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Items: 1 to 50 of 60

1.

Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface.

Biggi S, Pancher M, Stincardini C, Luotti S, Massignan T, Dalle Vedove A, Astolfi A, Gatto P, Lolli G, Barreca ML, Bonetto V, Adami V, Biasini E.

J Neurochem. 2020 Jan;152(1):136-150. doi: 10.1111/jnc.14805. Epub 2019 Jul 18.

PMID:
31264722
2.

Cyclophillin A deficiency accelerates RML-induced prion disease.

Bouybayoune I, Comerio L, Pasetto L, Bertani I, Bonetto V, Chiesa R.

Neurobiol Dis. 2019 Oct;130:104498. doi: 10.1016/j.nbd.2019.104498. Epub 2019 Jun 8.

PMID:
31181281
3.

Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS).

Mandrioli J, Crippa V, Cereda C, Bonetto V, Zucchi E, Gessani A, Ceroni M, Chio A, D'Amico R, Monsurrò MR, Riva N, Sabatelli M, Silani V, Simone IL, Sorarù G, Provenzani A, D'Agostino VG, Carra S, Poletti A.

BMJ Open. 2019 May 30;9(5):e028486. doi: 10.1136/bmjopen-2018-028486.

4.

[Idiopathic facial aseptic granuloma: A case report].

Garais JA, Bonetto VN, Frontino L, Salduna MD, Ruiz Lascano A.

Arch Argent Pediatr. 2019 Feb 1;117(1):e56-e58. doi: 10.5546/aap.2019.e56. Spanish.

5.

Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS.

Crociara P, Chieppa MN, Vallino Costassa E, Berrone E, Gallo M, Lo Faro M, Pintore MD, Iulini B, D'Angelo A, Perona G, Botter A, Formicola D, Rainoldi A, Paulis M, Vezzoni P, Meli F, Peverali FA, Bendotti C, Trolese MC, Pasetto L, Bonetto V, Lazzari G, Duchi R, Perota A, Lagutina I, Quadalti C, Gennero MS, Dezzutto D, Desiato R, Boido M, Ghibaudi M, Valentini MC, Caramelli M, Galli C, Casalone C, Corona C.

Neurobiol Dis. 2019 Apr;124:263-275. doi: 10.1016/j.nbd.2018.11.021. Epub 2018 Nov 22.

6.

A pilot trial of RNS60 in amyotrophic lateral sclerosis.

Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, Bendotti C, Bonetto V, De Marchi F, Rosen B, Hooker J, Cudkowicz M, Atassi N.

Muscle Nerve. 2019 Mar;59(3):303-308. doi: 10.1002/mus.26385. Epub 2018 Dec 26.

PMID:
30458059
7.

Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis.

Ferrara D, Pasetto L, Bonetto V, Basso M.

Front Neurosci. 2018 Aug 17;12:574. doi: 10.3389/fnins.2018.00574. eCollection 2018. Review.

8.

Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease.

Pasetto L, Olivari D, Nardo G, Trolese MC, Bendotti C, Piccirillo R, Bonetto V.

PLoS One. 2018 May 29;13(5):e0198089. doi: 10.1371/journal.pone.0198089. eCollection 2018.

9.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Aiello FB, Guszczynski T, Li W, Hixon JA, Jiang Q, Hodge DL, Massignan T, Di Lisio C, Merchant A, Procopio AD, Bonetto V, Durum SK.

Cell Signal. 2018 Jul;47:131-141. doi: 10.1016/j.cellsig.2018.03.008. Epub 2018 Mar 24.

PMID:
29581031
10.

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.

Vallarola A, Sironi F, Tortarolo M, Gatto N, De Gioia R, Pasetto L, De Paola M, Mariani A, Ghosh S, Watson R, Kalmes A, Bonetto V, Bendotti C.

J Neuroinflammation. 2018 Mar 1;15(1):65. doi: 10.1186/s12974-018-1101-0.

11.

Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis.

