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Items: 19


Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Bonifacino AC, Krouse AE, Linde N, Hsieh MM, Donahue RE, Dunbar CE, Kean LS, Tisdale JF.

Mol Ther. 2019 Jun 5. pii: S1525-0016(19)30269-2. doi: 10.1016/j.ymthe.2019.05.022. [Epub ahead of print]


Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys.

Demirci S, Mora JJH, Yapundich M, Drysdale C, Gamer J, Nassehi T, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Tisdale JF, Uchida N.

Exp Hematol. 2019 Jun 5. pii: S0301-472X(19)30324-8. doi: 10.1016/j.exphem.2019.05.005. [Epub ahead of print]


Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients.

Uchida N, Fujita A, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

Hum Gene Ther Clin Dev. 2017 Sep;28(3):136-144. doi: 10.1089/humc.2017.029. Epub 2017 Apr 17.


Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model.

Uchida N, Weitzel RP, Shvygin A, Skala LP, Raines L, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

Mol Ther Methods Clin Dev. 2016 Sep 14;3:16059. doi: 10.1038/mtm.2016.59. eCollection 2016.


Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study.

Donahue RE, Srinivasula S, Uchida N, Kim I, St Claire A, Duralde G, DeGrange P, St Claire M, Reba RC, Bonifacino AC, Krouse AE, Metzger ME, Paik CH, Lane HC, Tisdale JF, Di Mascio M.

Blood. 2015 Dec 10;126(24):2632-41. doi: 10.1182/blood-2015-07-657346. Epub 2015 Oct 22.


Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS.

Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012.


Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model.

Uchida N, Weitzel RP, Evans ME, Green R, Bonifacino AC, Krouse AE, Metzger ME, Hsieh MM, Donahue RE, Tisdale JF.

Gene Ther. 2014 Feb;21(2):148-57. doi: 10.1038/gt.2013.67. Epub 2013 Nov 21.


Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.

Uchida N, Evans ME, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Sellers SE, Dunbar CE, Donahue RE, Tisdale JF.

Mol Ther Nucleic Acids. 2013 Sep 17;2:e122. doi: 10.1038/mtna.2013.49.


High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector.

Uchida N, Hargrove PW, Lap CJ, Evans ME, Phang O, Bonifacino AC, Krouse AE, Metzger ME, Nguyen AD, Hsieh MM, Wolfsberg TG, Donahue RE, Persons DA, Tisdale JF.

Mol Ther. 2012 Oct;20(10):1882-92. doi: 10.1038/mt.2012.159. Epub 2012 Aug 7.


Significant mobilization of both conventional and regulatory T cells with AMD3100.

Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE.

Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11.


Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE.

Cell Stem Cell. 2011 Apr 8;8(4):445-58. doi: 10.1016/j.stem.2011.02.003.


High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.

Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS.

J Virol. 2010 Nov;84(22):11771-80. doi: 10.1128/JVI.01355-10. Epub 2010 Sep 15.


Development of a human immunodeficiency virus type 1-based lentiviral vector that allows efficient transduction of both human and rhesus blood cells.

Uchida N, Washington KN, Hayakawa J, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

J Virol. 2009 Oct;83(19):9854-62. doi: 10.1128/JVI.00357-09. Epub 2009 Jul 22.


Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures.

Donahue RE, Jin P, Bonifacino AC, Metzger ME, Ren J, Wang E, Stroncek DF.

Blood. 2009 Sep 17;114(12):2530-41. doi: 10.1182/blood-2009-04-214403. Epub 2009 Jul 14.


Intracoronary infusion of autologous mononuclear cells from bone marrow or granulocyte colony-stimulating factor-mobilized apheresis product may not improve remodelling, contractile function, perfusion, or infarct size in a swine model of large myocardial infarction.

de Silva R, Raval AN, Hadi M, Gildea KM, Bonifacino AC, Yu ZX, Yau YY, Leitman SF, Bacharach SL, Donahue RE, Read EJ, Lederman RJ.

Eur Heart J. 2008 Jul;29(14):1772-82. doi: 10.1093/eurheartj/ehn216. Epub 2008 May 23.


Paradoxical drop in circulating neutrophil count following granulocyte-colony stimulating factor and stem cell factor administration in rhesus macaques.

Gordon BC, Revenis AM, Bonifacino AC, Sander WE, Metzger ME, Krouse AE, Usherson TN, Donahue RE.

Exp Hematol. 2007 Jun;35(6):872-8.


Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.

Kelly PF, Donahue RE, Vandergriff JA, Takatoku M, Bonifacino AC, Agricola BA, Metzger ME, Dunbar CE, Nienhuis AW, Vanin EF.

Blood Cells Mol Dis. 2003 Jan-Feb;30(1):132-43.


Mechanism of copper-mediated inactivation of herpes simplex virus.

Sagripanti JL, Routson LB, Bonifacino AC, Lytle CD.

Antimicrob Agents Chemother. 1997 Apr;41(4):812-7.

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