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Items: 1 to 50 of 57

1.

Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration.

Kitajima T, Mizote S, Bonifácio MJ, Umemura T, Yoneda K, Moser P, Soares-da-Silva P, Tanaka M.

Neuropharmacology. 2018 Dec;143:282-288. doi: 10.1016/j.neuropharm.2018.10.001. Epub 2018 Oct 2.

2.

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase.

Kiss LE, Beliaev A, Ferreira HS, Rosa CP, Bonifácio MJ, Loureiro AI, Pires NM, Palma PN, Soares-da-Silva P.

ChemMedChem. 2018 Oct 22;13(20):2177-2188. doi: 10.1002/cmdc.201800393. Epub 2018 Sep 11.

3.

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

Gonçalves D, Alves G, Fortuna A, Bonifácio MJ, Soares-da-Silva P, Falcão A.

Neuropharmacology. 2017 Oct;125:146-155. doi: 10.1016/j.neuropharm.2017.07.019. Epub 2017 Jul 19.

PMID:
28734868
4.

Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.

Rocha JF, Sicard É, Fauchoux N, Falcão A, Santos A, Loureiro AI, Pinto R, Bonifácio MJ, Nunes T, Almeida L, Soares-da-Silva P.

Br J Clin Pharmacol. 2017 Mar;83(3):540-553. doi: 10.1111/bcp.13156. Epub 2016 Dec 2.

5.

Carbamazepine aggravates absence seizures in two dedicated mouse models.

Pires NM, Bonifácio MJ, Soares-da-Silva P.

Pharmacol Rep. 2015 Oct;67(5):986-95. doi: 10.1016/j.pharep.2015.03.007. Epub 2015 Mar 23.

PMID:
26398395
6.

An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures.

Pedro AQ, Martins LM, Dias JM, Bonifácio MJ, Queiroz JA, Passarinha LA.

Microb Cell Fact. 2015 Aug 7;14:113. doi: 10.1186/s12934-015-0304-7.

7.

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action.

Soares-da-Silva P, Pires N, Bonifácio MJ, Loureiro AI, Palma N, Wright LC.

Pharmacol Res Perspect. 2015 Mar;3(2):e00124. doi: 10.1002/prp2.124. Epub 2015 Mar 30. Review.

8.

Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat.

Loureiro AI, Bonifácio MJ, Fernandes-Lopes C, Pires N, Igreja B, Wright LC, Soares-da-Silva P.

Xenobiotica. 2015;45(9):828-39. doi: 10.3109/00498254.2015.1018985. Epub 2015 Jun 10.

PMID:
25915108
9.

Evaluation of Mut(S) and Mut⁺ Pichia pastoris strains for membrane-bound catechol-O-methyltransferase biosynthesis.

Pedro AQ, Oppolzer D, Bonifácio MJ, Maia CJ, Queiroz JA, Passarinha LA.

Appl Biochem Biotechnol. 2015 Apr;175(8):3840-55. doi: 10.1007/s12010-015-1551-0. Epub 2015 Feb 25.

PMID:
25712908
10.

Characterization of the interaction of the novel antihypertensive etamicastat with human dopamine-β-hydroxylase: comparison with nepicastat.

Bonifácio MJ, Sousa F, Neves M, Palma N, Igreja B, Pires NM, Wright LC, Soares-da-Silva P.

Eur J Pharmacol. 2015 Mar 15;751:50-8. doi: 10.1016/j.ejphar.2015.01.034. Epub 2015 Jan 29.

PMID:
25641750
11.

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.

Doeser A, Dickhof G, Reitze M, Uebachs M, Schaub C, Pires NM, Bonifácio MJ, Soares-da-Silva P, Beck H.

Brain. 2015 Feb;138(Pt 2):371-87. doi: 10.1093/brain/awu339. Epub 2014 Dec 2.

PMID:
25472797
12.

Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat.

Bonifácio MJ, Torrão L, Loureiro AI, Palma PN, Wright LC, Soares-da-Silva P.

Br J Pharmacol. 2015 Apr;172(7):1739-52. doi: 10.1111/bph.13020. Epub 2015 Jan 20.

13.

Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat.

Igreja B, Pires NM, Bonifácio MJ, Loureiro AI, Fernandes-Lopes C, Wright LC, Soares-da-Silva P.

Hypertens Res. 2015 Jan;38(1):30-8. doi: 10.1038/hr.2014.143. Epub 2014 Oct 9.

PMID:
25298210
14.

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.

Hebeisen S, Pires N, Loureiro AI, Bonifácio MJ, Palma N, Whyment A, Spanswick D, Soares-da-Silva P.

Neuropharmacology. 2015 Feb;89:122-35. doi: 10.1016/j.neuropharm.2014.09.008. Epub 2014 Sep 19.

PMID:
25242737
15.

Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat.

Loureiro AI, Bonifácio MJ, Fernandes-Lopes C, Igreja B, Wright LC, Soares-da-Silva P.

