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Residual β cell function and monogenic variants in long-duration type 1 diabetes patients.

Yu MG, Keenan HA, Shah HS, Frodsham SG, Pober D, He Z, Wolfson EA, D'Eon S, Tinsley LJ, Bonner-Weir S, Pezzolesi MG, King GL.

J Clin Invest. 2019 Jul 2;130. pii: 127397. doi: 10.1172/JCI127397. eCollection 2019 Jul 2.


Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes.

Aguayo-Mazzucato C, Andle J, Lee TB Jr, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir S.

Cell Metab. 2019 Jul 2;30(1):129-142.e4. doi: 10.1016/j.cmet.2019.05.006. Epub 2019 May 30.


Generation of Pancreatic Ductal Organoids and Whole-Mount Immunostaining of Intact Organoids.

Rezanejad H, Lock JH, Sullivan BA, Bonner-Weir S.

Curr Protoc Cell Biol. 2019 Jun;83(1):e82. doi: 10.1002/cpcb.82. Epub 2018 Dec 12.


T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.

Aguayo-Mazzucato C, Lee TB Jr, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S.

Diabetes. 2018 Jul;67(7):1322-1331. doi: 10.2337/db18-0030. Epub 2018 Apr 6.


Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJP.

Stem Cell Reports. 2018 Mar 13;10(3):712-724. doi: 10.1016/j.stemcr.2018.02.005.


Heterogeneity of SOX9 and HNF1β in Pancreatic Ducts Is Dynamic.

Rezanejad H, Ouziel-Yahalom L, Keyzer CA, Sullivan BA, Hollister-Lock J, Li WC, Guo L, Deng S, Lei J, Markmann J, Bonner-Weir S.

Stem Cell Reports. 2018 Mar 13;10(3):725-738. doi: 10.1016/j.stemcr.2018.01.028. Epub 2018 Mar 1.


Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.

Aguayo-Mazzucato C, Bonner-Weir S.

Cell Metab. 2018 Jan 9;27(1):57-67. doi: 10.1016/j.cmet.2017.08.007. Epub 2017 Sep 7. Review.


β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.

Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB Jr, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S.

Cell Metab. 2017 Apr 4;25(4):898-910.e5. doi: 10.1016/j.cmet.2017.03.015.


Evidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors.

Ebrahimi A, Jung MH, Dreyfuss JM, Pan H, Sgroi D, Bonner-Weir S, Weir GC.

Islets. 2017 Mar 4;9(2):19-29. doi: 10.1080/19382014.2017.1283083.


GABA Signaling Stimulates β Cell Regeneration in Diabetic Mice.

Weir GC, Bonner-Weir S.

Cell. 2017 Jan 12;168(1-2):7-9. doi: 10.1016/j.cell.2016.12.006. Epub 2017 Jan 12.


V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.

Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy PA.

Stem Cells Transl Med. 2016 Nov;5(11):1525-1537. doi: 10.5966/sctm.2015-0318. Epub 2016 Jul 12.


Physiology: Pancreatic β-cell heterogeneity revisited.

Bonner-Weir S, Aguayo-Mazzucato C.

Nature. 2016 Jul 21;535(7612):365-6. Epub 2016 Jul 13. No abstract available.


Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice.

Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF.

JCI Insight. 2016;1(3). pii: e80749. Epub 2016 Mar 17.


Dynamic development of the pancreas from birth to adulthood.

Bonner-Weir S, Aguayo-Mazzucato C, Weir GC.

Ups J Med Sci. 2016 May;121(2):155-8. doi: 10.3109/03009734.2016.1154906. Epub 2016 Mar 21. Review.


Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.

Cavelti-Weder C, Li W, Zumsteg A, Stemann M, Yamada T, Bonner-Weir S, Weir G, Zhou Q.

Curr Pathobiol Rep. 2015 Mar 1;3(1):57-65. Epub 2015 Jan 30.


Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.

Cavelti-Weder C, Li W, Zumsteg A, Stemann-Andersen M, Zhang Y, Yamada T, Wang M, Lu J, Jermendy A, Bee YM, Bonner-Weir S, Weir GC, Zhou Q.

Diabetologia. 2016 Mar;59(3):522-32. doi: 10.1007/s00125-015-3838-7. Epub 2015 Dec 23.


Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.

Nishimura W, Kapoor A, El Khattabi I, Jin W, Yasuda K, Bonner-Weir S, Sharma A.

PLoS One. 2015 Nov 5;10(11):e0142286. doi: 10.1371/journal.pone.0142286. eCollection 2015.


MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.

Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S.

J Clin Endocrinol Metab. 2015 Oct;100(10):3651-9. doi: 10.1210/jc.2015-2632. Epub 2015 Jul 24.


Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells.

Yamada T, Cavelti-Weder C, Caballero F, Lysy PA, Guo L, Sharma A, Li W, Zhou Q, Bonner-Weir S, Weir GC.

Endocrinology. 2015 Jun;156(6):2029-38. doi: 10.1210/en.2014-1987. Epub 2015 Apr 2.


Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All.

Bonner-Weir S, Sullivan BA, Weir GC.

J Histochem Cytochem. 2015 Aug;63(8):604-12. doi: 10.1369/0022155415570969. Epub 2015 Jan 20.


Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells.

Sullivan BA, Hollister-Lock J, Bonner-Weir S, Weir GC.

Diabetes. 2015 May;64(5):1698-702. doi: 10.2337/db14-1675. Epub 2014 Dec 8.


β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.

Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, Markmann J, Piemonti L, Sokal EM, Bonner-Weir S, Lysy PA.

Cell Reprogram. 2014 Dec;16(6):456-66. doi: 10.1089/cell.2014.0025. Erratum in: Cell Reprogram. 2015 Feb;17(1):88.


ANGPTL8/betatrophin does not control pancreatic beta cell expansion.

Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J.

Cell. 2014 Oct 23;159(3):691-6. doi: 10.1016/j.cell.2014.09.027.


Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies.

Bonner-Weir S, In't Veld PA, Weir GC.

Diabetes Obes Metab. 2014 Jul;16(7):661-6. doi: 10.1111/dom.12257. Epub 2014 Jan 29.


β-cell dedifferentiation in diabetes is important, but what is it?

Weir GC, Aguayo-Mazzucato C, Bonner-Weir S.

Islets. 2013 Sep-Dec;5(5):233-7. doi: 10.4161/isl.27494. Epub 2013 Dec 19. Review.


Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.

Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP.

Diabetes. 2014 Apr;63(4):1303-14. doi: 10.2337/db13-1268. Epub 2013 Nov 12.


Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes.

King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC.

PLoS One. 2013 Oct 18;8(10):e77452. doi: 10.1371/journal.pone.0077452. eCollection 2013.


Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.

He KH, Juhl K, Karadimos M, El Khattabi I, Fitzpatrick C, Bonner-Weir S, Sharma A.

Dev Biol. 2014 Jan 1;385(1):2-12. doi: 10.1016/j.ydbio.2013.10.024. Epub 2013 Oct 29. Erratum in: Dev Biol. 2014 Feb 15;386(2):484-5.


Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration.

Cavelti-Weder C, Shtessel M, Reuss JE, Jermendy A, Yamada T, Caballero F, Bonner-Weir S, Weir GC.

Endocrinology. 2013 Dec;154(12):4493-502. doi: 10.1210/en.2013-1463. Epub 2013 Sep 12.


TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice.

Wu F, Guo L, Jakubowski A, Su L, Li WC, Bonner-Weir S, Burkly LC.

PLoS One. 2013 Aug 26;8(8):e72132. doi: 10.1371/journal.pone.0072132. eCollection 2013.


Making β cells from adult cells within the pancreas.

