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Pre-treatment with the CDK4/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells.

Cretella D, Fumarola C, Bonelli M, Alfieri R, La Monica S, Digiacomo G, Cavazzoni A, Galetti M, Generali D, Petronini PG.

Sci Rep. 2019 Sep 10;9(1):13014. doi: 10.1038/s41598-019-49484-4.


Acquired BRAF G469A Mutation as a Resistance Mechanism to First-Line Osimertinib Treatment in NSCLC Cell Lines Harboring an EGFR Exon 19 Deletion.

La Monica S, Minari R, Cretella D, Bonelli M, Fumarola C, Cavazzoni A, Galetti M, Digiacomo G, Riccardi F, Petronini PG, Tiseo M, Alfieri R.

Target Oncol. 2019 Sep 9. doi: 10.1007/s11523-019-00669-x. [Epub ahead of print]


IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs.

Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B, Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T.

Exp Mol Med. 2019 Jul 8;51(7):75. doi: 10.1038/s12276-019-0267-6.


MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.

Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M, Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J, Bergthaler A, Steiner G, Blüml S.

Front Immunol. 2019 Jun 13;10:1367. doi: 10.3389/fimmu.2019.01367. eCollection 2019.



Araújo GGAS, Souza DDSE, Rameh-de-Albuquerque LC, Fernandes THT, Bonelli MA, Costa FS.

J Zoo Wildl Med. 2019 Jun 13;50(2):447-452. doi: 10.1638/2018-0126.


Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC.

La Monica S, Minari R, Cretella D, Flammini L, Fumarola C, Bonelli M, Cavazzoni A, Digiacomo G, Galetti M, Madeddu D, Falco A, Lagrasta CA, Squadrilli A, Barocelli E, Romanel A, Quaini F, Petronini PG, Tiseo M, Alfieri R.

J Exp Clin Cancer Res. 2019 May 28;38(1):222. doi: 10.1186/s13046-019-1240-x.


A First Attempt to Produce Proteins from Insects by Means of a Circular Economy.

Cappellozza S, Leonardi MG, Savoldelli S, Carminati D, Rizzolo A, Cortellino G, Terova G, Moretto E, Badaile A, Concheri G, Saviane A, Bruno D, Bonelli M, Caccia S, Casartelli M, Tettamanti G.

Animals (Basel). 2019 May 24;9(5). pii: E278. doi: 10.3390/ani9050278.


The digestive system of the adult Hermetia illucens (Diptera: Stratiomyidae): morphological features and functional properties.

Bruno D, Bonelli M, Cadamuro AG, Reguzzoni M, Grimaldi A, Casartelli M, Tettamanti G.

Cell Tissue Res. 2019 May 3. doi: 10.1007/s00441-019-03025-7. [Epub ahead of print]


Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines.

Fumarola C, Bozza N, Castelli R, Ferlenghi F, Marseglia G, Lodola A, Bonelli M, La Monica S, Cretella D, Alfieri R, Minari R, Galetti M, Tiseo M, Ardizzoni A, Mor M, Petronini PG.

Front Oncol. 2019 Mar 26;9:179. doi: 10.3389/fonc.2019.00179. eCollection 2019.


Treg cells in autoimmunity: from identification to Treg-based therapies.

Göschl L, Scheinecker C, Bonelli M.

Semin Immunopathol. 2019 May;41(3):301-314. doi: 10.1007/s00281-019-00741-8. Epub 2019 Apr 5. Review.


Structural and Functional Characterization of Hermetia illucens Larval Midgut.

Bonelli M, Bruno D, Caccia S, Sgambetterra G, Cappellozza S, Jucker C, Tettamanti G, Casartelli M.

Front Physiol. 2019 Mar 8;10:204. doi: 10.3389/fphys.2019.00204. eCollection 2019.


Long-term computed tomography follow-up in great Danes with or without signs of osseous- associated cervical Spondylomyelopathy.

Vansteenkiste D, Martin-Vaquero P, Bonelli M, da Costa LB, da Costa RC.

BMC Vet Res. 2019 Mar 12;15(1):90. doi: 10.1186/s12917-019-1835-7.


Functionality of the support to the family of children with pneumonia.

Souza ROD, Borges AA, Bonelli MA, Dupas G.

Rev Gaucha Enferm. 2019 Feb 18;40:e20180118. doi: 10.1590/1983-1447.2018.20180118. Portuguese, English.


The Intestinal Microbiota of Hermetia illucens Larvae Is Affected by Diet and Shows a Diverse Composition in the Different Midgut Regions.

