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Items: 1 to 50 of 74

1.

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.

Escobar G, Barbarossa L, Barbiera G, Norelli M, Genua M, Ranghetti A, Plati T, Camisa B, Brombin C, Cittaro D, Annoni A, Bondanza A, Ostuni R, Gentner B, Naldini L.

Nat Commun. 2018 Jul 24;9(1):2896. doi: 10.1038/s41467-018-05315-0.

2.

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.

Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.

Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.

PMID:
29808007
3.

CD44v6 as innovative sarcoma target for CAR-redirected CIK cells.

Leuci V, Casucci GM, Grignani G, Rotolo R, Rossotti U, Vigna E, Gammaitoni L, Mesiano G, Fiorino E, Donini C, Pisacane A, Ambrosio LD, Pignochino Y, Aglietta M, Bondanza A, Sangiolo D.

Oncoimmunology. 2018 Feb 15;7(5):e1423167. doi: 10.1080/2162402X.2017.1423167. eCollection 2018.

4.

Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP.

Greco R, Ciceri F, Noviello M, Bondanza A, Vago L, Oliveira G, Peccatori J, Cieri N, Ruggeri A, Koehl U, Fleischhauer K, Rocha V, Dazzi F, van der Werf SM, Eikema DJ, Terwel SR, Kuball J, Toubert A, Chabannon C, Bonini C; EBMT Cellular Therapy and Immunobiology Working Party (CTIWP).

Bone Marrow Transplant. 2018 Sep;53(9):1201-1205. doi: 10.1038/s41409-018-0167-8. Epub 2018 Apr 17. No abstract available.

PMID:
29666449
5.

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies.

Chabannon C, Kuball J, Bondanza A, Dazzi F, Pedrazzoli P, Toubert A, Ruggeri A, Fleischhauer K, Bonini C.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaap9630. doi: 10.1126/scitranslmed.aap9630. Review.

PMID:
29643233
6.

Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene.

Casucci M, Falcone L, Camisa B, Norelli M, Porcellini S, Stornaiuolo A, Ciceri F, Traversari C, Bordignon C, Bonini C, Bondanza A.

Front Immunol. 2018 Mar 21;9:507. doi: 10.3389/fimmu.2018.00507. eCollection 2018.

7.

Jon van Rood (1926-2017).

Mueller C, Bonini C, Foeken L, Chabannon C, Bondanza A, Fleischhauer K, Velardi A, Kröger N, Kuball J, Mohty M.

Bone Marrow Transplant. 2017 Dec;52(12):1587. doi: 10.1038/bmt.2017.242. No abstract available.

PMID:
29209062
8.

Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy.

Sandri S, De Sanctis F, Lamolinara A, Boschi F, Poffe O, Trovato R, Fiore A, Sartori S, Sbarbati A, Bondanza A, Cesaro S, Krampera M, Scupoli MT, Nishimura MI, Iezzi M, Sartoris S, Bronte V, Ugel S.

Oncotarget. 2017 May 23;8(50):86987-87001. doi: 10.18632/oncotarget.18115. eCollection 2017 Oct 20.

9.

A New Clinicobiological Scoring System for the Prediction of Infection-Related Mortality and Survival after Allogeneic Hematopoietic Stem Cell Transplantation.

Forcina A, Rancoita PMV, Marcatti M, Greco R, Lupo-Stanghellini MT, Carrabba M, Marasco V, Di Serio C, Bernardi M, Peccatori J, Corti C, Bondanza A, Ciceri F.

Biol Blood Marrow Transplant. 2017 Dec;23(12):2151-2158. doi: 10.1016/j.bbmt.2017.08.010. Epub 2017 Aug 12.

PMID:
28807767
10.

IL-10-Engineered Human CD4+ Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism.

Locafaro G, Andolfi G, Russo F, Cesana L, Spinelli A, Camisa B, Ciceri F, Lombardo A, Bondanza A, Roncarolo MG, Gregori S.

