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Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

Santecchia I, Vernel-Pauillac F, Rasid O, Quintin J, Gomes-Solecki M, Boneca IG, Werts C.

PLoS Pathog. 2019 May 20;15(5):e1007811. doi: 10.1371/journal.ppat.1007811. eCollection 2019 May.


N-Deacetylases required for muramic-δ-lactam production are involved in Clostridium difficile sporulation, germination, and heat resistance.

Coullon H, Rifflet A, Wheeler R, Janoir C, Boneca IG, Candela T.

J Biol Chem. 2018 Nov 23;293(47):18040-18054. doi: 10.1074/jbc.RA118.004273. Epub 2018 Sep 28.


A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.

Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG.

J Biol Chem. 2018 Apr 20;293(16):6000-6010. doi: 10.1074/jbc.RA117.001095. Epub 2018 Feb 26.


LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

Ratet G, Santecchia I, Fanton d'Andon M, Vernel-Pauillac F, Wheeler R, Lenormand P, Fischer F, Lechat P, Haake DA, Picardeau M, Boneca IG, Werts C.

PLoS Pathog. 2017 Dec 6;13(12):e1006725. doi: 10.1371/journal.ppat.1006725. eCollection 2017 Dec.


Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex.

Contreras-Martel C, Martins A, Ecobichon C, Trindade DM, Matteï PJ, Hicham S, Hardouin P, Ghachi ME, Boneca IG, Dessen A.

Nat Commun. 2017 Oct 3;8(1):776. doi: 10.1038/s41467-017-00783-2.


Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum.

Parente MR, Forte E, Falabella M, Boneca IG, Teixeira M, Giuffrè A, Saraiva LM.

Sci Rep. 2017 Aug 30;7(1):9909. doi: 10.1038/s41598-017-10375-1.


Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling.

Ohlsson C, Nigro G, Boneca IG, Bäckhed F, Sansonetti P, Sjögren K.

Cell Immunol. 2017 Jul;317:55-58. doi: 10.1016/j.cellimm.2017.05.003. Epub 2017 May 19.


Unusual α-Carbon Hydroxylation of Proline Promotes Active-Site Maturation.

Fadouloglou VE, Balomenou S, Aivaliotis M, Kotsifaki D, Arnaouteli S, Tomatsidou A, Efstathiou G, Kountourakis N, Miliara S, Griniezaki M, Tsalafouta A, Pergantis SA, Boneca IG, Glykos NM, Bouriotis V, Kokkinidis M.

J Am Chem Soc. 2017 Apr 19;139(15):5330-5337. doi: 10.1021/jacs.6b12209. Epub 2017 Apr 5.


Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases.

Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG.

Antibiotics (Basel). 2017 Feb 22;6(1). pii: E8. doi: 10.3390/antibiotics6010008.


Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

Daillère R, Vétizou M, Waldschmitt N, Yamazaki T, Isnard C, Poirier-Colame V, Duong CPM, Flament C, Lepage P, Roberti MP, Routy B, Jacquelot N, Apetoh L, Becharef S, Rusakiewicz S, Langella P, Sokol H, Kroemer G, Enot D, Roux A, Eggermont A, Tartour E, Johannes L, Woerther PL, Chachaty E, Soria JC, Golden E, Formenti S, Plebanski M, Madondo M, Rosenstiel P, Raoult D, Cattoir V, Boneca IG, Chamaillard M, Zitvogel L.

Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.


Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome.

Pitt JM, Vétizou M, Waldschmitt N, Kroemer G, Chamaillard M, Boneca IG, Zitvogel L.

Cancer Res. 2016 Aug 15;76(16):4602-7. doi: 10.1158/0008-5472.CAN-16-0448. Epub 2016 Jul 29. Review.


Role of the N-Acetylmuramoyl-l-Alanyl Amidase, AmiA, of Helicobacter pylori in Peptidoglycan Metabolism, Daughter Cell Separation, and Virulence.