Filareti M, Luotti S, Pasetto L, Pignataro M, Paolella K, Messina P, Pupillo E, Filosto M, Lunetta C, Mandrioli J, Fuda G, Calvo A, Chiò A, Corbo M, Bendotti C, Beghi E, Bonetto V.

Front Mol Neurosci. 2017 Apr 6;10:99. doi: 10.3389/fnmol.2017.00099. eCollection 2017.

12.

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

Pasetto L, Pozzi S, Castelnovo M, Basso M, Estevez AG, Fumagalli S, De Simoni MG, Castellaneta V, Bigini P, Restelli E, Chiesa R, Trojsi F, Monsurrò MR, Callea L, Malešević M, Fischer G, Freschi M, Tortarolo M, Bendotti C, Bonetto V.

J Neurosci. 2017 Feb 8;37(6):1413-1427. doi: 10.1523/JNEUROSCI.2462-16.2016. Epub 2016 Dec 23.

13.

Extracellular Vesicles and a Novel Form of Communication in the Brain.

Basso M, Bonetto V.

Front Neurosci. 2016 Mar 31;10:127. doi: 10.3389/fnins.2016.00127. eCollection 2016. Review.

14.

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.

Nardo G, Trolese MC, Tortarolo M, Vallarola A, Freschi M, Pasetto L, Bonetto V, Bendotti C.

Brain Pathol. 2016 Mar;26(2):237-47. doi: 10.1111/bpa.12351. Review.

PMID:
26780365
15.

Introduction.

Bendotti C, Bonetto V, Migheli A.

Brain Pathol. 2016 Mar;26(2):224-6. doi: 10.1111/bpa.12349. No abstract available.

PMID:
26780164
16.

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression.

Tortarolo M, Vallarola A, Lidonnici D, Battaglia E, Gensano F, Spaltro G, Fiordaliso F, Corbelli A, Garetto S, Martini E, Pasetto L, Kallikourdis M, Bonetto V, Bendotti C.

J Neurochem. 2015 Oct;135(1):109-24. doi: 10.1111/jnc.13154. Epub 2015 Jun 4.

17.

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

Lauranzano E, Pozzi S, Pasetto L, Stucchi R, Massignan T, Paolella K, Mombrini M, Nardo G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V.

Brain. 2015 Apr;138(Pt 4):974-91. doi: 10.1093/brain/awv005. Epub 2015 Feb 12.

PMID:
25678563
18.

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.

Marino M, Papa S, Crippa V, Nardo G, Peviani M, Cheroni C, Trolese MC, Lauranzano E, Bonetto V, Poletti A, DeBiasi S, Ferraiuolo L, Shaw PJ, Bendotti C.

Neurobiol Aging. 2015 Jan;36(1):492-504. doi: 10.1016/j.neurobiolaging.2014.06.026. Epub 2014 Jul 2.

PMID:
25085783
19.

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets.

Sileno S, D'Oria V, Stucchi R, Alessio M, Petrini S, Bonetto V, Maechler P, Bertuzzi F, Grasso V, Paolella K, Barbetti F, Massa O.

J Proteomics. 2014 Jan 16;96:314-27. doi: 10.1016/j.jprot.2013.11.011. Epub 2013 Nov 27.

20.

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10.

Lucchetti J, Marino M, Papa S, Tortarolo M, Guiso G, Pozzi S, Bonetto V, Caccia S, Beghi E, Bendotti C, Gobbi M.

PLoS One. 2013 Jul 23;8(7):e69540. doi: 10.1371/journal.pone.0069540. Print 2013.

21.

Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.

Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, Spaltro G, Lidonnici D, Gensano F, Battaglia E, Bendotti C, Bonetto V.

J Biol Chem. 2013 May 31;288(22):15699-711. doi: 10.1074/jbc.M112.425066. Epub 2013 Apr 16.

22.

Serological Proteome Analysis (SERPA) as a tool for the identification of new candidate autoantigens in type 1 diabetes.

Massa O, Alessio M, Russo L, Nardo G, Bonetto V, Bertuzzi F, Paladini A, Iafusco D, Patera P, Federici G, Not T, Tiberti C, Bonfanti R, Barbetti F.

