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Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation.

Collier DM, Villalba N, Sackheim A, Bonev AD, Miller ZD, Moore JS, Shui B, Lee JC, Lee FK, Reining S, Kotlikoff MI, Nelson MT, Freeman K.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1309-H1322. doi: 10.1152/ajpheart.00655.2018. Epub 2019 Mar 8.


The KV 7 channel activator retigabine suppresses mouse urinary bladder afferent nerve activity without affecting detrusor smooth muscle K+ channel currents.

Tykocki NR, Heppner TJ, Dalsgaard T, Bonev AD, Nelson MT.

J Physiol. 2019 Feb;597(3):935-950. doi: 10.1113/JP277021. Epub 2018 Dec 26.


Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase.

Sheehe JL, Bonev AD, Schmoker AM, Ballif BA, Nelson MT, Moon TM, Dostmann WR.

J Biol Chem. 2018 Oct 26;293(43):16791-16802. doi: 10.1074/jbc.RA118.004363. Epub 2018 Sep 11.


Lack of direct effect of adiponectin on vascular smooth muscle cell BKCa channels or Ca2+ signaling in the regulation of small artery pressure-induced constriction.

Baylie R, Ahmed M, Bonev AD, Hill-Eubanks DC, Heppner TJ, Nelson MT, Greenstein AS.

Physiol Rep. 2017 Aug;5(16). pii: e13337. doi: 10.14814/phy2.13337.


Inhibition of vascular smooth muscle inward-rectifier K+ channels restores myogenic tone in mouse urinary bladder arterioles.

Tykocki NR, Bonev AD, Longden TA, Heppner TJ, Nelson MT.

Am J Physiol Renal Physiol. 2017 May 1;312(5):F836-F847. doi: 10.1152/ajprenal.00682.2016. Epub 2017 Feb 1.


Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

Khavandi K, Baylie RA, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD, Nelson MT, Greenstein AS.

Sci Signal. 2016 Oct 11;9(449):ra100. doi: 10.1126/scisignal.aaf6625.


Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function.

Povlsen GK, Longden TA, Bonev AD, Hill-Eubanks DC, Nelson MT.

J Cereb Blood Flow Metab. 2016 Jul;36(7):1195-201. doi: 10.1177/0271678X16638350. Epub 2016 Apr 6.


Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.

Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT.

J Physiol. 2016 Jun 15;594(12):3271-85. doi: 10.1113/JP271652. Epub 2016 Mar 4.


Impairment of IKCa channels contributes to uteroplacental endothelial dysfunction in rat diabetic pregnancy.

Gokina NI, Bonev AD, Phillips J, Gokin AP, Veilleux K, Oppenheimer K, Goloman G.

Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H592-604. doi: 10.1152/ajpheart.00901.2014. Epub 2015 Jun 19.


Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.

Dabertrand F, Krøigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E796-805. doi: 10.1073/pnas.1420765112. Epub 2015 Feb 2.


AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.

Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.

Sci Signal. 2014 Jul 8;7(333):ra66. doi: 10.1126/scisignal.2005052.


NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC.

J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20.


Role of impaired endothelial cell Ca(2+) signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy.

Gokina NI, Bonev AD, Gokin AP, Goloman G.

Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H935-45. doi: 10.1152/ajpheart.00513.2012. Epub 2013 Feb 1.


Subarachnoid blood converts neurally evoked vasodilation to vasoconstriction in rat brain cortex.

Koide M, Bonev AD, Nelson MT, Wellman GC.

Acta Neurochir Suppl. 2013;115:167-71. doi: 10.1007/978-3-7091-1192-5_32.


Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC, Nelson MT.

Science. 2012 May 4;336(6081):597-601. doi: 10.1126/science.1216283.


Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels.

Koide M, Bonev AD, Nelson MT, Wellman GC.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1387-95. doi: 10.1073/pnas.1121359109. Epub 2012 Apr 30.


Sympathetic nerve stimulation induces local endothelial Ca2+ signals to oppose vasoconstriction of mouse mesenteric arteries.

Nausch LW, Bonev AD, Heppner TJ, Tallini Y, Kotlikoff MI, Nelson MT.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H594-602. doi: 10.1152/ajpheart.00773.2011. Epub 2011 Dec 2.


Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow.

Hannah RM, Dunn KM, Bonev AD, Nelson MT.

J Cereb Blood Flow Metab. 2011 May;31(5):1175-86. doi: 10.1038/jcbfm.2010.214. Epub 2010 Dec 22.


Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone.

Koide M, Nystoriak MA, Krishnamoorthy G, O'Connor KP, Bonev AD, Nelson MT, Wellman GC.

J Cereb Blood Flow Metab. 2011 Jan;31(1):3-16. doi: 10.1038/jcbfm.2010.143. Epub 2010 Aug 25.


Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.

Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3811-6. doi: 10.1073/pnas.0914722107. Epub 2010 Feb 2.


Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons.

Obata F, Tohyama K, Bonev AD, Kolling GL, Keepers TR, Gross LK, Nelson MT, Sato S, Obrig TG.

J Infect Dis. 2008 Nov 1;198(9):1398-406. doi: 10.1086/591911.


Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections.

