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Items: 1 to 50 of 486

1.

Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community.

Matsukawa M, Igarashi M, Watanabe H, Qin L, Ohnishi M, Terajima J, Iyoda S, Morita-Ishihara T, Tateda K, Ishii Y, Saga T, Aoki K, Bonomo RA.

Epidemiol Infect. 2019 Jan;147:e148. doi: 10.1017/S0950268819000426.

PMID:
30869058
2.

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.

Barnes MD, Kumar V, Bethel CR, Moussa SH, O'Donnell J, Rutter JD, Good CE, Hujer KM, Hujer AM, Marshall SH, Kreiswirth BN, Richter SS, Rather PN, Jacobs MR, Papp-Wallace KM, van den Akker F, Bonomo RA.

MBio. 2019 Mar 12;10(2). pii: e00159-19. doi: 10.1128/mBio.00159-19.

3.

Beyond piperacillin-tazobactam: cefepime and AAI101 as a potent β-lactam-β-lactamase inhibitor combination.

Papp-Wallace KM, Bethel CR, Caillon J, Barnes MD, Potel G, Bajaksouzian S, Rutter JD, Reghal A, Shapiro S, Taracila MA, Jacobs MR, Bonomo RA, Jacqueline C.

Antimicrob Agents Chemother. 2019 Mar 11. pii: AAC.00105-19. doi: 10.1128/AAC.00105-19. [Epub ahead of print]

PMID:
30858223
4.

A Primer on AmpC Beta-Lactamases: Necessary Knowledge for an Increasingly Multidrug-Resistant World.

Tamma PD, Doi Y, Bonomo RA, Johnson JK, Simner PJ; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2019 Mar 6. pii: ciz173. doi: 10.1093/cid/ciz173. [Epub ahead of print]

PMID:
30838380
5.

Whole Genome Sequence Analysis of Burkholderia contaminans FFH2055 Strain Reveals the Presence of Putative β-Lactamases.

Degrossi JJ, Merino C, Isasmendi AM, Ibarra LM, Collins C, Bo NE, Papalia M, Fernandez JS, Hernandez CM, Papp-Wallace KM, Bonomo RA, Vazquez MS, Power P, Ramirez MS.

Curr Microbiol. 2019 Feb 19. doi: 10.1007/s00284-019-01653-4. [Epub ahead of print]

PMID:
30783798
6.

Shedding of methicillin-resistant Staphylococcus aureus by colonized patients during procedures and patient care activities.

Alhmidi H, Cadnum JL, Koganti S, Jencson AL, Rutter JD, Bonomo RA, Wilson BM, Mayer J, Samore MH, Donskey CJ.

Infect Control Hosp Epidemiol. 2019 Feb 19:1-5. doi: 10.1017/ice.2018.342. [Epub ahead of print]

PMID:
30777587
7.

The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Logan LK, Medernach RL, Domitrovic TN, Rispens JR, Hujer AM, Qureshi NK, Marshall SH, Nguyen DC, Rudin SD, Zheng X, Konda S, Weinstein RA, Bonomo RA.

Infect Dis Ther. 2019 Feb 16. doi: 10.1007/s40121-019-0237-2. [Epub ahead of print]

PMID:
30772921
8.

Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro.

Pandey R, Chen L, Manca C, Jenkins S, Glaser L, Vinnard C, Stone G, Lee J, Mathema B, Nuermberger EL, Bonomo RA, Kreiswirth BN.

MBio. 2019 Feb 12;10(1). pii: e02895-18. doi: 10.1128/mBio.02895-18.

9.

Antibiotic collateral sensitivity is contingent on the repeatability of evolution.

Nichol D, Rutter J, Bryant C, Hujer AM, Lek S, Adams MD, Jeavons P, Anderson ARA, Bonomo RA, Scott JG.

Nat Commun. 2019 Jan 18;10(1):334. doi: 10.1038/s41467-018-08098-6.

10.

