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Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia.

Yu-Taeger L, Ott T, Bonsi P, Tomczak C, Wassouf Z, Martella G, Sciamanna G, Imbriani P, Ponterio G, Tassone A, Schulze-Hentrich JM, Goodchild R, Riess O, Pisani A, Grundmann-Hauser K, Nguyen HP.

Neurobiol Dis. 2019 Oct 30:104634. doi: 10.1016/j.nbd.2019.104634. [Epub ahead of print]


Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson's Disease.

Imbriani P, Tassone A, Meringolo M, Ponterio G, Madeo G, Pisani A, Bonsi P, Martella G.

Int J Mol Sci. 2019 Jul 11;20(14). pii: E3407. doi: 10.3390/ijms20143407.


The neurobiological basis for novel experimental therapeutics in dystonia.

Downs AM, Roman KM, Campbell SA, Pisani A, Hess EJ, Bonsi P.

Neurobiol Dis. 2019 Oct;130:104526. doi: 10.1016/j.nbd.2019.104526. Epub 2019 Jul 4. Review.


RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models.

Bonsi P, Ponterio G, Vanni V, Tassone A, Sciamanna G, Migliarini S, Martella G, Meringolo M, Dehay B, Doudnikoff E, Zachariou V, Goodchild RE, Mercuri NB, D'Amelio M, Pasqualetti M, Bezard E, Pisani A.

EMBO Mol Med. 2019 Jan;11(1). pii: e9283. doi: 10.15252/emmm.201809283.


Synaptic Plasticity Changes: Hallmark for Neurological and Psychiatric Disorders.

Martella G, Bonsi P, Johnson SW, Quartarone A.

Neural Plast. 2018 Oct 23;2018:9230704. doi: 10.1155/2018/9230704. eCollection 2018. No abstract available.


Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum.

Maltese M, Stanic J, Tassone A, Sciamanna G, Ponterio G, Vanni V, Martella G, Imbriani P, Bonsi P, Mercuri NB, Gardoni F, Pisani A.

Elife. 2018 Mar 5;7. pii: e33331. doi: 10.7554/eLife.33331.


Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.

Ponterio G, Tassone A, Sciamanna G, Vanni V, Meringolo M, Santoro M, Mercuri NB, Bonsi P, Pisani A.

Mov Disord. 2018 Feb;33(2):310-320. doi: 10.1002/mds.27212. Epub 2017 Nov 18.


The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum.

Martella G, Meringolo M, Trobiani L, De Jaco A, Pisani A, Bonsi P.

Eur J Neurosci. 2018 Mar;47(6):701-708. doi: 10.1111/ejn.13705. Epub 2017 Oct 4.


Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition.

Maltese M, Martella G, Imbriani P, Schuermans J, Billion K, Sciamanna G, Farook F, Ponterio G, Tassone A, Santoro M, Bonsi P, Pisani A, Goodchild RE.

Neurobiol Dis. 2017 Dec;108:128-139. doi: 10.1016/j.nbd.2017.08.007. Epub 2017 Aug 18.


Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.

D'Angelo V, Castelli V, Giorgi M, Cardarelli S, Saverioni I, Palumbo F, Bonsi P, Pisani A, GiampĂ  C, Sorge R, Biagioni S, Fusco FR, Sancesario G.

J Neurosci. 2017 Feb 22;37(8):2112-2124. doi: 10.1523/JNEUROSCI.3207-15.2016. Epub 2017 Jan 23.


Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice.

Martella G, Madeo G, Maltese M, Vanni V, Puglisi F, Ferraro E, Schirinzi T, Valente EM, Bonanni L, Shen J, Mandolesi G, Mercuri NB, Bonsi P, Pisani A.

Neurobiol Dis. 2016 Jul;91:21-36. doi: 10.1016/j.nbd.2015.12.020. Epub 2016 Feb 23.


Optogenetic stimulation reveals distinct modulatory properties of thalamostriatal vs corticostriatal glutamatergic inputs to fast-spiking interneurons.

Sciamanna G, Ponterio G, Mandolesi G, Bonsi P, Pisani A.

Sci Rep. 2015 Nov 17;5:16742. doi: 10.1038/srep16742.


Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice.

Madeo G, Schirinzi T, Maltese M, Martella G, Rapino C, Fezza F, Mastrangelo N, Bonsi P, Maccarrone M, Pisani A.

Neuropharmacology. 2016 Feb;101:460-70. doi: 10.1016/j.neuropharm.2015.10.021. Epub 2015 Oct 20.


Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia.

Vanni V, Puglisi F, Bonsi P, Ponterio G, Maltese M, Pisani A, Mandolesi G.

Exp Neurol. 2015 Sep;271:457-67. doi: 10.1016/j.expneurol.2015.07.005. Epub 2015 Jul 14.


Rhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons.

