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Items: 31

1.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008.

PMID:
29570999
2.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.

Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242.

3.

Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1703-1709. doi: 10.1093/gerona/glx041.

PMID:
28329397
4.

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Bonkowski MS, Sinclair DA.

Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24. Review.

5.

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.

Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC.

Sci Rep. 2016 Mar 18;6:23229. doi: 10.1038/srep23229.

6.

Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.

Koopman JJ, van Heemst D, van Bodegom D, Bonkowski MS, Sun LY, Bartke A.

Aging (Albany NY). 2016 Mar;8(3):539-46.

7.

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.

Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA.

J Biol Chem. 2016 Jan 29;291(5):2119-35. doi: 10.1074/jbc.M115.675645. Epub 2015 Dec 11.

8.

Metabolic alterations due to caloric restriction and every other day feeding in normal and growth hormone receptor knockout mice.

Westbrook R, Bonkowski MS, Arum O, Strader AD, Bartke A.

J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):25-33. doi: 10.1093/gerona/glt080. Epub 2013 Jul 5.

9.

Deviation of innate circadian period from 24 h reduces longevity in mice.

Libert S, Bonkowski MS, Pointer K, Pletcher SD, Guarente L.

Aging Cell. 2012 Oct;11(5):794-800. doi: 10.1111/j.1474-9726.2012.00846.x. Epub 2012 Jul 12.

10.

Effects of adult onset mild calorie restriction on weight of reproductive organs, plasma parameters and gene expression in male mice.

Rocha JS, Bonkowski MS, Masternak MM, França LR, Bartke A.

Anim Reprod. 2012 Jan 1;9(1):40-51.

11.

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP.

Genes Dev. 2009 Dec 15;23(24):2812-7. doi: 10.1101/gad.1839209. Erratum in: Genes Dev. 2010 Mar 1;24(5):516.

12.

The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.

Arum O, Bonkowski MS, Rocha JS, Bartke A.

Aging Cell. 2009 Dec;8(6):756-60. doi: 10.1111/j.1474-9726.2009.00520.x. Epub 2009 Sep 11.

13.

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?

Panici JA, Wang F, Bonkowski MS, Spong A, Bartke A, Pawlikowska L, Kwok PY, Masternak MM.

J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1126-33. doi: 10.1093/gerona/glp111. Epub 2009 Aug 25.

14.

Insulin sensitivity as a key mediator of growth hormone actions on longevity.

Masternak MM, Panici JA, Bonkowski MS, Hughes LF, Bartke A.

J Gerontol A Biol Sci Med Sci. 2009 May;64(5):516-21. doi: 10.1093/gerona/glp024. Epub 2009 Mar 20.

15.

Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice.

Westbrook R, Bonkowski MS, Strader AD, Bartke A.

J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):443-51. doi: 10.1093/gerona/gln075. Epub 2009 Mar 13.

16.

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity.

Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al Regaiey KA, Westbrook R, Spong A, Panici J, Masternak MM, Kopchick JJ, Bartke A.

PLoS One. 2009;4(2):e4567. doi: 10.1371/journal.pone.0004567. Epub 2009 Feb 23.

17.

Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction.

Giani JF, Bonkowski MS, Muñoz MC, Masternak MM, Turyn D, Bartke A, Dominici FP.

J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):788-97.

PMID:
18772466
18.

Mild calorie restriction does not affect testosterone levels and testicular gene expression in mutant mice.

Rocha JS, Bonkowski MS, França LR, Bartke A.

Exp Biol Med (Maywood). 2007 Sep;232(8):1050-63.

PMID:
17720951
19.

Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis.

Rocha JS, Bonkowski MS, de França LR, Bartke A.

Mech Ageing Dev. 2007 Apr;128(4):317-31. Epub 2007 Feb 20.

PMID:
17376513
20.

Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle.

Al-Regaiey KA, Masternak MM, Bonkowski MS, Panici JA, Kopchick JJ, Bartke A.

J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):18-26.

PMID:
17301033
21.

Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice.

Bartke A, Masternak MM, Al-Regaiey KA, Bonkowski MS.

Interdiscip Top Gerontol. 2007;35:69-82. Review.

PMID:
17063033
22.

Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics.

Bonkowski MS, Pamenter RW, Rocha JS, Masternak MM, Panici JA, Bartke A.

J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):562-7.

PMID:
16799137
23.

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.

Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7901-5. Epub 2006 May 8.

24.

Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart.

Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Wang Z, Bartke A.

Exp Gerontol. 2006 Apr;41(4):417-29. Epub 2006 Mar 9.

25.

Increased sensitivity to GH in liver of Ames dwarf (Prop1df/Prop1df) mice related to diminished CIS abundance.

Miquet JG, Sotelo AI, Dominici FP, Bonkowski MS, Bartke A, Turyn D.

J Endocrinol. 2005 Dec;187(3):387-97.

PMID:
16423818
26.

Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice.

Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Bartke A.

J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1394-8.

PMID:
16339324
27.

Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice.

Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Bonkowski MS, Panici JA, Przybylski GK, Bartke A.

J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1238-45.

PMID:
16282554
28.

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.

Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Bartke A.

Exp Gerontol. 2005 Aug-Sep;40(8-9):679-84.

PMID:
16054319
29.

Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice.

Masternak MM, Al-Regaiey KA, Bonkowski MS, Panici JA, Bartke A.

Exp Gerontol. 2005 Jun;40(6):491-7.

PMID:
15935586
30.

Effects of long-term caloric restriction on early steps of the insulin-signaling system in mouse skeletal muscle.

Argentino DP, Dominici FP, Al-Regaiey K, Bonkowski MS, Bartke A, Turyn D.

J Gerontol A Biol Sci Med Sci. 2005 Jan;60(1):28-34.

PMID:
15741279
31.

Divergent effects of caloric restriction on gene expression in normal and long-lived mice.

Masternak MM, Al-Regaiey K, Bonkowski MS, Panici J, Sun L, Wang J, Przybylski GK, Bartke A.

J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):784-8.

PMID:
15345726

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