Eur J Pharmacol. 2014 Oct 5;740:285-94. doi: 10.1016/j.ejphar.2014.07.027. Epub 2014 Jul 21.

PMID:
25058908
16.

Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase.

Espírito Santo GM, Pedro AQ, Oppolzer D, Bonifácio MJ, Queiroz JA, Silva F, Passarinha LA.

Biotechnol Rep (Amst). 2014 May 27;3:34-41. doi: 10.1016/j.btre.2014.05.005. eCollection 2014 Sep.

17.

Recovery of biological active catechol-O-methyltransferase isoforms from Q-sepharose.

Correia FF, Santos FM, Pedro AQ, Bonifácio MJ, Queiroz JA, Passarinha LA.

J Sep Sci. 2014 Jan;37(1-2):20-9. doi: 10.1002/jssc.201300977. Epub 2013 Nov 27.

PMID:
24285473
18.

Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor.

Bonifácio MJ, Sutcliffe JS, Torrão L, Wright LC, Soares-da-Silva P.

Neuropharmacology. 2014 Feb;77:334-41. doi: 10.1016/j.neuropharm.2013.10.014. Epub 2013 Oct 19.

PMID:
24148813
19.

N-acetylation of etamicastat, a reversible dopamine-β-hydroxylase inhibitor.

Loureiro AI, Fernandes-Lopes C, Bonifácio MJ, Wright LC, Soares-da-Silva P.

Drug Metab Dispos. 2013 Dec;41(12):2081-6. doi: 10.1124/dmd.113.053736. Epub 2013 Sep 6.

PMID:
24013186
20.

Performance of hydrophobic interaction ligands for human membrane-bound catechol-O-methyltransferase purification.

Santos FM, Pedro AQ, Soares RF, Martins R, Bonifácio MJ, Queiroz JA, Passarinha LA.

J Sep Sci. 2013 Jun;36(11):1693-702. doi: 10.1002/jssc.201300010. Epub 2013 May 3.

PMID:
23495043
21.

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects.

Rocha JF, Almeida L, Falcão A, Palma PN, Loureiro AI, Pinto R, Bonifácio MJ, Wright LC, Nunes T, Soares-da-Silva P.

Br J Clin Pharmacol. 2013 Nov;76(5):763-75. doi: 10.1111/bcp.12081.

22.

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

Almeida L, Rocha JF, Falcão A, Palma PN, Loureiro AI, Pinto R, Bonifácio MJ, Wright LC, Nunes T, Soares-da-Silva P.

Clin Pharmacokinet. 2013 Feb;52(2):139-51. doi: 10.1007/s40262-012-0024-7.

PMID:
23248072
23.

Optimization of fermentation conditions for the production of human soluble catechol-O-methyltransferase by Escherichia coli using artificial neural network.

Silva R, Ferreira S, Bonifácio MJ, Dias JM, Queiroz JA, Passarinha LA.

J Biotechnol. 2012 Aug 31;160(3-4):161-8. doi: 10.1016/j.jbiotec.2012.03.025. Epub 2012 Apr 5.

PMID:
22498435
24.

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

Palma PN, Bonifácio MJ, Loureiro AI, Soares-da-Silva P.

J Comput Chem. 2012 Apr 5;33(9):970-86. doi: 10.1002/jcc.22926. Epub 2012 Jan 25.

PMID:
22278964
25.

A novel prokaryotic expression system for biosynthesis of recombinant human membrane-bound catechol-O-methyltransferase.

Pedro AQ, Bonifácio MJ, Queiroz JA, Maia CJ, Passarinha LA.

J Biotechnol. 2011 Nov 10;156(2):141-6. doi: 10.1016/j.jbiotec.2011.08.022. Epub 2011 Aug 25.

PMID:
21889552
26.

Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation.

Loureiro AI, Fernandes-Lopes C, Bonifácio MJ, Wright LC, Soares-da-Silva P.

Drug Metab Dispos. 2011 Sep;39(9):1486-94. doi: 10.1124/dmd.111.038620. Epub 2011 Jun 14.

PMID:
21673130
27.

In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs.

Sousa e Silva JP, Lobo JS, Bonifácio MJ, Machado R, Falcão A, Soares-da-Silva P.

J Pharm Pharmacol. 2011 Jun;63(6):780-5. doi: 10.1111/j.2042-7158.2011.01278.x. Epub 2011 Apr 28.

PMID:
21585375
28.

Analysis of hSCOMT adsorption in bioaffinity chromatography with immobilized amino acids: the influence of pH and ionic strength.

Costa SR, Bonifácio MJ, Queiroz JA, Passarinha LA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jun 1;879(19):1704-6. doi: 10.1016/j.jchromb.2011.03.056. Epub 2011 Apr 12.

PMID:
21543270
29.

Single-dose tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5-453), a new dopamine β-hydroxylase inhibitor, in healthy subjects.