Chaput C, Ecobichon C, Pouradier N, Rousselle JC, Namane A, Boneca IG.

Microb Drug Resist. 2016 Sep;22(6):477-86. doi: 10.1089/mdr.2016.0070. Epub 2016 Jul 22.


The 4(th) Great Wall Symposium, 2015.

Boneca IG.

Microb Drug Resist. 2016 Sep;22(6):445. doi: 10.1089/mdr.2016.28999.igb. Epub 2016 Jun 29. No abstract available.


Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors.

Pitt JM, Vétizou M, Daillère R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, Zitvogel L.

Immunity. 2016 Jun 21;44(6):1255-69. doi: 10.1016/j.immuni.2016.06.001. Review.


Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L.

Science. 2015 Nov 27;350(6264):1079-84. doi: 10.1126/science.aad1329. Epub 2015 Nov 5.


Paenibacillus faecis sp. nov., isolated from human faeces.

Clermont D, Gomard M, Hamon S, Bonne I, Fernandez JC, Wheeler R, Malosse C, Chamot-Rooke J, Gribaldo S, Boneca IG, Bizet C.

Int J Syst Evol Microbiol. 2015 Dec;65(12):4621-6. doi: 10.1099/ijsem.0.000622. Epub 2015 Sep 18.


Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.

Veyrier FJ, Biais N, Morales P, Belkacem N, Guilhen C, Ranjeva S, Sismeiro O, Péhau-Arnaudet G, Rocha EP, Werts C, Taha MK, Boneca IG.

PLoS Genet. 2015 Jul 10;11(7):e1005338. doi: 10.1371/journal.pgen.1005338. eCollection 2015 Jul.


MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G.

Science. 2015 Aug 28;349(6251):989-93. doi: 10.1126/science.aac4263. Epub 2015 Jul 9.


Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics.

Ratet G, Veyrier FJ, Fanton d'Andon M, Kammerscheit X, Nicola MA, Picardeau M, Boneca IG, Werts C.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3359. doi: 10.1371/journal.pntd.0003359. eCollection 2014 Dec.


Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2631-9. doi: 10.1107/S1399004714016770. Epub 2014 Sep 27.


Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.

Burke TP, Loukitcheva A, Zemansky J, Wheeler R, Boneca IG, Portnoy DA.

J Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25.


FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity.

Justino MC, Parente MR, Boneca IG, Saraiva LM.

FEBS J. 2014 Oct;281(19):4495-505. doi: 10.1111/febs.12958. Epub 2014 Sep 1.


Harnessing the intestinal microbiome for optimal therapeutic immunomodulation.

Viaud S, Daillère R, Boneca IG, Lepage P, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L.

Cancer Res. 2014 Aug 15;74(16):4217-21. doi: 10.1158/0008-5472.CAN-14-0987. Epub 2014 Jul 29. Review.


The Great Wall Symposium.

Boneca IG.

Microb Drug Resist. 2014 Jun;20(3):189. doi: 10.1089/mdr.2014.1501. No abstract available.


N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis.

Candela T, Balomenou S, Aucher W, Bouriotis V, Simore JP, Fouet A, Boneca IG.

Microb Drug Resist. 2014 Jun;20(3):222-30. doi: 10.1089/mdr.2014.0063. Epub 2014 May 15.


Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud S, Daillère R, Boneca IG, Lepage P, Langella P, Chamaillard M, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L.

Cell Death Differ. 2015 Feb;22(2):199-214. doi: 10.1038/cdd.2014.56. Epub 2014 May 16. Review.


Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells.

Mustapha P, Paris I, Garcia M, Tran CT, Cremniter J, Garnier M, Faure JP, Barthes T, Boneca IG, Morel F, Lecron JC, Burucoa C, Bodet C.