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Luterbach CL, Boshe A, Henderson HI, Cober E, Richter SS, Salata RA, Kalayjian RC, Watkins RR, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Doi Y, Kaye KS, Evans S, Fowler VG Jr, Bonomo RA, van Duin D.

Open Forum Infect Dis. 2018 Dec 14;6(1):ofy351. doi: 10.1093/ofid/ofy351. eCollection 2019 Jan.

11.

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.

Traglia GM, Place K, Dotto C, Fernandez JS, Montaña S, Bahiense CDS, Soler-Bistue A, Iriarte A, Perez F, Tolmasky ME, Bonomo RA, Melano RG, Ramírez MS.

Int J Antimicrob Agents. 2019 Jan 3. pii: S0924-8579(18)30383-2. doi: 10.1016/j.ijantimicag.2018.12.013. [Epub ahead of print]

PMID:
30611868
12.

A Comparison of Cefazolin Versus Ceftriaxone for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia in a Tertiary Care VA Medical Center.

Carr DR, Stiefel U, Bonomo RA, Burant CJ, Sims SV.

Open Forum Infect Dis. 2018 May 18;5(5):ofy089. doi: 10.1093/ofid/ofy089. eCollection 2018 May.

13.

1H, 13C, and 15N backbone resonance assignments for KPC-2, a class A serine-β-lactamase.

VanPelt J, Shurina BA, Ramelot TA, Bonomo RA, Page RC.

Biomol NMR Assign. 2018 Dec 14. doi: 10.1007/s12104-018-9866-8. [Epub ahead of print]

PMID:
30552637
14.

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa.

Barnes MD, Taracila MA, Rutter JD, Bethel CR, Galdadas I, Hujer AM, Caselli E, Prati F, Dekker JP, Papp-Wallace KM, Haider S, Bonomo RA.

MBio. 2018 Dec 11;9(6). pii: e02085-18. doi: 10.1128/mBio.02085-18.

15.

Human fluids alter DNA-acquisition in Acinetobacter baumannii.

Martinez J, Liu C, Rodman N, Fernandez JS, Barberis C, Sieira R, Perez F, Bonomo RA, Ramirez MS.

Diagn Microbiol Infect Dis. 2019 Mar;93(3):183-187. doi: 10.1016/j.diagmicrobio.2018.10.010. Epub 2018 Oct 23.

PMID:
30420211
16.

Sequential Multiple Assignment Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS).

Evans SR, Follmann D, Liu Y, Holland T, Doernberg SB, Rouphael N, Hamasaki T, Jiang Y, Lok JJ, Tran TTT, Harris AD, Fowler VG Jr, Boucher H, Kreiswirth BN, Bonomo RA, van Duin D, Paterson DL, Chambers H.

Clin Infect Dis. 2018 Oct 23. doi: 10.1093/cid/ciy912. [Epub ahead of print]

PMID:
30351426
17.

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.

Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01754-18. doi: 10.1128/AAC.01754-18. Print 2019 Jan.

PMID:
30348667
18.

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Jacobs MR, Abdelhamed AM, Good CE, Rhoads DD, Hujer KM, Hujer AM, Domitrovic TN, Rudin SD, Richter SS, van Duin D, Kreiswirth BN, Greco C, Fouts DE, Bonomo RA.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01801-18. doi: 10.1128/AAC.01801-18. Print 2019 Jan.

PMID:
30323050
19.

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections.

Isler B, Doi Y, Bonomo RA, Paterson DL.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01110-18. doi: 10.1128/AAC.01110-18. Print 2019 Jan. Review.

PMID:
30323035
20.

Epidemiology of Carbapenem-Resistant Enterobacteriaceae at a Long-term Acute Care Hospital.

Chopra T, Rivard C, Awali RA, Krishna A, Bonomo RA, Perez F, Kaye KS.

Open Forum Infect Dis. 2018 Oct 3;5(10):ofy224. doi: 10.1093/ofid/ofy224. eCollection 2018 Oct.

21.

Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii.