Bruno D, Bonelli M, De Filippis F, Di Lelio I, Tettamanti G, Casartelli M, Ercolini D, Caccia S.

Appl Environ Microbiol. 2019 Jan 9;85(2). pii: e01864-18. doi: 10.1128/AEM.01864-18. Print 2019 Jan 15.


Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.

Castelli R, Bozza N, Cavazzoni A, Bonelli M, Vacondio F, Ferlenghi F, Callegari D, Silva C, Rivara S, Lodola A, Digiacomo G, Fumarola C, Alfieri R, Petronini PG, Mor M.

Eur J Med Chem. 2019 Jan 15;162:507-524. doi: 10.1016/j.ejmech.2018.11.029. Epub 2018 Nov 13.


CCR6 controls autoimmune but not innate immunity-driven experimental arthritis.

Bonelli M, Puchner A, Göschl L, Hayer S, Niederreiter B, Steiner G, Tillmann K, Plasenzotti R, Podesser B, Georgel P, Smolen J, Scheinecker C, Blüml S.

J Cell Mol Med. 2018 Nov;22(11):5278-5285. doi: 10.1111/jcmm.13783. Epub 2018 Aug 22.


Response to: "The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials".

Blake K, Bonelli M, Ponzano S, Enzmann H; European Medicines Agency Committee for Human Medicinal Products “First-in-Human Guideline Drafting Group”.

Clin Pharmacol Ther. 2018 Nov;104(5):798. doi: 10.1002/cpt.1148. Epub 2018 Jul 14. No abstract available.


Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs.

Gadina M, Johnson C, Schwartz D, Bonelli M, Hasni S, Kanno Y, Changelian P, Laurence A, O'Shea JJ.

J Leukoc Biol. 2018 Sep;104(3):499-514. doi: 10.1002/JLB.5RI0218-084R. Epub 2018 Jul 12. Review.


Non-classical monocytes as mediators of tissue destruction in arthritis.

Puchner A, Saferding V, Bonelli M, Mikami Y, Hofmann M, Brunner JS, Caldera M, Goncalves-Alves E, Binder NB, Fischer A, Simader E, Steiner CW, Leiss H, Hayer S, Niederreiter B, Karonitsch T, Koenders MI, Podesser BK, O'Shea JJ, Menche J, Smolen JS, Redlich K, Blüml S.

Ann Rheum Dis. 2018 Oct;77(10):1490-1497. doi: 10.1136/annrheumdis-2018-213250. Epub 2018 Jun 29.


In vitro evaluation of 225 Ac-DOTA-substance P for targeted alpha therapy of glioblastoma multiforme.

Majkowska-Pilip A, Rius M, Bruchertseifer F, Apostolidis C, Weis M, Bonelli M, Laurenza M, Królicki L, Morgenstern A.

Chem Biol Drug Des. 2018 Jul;92(1):1344-1356. doi: 10.1111/cbdd.13199. Epub 2018 Apr 23.


The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells.

Cretella D, Ravelli A, Fumarola C, La Monica S, Digiacomo G, Cavazzoni A, Alfieri R, Biondi A, Generali D, Bonelli M, Petronini PG.

J Exp Clin Cancer Res. 2018 Mar 27;37(1):72. doi: 10.1186/s13046-018-0741-3. No abstract available.


Commentary on the EMA Guideline on strategies to identify and mitigate risks for first-in-human and early clinical trials with investigational medicinal products.

van Gerven J, Bonelli M.

Br J Clin Pharmacol. 2018 Jul;84(7):1401-1409. doi: 10.1111/bcp.13550. Epub 2018 May 30. No abstract available.


Development of a finite element model of the ligamentous cervical vertebral column of a Great Dane.

Bonelli MA, Shah A, Goel V, Costa FS, da Costa RC.

Res Vet Sci. 2018 Jun;118:97-100. doi: 10.1016/j.rvsc.2018.01.011. Epub 2018 Jan 31.


How does abatacept really work in rheumatoid arthritis?

Bonelli M, Scheinecker C.

Curr Opin Rheumatol. 2018 May;30(3):295-300. doi: 10.1097/BOR.0000000000000491. Review.


A particular case of accidental asphyxiation.

D'Ovidio C, Rosato E, Bonelli M, Carnevale A, Marsella LT.

Med Sci Law. 2018 Jan;58(1):55-57. doi: 10.1177/0025802417747430. Epub 2017 Dec 28.


Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines.

