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Items: 1 to 50 of 160

1.

Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients.

Bonig H, Kuçi Z, Kuçi S, Bakhtiar S, Basu O, Bug G, Dennis M, Greil J, Barta A, Kállay KM, Lang P, Lucchini G, Pol R, Schulz A, Sykora KW, Teichert von Luettichau I, Herter-Sprie G, Ashab Uddin M, Jenkin P, Alsultan A, Buechner J, Stein J, Kelemen A, Jarisch A, Soerensen J, Salzmann-Manrique E, Hutter M, Schäfer R, Seifried E, Paneesha S, Novitzky-Basso I, Gefen A, Nevo N, Beutel G, Schlegel PG, Klingebiel T, Bader P.

Cells. 2019 Dec 5;8(12). pii: E1577. doi: 10.3390/cells8121577.

2.

Management of adults and children undergoing CAR t-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE).

Yakoub-Agha I, Chabannon C, Bader P, Basak GW, Bonig H, Ciceri F, Corbacioglu S, Duarte RF, Einsele H, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Robinson S, Saccardi R, Sanchez-Guijo F, Snowden JA, Srour M, Styczynski J, Urbano-Ispizua A, Hayden PJ, Kröger N.

Haematologica. 2019 Nov 21. pii: haematol.2019.229781. doi: 10.3324/haematol.2019.229781. [Epub ahead of print]

3.

Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.

Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bonig H, Dimmeler S, Zeiher AM, Rieger MA.

Haematologica. 2019 Nov 7. pii: haematol.2019.224402. doi: 10.3324/haematol.2019.224402. [Epub ahead of print]

4.

Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization.

Shin S, Kim J, Kim-Wanner SZ, Bönig H, Cho SR, Kim S, Choi JR, Lee KA.

PLoS One. 2019 Nov 7;14(11):e0225278. doi: 10.1371/journal.pone.0225278. eCollection 2019.

5.

Modest and nonessential roles of the endocannabinoid system in immature hematopoiesis of mice.

Danner E, Hoffmann F, Lee SY, Cordes F, Orban S, Dauber K, Chudziak D, Spohn G, Wiercinska E, Tast B, Karpova D, Bonig H.

Exp Hematol. 2019 Oct;78:35-45. doi: 10.1016/j.exphem.2019.09.022. Epub 2019 Sep 25.

PMID:
31562901
6.

Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen.

Stenzinger M, Karpova D, Unterrainer C, Harenkamp S, Wiercinska E, Hoerster K, Pfeffer M, Maronde E, Bonig H.

Cells. 2019 Sep 5;8(9). pii: E1033. doi: 10.3390/cells8091033.

7.

Clinical Use of Mesenchymal Stromal Cells in the Treatment of Acute Graft-versus-Host Disease.

Elgaz S, Kuçi Z, Kuçi S, Bönig H, Bader P.

Transfus Med Hemother. 2019 Feb;46(1):27-34. doi: 10.1159/000496809. Epub 2019 Feb 4. Review.

8.

Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells.

Bremm M, Pfeffermann LM, Cappel C, Katzki V, Erben S, Betz S, Quaiser A, Merker M, Bonig H, Schmidt M, Klingebiel T, Bader P, Huenecke S, Rettinger E.

Front Immunol. 2019 May 31;10:1218. doi: 10.3389/fimmu.2019.01218. eCollection 2019.

9.

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.

Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bonig H, Scholz A, Pfeifer H, Martin H, Schmid T, Brüne B, Scheich S, Steffen B, Riemann J, Hermann S, Dukat A, Bug G, Brandts CH, Wagner S, Serve H, Rieger MA.

Cell Rep. 2019 May 14;27(7):2022-2028.e3. doi: 10.1016/j.celrep.2019.04.064.

10.

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.

Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF.

J Clin Invest. 2019 May 14;129(7):2745-2759. doi: 10.1172/JCI124738.