Quinn B, Rodman N, Jara E, Fernandez JS, Martinez J, Traglia GM, Montaña S, Cantera V, Place K, Bonomo RA, Iriarte A, Ramírez MS.

Sci Rep. 2018 Oct 3;8(1):14741. doi: 10.1038/s41598-018-33072-z.

22.

Community Origins and Regional Differences Highlight Risk of Plasmid-Mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Logan LK, Medernach RL, Rispens JR, Marshall SH, Hujer AM, Domitrovic TN, Rudin SD, Zheng X, Qureshi NK, Konda S, Hayden MK, Weinstein RA, Bonomo RA.

Pediatr Infect Dis J. 2018 Sep 29. doi: 10.1097/INF.0000000000002205. [Epub ahead of print]

PMID:
30281548
23.

Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam against Pseudomonas aeruginosa: PRIMERS IV.

Evans SR, Tran TTT, Hujer AM, Hill CB, Hujer KM, Mediavilla JR, Manca C, Domitrovic TN, Perez F, Farmer M, Pitzer KM, Wilson BM, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Fowler VG Jr, Chambers HF, Bonomo RA; Antibacterial Resistance Leadership Group (ARLG).

Clin Infect Dis. 2018 Sep 20. doi: 10.1093/cid/ciy801. [Epub ahead of print]

PMID:
30239599
24.

Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation.

Knight DB, Rudin SD, Bonomo RA, Rather PN.

Front Microbiol. 2018 Aug 21;9:1902. doi: 10.3389/fmicb.2018.01902. eCollection 2018.

25.

A Multi-Centered Case-Case-Control Study of Factors Associated with Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults.

Logan LK, Nguyen DC, Scaggs Huang FA, Qureshi NK, Charnot-Katsikas A, Bartlett AH, Zheng X, Hujer AM, Domitrovic TN, Marshall SH, Bonomo RA, Weinstein RA.

Pediatr Infect Dis J. 2018 Aug 30. doi: 10.1097/INF.0000000000002176. [Epub ahead of print]

PMID:
30169484
26.

Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance.

Galdadas I, Lovera S, Pérez-Hernández G, Barnes MD, Healy J, Afsharikho H, Woodford N, Bonomo RA, Gervasio FL, Haider S.

Sci Rep. 2018 Aug 27;8(1):12916. doi: 10.1038/s41598-018-31176-0.

27.

A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-β-lactamase SPS-1.

Cheng Z, VanPelt J, Bergstrom A, Bethel C, Katko A, Miller C, Mason K, Cumming E, Zhang H, Kimble RL, Fullington S, Bretz SL, Nix JC, Bonomo RA, Tierney DL, Page RC, Crowder MW.

Biochemistry. 2018 Sep 4;57(35):5218-5229. doi: 10.1021/acs.biochem.8b00728. Epub 2018 Aug 21.

28.

Ibrutinib Therapy and Mycobacterium chelonae Skin and Soft Tissue Infection.

Dousa KM, Babiker A, Van Aartsen D, Shah N, Bonomo RA, Johnson JL, Skalweit MJ.

Open Forum Infect Dis. 2018 Jul 18;5(7):ofy168. doi: 10.1093/ofid/ofy168. eCollection 2018 Jul.

29.

Ceftazidime/Avibactam, Meropenem/Vaborbactam, or Both? Clinical and Formulary Considerations.

Pogue JM, Bonomo RA, Kaye KS.

Clin Infect Dis. 2019 Jan 18;68(3):519-524. doi: 10.1093/cid/ciy576.

PMID:
30020449
30.

Correction to Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.

Chen AY, Thomas PW, Stewart AC, Bergstrom A, Cheng Z, Miller C, Bethel CR, Marshall SH, Credille CV, Riley CL, Page RC, Bonomo RA, Crowder MW, Tierney DL, Fast W, Cohen SM.

J Med Chem. 2018 Jul 26;61(14):6400. doi: 10.1021/acs.jmedchem.8b01057. Epub 2018 Jul 18. No abstract available.

