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Items: 1 to 50 of 136

1.

Rewiring of the Transcription Factor Network in Acute Myeloid Leukemia.

Assi SA, Bonifer C, Cockerill PN.

Cancer Inform. 2019 Jun 25;18:1176935119859863. doi: 10.1177/1176935119859863. eCollection 2019.

2.

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Gilmour J, O'Connor L, Middleton CP, Keane P, Gillemans N, Cazier JB, Philipsen S, Bonifer C.

Epigenetics Chromatin. 2019 Jun 4;12(1):33. doi: 10.1186/s13072-019-0282-9.

3.

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2019 Apr 15;35(4):705. doi: 10.1016/j.ccell.2019.03.012. No abstract available.

4.

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma.

Edginton-White B, Cauchy P, Assi SA, Hartmann S, Riggs AG, Mathas S, Cockerill PN, Bonifer C.

Leukemia. 2019 Jun;33(6):1463-1474. doi: 10.1038/s41375-018-0311-x. Epub 2018 Dec 13.

5.

Subtype-specific regulatory network rewiring in acute myeloid leukemia.

Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN, Bonifer C.

Nat Genet. 2019 Jan;51(1):151-162. doi: 10.1038/s41588-018-0270-1. Epub 2018 Nov 12.

6.

Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia.

Potluri S, Coleman D, Bonifer C.

Stem Cell Investig. 2018 Sep 30;5:30. doi: 10.21037/sci.2018.09.03. eCollection 2018. No abstract available.

7.

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2018 Oct 8;34(4):626-642.e8. doi: 10.1016/j.ccell.2018.08.015. Erratum in: Cancer Cell. 2019 Apr 15;35(4):705.

8.

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.

de Boer B, Prick J, Pruis MG, Keane P, Imperato MR, Jaques J, Brouwers-Vos AZ, Hogeling SM, Woolthuis CM, Nijk MT, Diepstra A, Wandinger S, Versele M, Attar RM, Cockerill PN, Huls G, Vellenga E, Mulder AB, Bonifer C, Schuringa JJ.

Cancer Cell. 2018 Oct 8;34(4):674-689.e8. doi: 10.1016/j.ccell.2018.08.014. Epub 2018 Sep 20.

PMID:
30245083
9.

The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification.

Gilmour J, Assi SA, Noailles L, Lichtinger M, Obier N, Bonifer C.

Sci Rep. 2018 Jul 10;8(1):10410. doi: 10.1038/s41598-018-28506-7.

10.

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.

Loke J, Chin PS, Keane P, Pickin A, Assi SA, Ptasinska A, Imperato MR, Cockerill PN, Bonifer C.

Blood Adv. 2018 Feb 13;2(3):271-284. doi: 10.1182/bloodadvances.2017012781.

11.

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH.

EBioMedicine. 2017 Nov;25:188. doi: 10.1016/j.ebiom.2017.10.029. Epub 2017 Oct 31. No abstract available.

12.

Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc Min/+ mouse model of intestinal tumorigenesis.

Hull MA, Cuthbert RJ, Ko CWS, Scott DJ, Cartwright EJ, Hawcroft G, Perry SL, Ingram N, Carr IM, Markham AF, Bonifer C, Coletta PL.

Sci Rep. 2017 Jul 20;7(1):6074. doi: 10.1038/s41598-017-06253-5.

13.

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.

Lin S, Ptasinska A, Chen X, Shrestha M, Assi SA, Chin PS, Imperato MR, Aronow BJ, Zhang J, Weirauch MT, Bonifer C, Mulloy JC.

Blood. 2017 Sep 7;130(10):1213-1222. doi: 10.1182/blood-2016-11-750976. Epub 2017 Jul 14.

14.

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Soria NM, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, Bonifer C.

Cell Rep. 2017 May 23;19(8):1654-1668. doi: 10.1016/j.celrep.2017.05.005.

15.

Runx1 Structure and Function in Blood Cell Development.

Bonifer C, Levantini E, Kouskoff V, Lacaud G.

Adv Exp Med Biol. 2017;962:65-81. doi: 10.1007/978-981-10-3233-2_5. Review.

PMID:
28299651
16.

Chromatin priming of genes in development: Concepts, mechanisms and consequences.

Bonifer C, Cockerill PN.

Exp Hematol. 2017 May;49:1-8. doi: 10.1016/j.exphem.2017.01.003. Epub 2017 Feb 7. Review.

17.

The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease.

O'Connor L, Gilmour J, Bonifer C.

Yale J Biol Med. 2016 Dec 23;89(4):513-525. eCollection 2016 Dec. Review.

18.

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

Lin S, Luo RT, Ptasinska A, Kerry J, Assi SA, Wunderlich M, Imamura T, Kaberlein JJ, Rayes A, Althoff MJ, Anastasi J, O'Brien MM, Meetei AR, Milne TA, Bonifer C, Mulloy JC, Thirman MJ.

Cancer Cell. 2016 Nov 14;30(5):737-749. doi: 10.1016/j.ccell.2016.10.008.