11.

Clearance of Hematologic Malignancies by Allogeneic Cytokine-Induced Killer Cell or Donor Lymphocyte Infusions.

Merker M, Salzmann-Manrique E, Katzki V, Huenecke S, Bremm M, Bakhtiar S, Willasch A, Jarisch A, Soerensen J, Schulz A, Meisel R, Bug G, Bonig H, Klingebiel T, Bader P, Rettinger E.

Biol Blood Marrow Transplant. 2019 Jul;25(7):1281-1292. doi: 10.1016/j.bbmt.2019.03.004. Epub 2019 Mar 13.

PMID:
30878607
12.

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.

Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28.

PMID:
30816345
13.

FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation.

Steiner M, Schneider L, Yillah J, Gerlach K, Kuvardina ON, Meyer A, Maring A, Bonig H, Seifried E, Zörnig M, Lausen J.

PLoS One. 2019 Jan 17;14(1):e0210515. doi: 10.1371/journal.pone.0210515. eCollection 2019.

14.

Mobilized peripheral blood stem cell apheresis via Hickman catheter in pediatric patients.

Doberschuetz N, Soerensen J, Bonig H, Willasch A, Rettinger E, Pfirrmann V, Salzmann-Manrique E, Schäfer R, Klingebiel T, Bader P, Jarisch A.

Transfusion. 2019 Mar;59(3):1061-1068. doi: 10.1111/trf.15113. Epub 2019 Jan 4.

PMID:
30610749
15.

A Proof of the Low Speed Centrifugation Concept in Rodents: New Perspectives for In Vivo Research.

Ghanaati S, Al-Maawi S, Herrera-Vizcaino C, Alves GG, Calasans-Maia MD, Sader R, Kirkpatrick CJ, Choukroun J, Bonig H, Mourão CFAB.

Tissue Eng Part C Methods. 2018 Nov;24(11):659-670. doi: 10.1089/ten.TEC.2018.0236.

PMID:
30358494
16.

Risks of leukapheresis and how to manage them-A non-systematic review.

Stenzinger M, Bonig H.

Transfus Apher Sci. 2018 Oct;57(5):628-634. doi: 10.1016/j.transci.2018.09.008. Epub 2018 Sep 15. Review.

PMID:
30287071
17.

Epstein-Barr virus-specific cytokine-induced killer cells for treatment of Epstein-Barr virus-related malignant lymphoma.

Pfeffermann LM, Pfirrmann V, Huenecke S, Bremm M, Bonig H, Kvasnicka HM, Klingebiel T, Bader P, Rettinger E.

Cytotherapy. 2018 Jun;20(6):839-850. doi: 10.1016/j.jcyt.2018.04.005. Epub 2018 May 10.

18.

The osteo-inductive activity of bone-marrow-derived mononuclear cells resides within the CD14+ population and is independent of the CD34+ population.

Henrich D, Seebach C, Verboket R, Schaible A, Marzi I, Bonig H.

Eur Cell Mater. 2018 Mar 6;35:165-177. doi: 10.22203/eCM.v035a12.

19.

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors.

Holstein M, Mesa-Nuñez C, Miskey C, Almarza E, Poletti V, Schmeer M, Grueso E, Ordóñez Flores JC, Kobelt D, Walther W, Aneja MK, Geiger J, Bonig HB, Izsvák Z, Schleef M, Rudolph C, Mavilio F, Bueren JA, Guenechea G, Ivics Z.

Mol Ther. 2018 Apr 4;26(4):1137-1153. doi: 10.1016/j.ymthe.2018.01.012. Epub 2018 Jan 31.

20.

Generation of alloreactivity-reduced donor lymphocyte products retaining memory function by fully automatic depletion of CD45RA-positive cells.

Müller N, Landwehr K, Langeveld K, Stenzel J, Pouwels W, van der Hoorn MAWG, Seifried E, Bonig H.