Infect Immun. 2014 Jul;82(7):2881-9. doi: 10.1128/IAI.01517-13. Epub 2014 Apr 28.


The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa.

Rossez Y, Gosset P, Boneca IG, Magalhães A, Ecobichon C, Reis CA, Cieniewski-Bernard C, Joncquel Chevalier Curt M, Léonard R, Maes E, Sperandio B, Slomianny C, Sansonetti PJ, Michalski JC, Robbe-Masselot C.

J Infect Dis. 2014 Oct 15;210(8):1286-95. doi: 10.1093/infdis/jiu239. Epub 2014 Apr 21.


The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.

Irving AT, Mimuro H, Kufer TA, Lo C, Wheeler R, Turner LJ, Thomas BJ, Malosse C, Gantier MP, Casillas LN, Votta BJ, Bertin J, Boneca IG, Sasakawa C, Philpott DJ, Ferrero RL, Kaparakis-Liaskos M.

Cell Host Microbe. 2014 May 14;15(5):623-35. doi: 10.1016/j.chom.2014.04.001. Epub 2014 Apr 17.


CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma.

Ait Yahia S, Azzaoui I, Everaere L, Vorng H, Chenivesse C, Marquillies P, Duez C, Delacre M, Grandjean T, Balsamelli J, Fanton d'Andon M, Fan Y, Ple C, Werts C, Boneca IG, Wallaert B, Chamaillard M, Tsicopoulos A.

Am J Respir Crit Care Med. 2014 Apr 15;189(8):899-908. doi: 10.1164/rccm.201310-1827OC.


Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, Labrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Immunity. 2014 Mar 20;40(3):436-50. doi: 10.1016/j.immuni.2014.03.002.


Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

Fanton d'Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamandé S, Vandewalle A, Boneca IG, Goujon JM, Werts C.

PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2664. doi: 10.1371/journal.pntd.0002664. eCollection 2014. Erratum in: PLoS Negl Trop Dis. 2014 Apr;8(4):e2802.


Draft Genome Sequence of Strain X47-2AL, a Feline Helicobacter pylori Isolate.

Veyrier FJ, Ecobichon C, Boneca IG.

Genome Announc. 2013 Dec 19;1(6). pii: e01095-13. doi: 10.1128/genomeA.01095-13.


N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis.

Hansen JM, Golchin SA, Veyrier FJ, Domenech P, Boneca IG, Azad AK, Rajaram MV, Schlesinger LS, Divangahi M, Reed MB, Behr MA.

J Infect Dis. 2014 Apr 1;209(7):1045-54. doi: 10.1093/infdis/jit622. Epub 2013 Nov 21.


The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L.

Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.


The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium.

Williams AH, Boneca IG, Burrows LL, Bugg TD.

Res Microbiol. 2014 Jan;165(1):60-7. doi: 10.1016/j.resmic.2013.11.002. Epub 2013 Nov 15. No abstract available.


Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress.

Kaplan Zeevi M, Shafir NS, Shaham S, Friedman S, Sigal N, Nir Paz R, Boneca IG, Herskovits AA.

J Bacteriol. 2013 Dec;195(23):5250-61. doi: 10.1128/JB.00794-13. Epub 2013 Sep 20.


The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.

Ammam F, Meziane-Cherif D, Mengin-Lecreulx D, Blanot D, Patin D, Boneca IG, Courvalin P, Lambert T, Candela T.

Mol Microbiol. 2013 Aug;89(4):612-25. doi: 10.1111/mmi.12299. Epub 2013 Jul 12.


Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

Zarantonelli ML, Skoczynska A, Antignac A, El Ghachi M, Deghmane AE, Szatanik M, Mulet C, Werts C, Peduto L, d'Andon MF, Thouron F, Nato F, Lebourhis L, Philpott DJ, Girardin SE, Vives FL, Sansonetti P, Eberl G, Pedron T, Taha MK, Boneca IG.