19.

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate.

Obier N, Cauchy P, Assi SA, Gilmour J, Lie-A-Ling M, Lichtinger M, Hoogenkamp M, Noailles L, Cockerill PN, Lacaud G, Kouskoff V, Bonifer C.

Development. 2016 Dec 1;143(23):4324-4340. Epub 2016 Oct 17.

20.

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.

Obier N, Bonifer C.

FEBS Lett. 2016 Nov;590(22):4105-4115. doi: 10.1002/1873-3468.12343. Epub 2016 Aug 18. Review.

21.

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH.

EBioMedicine. 2016 Jun;8:117-131. doi: 10.1016/j.ebiom.2016.04.032. Epub 2016 Apr 29. Erratum in: EBioMedicine. 2017 Nov;25:188.

22.

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Goode DK, Obier N, Vijayabaskar MS, Lie-A-Ling M, Lilly AJ, Hannah R, Lichtinger M, Batta K, Florkowska M, Patel R, Challinor M, Wallace K, Gilmour J, Assi SA, Cauchy P, Hoogenkamp M, Westhead DR, Lacaud G, Kouskoff V, Göttgens B, Bonifer C.

Dev Cell. 2016 Mar 7;36(5):572-87. doi: 10.1016/j.devcel.2016.01.024. Epub 2016 Feb 25.

23.

Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

Bevington SL, Cauchy P, Piper J, Bertrand E, Lalli N, Jarvis RC, Gilding LN, Ott S, Bonifer C, Cockerill PN.

EMBO J. 2016 Mar 1;35(5):515-35. doi: 10.15252/embj.201592534. Epub 2016 Jan 21.

24.

NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.

Busch R, Murti K, Liu J, Patra AK, Muhammad K, Knobeloch KP, Lichtinger M, Bonifer C, Wörtge S, Waisman A, Reifenberg K, Ellenrieder V, Serfling E, Avots A.

Eur J Immunol. 2016 Mar;46(3):634-46. doi: 10.1002/eji.201545925. Epub 2016 Jan 8.

25.

Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors.

Piper J, Assi SA, Cauchy P, Ladroue C, Cockerill PN, Bonifer C, Ott S.

BMC Genomics. 2015 Nov 25;16:1000. doi: 10.1186/s12864-015-2081-4.

26.

Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance.

Bonifer C, Cockerill PN.

Trends Cancer. 2015 Nov;1(3):157-160. doi: 10.1016/j.trecan.2015.10.003. Epub 2015 Nov 5.

PMID:
28741472
27.

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

Goyama S, Schibler J, Gasilina A, Shrestha M, Lin S, Link KA, Chen J, Whitman SP, Bloomfield CD, Nicolet D, Assi SA, Ptasinska A, Heidenreich O, Bonifer C, Kitamura T, Nassar NN, Mulloy JC.

Leukemia. 2016 Mar;30(3):728-39. doi: 10.1038/leu.2015.275. Epub 2015 Oct 9.

28.

C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis.

van Oevelen C, Collombet S, Vicent G, Hoogenkamp M, Lepoivre C, Badeaux A, Bussmann L, Sardina JL, Thieffry D, Beato M, Shi Y, Bonifer C, Graf T.

Stem Cell Reports. 2015 Aug 11;5(2):232-47. doi: 10.1016/j.stemcr.2015.06.007. Epub 2015 Jul 30.

29.

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature.

Cauchy P, James SR, Zacarias-Cabeza J, Ptasinska A, Imperato MR, Assi SA, Piper J, Canestraro M, Hoogenkamp M, Raghavan M, Loke J, Akiki S, Clokie SJ, Richards SJ, Westhead DR, Griffiths MJ, Ott S, Bonifer C, Cockerill PN.

Cell Rep. 2015 Aug 4;12(5):821-36. doi: 10.1016/j.celrep.2015.06.069. Epub 2015 Jul 23.

30.

The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype.

Forster VJ, Nahari MH, Martinez-Soria N, Bradburn AK, Ptasinska A, Assi SA, Fordham SE, McNeil H, Bonifer C, Heidenreich O, Allan JM.

Leukemia. 2016 Jan;30(1):250-3. doi: 10.1038/leu.2015.133. Epub 2015 Jun 8. No abstract available.

31.

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Regha K, Assi SA, Tsoulaki O, Gilmour J, Lacaud G, Bonifer C.

Nat Commun. 2015 May 28;6:7203. doi: 10.1038/ncomms8203.

32.

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.

Ponnusamy K, Kohrs N, Ptasinska A, Assi SA, Herold T, Hiddemann W, Lausen J, Bonifer C, Henschler R, Wichmann C.

Oncogenesis. 2015 Apr 13;4:e146. doi: 10.1038/oncsis.2015.6.

33.

The RUNX1-PU.1 axis in the control of hematopoiesis.

Imperato MR, Cauchy P, Obier N, Bonifer C.

Int J Hematol. 2015 Apr;101(4):319-29. doi: 10.1007/s12185-015-1762-8. Epub 2015 Mar 8. Review.