La Monica S, Cretella D, Bonelli M, Fumarola C, Cavazzoni A, Digiacomo G, Flammini L, Barocelli E, Minari R, Naldi N, Petronini PG, Tiseo M, Alfieri R.

J Exp Clin Cancer Res. 2017 Dec 4;36(1):174. doi: 10.1186/s13046-017-0653-7.


Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism.

Fumarola C, Cretella D, La Monica S, Bonelli MA, Alfieri R, Caffarra C, Quaini F, Madeddu D, Falco A, Cavazzoni A, Digiacomo G, Mazzaschi G, Vivo V, Barocelli E, Tiseo M, Petronini PG, Ardizzoni A.

Oncotarget. 2017 Jul 17;8(54):91841-91859. doi: 10.18632/oncotarget.19279. eCollection 2017 Nov 3.


Promoting Safe Early Clinical Research of Novel Drug Candidates: A European Union Regulatory Perspective.

Ponzano S, Blake K, Bonelli M, Enzmann H; European Medicines Agency Committee for Human Medicinal Products “First-in-Human Guideline Drafting Group”.

Clin Pharmacol Ther. 2018 Apr;103(4):564-566. doi: 10.1002/cpt.899. Epub 2017 Nov 6.


Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions.

Sheean ME, Stoyanova-Beninska V, Capovilla G, Duarte D, Hofer MP, Hoffmann M, Magrelli A, Mariz S, Tsigkos S, Shaili E, Polsinelli B, Ricciardi M, Bonelli M, Balabanov P, Larsson K, Sepodes B.

Drug Discov Today. 2018 Jan;23(1):26-48. doi: 10.1016/j.drudis.2017.09.015. Epub 2017 Oct 4. Review.


A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.

Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W.

J Autoimmun. 2018 Jan;86:51-61. doi: 10.1016/j.jaut.2017.09.008. Epub 2017 Sep 28.


Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN.

Cavazzoni A, La Monica S, Alfieri R, Ravelli A, Van Der Steen N, Sciarrillo R, Madeddu D, Lagrasta CAM, Quaini F, Bonelli M, Fumarola C, Cretella D, Digiacomo G, Tiseo M, Peters GJ, Ardizzoni A, Petronini PG, Giovannetti E.

Oncotarget. 2017 May 23;8(32):53068-53083. doi: 10.18632/oncotarget.18087. eCollection 2017 Aug 8.


New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway.

Alfieri R, Giovannetti E, Bonelli M, Cavazzoni A.

Front Oncol. 2017 Aug 9;7:170. doi: 10.3389/fonc.2017.00170. eCollection 2017. Review.


Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep.

Camassa JA, Diogo CC, Bordelo JPA, Bonelli MA, Viegas CA, Azevedo JT, Dourado N, Dias IR.

BMC Vet Res. 2017 Aug 15;13(1):239. doi: 10.1186/s12917-017-1170-9.


Artificial neural networks to evaluate organic and inorganic contamination in agricultural soils.

Bonelli MG, Ferrini M, Manni A.

Chemosphere. 2017 Nov;186:124-131. doi: 10.1016/j.chemosphere.2017.07.116. Epub 2017 Jul 28.


Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells.

Bonelli MA, Digiacomo G, Fumarola C, Alfieri R, Quaini F, Falco A, Madeddu D, La Monica S, Cretella D, Ravelli A, Ulivi P, Tebaldi M, Calistri D, Delmonte A, Ampollini L, Carbognani P, Tiseo M, Cavazzoni A, Petronini PG.

Neoplasia. 2017 Aug;19(8):637-648. doi: 10.1016/j.neo.2017.05.003. Epub 2017 Jul 11.


MicroRNA-146a governs fibroblast activation and joint pathology in arthritis.

Saferding V, Puchner A, Goncalves-Alves E, Hofmann M, Bonelli M, Brunner JS, Sahin E, Niederreiter B, Hayer S, Kiener HP, Einwallner E, Nehmar R, Carapito R, Georgel P, Koenders MI, Boldin M, Schabbauer G, Kurowska-Stolarska M, Steiner G, Smolen JS, Redlich K, Blüml S.

J Autoimmun. 2017 Aug;82:74-84. doi: 10.1016/j.jaut.2017.05.006. Epub 2017 May 22.


Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy.

Bonelli MA, da Costa RC, Martin-Vaquero P, Lima CG.

BMC Vet Res. 2017 Mar 24;13(1):77. doi: 10.1186/s12917-017-0997-4.


Uric acid versus non-uric acid renal stones: in vivo differentiation with spectral CT.