PMID:
30019584
31.

Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Kanwar A, Marshall SH, Perez F, Tomas M, Jacobs MR, Hujer AM, Domitrovic TN, Rudin SD, Rojas LJ, Kreiswirth BN, Chen L, Quinones-Mateu M, van Duin D, Bonomo RA; Antibacterial Resistance Leadership Group.

Open Forum Infect Dis. 2018 Apr 23;5(4):ofy054. doi: 10.1093/ofid/ofy054. eCollection 2018 Apr.

32.

Predictors of outcome in patients with severe sepsis or septic shock due to extended-spectrum β-lactamase-producing Enterobacteriaceae.

Russo A, Falcone M, Gutiérrez-Gutiérrez B, Calbo E, Almirante B, Viale PL, Oliver A, Ruiz-Garbajosa P, Gasch O, Gozalo M, Pitout J, Akova M, Peña C, Cisneros JM, Hernández-Torres A, Farcomeni A, Prim N, Origüen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Karaiskos I, de la Calle C, Pérez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Mora-Rillo M, Rodriguez-Gomez J, Souli M, Bonomo RA, Paterson DL, Carmeli Y, Pascual A, Rodríguez-Baño J, Venditti M; REIPI/ESGBIS/INCREMENT investigators.

Int J Antimicrob Agents. 2018 Nov;52(5):577-585. doi: 10.1016/j.ijantimicag.2018.06.018. Epub 2018 Jun 30.

PMID:
29969692
33.

Ceftazidime/avibactam versus standard-of-care agents against carbapenem-resistant Enterobacteriaceae harbouring blaKPC in a one-compartment pharmacokinetic/pharmacodynamic model.

Barber KE, Pogue JM, Warnock HD, Bonomo RA, Kaye KS.

J Antimicrob Chemother. 2018 Sep 1;73(9):2405-2410. doi: 10.1093/jac/dky213.

PMID:
29939267
34.

Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains.

Yu F, Lv J, Niu S, Du H, Tang YW, Pitout JDD, Bonomo RA, Kreiswirth BN, Chen L.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00731-18. doi: 10.1128/JCM.00731-18. Print 2018 Sep.

35.

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.

Cheng Z, Thomas PW, Ju L, Bergstrom A, Mason K, Clayton D, Miller C, Bethel CR, VanPelt J, Tierney DL, Page RC, Bonomo RA, Fast W, Crowder MW.

J Biol Chem. 2018 Aug 10;293(32):12606-12618. doi: 10.1074/jbc.RA118.003835. Epub 2018 Jun 16.

36.

In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

Yu F, Lv J, Niu S, Du H, Tang YW, Bonomo RA, Kreiswirth BN, Chen L.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e01031-18. doi: 10.1128/AAC.01031-18. Print 2018 Aug.

37.

It's too soon to pull the plug on antibiotic cycling.

Nichol D, Bonomo RA, Scott JG.

Lancet Infect Dis. 2018 May;18(5):493. doi: 10.1016/S1473-3099(18)30214-7. No abstract available.

PMID:
29695354
38.

The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters.

Ju LC, Cheng Z, Fast W, Bonomo RA, Crowder MW.

Trends Pharmacol Sci. 2018 Jul;39(7):635-647. doi: 10.1016/j.tips.2018.03.007. Epub 2018 Apr 18. Review.

PMID:
29680579
39.

Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.

van den Akker F, Bonomo RA.

Front Microbiol. 2018 Apr 5;9:622. doi: 10.3389/fmicb.2018.00622. eCollection 2018. Review.

40.

Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.

Ghiglione B, Rodríguez MM, Curto L, Brunetti F, Dropa M, Bonomo RA, Power P, Gutkind G.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00116-18. doi: 10.1128/AAC.00116-18. Print 2018 Jun.

41.

Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.

Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V, Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S, Ravikumar T, Deshpande PK, Patil V, Yeole R, Bhagwat SS, Patel MV, van den Akker F, Bonomo RA.