Cell Host Microbe. 2013 Jun 12;13(6):735-45. doi: 10.1016/j.chom.2013.04.016.


Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.

Correia M, Michel V, Osório H, El Ghachi M, Bonis M, Boneca IG, De Reuse H, Matos AA, Lenormand P, Seruca R, Figueiredo C, Machado JC, Touati E.

PLoS One. 2013;8(4):e60657. doi: 10.1371/journal.pone.0060657. Epub 2013 Apr 5.


Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response.

Derbise A, Pierre F, Merchez M, Pradel E, Laouami S, Ricard I, Sirard JC, Fritz J, Lemaître N, Akinbi H, Boneca IG, Sebbane F.

J Infect Dis. 2013 May 15;207(10):1535-43. doi: 10.1093/infdis/jit057. Epub 2013 Feb 12.


De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis.

Veyrier FJ, Williams AH, Mesnage S, Schmitt C, Taha MK, Boneca IG.

Mol Microbiol. 2013 Mar;87(5):1100-12. doi: 10.1111/mmi.12153. Epub 2013 Feb 3.


Distinct functions of polysaccharide deacetylases in cell shape, neutral polysaccharide synthesis and virulence of Bacillus anthracis.

Balomenou S, Fouet A, Tzanodaskalaki M, Couture-Tosi E, Bouriotis V, Boneca IG.

Mol Microbiol. 2013 Feb;87(4):867-83. doi: 10.1111/mmi.12137. Epub 2013 Jan 21.


Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.

Zigmond E, Varol C, Farache J, Elmaliah E, Satpathy AT, Friedlander G, Mack M, Shpigel N, Boneca IG, Murphy KM, Shakhar G, Halpern Z, Jung S.

Immunity. 2012 Dec 14;37(6):1076-90. doi: 10.1016/j.immuni.2012.08.026. Epub 2012 Dec 6.


Peptidoglycan maturation enzymes affect flagellar functionality in bacteria.

Roure S, Bonis M, Chaput C, Ecobichon C, Mattox A, Barrière C, Geldmacher N, Guadagnini S, Schmitt C, Prévost MC, Labigne A, Backert S, Ferrero RL, Boneca IG.

Mol Microbiol. 2012 Nov;86(4):845-56. doi: 10.1111/mmi.12019. Epub 2012 Sep 21. Erratum in: Mol Microbiol. 2013 Apr;88(2):456-7.


Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota.

Bosco-Drayon V, Poidevin M, Boneca IG, Narbonne-Reveau K, Royet J, Charroux B.

Cell Host Microbe. 2012 Aug 16;12(2):153-65. doi: 10.1016/j.chom.2012.06.002.


Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori.

Rossez Y, Maes E, Lefebvre Darroman T, Gosset P, Ecobichon C, Joncquel Chevalier Curt M, Boneca IG, Michalski JC, Robbe-Masselot C.

Glycobiology. 2012 Sep;22(9):1193-206. doi: 10.1093/glycob/cws072. Epub 2012 Apr 21.


The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.

Bonis M, Williams A, Guadagnini S, Werts C, Boneca IG.

Microb Drug Resist. 2012 Jun;18(3):230-9. doi: 10.1089/mdr.2011.0231. Epub 2012 Mar 20.


Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

Lacroix-Lamandé S, d'Andon MF, Michel E, Ratet G, Philpott DJ, Girardin SE, Boneca IG, Vandewalle A, Werts C.

J Immunol. 2012 Mar 15;188(6):2805-14. doi: 10.4049/jimmunol.1101987. Epub 2012 Feb 8.


Helicobacter pylori has an unprecedented nitric oxide detoxifying system.

Justino MC, Ecobichon C, Fernandes AF, Boneca IG, Saraiva LM.

Antioxid Redox Signal. 2012 Nov 1;17(9):1190-200. doi: 10.1089/ars.2011.4304. Epub 2012 Mar 6.


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