLoS Genet. 2017 Sep 28;13(9):e1006973. doi: 10.1371/journal.pgen.1006973. eCollection 2017 Sep.


Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA.

Cell Rep. 2017 Sep 12;20(11):2735-2748. doi: 10.1016/j.celrep.2017.08.074.


The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE.

Nat Commun. 2017 Sep 11;8(1):499. doi: 10.1038/s41467-017-00547-y.


Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Sep;13(9):982-993. doi: 10.1038/nchembio.2436. Epub 2017 Jul 24. Erratum in: Nat Chem Biol. 2017 Nov 21;13(12 ):1286. Nat Chem Biol. 2017 Nov 21;13(12 ):1286.


A functional MRI study on how oxytocin affects decision making in social dilemmas: Cooperate as long as it pays off, aggress only when you think you can win.

Lambert B, Declerck CH, Boone C, Parizel PM.

Horm Behav. 2017 Aug;94:145-152. doi: 10.1016/j.yhbeh.2017.06.011. Epub 2017 Jul 29.


Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.

Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M.

Nat Commun. 2017 Jul 3;8(1):53. doi: 10.1038/s41467-017-00064-y.


Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.


Development of a Clinically Useful Algorithm for Tractography-Based Ventral Intermediate Nucleus Targeting.

Purvis TE, Boone C, Anderson WS.

Neurosurgery. 2017 May 1;80(5):N24-N25. doi: 10.1093/neuros/nyx099. No abstract available.


Mechanisms of suppression: The wiring of genetic resilience.

van Leeuwen J, Pons C, Boone C, Andrews BJ.

Bioessays. 2017 Jul;39(7). doi: 10.1002/bies.201700042. Epub 2017 Jun 5. Review.


Post-resistance exercise ingestion of milk protein attenuates plasma TNFα and TNFr1 expression on monocyte subpopulations.

Wells AJ, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR, Hoffman JR.

Amino Acids. 2017 Aug;49(8):1415-1426. doi: 10.1007/s00726-017-2443-0. Epub 2017 May 29.


Identifying pathogenicity of human variants via paralog-based yeast complementation.

Yang F, Sun S, Tan G, Costanzo M, Hill DE, Vidal M, Andrews BJ, Boone C, Roth FP.

PLoS Genet. 2017 May 25;13(5):e1006779. doi: 10.1371/journal.pgen.1006779. eCollection 2017 May.


Automated analysis of high-content microscopy data with deep learning.

Kraus OZ, Grys BT, Ba J, Chong Y, Frey BJ, Boone C, Andrews BJ.

Mol Syst Biol. 2017 Apr 18;13(4):924. doi: 10.15252/msb.20177551.


Zika: A scourge in urban slums.

Snyder RE, Boone CE, Cardoso CA, Aguiar-Alves F, Neves FP, Riley LW.

PLoS Negl Trop Dis. 2017 Mar 23;11(3):e0005287. doi: 10.1371/journal.pntd.0005287. eCollection 2017 Mar. No abstract available.

39. A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.

Usaj M, Tan Y, Wang W, VanderSluis B, Zou A, Myers CL, Costanzo M, Andrews B, Boone C.

G3 (Bethesda). 2017 May 5;7(5):1539-1549. doi: 10.1534/g3.117.040220.


Oxidative stress, metabolomics profiling, and mechanism of local anesthetic induced cell death in yeast.

Boone CHT, Grove RA, Adamcova D, Seravalli J, Adamec J.

Redox Biol. 2017 Aug;12:139-149. doi: 10.1016/j.redox.2017.01.025. Epub 2017 Feb 3.


Genetic and genomic evidence of niche partitioning and adaptive radiation in mountain pine beetle fungal symbionts.

Ojeda Alayon DI, Tsui CK, Feau N, Capron A, Dhillon B, Zhang Y, Massoumi Alamouti S, Boone CK, Carroll AL, Cooke JE, Roe AD, Sperling FA, Hamelin RC.

Mol Ecol. 2017 Apr;26(7):2077-2091. doi: 10.1111/mec.14074. Epub 2017 Mar 22.


Cation Dependent Surface Charge Regulation in Gated Nanofluidic Devices.

Fuest M, Rangharajan KK, Boone C, Conlisk AT, Prakash S.

Anal Chem. 2017 Feb 7;89(3):1593-1601. doi: 10.1021/acs.analchem.6b03653. Epub 2017 Jan 6.


Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.


Trust as commodity: social value orientation affects the neural substrates of learning to cooperate.

Lambert B, Declerck CH, Emonds G, Boone C.

Soc Cogn Affect Neurosci. 2017 Apr 1;12(4):609-617. doi: 10.1093/scan/nsw170.


Impact of smoking on postoperative complications after anterior cervical discectomy and fusion.

Purvis TE, Rodriguez HJ, Ahmed AK, Boone C, De la Garza-Ramos R, Elder BD, Goodwin CR, Sciubba DM.

J Clin Neurosci. 2017 Apr;38:106-110. doi: 10.1016/j.jocn.2016.12.044. Epub 2017 Jan 16.


Acute effects of a beverage containing bitter melon extract (CARELA) on postprandial glycemia among prediabetic adults.

Boone CH, Stout JR, Gordon JA, Redd MJ, Church DD, Oliveira LP, Fukuda DH, Hoffman JR.

Nutr Diabetes. 2017 Jan 16;7(1):e241. doi: 10.1038/nutd.2016.51.


A proteomic approach to identify metalloproteins and metal-binding proteins in liver from diabetic rats.

Braga CP, Vieira JCS, Grove RA, Boone CHT, Leite AL, Buzalaf MAR, Fernandes AAH, Adamec J, Padilha PM.

Int J Biol Macromol. 2017 Mar;96:817-832. doi: 10.1016/j.ijbiomac.2016.12.073. Epub 2017 Jan 3.


Exercise-Induced Hormone Elevations Are Related to Muscle Growth.

Mangine GT, Hoffman JR, Gonzalez AM, Townsend JR, Wells AJ, Jajtner AR, Beyer KS, Boone CH, Wang R, Miramonti AA, LaMonica MB, Fukuda DH, Witta EL, Ratamess NA, Stout JR.

J Strength Cond Res. 2017 Jan;31(1):45-53. doi: 10.1519/JSC.0000000000001491.


The effect of renal dysfunction on short-term outcomes after lumbar fusion.

Purvis TE, Kessler RA, Boone C, Elder BD, Goodwin CR, Sciubba DM.

Clin Neurol Neurosurg. 2017 Feb;153:8-13. doi: 10.1016/j.clineuro.2016.12.002. Epub 2016 Dec 6.


Machine learning and computer vision approaches for phenotypic profiling.

Grys BT, Lo DS, Sahin N, Kraus OZ, Morris Q, Boone C, Andrews BJ.

J Cell Biol. 2017 Jan 2;216(1):65-71. doi: 10.1083/jcb.201610026. Epub 2016 Dec 9. Review.

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