J Proteomics. 2013 Apr 26;82:263-73. doi: 10.1016/j.jprot.2013.02.030. Epub 2013 Mar 14.

PMID:
23500132
23.

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.

Biasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA.

J Neurosci. 2013 Feb 6;33(6):2408-18. doi: 10.1523/JNEUROSCI.3406-12.2013.

24.

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells.

Biasini E, Turnbaugh JA, Massignan T, Veglianese P, Forloni G, Bonetto V, Chiesa R, Harris DA.

PLoS One. 2012;7(3):e33472. doi: 10.1371/journal.pone.0033472. Epub 2012 Mar 12.

25.

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O.

Acta Diabetol. 2013 Feb;50(1):61-72. doi: 10.1007/s00592-012-0381-6. Epub 2012 Mar 3.

PMID:
22382775
26.

Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells.

Nardo G, Pozzi S, Pignataro M, Lauranzano E, Spano G, Garbelli S, Mantovani S, Marinou K, Papetti L, Monteforte M, Torri V, Paris L, Bazzoni G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V.

PLoS One. 2011;6(10):e25545. doi: 10.1371/journal.pone.0025545. Epub 2011 Oct 5.

27.

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.

Manzoni C, Colombo L, Bigini P, Diana V, Cagnotto A, Messa M, Lupi M, Bonetto V, Pignataro M, Airoldi C, Sironi E, Williams A, Salmona M.

PLoS One. 2011;6(9):e24909. doi: 10.1371/journal.pone.0024909. Epub 2011 Sep 23.

28.

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.

Massignan T, Biasini E, Lauranzano E, Veglianese P, Pignataro M, Fioriti L, Harris DA, Salmona M, Chiesa R, Bonetto V.

Mol Cell Proteomics. 2010 Apr;9(4):611-22. doi: 10.1074/mcp.M900271-MCP200. Epub 2009 Dec 7.

29.

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

Basso M, Samengo G, Nardo G, Massignan T, D'Alessandro G, Tartari S, Cantoni L, Marino M, Cheroni C, De Biasi S, Giordana MT, Strong MJ, Estevez AG, Salmona M, Bendotti C, Bonetto V.

PLoS One. 2009 Dec 2;4(12):e8130. doi: 10.1371/journal.pone.0008130.

30.

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

Massignan T, Stewart RS, Biasini E, Solomon IH, Bonetto V, Chiesa R, Harris DA.

J Biol Chem. 2010 Mar 5;285(10):7752-65. doi: 10.1074/jbc.M109.064949. Epub 2009 Nov 24.

31.

Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.

Nardo G, Pozzi S, Mantovani S, Garbelli S, Marinou K, Basso M, Mora G, Bendotti C, Bonetto V.

Antioxid Redox Signal. 2009 Jul;11(7):1559-67. doi: 10.1089/ARS.2009.2548.

PMID:
19290778
32.

Myosin as a potential redox-sensor: an in vitro study.

Passarelli C, Petrini S, Pastore A, Bonetto V, Sale P, Gaeta LM, Tozzi G, Bertini E, Canepari M, Rossi R, Piemonte F.

J Muscle Res Cell Motil. 2008;29(2-5):119-26. doi: 10.1007/s10974-008-9145-x. Epub 2008 Sep 9.

PMID:
18780150
33.

Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse.

Massignan T, Casoni F, Basso M, Stefanazzi P, Biasini E, Tortarolo M, Salmona M, Gianazza E, Bendotti C, Bonetto V.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):719-25. Epub 2006 Dec 20.

PMID:
17196550
34.

Regulation of redox-sensitive exofacial protein thiols in CHO cells.

Laragione T, Gianazza E, Tonelli R, Bigini P, Mennini T, Casoni F, Massignan T, Bonetto V, Ghezzi P.

Biol Chem. 2006 Oct-Nov;387(10-11):1371-6. Review.

PMID:
17081109
35.

Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice.