Sciamanna G, Napolitano F, Pelosi B, Bonsi P, Vitucci D, Nuzzo T, Punzo D, Ghiglieri V, Ponterio G, Pasqualetti M, Pisani A, Usiello A.

Neurobiol Dis. 2015 Jun;78:146-61. doi: 10.1016/j.nbd.2015.03.021. Epub 2015 Mar 26.


Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.

Eskow Jaunarajs KL, Bonsi P, Chesselet MF, Standaert DG, Pisani A.

Prog Neurobiol. 2015 Apr;127-128:91-107. doi: 10.1016/j.pneurobio.2015.02.002. Epub 2015 Feb 17. Review.


Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.

Maltese M, Martella G, Madeo G, Fagiolo I, Tassone A, Ponterio G, Sciamanna G, Burbaud P, Conn PJ, Bonsi P, Pisani A.

Mov Disord. 2014 Nov;29(13):1655-65. doi: 10.1002/mds.26009. Epub 2014 Sep 4.


Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia.

Sciamanna G, Ponterio G, Tassone A, Maltese M, Madeo G, Martella G, Poli S, Schirinzi T, Bonsi P, Pisani A.

Neuropharmacology. 2014 Oct;85:440-50. doi: 10.1016/j.neuropharm.2014.06.013. Epub 2014 Jun 19.


Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia.

Martella G, Maltese M, Nisticò R, Schirinzi T, Madeo G, Sciamanna G, Ponterio G, Tassone A, Mandolesi G, Vanni V, Pignatelli M, Bonsi P, Pisani A.

Neurobiol Dis. 2014 May;65:124-32. doi: 10.1016/j.nbd.2014.01.016. Epub 2014 Feb 3.


PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity.

Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, Puglisi-Allegra S, Bonsi P, Pisani A.

Mov Disord. 2014 Jan;29(1):41-53. doi: 10.1002/mds.25724. Epub 2013 Oct 25.


Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum.

Ponterio G, Tassone A, Sciamanna G, Riahi E, Vanni V, Bonsi P, Pisani A.

Neuropharmacology. 2013 Dec;75:78-85. doi: 10.1016/j.neuropharm.2013.07.006. Epub 2013 Jul 25.


Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry.

Puglisi F, Vanni V, Ponterio G, Tassone A, Sciamanna G, Bonsi P, Pisani A, Mandolesi G.

PLoS One. 2013 Jun 19;8(6):e68063. doi: 10.1371/journal.pone.0068063. Print 2013.


Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.

Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A, Bonsi P, Picconi B, Cupini LM, Materazzi S, Geppetti P, Sarchielli P, Calabresi P.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18985-90. doi: 10.1073/pnas.1215435109. Epub 2012 Oct 29.


Cholinergic dysfunction alters synaptic integration between thalamostriatal and corticostriatal inputs in DYT1 dystonia.

Sciamanna G, Tassone A, Mandolesi G, Puglisi F, Ponterio G, Martella G, Madeo G, Bernardi G, Standaert DG, Bonsi P, Pisani A.

J Neurosci. 2012 Aug 29;32(35):11991-2004. doi: 10.1523/JNEUROSCI.0041-12.2012.


Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.

Sciamanna G, Tassone A, Martella G, Mandolesi G, Puglisi F, Cuomo D, Madeo G, Ponterio G, Standaert DG, Bonsi P, Pisani A.

PLoS One. 2011;6(9):e24261. doi: 10.1371/journal.pone.0024261. Epub 2011 Sep 2.


Experimental models of dystonia.

Tassone A, Sciamanna G, Bonsi P, Martella G, Pisani A.

Int Rev Neurobiol. 2011;98:551-72. doi: 10.1016/B978-0-12-381328-2.00020-1. Review.


Aberrant striatal synaptic plasticity in monogenic parkinsonisms.

Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, Pisani A.

Neuroscience. 2012 Jun 1;211:126-35. doi: 10.1016/j.neuroscience.2011.07.065. Epub 2011 Aug 2. Review.


Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission.

Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, Borsini F, Pisani A, Bonsi P.

Neuropharmacology. 2011 Sep;61(4):632-7. doi: 10.1016/j.neuropharm.2011.05.004. Epub 2011 May 19.


Centrality of striatal cholinergic transmission in Basal Ganglia function.

Bonsi P, Cuomo D, Martella G, Madeo G, Schirinzi T, Puglisi F, Ponterio G, Pisani A.

Front Neuroanat. 2011 Feb 7;5:6. doi: 10.3389/fnana.2011.00006. eCollection 2011.


Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease.

Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P.

Neuroscience. 2011 Mar 17;177:240-51. doi: 10.1016/j.neuroscience.2010.12.057. Epub 2010 Dec 31.


Electrophysiology of 5-HT6 receptors.

Tassone A, Madeo G, Sciamanna G, Pisani A, Bonsi P.

