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Items: 14

1.

Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.

Parrish JP, Lee SK, Boojamra CG, Hui H, Babusis D, Brown B, Shih IH, Feng JY, Ray AS, Mackman RL.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3354-7. doi: 10.1016/j.bmcl.2013.03.095. Epub 2013 Apr 2.

PMID:
23639543
2.

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.

Mackman RL, Ray AS, Hui HC, Zhang L, Birkus G, Boojamra CG, Desai MC, Douglas JL, Gao Y, Grant D, Laflamme G, Lin KY, Markevitch DY, Mishra R, McDermott M, Pakdaman R, Petrakovsky OV, Vela JE, Cihlar T.

Bioorg Med Chem. 2010 May 15;18(10):3606-17. doi: 10.1016/j.bmc.2010.03.041. Epub 2010 Mar 27.

PMID:
20409721
3.

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

Lansdon EB, Samuel D, Lagpacan L, Brendza KM, White KL, Hung M, Liu X, Boojamra CG, Mackman RL, Cihlar T, Ray AS, McGrath ME, Swaminathan S.

J Mol Biol. 2010 Apr 9;397(4):967-78. doi: 10.1016/j.jmb.2010.02.019. Epub 2010 Feb 13.

PMID:
20156454
4.

Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.

Boojamra CG, Parrish JP, Sperandio D, Gao Y, Petrakovsky OV, Lee SK, Markevitch DY, Vela JE, Laflamme G, Chen JM, Ray AS, Barron AC, Sparacino ML, Desai MC, Kim CU, Cihlar T, Mackman RL.

Bioorg Med Chem. 2009 Feb 15;17(4):1739-46. doi: 10.1016/j.bmc.2008.12.028. Epub 2008 Dec 24.

PMID:
19179082
5.

Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.

Boojamra CG, Mackman RL, Markevitch DY, Prasad V, Ray AS, Douglas J, Grant D, Kim CU, Cihlar T.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1120-3. doi: 10.1016/j.bmcl.2007.11.125. Epub 2007 Dec 5.

PMID:
18164198
6.

Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.

Mackman RL, Lin KY, Boojamra CG, Hui H, Douglas J, Grant D, Petrakovsky O, Prasad V, Ray AS, Cihlar T.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1116-9. Epub 2007 Dec 5.

PMID:
18082402
7.

Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: a comparison of phosphonates and corresponding nucleosides.

Mackman RL, Zhang L, Prasad V, Boojamra CG, Chen J, Douglas J, Grant D, Laflamme G, Hui H, Kim CU, Parrish J, Stoycheva AD, Swaminathan S, Wang K, Cihlar T.

Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):573-7.

PMID:
18066858
8.

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Cihlar T, Ray AS, Boojamra CG, Zhang L, Hui H, Laflamme G, Vela JE, Grant D, Chen J, Myrick F, White KL, Gao Y, Lin KY, Douglas JL, Parkin NT, Carey A, Pakdaman R, Mackman RL.

Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. Epub 2007 Dec 3.

9.

Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.

Ray AS, Vela JE, Boojamra CG, Zhang L, Hui H, Callebaut C, Stray K, Lin KY, Gao Y, Mackman RL, Cihlar T.

Antimicrob Agents Chemother. 2008 Feb;52(2):648-54. Epub 2007 Dec 3.

10.

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.

Mackman RL, Boojamra CG, Prasad V, Zhang L, Lin KY, Petrakovsky O, Babusis D, Chen J, Douglas J, Grant D, Hui HC, Kim CU, Markevitch DY, Vela J, Ray A, Cihlar T.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6785-9. Epub 2007 Oct 17.

PMID:
18029175
11.

Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.

Mackman RL, Zhang L, Prasad V, Boojamra CG, Douglas J, Grant D, Hui H, Kim CU, Laflamme G, Parrish J, Stoycheva AD, Swaminathan S, Wang K, Cihlar T.

Bioorg Med Chem. 2007 Aug 15;15(16):5519-28. Epub 2007 May 25.

PMID:
17562366
12.

Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.

Boojamra CG, Lemoine RC, Blais J, Vernier NG, Stein KA, Magon A, Chamberland S, Hecker SJ, Lee VJ.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3305-9.

PMID:
12951115
13.

Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin.

Boojamra CG, Lemoine RC, Lee JC, Léger R, Stein KA, Vernier NG, Magon A, Lomovskaya O, Martin PK, Chamberland S, Lee MD, Hecker SJ, Lee VJ.

J Am Chem Soc. 2001 Feb 7;123(5):870-4.

PMID:
11456620
14.

Synthesis of beta-C-Glycosides of N-Acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups.

Roe BA, Boojamra CG, Griggs JL, Bertozzi CR.

J Org Chem. 1996 Sep 6;61(18):6442-6445. No abstract available.

PMID:
11667491

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