Cytotherapy. 2018 Apr;20(4):532-542. doi: 10.1016/j.jcyt.2018.01.006. Epub 2018 Mar 2.

PMID:
29500069
21.

CAR T-cells targeting FLT3 have potent activity against FLT3-ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib.

Jetani H, Garcia-Cadenas I, Nerreter T, Thomas S, Rydzek J, Meijide JB, Bonig H, Herr W, Sierra J, Einsele H, Hudecek M.

Leukemia. 2018 May;32(5):1168-1179. doi: 10.1038/s41375-018-0009-0. Epub 2018 Feb 5.

PMID:
29472720
22.

Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM).

Bader P, Kuçi Z, Bakhtiar S, Basu O, Bug G, Dennis M, Greil J, Barta A, Kállay KM, Lang P, Lucchini G, Pol R, Schulz A, Sykora KW, von Luettichau I, Herter-Sprie G, Uddin MA, Jenkin P, Alsultan A, Buechner J, Stein J, Kelemen A, Jarisch A, Soerensen J, Salzmann-Manrique E, Hutter M, Schäfer R, Seifried E, Klingebiel T, Bonig H, Kuçi S.

Bone Marrow Transplant. 2018 Jul;53(7):852-862. doi: 10.1038/s41409-018-0102-z. Epub 2018 Jan 29.

23.

Autologous cell-based therapy for treatment of large bone defects: from bench to bedside.

Verboket R, Leiblein M, Seebach C, Nau C, Janko M, Bellen M, Bönig H, Henrich D, Marzi I.

Eur J Trauma Emerg Surg. 2018 Oct;44(5):649-665. doi: 10.1007/s00068-018-0906-y. Epub 2018 Jan 19. Review.

24.

Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B.

Miesbach W, Meijer K, Coppens M, Kampmann P, Klamroth R, Schutgens R, Tangelder M, Castaman G, Schwäble J, Bonig H, Seifried E, Cattaneo F, Meyer C, Leebeek FWG.

Blood. 2018 Mar 1;131(9):1022-1031. doi: 10.1182/blood-2017-09-804419. Epub 2017 Dec 15.

25.

Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies.

Duchartre Y, Bachl S, Kim HN, Gang EJ, Lee S, Liu HC, Shung K, Xu R, Kruse A, Tachas G, Bonig H, Kim YM.

PLoS One. 2017 Nov 8;12(11):e0187684. doi: 10.1371/journal.pone.0187684. eCollection 2017.

26.

Hematopoietic transcription factors and differential cofactor binding regulate PRKACB isoform expression.

Kuvardina ON, Herkt S, Meyer A, Schneider L, Yillah J, Kohrs N, Bonig H, Seifried E, Müller-Tidow C, Lausen J.

Oncotarget. 2017 Apr 24;8(42):71685-71698. doi: 10.18632/oncotarget.17386. eCollection 2017 Sep 22.

27.

Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells.

Herkt SC, Kuvardina ON, Herglotz J, Schneider L, Meyer A, Pommerenke C, Salinas-Riester G, Seifried E, Bonig H, Lausen J.

Haematologica. 2018 Jan;103(1):18-29. doi: 10.3324/haematol.2017.174516. Epub 2017 Oct 12.

28.

The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: rationale and design of the BAMI trial.

Mathur A, Arnold R, Assmus B, Bartunek J, Belmans A, Bönig H, Crea F, Dimmeler S, Dowlut S, Fernández-Avilés F, Galiñanes M, Garcia-Dorado D, Hartikainen J, Hill J, Hogardt-Noll A, Homsy C, Janssens S, Kala P, Kastrup J, Martin J, Menasche P, Miklik R, Mozid A, San Román JA, Sanz-Ruiz R, Tendera M, Wojakowski W, Ylä-Herttuala S, Zeiher A.