Basso M, Massignan T, Samengo G, Cheroni C, De Biasi S, Salmona M, Bendotti C, Bonetto V.

J Biol Chem. 2006 Nov 3;281(44):33325-35. Epub 2006 Aug 30.

36.

Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity.

Biasini E, Massignan T, Fioriti L, Rossi V, Dossena S, Salmona M, Forloni G, Bonetto V, Chiesa R.

Proteomics. 2006 May;6(9):2823-34.

PMID:
16572473
37.

Redox regulation of cyclophilin A by glutathionylation.

Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, Biasini E, Tonelli R, Eberini I, Gianazza E, Dai WW, Fratelli M, Salmona M, Sherry B, Bonetto V.

Proteomics. 2006 Feb;6(3):817-25.

PMID:
16372262
38.

Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

Ghezzi P, Bonetto V, Fratelli M.

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):964-72. Review.

PMID:
15998251
39.

Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.

Casoni F, Basso M, Massignan T, Gianazza E, Cheroni C, Salmona M, Bendotti C, Bonetto V.

J Biol Chem. 2005 Apr 22;280(16):16295-304. Epub 2005 Feb 7.

40.

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics.

Laragione T, Bonetto V, Casoni F, Massignan T, Bianchi G, Gianazza E, Ghezzi P.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14737-41. Epub 2003 Dec 1. Erratum in: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4718.

41.

Actin glutathionylation increases in fibroblasts of patients with Friedreich's ataxia: a potential role in the pathogenesis of the disease.

Pastore A, Tozzi G, Gaeta LM, Bertini E, Serafini V, Di Cesare S, Bonetto V, Casoni F, Carrozzo R, Federici G, Piemonte F.

J Biol Chem. 2003 Oct 24;278(43):42588-95. Epub 2003 Aug 11.

42.

Redox proteomics: identification of oxidatively modified proteins.

Ghezzi P, Bonetto V.

Proteomics. 2003 Jul;3(7):1145-53. Review.

PMID:
12872215
43.

Characterization of antimalarial SPf66 peptide using MALDI-TOF MS, CD and SEC.

Oliva A, Dorta M, Santoveña A, Bonetto V, Salmona M, Fariña J.

Peptides. 2002 Sep;23(9):1527-35.

PMID:
12217412
44.

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.

Casagrande S, Bonetto V, Fratelli M, Gianazza E, Eberini I, Massignan T, Salmona M, Chang G, Holmgren A, Ghezzi P.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9745-9. Epub 2002 Jul 15.

45.

Synthetic miniprion PrP106.

Bonetto V, Massignan T, Chiesa R, Morbin M, Mazzoleni G, Diomede L, Angeretti N, Colombo L, Forloni G, Tagliavini F, Salmona M.

J Biol Chem. 2002 Aug 30;277(35):31327-34. Epub 2002 Jun 10.

46.

Radiochemical and biological characteristics of 99mTc-UBI 29-41 for imaging of bacterial infections.

Welling MM, Mongera S, Lupetti A, Balter HS, Bonetto V, Mazzi U, Pauwels EK, Nibbering PH.

Nucl Med Biol. 2002 May;29(4):413-22.

PMID:
12031876
47.

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes.

Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, Bonetto V, Mengozzi M, Duffieux F, Miclet E, Bachi A, Vandekerckhove J, Gianazza E, Ghezzi P.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3505-10.

48.

Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1.

Terao M, Kurosaki M, Marini M, Vanoni MA, Saltini G, Bonetto V, Bastone A, Federico C, Saccone S, Fanelli R, Salmona M, Garattini E.

J Biol Chem. 2001 Dec 7;276(49):46347-63. Epub 2001 Sep 18.

50.

Spleen antibacterial peptides: high levels of PR-39 and presence of two forms of NK-lysin.

Bonetto V, Andersson M, Bergman T, Sillard R, Norberg A, Mutt V, Jornvall H.

Cell Mol Life Sci. 1999 Oct 1;56(1-2):174-8.

PMID:
11213257

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