J Med Chem. 2018 May 10;61(9):4067-4086. doi: 10.1021/acs.jmedchem.8b00091. Epub 2018 Apr 20.

PMID:
29627985
42.

Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae.

Scheuerman O, Schechner V, Carmeli Y, Gutiérrez-Gutiérrez B, Calbo E, Almirante B, Viale PL, Oliver A, Ruiz-Garbajosa P, Gasch O, Gozalo M, Pitout J, Akova M, Peña C, Molina J, Hernández-Torres A, Venditti M, Prim N, Origüen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Karaiskos I, de la Calle C, Pérez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Navarro-San Francisco C, Bonomo RA, Paterson DL, Pascual A, Rodríguez-Baño J; REIPI/ESGBIS/INCREMENT investigators.

Infect Control Hosp Epidemiol. 2018 Jun;39(6):660-667. doi: 10.1017/ice.2018.63. Epub 2018 Apr 5.

PMID:
29618394
43.

Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae.

Papp-Wallace KM, Barnes MD, Alsop J, Taracila MA, Bethel CR, Becka SA, van Duin D, Kreiswirth BN, Kaye KS, Bonomo RA.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00174-18. doi: 10.1128/AAC.00174-18. Print 2018 Jun.

44.

Inactivation of the Pseudomonas-Derived Cephalosporinase-3 (PDC-3) by Relebactam.

Barnes MD, Bethel CR, Alsop J, Becka SA, Rutter JD, Papp-Wallace KM, Bonomo RA.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02406-17. doi: 10.1128/AAC.02406-17. Print 2018 May.

45.

Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins.

Richter SS, Karichu J, Otiso J, Van Heule H, Keller G, Cober E, Rojas LJ, Hujer AM, Hujer KM, Marshall S, Perez F, Rudin SD, Domitrovic TN, Kaye KS, Salata R, van Duin D, Bonomo RA.

Diagn Microbiol Infect Dis. 2018 May;91(1):89-92. doi: 10.1016/j.diagmicrobio.2018.01.005. Epub 2018 Jan 9.

PMID:
29456071
46.

Evidence to improve the treatment of infections caused by carbapenem-resistant Gram-negative bacteria.

Perez F, Bonomo RA.

Lancet Infect Dis. 2018 Apr;18(4):358-360. doi: 10.1016/S1473-3099(18)30112-9. Epub 2018 Feb 16. No abstract available.

PMID:
29456042
47.

Infectious Diseases Physicians: Leading the Way in Antimicrobial Stewardship.

Ostrowsky B, Banerjee R, Bonomo RA, Cosgrove SE, Davidson L, Doron S, Gilbert DN, Jezek A, Lynch JB 3rd, Septimus EJ, Siddiqui J, Iovine NM; Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and the Society for Healthcare Epidemiology of America.

Clin Infect Dis. 2018 Mar 19;66(7):995-1003. doi: 10.1093/cid/cix1093. No abstract available.

PMID:
29444247
48.

Probing the Mechanism of Inactivation of the FOX-4 Cephamycinase by Avibactam.

Nukaga M, Papp-Wallace KM, Hoshino T, Lefurgy ST, Bethel CR, Barnes MD, Zeiser ET, Johnson JK, Bonomo RA.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02371-17. doi: 10.1128/AAC.02371-17. Print 2018 May.

49.

New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance.

Tsalik EL, Bonomo RA, Fowler VG Jr.

Annu Rev Med. 2018 Jan 29;69:379-394. doi: 10.1146/annurev-med-052716-030320.

50.

DISC: Describing Infections of the Spine treated with Ceftaroline.

Watkins RR, Yendewa G, Burdette SD, Horattas S, Haller NA, Mangira C, Salata RA, Bonomo RA.

J Glob Antimicrob Resist. 2018 Jun;13:146-151. doi: 10.1016/j.jgar.2018.01.001. Epub 2018 Jan 11.

PMID:
29337085

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