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Items: 20


Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na+/H+ exchanger isoform 3.

Muthusamy S, Jeong JJ, Cheng M, Bonzo JA, Kumar A, Gonzalez FJ, Borthakur A, Dudeja PK, Saksena S, Malakooti J.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G14-G21. doi: 10.1152/ajpgi.00225.2017. Epub 2017 Sep 7.


Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.

Brocker CN, Yue J, Kim D, Qu A, Bonzo JA, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G283-G299. doi: 10.1152/ajpgi.00205.2016. Epub 2017 Jan 12.


Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo.

Bonzo JA, Brocker C, Jiang C, Wang RH, Deng CX, Gonzalez FJ.

Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E824-37. doi: 10.1152/ajpendo.00175.2013. Epub 2014 Feb 4.


Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.

Ciappio ED, Krausz KW, Rochman M, Furusawa T, Bonzo JA, Tessarollo L, Gonzalez FJ, Bustin M.

PLoS One. 2014 Jan 2;9(1):e84583. doi: 10.1371/journal.pone.0084583. eCollection 2014.


Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL.

Chem Res Toxicol. 2013 Jul 15;26(7):1088-96. doi: 10.1021/tx4001013. Epub 2013 Jun 7.


Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair.

Manna SK, Krausz KW, Bonzo JA, Idle JR, Gonzalez FJ.

J Proteome Res. 2013 May 3;12(5):2269-81. doi: 10.1021/pr400161k. Epub 2013 Apr 24.


Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model.

Johnson CH, Manna SK, Krausz KW, Bonzo JA, Divelbiss RD, Hollingshead MG, Gonzalez FJ.

Metabolites. 2013 Aug 7;3(3):658-72. doi: 10.3390/metabo3030658.


Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.

Johnson CH, Bonzo JA, Cheng J, Krausz KW, Kang DW, Luecke H, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2013 Feb;41(2):406-13. doi: 10.1124/dmd.112.048009. Epub 2012 Nov 16.


Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice.

Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ.

J Biol Chem. 2012 Mar 2;287(10):7345-56. doi: 10.1074/jbc.M111.334599. Epub 2012 Jan 12.


Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus.

Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, Aslam S, Tigno X, Weinstein JN, Hansen BC, Idle JR, Gonzalez FJ.

J Biol Chem. 2011 Jun 3;286(22):19511-22. doi: 10.1074/jbc.M111.221739. Epub 2011 Apr 12.


The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.

Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M.

Hepatology. 2011 Jun;53(6):2063-74. doi: 10.1002/hep.24280.


Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo.

Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ.

Mol Endocrinol. 2010 Dec;24(12):2343-55. doi: 10.1210/me.2010-0130. Epub 2010 Oct 13.


The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver.

Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V.

PPAR Res. 2010;2010:352957. doi: 10.1155/2010/352957. Epub 2011 Mar 6.


Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.

Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH.

J Biol Chem. 2008 Mar 21;283(12):7901-11. doi: 10.1074/jbc.M709244200. Epub 2008 Jan 7.


Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH.

Drug Metab Dispos. 2007 Mar;35(3):419-27. Epub 2006 Dec 6.


The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O.

Hepatology. 2006 Aug;44(2):368-78.


The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1.

Yueh MF, Bonzo JA, Tukey RH.

Methods Enzymol. 2005;400:75-91.


Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest.

Bonzo JA, Chen S, Galijatovic A, Tukey RH.

Mol Pharmacol. 2005 Apr;67(4):1247-56. Epub 2005 Jan 3.


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