PMID:
25749719
34.

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!

Kreher S, Cauchy P, Bonifer C, Mathas S.

Cytokine. 2015 Mar;72(1):115-7. doi: 10.1016/j.cyto.2014.12.012. Epub 2015 Jan 10. No abstract available.

PMID:
25585876
35.

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B, Bonifer C, Mathas S.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4513-22. doi: 10.1073/pnas.1406985111. Epub 2014 Oct 6.

36.

Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.

Ptasinska A, Assi SA, Martinez-Soria N, Imperato MR, Piper J, Cauchy P, Pickin A, James SR, Hoogenkamp M, Williamson D, Wu M, Tenen DG, Ott S, Westhead DR, Cockerill PN, Heidenreich O, Bonifer C.

Cell Rep. 2014 Sep 25;8(6):1974-1988. doi: 10.1016/j.celrep.2014.08.024. Epub 2014 Sep 18.

37.

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

Lie-A-Ling M, Marinopoulou E, Li Y, Patel R, Stefanska M, Bonifer C, Miller C, Kouskoff V, Lacaud G.

Blood. 2014 Sep 11;124(11):e11-20. doi: 10.1182/blood-2014-04-572958. Epub 2014 Jul 31.

38.

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Gilmour J, Assi SA, Jaegle U, Kulu D, van de Werken H, Clarke D, Westhead DR, Philipsen S, Bonifer C.

Development. 2014 Jun;141(12):2391-401. doi: 10.1242/dev.106054. Epub 2014 May 21.

39.

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG.

Cancer Cell. 2013 Nov 11;24(5):575-88. doi: 10.1016/j.ccr.2013.09.018. Epub 2013 Oct 31. Erratum in: Cancer Cell. 2014 Feb 10;25(2):257. Diruscio, Annalisa [corrected to Di Ruscio, Annalisa].

40.

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells.

Xiang P, Wei W, Lo C, Rosten P, Hou J, Hoodless PA, Bilenky M, Bonifer C, Cockerill PN, Kirkpatrick A, Gottgens B, Hirst M, Humphries KR.

Leukemia. 2014 Feb;28(2):433-6. doi: 10.1038/leu.2013.287. Epub 2013 Oct 7. No abstract available.

PMID:
24097337
41.

Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data.

Piper J, Elze MC, Cauchy P, Cockerill PN, Bonifer C, Ott S.

Nucleic Acids Res. 2013 Nov;41(21):e201. doi: 10.1093/nar/gkt850. Epub 2013 Sep 25. Erratum in: Nucleic Acids Res. 2014;42(17):11272.

42.

Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: the polycomb connection.

Ray D, Kwon SY, Ptasinska A, Bonifer C.

Cell Cycle. 2013 Jul 15;12(14):2159-60. No abstract available.

43.

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

Ray D, Kwon SY, Tagoh H, Heidenreich O, Ptasinska A, Bonifer C.

Blood. 2013 Aug 1;122(5):759-69. doi: 10.1182/blood-2013-02-482497. Epub 2013 Apr 24.

44.

The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus.

Sauter KA, Bouhlel MA, O'Neal J, Sester DP, Tagoh H, Ingram RM, Pridans C, Bonifer C, Hume DA.

PLoS One. 2013;8(1):e54935. doi: 10.1371/journal.pone.0054935. Epub 2013 Jan 31.

45.

The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

Ladopoulos V, Hofemeister H, Hoogenkamp M, Riggs AD, Stewart AF, Bonifer C.

Mol Cell Biol. 2013 Apr;33(7):1383-93. doi: 10.1128/MCB.01721-12. Epub 2013 Jan 28.

46.

Why detailed model gene studies in higher eukaryotes are still necessary.

Bonifer C.

Immunology. 2013 Jun;139(2):158-60. doi: 10.1111/imm.12066. Review.

47.

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

Lichtinger M, Ingram R, Hannah R, Müller D, Clarke D, Assi SA, Lie-A-Ling M, Noailles L, Vijayabaskar MS, Wu M, Tenen DG, Westhead DR, Kouskoff V, Lacaud G, Göttgens B, Bonifer C.

EMBO J. 2012 Nov 14;31(22):4318-33. doi: 10.1038/emboj.2012.275. Epub 2012 Oct 12.

48.

The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers.

Baxter EW, Mirabella F, Bowers SR, James SR, Bonavita AM, Bertrand E, Strogantsev R, Hawwari A, Bert AG, Gonzalez de Arce A, West AG, Bonifer C, Cockerill PN.

J Immunol. 2012 Nov 1;189(9):4459-69. doi: 10.4049/jimmunol.1201915. Epub 2012 Sep 28.

49.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G.

Blood. 2012 Jul 12;120(2):314-22. doi: 10.1182/blood-2011-10-386094. Epub 2012 Jun 5.

50.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C.

Leukemia. 2012 Aug;26(8):1829-41. doi: 10.1038/leu.2012.49. Epub 2012 Feb 20.

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