Lombardo F, Bonatti M, Zamboni GA, Avesani G, Oberhofer N, Bonelli M, Pycha A, Pozzi Mucelli R, Bonatti G.

Clin Radiol. 2017 Jun;72(6):490-496. doi: 10.1016/j.crad.2017.01.018. Epub 2017 Feb 28.


Waste prevention impacts on small municipalities: Three experiences from northern Italy.

Bonelli M, Bosio L, Cavallo R, Gianolio U, Marengo P.

Waste Manag Res. 2016 Oct;34(10):1014-1025. Epub 2016 Aug 11.


New therapeutic strategies for malignant pleural mesothelioma.

Bonelli MA, Fumarola C, La Monica S, Alfieri R.

Biochem Pharmacol. 2017 Jan 1;123:8-18. doi: 10.1016/j.bcp.2016.07.012. Epub 2016 Jul 16. Review.


Combination of Gefitinib and Pemetrexed Prevents the Acquisition of TKI Resistance in NSCLC Cell Lines Carrying EGFR-Activating Mutation.

La Monica S, Madeddu D, Tiseo M, Vivo V, Galetti M, Cretella D, Bonelli M, Fumarola C, Cavazzoni A, Falco A, Gervasi A, Lagrasta CA, Naldi N, Barocelli E, Ardizzoni A, Quaini F, Petronini PG, Alfieri R.

J Thorac Oncol. 2016 Jul;11(7):1051-63. doi: 10.1016/j.jtho.2016.03.006. Epub 2016 Mar 19.


Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ.

Elife. 2016 Mar 21;5. pii: e08384. doi: 10.7554/eLife.08384.


Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis.

Bonelli M, Göschl L, Blüml S, Karonitsch T, Hirahara K, Ferner E, Steiner CW, Steiner G, Smolen JS, Scheinecker C.

Rheumatology (Oxford). 2016 Apr;55(4):710-20. doi: 10.1093/rheumatology/kev403. Epub 2015 Dec 16.


Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases.

Schwartz DM, Bonelli M, Gadina M, O'Shea JJ.

Nat Rev Rheumatol. 2016 Jan;12(1):25-36. doi: 10.1038/nrrheum.2015.167. Epub 2015 Dec 3. Review.


Isolation and Characterization of Circulating Tumor Cells in Squamous Cell Carcinoma of the Lung Using a Non-EpCAM-Based Capture Method.

Bozzetti C, Quaini F, Squadrilli A, Tiseo M, Frati C, Lagrasta C, Azzoni C, Bottarelli L, Galetti M, Alama A, Belletti S, Gatti R, Passaro A, Gradilone A, Cavazzoni A, Alfieri R, Petronini PG, Bonelli M, Falco A, Carubbi C, Pedrazzi G, Nizzoli R, Naldi N, Pinto C, Ardizzoni A.

PLoS One. 2015 Nov 16;10(11):e0142891. doi: 10.1371/journal.pone.0142891. eCollection 2015.


Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines.

Galetti M, Petronini PG, Fumarola C, Cretella D, La Monica S, Bonelli M, Cavazzoni A, Saccani F, Caffarra C, Andreoli R, Mutti A, Tiseo M, Ardizzoni A, Alfieri RR.

PLoS One. 2015 Nov 4;10(11):e0141795. doi: 10.1371/journal.pone.0141795. eCollection 2015.


Evaluation of cranial tibial and extensor carpi radialis reflexes before and after anesthetic block in cats.

Tudury EA, de Figueiredo ML, Fernandes TH, Araújo BM, Bonelli MA, Diogo CC, Silva AC, Santos CR, Rocha NL.

J Feline Med Surg. 2017 Feb;19(2):105-109. doi: 10.1177/1098612X15610368. Epub 2016 Jul 11.


Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis.

Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K.

Arthritis Res Ther. 2015 Aug 26;17:230. doi: 10.1186/s13075-015-0742-y.


Impact analysis of ICH S9 on non-clinical development of anticancer drugs.

Bonelli M, Di Giuseppe F, Beken S.

Regul Toxicol Pharmacol. 2015 Oct;73(1):361-6. doi: 10.1016/j.yrtph.2015.07.022. Epub 2015 Jul 30.


Factors in Free Fasciocutaneous Flap Complications: A Logistic Regression Analysis.

Reece EM, Bonelli MA, Livingston T, Mulligan PS, Rockwood J, Wilson JR, Zoldos J, Champagne L.

Plast Reconstr Surg. 2015 Jul;136(1):54e-58e. doi: 10.1097/PRS.0000000000001377.


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