Rocha JF, Vaz-Da-Silva M, Nunes T, Igreja B, Loureiro AI, Bonifácio MJ, Wright LC, Falcão A, Almeida L, Soares-Da-Silva P.

J Clin Pharmacol. 2012 Feb;52(2):156-70. doi: 10.1177/0091270010390805.

PMID:
21343348
30.

Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

Kiss LE, Ferreira HS, Torrão L, Bonifácio MJ, Palma PN, Soares-da-Silva P, Learmonth DA.

J Med Chem. 2010 Apr 22;53(8):3396-411. doi: 10.1021/jm1001524.

PMID:
20334432
31.

Assessment of COMT isolation by HIC using a dual salt system and low temperature.

Nunes VS, Bonifácio MJ, Queiroz JA, Passarinha LA.

Biomed Chromatogr. 2010 Aug;24(8):858-62. doi: 10.1002/bmc.1377.

PMID:
20024892
32.

Application of a fed-batch bioprocess for the heterologous production of hSCOMT in Escherichia coli.

Passrinha LA, Bonifacio MJ, Queiroz JA.

J Microbiol Biotechnol. 2009 Sep;19(9):972-81.

33.

Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.

Bonifácio MJ, Loureiro AI, Torrão L, Fernandes-Lopes C, Wright L, Pinho MJ, Soares-da-Silva P.

Biochem Pharmacol. 2009 Oct 15;78(8):1043-51. doi: 10.1016/j.bcp.2009.05.036. Epub 2009 Jun 6.

PMID:
19505437
34.

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.

Bonifácio MJ, Palma PN, Almeida L, Soares-da-Silva P.

CNS Drug Rev. 2007 Fall;13(3):352-79. Review.

35.

A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography.

Passarinha LA, Bonifácio MJ, Soares-da-Silva P, Queiroz JA.

J Chromatogr A. 2008 Jan 11;1177(2):287-96. Epub 2007 Jun 7.

PMID:
17588591
36.

Comparative study on the interaction of recombinant human soluble catechol-O-methyltransferase on some hydrophobic adsorbents.

Passarinha LA, Bonifácio MJ, Queiroz JA.

Biomed Chromatogr. 2007 Apr;21(4):430-8.

PMID:
17294500
37.

Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation.

Loureiro AI, Bonifácio MJ, Fernandes-Lopes C, Almeida L, Wright LC, Soares-Da-Silva P.

Drug Metab Dispos. 2006 Nov;34(11):1856-62. Epub 2006 Jun 21.

PMID:
16790555
38.

Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation.

Palma PN, Rodrigues ML, Archer M, Bonifácio MJ, Loureiro AI, Learmonth DA, Carrondo MA, Soares-da-Silva P.

Mol Pharmacol. 2006 Jul;70(1):143-53. Epub 2006 Apr 17.

PMID:
16618795
39.

Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex.

Rodrigues ML, Bonifácio MJ, Soares-da-Silva P, Carrondo MA, Archer M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt 1):118-20. Epub 2004 Dec 24.

40.
41.

Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.

Learmonth DA, Bonifácio MJ, Soares-da-Silva P.

J Med Chem. 2005 Dec 15;48(25):8070-8.

PMID:
16335931
42.

Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells.

Soares-Da-Silva P, Serrão MP, Pinho MJ, Bonifácio MJ.

FASEB J. 2004 Oct;18(13):1489-98.

PMID:
15466357
43.

Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension.

Pinho MJ, Gomes P, Serrão MP, Bonifácio MJ, Soares-da-Silva P.

Hypertension. 2003 Oct;42(4):613-8. Epub 2003 Sep 15.

PMID:
12975385
44.

Purification of membrane-bound catechol-O-methyltransferase.

Bonifácio MJ, Soares-da-Silva P.

Methods Mol Biol. 2003;228:231-8. No abstract available.

PMID:
12824557
45.

Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor.

Palma PN, Bonifácio MJ, Loureiro AI, Wright LC, Learmonth DA, Soares-da-Silva P.

Drug Metab Dispos. 2003 Mar;31(3):250-8.

PMID:
12584150
46.

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.

Bonifácio MJ, Vieira-Coelho MA, Soares-da-Silva P.

Eur J Pharmacol. 2003 Jan 24;460(2-3):163-70.

PMID:
12559377
47.

Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application.

Bonifácio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P.

Mol Pharmacol. 2002 Oct;62(4):795-805.

PMID:
12237326
48.

Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein.

Bonifácio MJ, Vieira-Coelho MA, Soares-da-Silva P.

Protein Expr Purif. 2001 Oct;23(1):106-12.

PMID:
11570851
49.

Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine.

Bonifácio MJ, Sheridan RD, Parada A, Cunha RA, Patmore L, Soares-da-Silva P.

Epilepsia. 2001 May;42(5):600-8.

50.

Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor.

Rodrigues ML, Archer M, Bonifácio MJ, Soares-da-Silva P, Carrondo MA.

Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):906-8. Epub 2001 May 25.

PMID:
11375525

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