Eur J Heart Fail. 2017 Nov;19(11):1545-1550. doi: 10.1002/ejhf.829. Epub 2017 Sep 25.

29.

Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the treatment of ErbB2-positive malignancies.

Nowakowska P, Romanski A, Miller N, Odendahl M, Bonig H, Zhang C, Seifried E, Wels WS, Tonn T.

Cancer Immunol Immunother. 2018 Jan;67(1):25-38. doi: 10.1007/s00262-017-2055-2. Epub 2017 Sep 6.

PMID:
28879551
30.

Promises and Challenges in Hematopoietic Stem Cell Gene Therapy.

Kohlscheen S, Bonig H, Modlich U.

Hum Gene Ther. 2017 Oct;28(10):782-799. doi: 10.1089/hum.2017.141. Review.

PMID:
28854824
31.

Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC.

Kim-Wanner SZ, Bug G, Steinmann J, Ajib S, Sorg N, Poppe C, Bunos M, Wingenfeld E, Hümmer C, Luxembourg B, Seifried E, Bonig H.

J Transl Med. 2017 Aug 11;15(1):174. doi: 10.1186/s12967-017-1277-6.

32.

A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization.

Shin S, Kim J, Kim-Wanner SZ, Bönig H, Cho SR, Kim S, Choi JR, Lee KA.

PLoS One. 2017 Jun 30;12(6):e0179986. doi: 10.1371/journal.pone.0179986. eCollection 2017. Erratum in: PLoS One. 2019 Nov 7;14(11):e0225278.

33.

RBC depletion from a PBSC graft.

Bonig H, Bug G.

Bone Marrow Transplant. 2017 Jul;52(7):1078-1079. doi: 10.1038/bmt.2017.72. Epub 2017 Apr 24. No abstract available.

PMID:
28436976
34.

Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells.

Karpova D, Ritchey JK, Holt MS, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig MP, Bonig H, DiPersio JF.

Blood. 2017 May 25;129(21):2939-2949. doi: 10.1182/blood-2016-10-746909. Epub 2017 Apr 11.

35.

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T.

Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001.

36.

Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer.

Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, Radeke HH.

Front Immunol. 2017 Jan 27;8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017.

37.

Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT.

Neuenhahn M, Albrecht J, Odendahl M, Schlott F, Dössinger G, Schiemann M, Lakshmipathi S, Martin K, Bunjes D, Harsdorf S, Weissinger EM, Menzel H, Verbeek M, Uharek L, Kröger N, Wagner E, Kobbe G, Schroeder T, Schmitt M, Held G, Herr W, Germeroth L, Bonig H, Tonn T, Einsele H, Busch DH, Grigoleit GU.

Leukemia. 2017 Oct;31(10):2161-2171. doi: 10.1038/leu.2017.16. Epub 2017 Jan 16.

PMID:
28090089
38.

HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling.

Walter R, Pan KT, Doebele C, Comoglio F, Tomska K, Bohnenberger H, Young RM, Jacobs L, Keller U, Bönig H, Engelke M, Rosenwald A, Urlaub H, Staudt LM, Serve H, Zenz T, Oellerich T.

Blood. 2017 Feb 2;129(5):598-608. doi: 10.1182/blood-2016-06-721423. Epub 2016 Nov 15.

39.

Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial.

Karpova D, Bräuninger S, Wiercinska E, Krämer A, Stock B, Graff J, Martin H, Wach A, Escot C, Douglas G, Romagnoli B, Chevalier E, Dembowski K, Hooftman L, Bonig H.

J Transl Med. 2017 Jan 3;15(1):2. doi: 10.1186/s12967-016-1107-2.

40.
41.

Healthy donor hematopoietic stem cell mobilization with biosimilar granulocyte-colony-stimulating factor: safety, efficacy, and graft performance.