Lysy PA, Weir GC, Bonner-Weir S.

Curr Diab Rep. 2013 Oct;13(5):695-703. doi: 10.1007/s11892-013-0400-1. Review.


PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.

Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S.

Diabetes. 2013 Oct;62(10):3459-68. doi: 10.2337/db12-1833. Epub 2013 Jun 17.


Conversion of mature human β-cells into glucagon-producing α-cells.

Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ.

Diabetes. 2013 Jul;62(7):2471-80. doi: 10.2337/db12-1001. Epub 2013 Apr 8.


Islet β cell mass in diabetes and how it relates to function, birth, and death.

Weir GC, Bonner-Weir S.

Ann N Y Acad Sci. 2013 Apr;1281:92-105. doi: 10.1111/nyas.12031. Epub 2013 Jan 30. Review.


Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.

Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC.

Cell Transplant. 2014 Feb;23(2):139-51. doi: 10.3727/096368912X659916. Epub 2013 Jan 2.


Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.

Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S.

Diabetes. 2013 May;62(5):1569-80. doi: 10.2337/db12-0849. Epub 2013 Jan 10.


Concise review: pancreas regeneration: recent advances and perspectives.

Lysy PA, Weir GC, Bonner-Weir S.

Stem Cells Transl Med. 2012 Feb;1(2):150-9. doi: 10.5966/sctm.2011-0025. Epub 2012 Jan 26. Review.


Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.

Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC.

Endocrinology. 2012 Nov;153(11):5180-7. doi: 10.1210/en.2012-1257. Epub 2012 Aug 23.


New clues to bariatric surgery's benefits.

Sarruf DA, Bonner-Weir S, Schwartz MW.

Nat Med. 2012 Jun 6;18(6):860-1. doi: 10.1038/nm.2801. No abstract available.


Islet neogenesis: a possible pathway for beta-cell replenishment.

Bonner-Weir S, Guo L, Li WC, Ouziel-Yahalom L, Lysy PA, Weir GC, Sharma A.

Rev Diabet Stud. 2012 Winter;9(4):407-16. doi: 10.1900/RDS.2012.9.407. Epub 2012 Dec 28. Review.


Stem cell approaches for diabetes: towards beta cell replacement.

Weir GC, Cavelti-Weder C, Bonner-Weir S.

Genome Med. 2011 Sep 27;3(9):61. doi: 10.1186/gm277.


Finally! A human pancreatic β cell line.

Weir GC, Bonner-Weir S.

J Clin Invest. 2011 Sep;121(9):3395-7. doi: 10.1172/JCI58899. Epub 2011 Aug 25.


Sleeping islets and the relationship between β-cell mass and function.

Weir GC, Bonner-Weir S.

Diabetes. 2011 Aug;60(8):2018-9. doi: 10.2337/db10-1808. No abstract available.


Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.

Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM.

PLoS One. 2011;6(6):e20832. doi: 10.1371/journal.pone.0020832. Epub 2011 Jun 16.


Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.

Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S.

Diabetologia. 2011 Mar;54(3):594-604. doi: 10.1007/s00125-010-2036-x. Epub 2011 Jan 16.


Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.

Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S.

Diabetologia. 2011 Mar;54(3):583-93. doi: 10.1007/s00125-010-2026-z. Epub 2010 Dec 29.


Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.

Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit F.

Genome Res. 2011 Jan;21(1):95-105. doi: 10.1101/gr.109173.110. Epub 2010 Nov 18.


Quantitative assessment of islets of Langerhans encapsulated in alginate.

Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CK.

Tissue Eng Part C Methods. 2011 Apr;17(4):435-49. doi: 10.1089/ten.TEC.2009.0510. Epub 2011 Jan 16.


Beta-cell growth and regeneration: replication is only part of the story.

Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A.

Diabetes. 2010 Oct;59(10):2340-8. doi: 10.2337/db10-0084. Review. No abstract available.

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