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ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges.

Jash A, Zhou YW, Gerardo DK, Ripperger TJ, Parikh BA, Piersma S, Jamwal DR, Kiela PR, Boon ACM, Yokoyama WM, Hsieh CS, Bhattacharya D.

Sci Rep. 2019 Oct 24;9(1):15257. doi: 10.1038/s41598-019-51860-z.


Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.

Peterson ST, Kennedy EA, Brigleb PH, Taylor GM, Urbanek K, Bricker TL, Lee S, Shin H, Dermody TS, Boon ACM, Baldridge MT.

J Virol. 2019 Oct 29;93(22). pii: e01073-19. doi: 10.1128/JVI.01073-19. Print 2019 Nov 15.


Therapeutic efficacy of favipiravir against Bourbon virus in mice.

Bricker TL, Shafiuddin M, Gounder AP, Janowski AB, Zhao G, Williams GD, Jagger BW, Diamond MS, Bailey T, Kwon JH, Wang D, Boon ACM.

PLoS Pathog. 2019 Jun 13;15(6):e1007790. doi: 10.1371/journal.ppat.1007790. eCollection 2019 Jun.


Pre-clinical study protocol: Blood transfusion in endotoxaemic shock.

Obonyo NG, Byrne L, Tung JP, Simonova G, Diab SD, Dunster KR, Passmore MR, Boon AC, See Hoe L, Engkilde-Pedersen S, Esguerra-Lallen A, Fauzi MH, Pimenta LP, Millar JE, Fanning JP, Van Haren F, Anstey CM, Cullen L, Suen J, Shekar K, Maitland K, Fraser JF.

MethodsX. 2019 May 9;6:1124-1132. doi: 10.1016/j.mex.2019.05.005. eCollection 2019.


RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging.

Shafiuddin M, Boon ACM.

J Mol Biol. 2019 Oct 4;431(21):4217-4228. doi: 10.1016/j.jmb.2019.03.018. Epub 2019 Mar 23. Review.


Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.

Passmore MR, Obonyo NG, Byrne L, Boon AC, Diab SD, Dunster KR, Fung YL, Spanevello MM, Fauzi MH, Pedersen SE, Simonova G, Anstey CM, Shekar K, Tung JP, Maitland K, Fraser JF.

Thromb Res. 2019 Apr;176:39-45. doi: 10.1016/j.thromres.2019.02.015. Epub 2019 Feb 12.


Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease.

Gounder AP, Boon ACM.

J Immunol. 2019 Jan 15;202(2):341-350. doi: 10.4049/jimmunol.1801010. Review.


Viral MHCI inhibition evades tissue-resident memory T cell formation and responses.

Lauron EJ, Yang L, Harvey IB, Sojka DK, Williams GD, Paley MA, Bern MD, Park E, Victorino F, Boon ACM, Yokoyama WM.

J Exp Med. 2019 Jan 7;216(1):117-132. doi: 10.1084/jem.20181077. Epub 2018 Dec 17.


Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock.

Passmore MR, Byrne L, Obonyo NG, See Hoe LE, Boon AC, Diab SD, Dunster KR, Bisht K, Tung JP, Fauzi MH, Narula M, Pedersen SE, Esguerra-Lallen A, Simonova G, Sultana A, Anstey CM, Shekar K, Maitland K, Suen JY, Fraser JF.

Respir Res. 2018 Nov 22;19(1):231. doi: 10.1186/s12931-018-0935-4.


Unintended Consequences: Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia.

Byrne L, Obonyo NG, Diab SD, Dunster KR, Passmore MR, Boon AC, Hoe LS, Pedersen S, Fauzi MH, Pimenta LP, Van Haren F, Anstey CM, Cullen L, Tung JP, Shekar K, Maitland K, Fraser JF.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054. doi: 10.1164/rccm.201801-0064OC.


Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer.

Gounder AP, Yokoyama CC, Jarjour NN, Bricker TL, Edelson BT, Boon ACM.

PLoS Pathog. 2018 Apr 26;14(4):e1007001. doi: 10.1371/journal.ppat.1007001. eCollection 2018 Apr.


Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea.

Bulmer AC, Bakrania B, Du Toit EF, Boon AC, Clark PJ, Powell LW, Wagner KH, Headrick JP.

Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H429-H447. doi: 10.1152/ajpheart.00417.2017. Epub 2018 Mar 30.


Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.

Nair S, Huynh JP, Lampropoulou V, Loginicheva E, Esaulova E, Gounder AP, Boon ACM, Schwarzkopf EA, Bradstreet TR, Edelson BT, Artyomov MN, Stallings CL, Diamond MS.

J Exp Med. 2018 Apr 2;215(4):1035-1045. doi: 10.1084/jem.20180118. Epub 2018 Mar 6.


Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication.

Williams GD, Townsend D, Wylie KM, Kim PJ, Amarasinghe GK, Kutluay SB, Boon ACM.

Nat Commun. 2018 Jan 31;9(1):465. doi: 10.1038/s41467-018-02886-w.


The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS.

Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336.


An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism.

Byrne L, Obonyo NG, Diab S, Dunster K, Passmore M, Boon AC, Hoe LS, Hay K, Van Haren F, Tung JP, Cullen L, Shekar K, Maitland K, Fraser JF.

Shock. 2018 Jan;49(1):99-107. doi: 10.1097/SHK.0000000000000904.


Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice.

DesRochers BL, Chen RE, Gounder AP, Pinto AK, Bricker T, Linton CN, Rogers CD, Williams GD, Webby RJ, Boon AC.

Virology. 2016 Jul;494:89-99. doi: 10.1016/j.virol.2016.04.013. Epub 2016 Apr 20.


A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation.

Williams GD, Pinto AK, Doll B, Boon ACM.

J Virol. 2016 Apr 14;90(9):4796-4806. doi: 10.1128/JVI.02761-15. Print 2016 May.


Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW.

Cell Host Microbe. 2016 Jan 13;19(1):102-13. doi: 10.1016/j.chom.2015.12.011.


Endogenously elevated bilirubin modulates kidney function and protects from circulating oxidative stress in a rat model of adenine-induced kidney failure.

Boon AC, Lam AK, Gopalan V, Benzie IF, Briskey D, Coombes JS, Fassett RG, Bulmer AC.

Sci Rep. 2015 Oct 26;5:15482. doi: 10.1038/srep15482.


Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families.

Pinto AK, Williams GD, Szretter KJ, White JP, Proença-Módena JL, Liu G, Olejnik J, Brien JD, Ebihara H, Mühlberger E, Amarasinghe G, Diamond MS, Boon AC.

J Virol. 2015 Sep;89(18):9465-76. doi: 10.1128/JVI.00996-15. Epub 2015 Jul 8.


Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum.

Boon AC, Hawkins CL, Coombes JS, Wagner KH, Bulmer AC.

Free Radic Biol Med. 2015 Sep;86:259-68. doi: 10.1016/j.freeradbiomed.2015.05.031. Epub 2015 Jun 6.


An anti-H5N1 influenza virus FcDART antibody is a highly efficacious therapeutic agent and prophylactic against H5N1 influenza virus infection.

Zanin M, Keck ZY, Rainey GJ, Lam CY, Boon AC, Rubrum A, Darnell D, Wong SS, Griffin Y, Xia J, Webster RG, Webby R, Johnson S, Foung S.

J Virol. 2015 Apr;89(8):4549-61. doi: 10.1128/JVI.00078-15. Epub 2015 Feb 11.


A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice.

Boon AC, Williams RW, Sinasac DS, Webby RJ.

BMC Genomics. 2014 Nov 24;15:1017. doi: 10.1186/1471-2164-15-1017.


Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations.

Boon AC, Bulmer AC, Coombes JS, Fassett RG.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F123-36. doi: 10.1152/ajprenal.00039.2014. Epub 2014 Apr 23. Review.


Binding of DC-SIGN to the hemagglutinin of influenza A viruses supports virus replication in DC-SIGN expressing cells.

Hillaire ML, Nieuwkoop NJ, Boon AC, de Mutsert G, Vogelzang-van Trierum SE, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

PLoS One. 2013;8(2):e56164. doi: 10.1371/journal.pone.0056164. Epub 2013 Feb 12.


Characterization of a porcine intestinal epithelial cell line for influenza virus production.

Sun Z, Huber VC, McCormick K, Kaushik RS, Boon AC, Zhu L, Hause B, Webby RJ, Fang Y.

J Gen Virol. 2012 Sep;93(Pt 9):2008-16. doi: 10.1099/vir.0.044388-0. Epub 2012 Jun 27.


Identifying antigenicity-associated sites in highly pathogenic H5N1 influenza virus hemagglutinin by using sparse learning.

Cai Z, Ducatez MF, Yang J, Zhang T, Long LP, Boon AC, Webby RJ, Wan XF.

J Mol Biol. 2012 Sep 7;422(1):145-55. doi: 10.1016/j.jmb.2012.05.011. Epub 2012 May 17.


Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome.

Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, Bulmer AC.

Free Radic Biol Med. 2012 May 15;52(10):2120-7. doi: 10.1016/j.freeradbiomed.2012.03.002. Epub 2012 Apr 14.


H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.

Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ.

MBio. 2011 Sep 6;2(5). pii: e00171-11. doi: 10.1128/mBio.00171-11. Print 2011.


Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.

Marcelin G, Aldridge JR, Duan S, Ghoneim HE, Rehg J, Marjuki H, Boon AC, McCullers JA, Webby RJ.

J Virol. 2011 Nov;85(21):11208-19. doi: 10.1128/JVI.00654-11. Epub 2011 Aug 24.


Genetic composition of contemporary swine influenza viruses in the West Central region of the United States of America.

Evseenko VA, Boon AC, Brockwell-Staats C, Franks J, Rubrum A, Daniels CS, Gramer MR, Webby RJ.

Influenza Other Respir Viruses. 2011 May;5(3):188-97. doi: 10.1111/j.1750-2659.2010.00189.x. Epub 2011 Jan 25.


Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model.

Boon AC, deBeauchamp J, Krauss S, Rubrum A, Webb AD, Webster RG, McElhaney J, Webby RJ.

J Virol. 2010 Aug;84(15):7662-7. doi: 10.1128/JVI.02444-09. Epub 2010 May 19.


Antigenic cross-reactivity among H5N1 viruses.

Boon AC, Webby RJ.

Curr Top Microbiol Immunol. 2009;333:25-40. doi: 10.1007/978-3-540-92165-3_2. Review.


Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.

Boon AC, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S, Finkelstein D, Neale G, Lu L, Williams RW, Webby RJ.

J Virol. 2009 Oct;83(20):10417-26. doi: 10.1128/JVI.00514-09. Epub 2009 Aug 12.


Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread.

Yen HL, Aldridge JR, Boon AC, Ilyushina NA, Salomon R, Hulse-Post DJ, Marjuki H, Franks J, Boltz DA, Bush D, Lipatov AS, Webby RJ, Rehg JE, Webster RG.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):286-91. doi: 10.1073/pnas.0811052106. Epub 2008 Dec 30.


Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses.

Sandbulte MR, Boon AC, Webby RJ, Riberdy JM.

Virology. 2008 Nov 10;381(1):22-8. doi: 10.1016/j.virol.2008.08.018. Epub 2008 Sep 17.


Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice.

Ilyushina NA, Hay A, Yilmaz N, Boon AC, Webster RG, Govorkova EA.

Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97. doi: 10.1128/AAC.01579-07. Epub 2008 Aug 25.


Role of terrestrial wild birds in ecology of influenza A virus (H5N1).

Boon AC, Sandbulte MR, Seiler P, Webby RJ, Songserm T, Guan Y, Webster RG.

Emerg Infect Dis. 2007 Nov;13(11):1720-4. doi: 10.3201/eid1311.070114.


Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry.

Rimmelzwaan GF, Nieuwkoop NJ, de Mutsert G, Boon AC, Kuiken T, Fouchier RA, Osterhaus AD.

Virus Res. 2007 Nov;129(2):175-81. Epub 2007 Aug 22.


Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans.

Sandbulte MR, Jimenez GS, Boon AC, Smith LR, Treanor JJ, Webby RJ.

PLoS Med. 2007 Feb;4(2):e59.


Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses.

Berkhoff EG, de Wit E, Geelhoed-Mieras MM, Boon AC, Symons J, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

Vaccine. 2006 Nov 10;24(44-46):6594-6. Epub 2006 Jun 6.


Fluorescent antigen-transfected target cell cytotoxic T lymphocyte assay for ex vivo detection of antigen-specific cell-mediated cytotoxicity.

van Baalen CA, Kwa D, Verschuren EJ, Reedijk ML, Boon AC, de Mutsert G, Rimmelzwaan GF, Osterhaus AD, Gruters RA.

J Infect Dis. 2005 Oct 1;192(7):1183-90. Epub 2005 Aug 30.


Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes.

Berkhoff EG, de Wit E, Geelhoed-Mieras MM, Boon AC, Symons J, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

J Virol. 2005 Sep;79(17):11239-46.


Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX.

Rimmelzwaan GF, Boon AC, Geelhoed-Mieras MM, Voeten JT, Fouchier RA, Osterhaus AD.

Vaccine. 2004 Jul 29;22(21-22):2769-75.


Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes.

Rimmelzwaan GF, Boon AC, Voeten JT, Berkhoff EG, Fouchier RA, Osterhaus AD.

Virus Res. 2004 Jul;103(1-2):97-100.


A mutation in the HLA-B*2705-restricted NP383-391 epitope affects the human influenza A virus-specific cytotoxic T-lymphocyte response in vitro.

Berkhoff EG, Boon AC, Nieuwkoop NJ, Fouchier RA, Sintnicolaas K, Osterhaus AD, Rimmelzwaan GF.

J Virol. 2004 May;78(10):5216-22.

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