Becker P, Schwebig A, Brauninger S, Bialleck H, Luxembourg B, Schulz M, Tsamadou C, Wiesneth M, Reinhardt P, Mytilineos J, Seidl C, Gattu S, Kaliakina N, Singh P, Schrezenmeier H, Seifried E, Bonig H.

Transfusion. 2016 Dec;56(12):3055-3064. doi: 10.1111/trf.13853. Epub 2016 Sep 16.

PMID:
27633122
42.

In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy.

Bremm M, Huenecke S, Zimmermann O, Pfirrmann V, Quaiser A, Bonig H, Soerensen J, Klingebiel T, Rettinger E, Bader P, Cappel C.

J Transl Med. 2016 Sep 13;14:264. doi: 10.1186/s12967-016-1024-4.

43.

Feasibility of CD3/CD19 depletion of a bone marrow graft.

Bonig H, Müller I.

Cytotherapy. 2016 Oct;18(10):1345-7. doi: 10.1016/j.jcyt.2016.07.001. Epub 2016 Aug 9. No abstract available.

PMID:
27519523
44.

Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow.

Thiel U, Wawer A, von Luettichau I, Bender HU, Blaeschke F, Grunewald TG, Steinborn M, Röper B, Bonig H, Klingebiel T, Bader P, Koscielniak E, Paulussen M, Dirksen U, Juergens H, Kolb HJ, Burdach SE.

Oncotarget. 2016 Oct 25;7(43):70959-70968. doi: 10.18632/oncotarget.10938.

45.

Optimization of individualized graft composition: CD3/CD19 depletion combined with CD34 selection for haploidentical transplantation.

Huenecke S, Bremm M, Cappel C, Esser R, Quaiser A, Bonig H, Jarisch A, Soerensen J, Klingebiel T, Bader P, Koehl U.

Transfusion. 2016 Sep;56(9):2336-45. doi: 10.1111/trf.13694. Epub 2016 Jun 27.

PMID:
27346253
46.

Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey.

Kuçi Z, Bönig H, Kreyenberg H, Bunos M, Jauch A, Janssen JW, Škifić M, Michel K, Eising B, Lucchini G, Bakhtiar S, Greil J, Lang P, Basu O, von Luettichau I, Schulz A, Sykora KW, Jarisch A, Soerensen J, Salzmann-Manrique E, Seifried E, Klingebiel T, Bader P, Kuçi S.

Haematologica. 2016 Aug;101(8):985-94. doi: 10.3324/haematol.2015.140368. Epub 2016 May 12.

47.

MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.

Kohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.

PLoS Genet. 2016 Mar 18;12(3):e1005946. doi: 10.1371/journal.pgen.1005946. eCollection 2016 Mar.

48.

Automation of cellular therapy product manufacturing: results of a split validation comparing CD34 selection of peripheral blood stem cell apheresis product with a semi-manual vs. an automatic procedure.

Hümmer C, Poppe C, Bunos M, Stock B, Wingenfeld E, Huppert V, Stuth J, Reck K, Essl M, Seifried E, Bonig H.

J Transl Med. 2016 Mar 16;14:76. doi: 10.1186/s12967-016-0826-8.

49.

Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak.

Winkler IG, Wiercinska E, Barbier V, Nowlan B, Bonig H, Levesque JP.

Exp Hematol. 2016 Apr;44(4):303-14.e1. doi: 10.1016/j.exphem.2016.01.001. Epub 2016 Jan 29.

PMID:
26827874
50.

Interleukin-15-activated cytokine-induced killer cells may sustain remission in leukemia patients after allogeneic stem cell transplantation: feasibility, safety and first insights on efficacy.

Rettinger E, Huenecke S, Bonig H, Merker M, Jarisch A, Soerensen J, Willasch A, Bug G, Schulz A, Klingebiel T, Bader P.

Haematologica. 2016 Apr;101(4):e153-6. doi: 10.3324/haematol.2015.138016. Epub 2016 Jan 14. No abstract available.

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