Ledoux J, Taylor MS, Bonev AD, Hannah RM, Solodushko V, Shui B, Tallini Y, Kotlikoff MI, Nelson MT.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9627-32. doi: 10.1073/pnas.0801963105. Epub 2008 Jul 9.


High blood pressure arising from a defect in vascular function.

Michael SK, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongjit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6702-7. doi: 10.1073/pnas.0802128105. Epub 2008 Apr 30.


Ca2+-activated K+ channels in murine endothelial cells: block by intracellular calcium and magnesium.

Ledoux J, Bonev AD, Nelson MT.

J Gen Physiol. 2008 Feb;131(2):125-35. doi: 10.1085/jgp.200709875. Epub 2008 Jan 14.


Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors.

Nausch LW, Ledoux J, Bonev AD, Nelson MT, Dostmann WR.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):365-70. doi: 10.1073/pnas.0710387105. Epub 2007 Dec 28.


Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy.

Telezhkin V, Goecks T, Bonev AD, Osol G, Gokina NI.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H272-84. Epub 2007 Nov 2.


Local potassium signaling couples neuronal activity to vasodilation in the brain.

Filosa JA, Bonev AD, Straub SV, Meredith AL, Wilkerson MK, Aldrich RW, Nelson MT.

Nat Neurosci. 2006 Nov;9(11):1397-1403.


Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery.

Mandalà M, Heppner TJ, Bonev AD, Nelson MT.

Nitric Oxide. 2007 Feb;16(1):104-9. Epub 2006 Jul 1.


Calcium waves in intact guinea pig gallbladder smooth muscle cells.

Balemba OB, Heppner TJ, Bonev AD, Nelson MT, Mawe GM.

Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G717-27. Epub 2006 May 18.


Spontaneous electrical rhythmicity and the role of the sarcoplasmic reticulum in the excitability of guinea pig gallbladder smooth muscle cells.

Balemba OB, Salter MJ, Heppner TJ, Bonev AD, Nelson MT, Mawe GM.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G655-64. Epub 2005 Nov 17.


Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation.

Wilkerson MK, Heppner TJ, Bonev AD, Nelson MT.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H240-7. Epub 2005 Aug 19.


Elementary purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle.

Heppner TJ, Bonev AD, Nelson MT.

J Physiol. 2005 Apr 1;564(Pt 1):201-12. Epub 2005 Jan 6.


Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.

Filosa JA, Bonev AD, Nelson MT.

Circ Res. 2004 Nov 12;95(10):e73-81. Epub 2004 Oct 21.


Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.

Heppner TJ, Bonev AD, Eckman DM, Gomez MF, Petkov GV, Nelson MT.

Pharmacology. 2005 Jan;73(1):15-22. Epub 2004 Sep 27.


Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.

Heppner TJ, Herrera GM, Bonev AD, Hill-Eubanks D, Nelson MT.

Adv Exp Med Biol. 2003;539(Pt A):347-57. Review.


Inhibition of Ca++ sparks by oxyhemoglobin in rabbit cerebral arteries.

Jewell RP, Saundry CM, Bonev AD, Tranmer BI, Wellman GC.

J Neurosurg. 2004 Feb;100(2):295-302.


Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure.

Taylor MS, Bonev AD, Gross TP, Eckman DM, Brayden JE, Bond CT, Adelman JP, Nelson MT.

Circ Res. 2003 Jul 25;93(2):124-31. Epub 2003 Jun 12.


Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries.

Heppner TJ, Bonev AD, Santana LF, Nelson MT.

Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2169-76.


Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle.

Gomez MF, Stevenson AS, Bonev AD, Hill-Eubanks DC, Nelson MT.

J Biol Chem. 2002 Oct 4;277(40):37756-64. Epub 2002 Jul 26.


Ca2+ sparks and their function in human cerebral arteries.

Wellman GC, Nathan DJ, Saundry CM, Perez G, Bonev AD, Penar PL, Tranmer BI, Nelson MT.

Stroke. 2002 Mar;33(3):802-8.


Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle.

Petkov GV, Bonev AD, Heppner TJ, Brenner R, Aldrich RW, Nelson MT.

J Physiol. 2001 Dec 1;537(Pt 2):443-52.


Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle.

Pérez GJ, Bonev AD, Nelson MT.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C1769-75.


Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP.

Wellman GC, Santana LF, Bonev AD, Nelson MT.

Am J Physiol Cell Physiol. 2001 Sep;281(3):C1029-37.


Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.

Petkov GV, Heppner TJ, Bonev AD, Herrera GM, Nelson MT.

Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1427-33.


Vasoregulation by the beta1 subunit of the calcium-activated potassium channel.

Brenner R, Peréz GJ, Bonev AD, Eckman DM, Kosek JC, Wiler SW, Patterson AJ, Nelson MT, Aldrich RW.

Nature. 2000 Oct 19;407(6806):870-6.


Intracellular calcium events activated by ATP in murine colonic myocytes.

Bayguinov O, Hagen B, Bonev AD, Nelson MT, Sanders KM.

Am J Physiol Cell Physiol. 2000 Jul;279(1):C126-35.


Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.

Bradley KK, Jaggar JH, Bonev AD, Heppner TJ, Flynn ER, Nelson MT, Horowitz B.

J Physiol. 1999 Mar 15;515 ( Pt 3):639-51.

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