Int Rev Neurobiol. 2010;94:111-28. doi: 10.1016/B978-0-12-384976-2.00005-8. Review. No abstract available.


Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.

Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A.

Brain. 2009 Sep;132(Pt 9):2336-49. doi: 10.1093/brain/awp194. Epub 2009 Jul 29.


Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.

Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A.

Neurobiol Dis. 2009 Apr;34(1):133-45. doi: 10.1016/j.nbd.2009.01.001. Epub 2009 Jan 13.


Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.

Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada T, Bonsi P, Shen J, Pisani A.

Exp Neurol. 2009 Feb;215(2):388-96. doi: 10.1016/j.expneurol.2008.11.001. Epub 2008 Nov 21.


Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro.

Martella G, Bonsi P, Sciamanna G, Platania P, Madeo G, Tassone A, Cuomo D, Pisani A.

Epilepsia. 2009 Apr;50(4):702-10. doi: 10.1111/j.1528-1167.2008.01915.x. Epub 2008 Dec 4.


Mitochondrial toxins in Basal Ganglia disorders: from animal models to therapeutic strategies.

Bonsi P, Cuomo D, Martella G, Sciamanna G, Tolu M, Calabresi P, Bernardi G, Pisani A.

Curr Neuropharmacol. 2006 Jan;4(1):69-75.


Distinct roles of group I mGlu receptors in striatal function.

Bonsi P, Platania P, Martella G, Madeo G, Vita D, Tassone A, Bernardi G, Pisani A.

Neuropharmacology. 2008 Sep;55(4):392-5. doi: 10.1016/j.neuropharm.2008.05.020. Epub 2008 Jul 7. Review.


Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum.

Bonsi P, Martella G, Cuomo D, Platania P, Sciamanna G, Bernardi G, Wess J, Pisani A.

J Neurosci. 2008 Jun 11;28(24):6258-63. doi: 10.1523/JNEUROSCI.1678-08.2008.


Age-related functional changes of high-voltage-activated calcium channels in different neuronal subtypes of mouse striatum.

Martella G, Spadoni F, Sciamanna G, Tassone A, Bernardi G, Pisani A, Bonsi P.

Neuroscience. 2008 Mar 18;152(2):469-76. doi: 10.1016/j.neuroscience.2007.12.040. Epub 2008 Jan 9.


Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. Epub 2007 Jun 11.


Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons.

Bonsi P, Sciamanna G, Mitrano DA, Cuomo D, Bernardi G, Platania P, Smith Y, Pisani A.

Eur J Neurosci. 2007 Mar;25(5):1319-31.


Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors.

Bonsi P, Cuomo D, Ding J, Sciamanna G, Ulrich S, Tscherter A, Bernardi G, Surmeier DJ, Pisani A.

Neuropsychopharmacology. 2007 Aug;32(8):1840-54. Epub 2007 Jan 3.


Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia.

Pisani A, Martella G, Tscherter A, Bonsi P, Sharma N, Bernardi G, Standaert DG.

Neurobiol Dis. 2006 Nov;24(2):318-25. Epub 2006 Aug 28.


NR2B subunit exerts a critical role in postischemic synaptic plasticity.

Picconi B, Tortiglione A, Barone I, Centonze D, Gardoni F, Gubellini P, Bonsi P, Pisani A, Bernardi G, Di Luca M, Calabresi P.

Stroke. 2006 Jul;37(7):1895-901. Epub 2006 Jun 1.


Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease.

Bonsi P, Cuomo D, Picconi B, Sciamanna G, Tscherter A, Tolu M, Bernardi G, Calabresi P, Pisani A.

Amino Acids. 2007 Feb;32(2):189-95. Epub 2006 May 22. Review.


Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.

Picconi B, Passino E, Sgobio C, Bonsi P, Barone I, Ghiglieri V, Pisani A, Bernardi G, Ammassari-Teule M, Calabresi P.

Neurobiol Dis. 2006 Apr;22(1):143-52. Epub 2005 Dec 2.


Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons.

Bonsi P, Cuomo D, De Persis C, Centonze D, Bernardi G, Calabresi P, Pisani A.

Neuropharmacology. 2005;49 Suppl 1:104-13.


Pathological synaptic plasticity in the striatum: implications for Parkinson's disease.

Picconi B, Pisani A, Barone I, Bonsi P, Centonze D, Bernardi G, Calabresi P.

Neurotoxicology. 2005 Oct;26(5):779-83. Epub 2005 May 31. Review.


Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity.

Martella G, De Persis C, Bonsi P, Natoli S, Cuomo D, Bernardi G, Calabresi P, Pisani A.

Epilepsia. 2005 May;46(5):624-35.


Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons.

Bonsi P, De Persis C, Calabresi P, Bernardi G, Pisani A.

Learn Mem. 2004 Nov-Dec;11(6):755-60. Epub 2004 Nov 10.

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