Mol Ther. 2017 Oct 4;25(10):2254-2269. doi: 10.1016/j.ymthe.2017.06.029. Epub 2017 Jul 5.

11.

Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts.

Hartmann J, Schüßler-Lenz M, Bondanza A, Buchholz CJ.

EMBO Mol Med. 2017 Sep;9(9):1183-1197. doi: 10.15252/emmm.201607485. Review.

12.

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

Mastaglio S, Genovese P, Magnani Z, Ruggiero E, Landoni E, Camisa B, Schiroli G, Provasi E, Lombardo A, Reik A, Cieri N, Rocchi M, Oliveira G, Escobar G, Casucci M, Gentner B, Spinelli A, Mondino A, Bondanza A, Vago L, Ponzoni M, Ciceri F, Holmes MC, Naldini L, Bonini C.

Blood. 2017 Aug 3;130(5):606-618. doi: 10.1182/blood-2016-08-732636. Epub 2017 Jun 21.

13.

Acute Myeloid Leukemia Targeting by Chimeric Antigen Receptor T Cells: Bridging the Gap from Preclinical Modeling to Human Studies.

Rotiroti MC, Arcangeli S, Casucci M, Perriello V, Bondanza A, Biondi A, Tettamanti S, Biagi E.

Hum Gene Ther. 2017 Mar;28(3):231-241. doi: 10.1089/hum.2016.092. Epub 2016 Dec 1. Review.

PMID:
27967241
14.

Control of infectious mortality due to carbapenemase-producing Klebsiella pneumoniae in hematopoietic stem cell transplantation.

Forcina A, Baldan R, Marasco V, Cichero P, Bondanza A, Noviello M, Piemontese S, Soliman C, Greco R, Lorentino F, Giglio F, Messina C, Carrabba M, Bernardi M, Peccatori J, Moro M, Biancardi A, Nizzero P, Scarpellini P, Cirillo DM, Mancini N, Corti C, Clementi M, Ciceri F.

Bone Marrow Transplant. 2017 Jan;52(1):114-119. doi: 10.1038/bmt.2016.234. Epub 2016 Sep 26.

PMID:
27668762
15.

Modeling Human Graft-Versus-Host Disease in Immunocompromised Mice.

Norelli M, Camisa B, Bondanza A.

Methods Mol Biol. 2016;1393:127-32. doi: 10.1007/978-1-4939-3338-9_12.

PMID:
27033222
16.

Clinical pharmacology of CAR-T cells: Linking cellular pharmacodynamics to pharmacokinetics and antitumor effects.

Norelli M, Casucci M, Bonini C, Bondanza A.

Biochim Biophys Acta. 2016 Jan;1865(1):90-100. doi: 10.1016/j.bbcan.2015.12.001. Epub 2015 Dec 31. Review.

PMID:
26748354
17.

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

Oliveira G, Ruggiero E, Stanghellini MT, Cieri N, D'Agostino M, Fronza R, Lulay C, Dionisio F, Mastaglio S, Greco R, Peccatori J, Aiuti A, Ambrosi A, Biasco L, Bondanza A, Lambiase A, Traversari C, Vago L, von Kalle C, Schmidt M, Bordignon C, Ciceri F, Bonini C.

Sci Transl Med. 2015 Dec 9;7(317):317ra198. doi: 10.1126/scitranslmed.aac8265. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er9. D'Agostino, Mattio [corrected to D'Agostino, Mattia].

PMID:
26659572
18.

Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival.

Di Lullo G, Marcatti M, Heltai S, Brunetto E, Tresoldi C, Bondanza A, Bonini C, Ponzoni M, Tonon G, Ciceri F, Bordignon C, Protti MP.

Oncoimmunology. 2015 Feb 3;4(5):e1005460. eCollection 2015 May.

19.

Early recovery of CMV immunity after HLA-haploidentical hematopoietic stem cell transplantation as a surrogate biomarker for a reduced risk of severe infections overall.

Noviello M, Forcina A, Veronica V, Crocchiolo R, Stanghellini MT, Carrabba M, Greco R, Vago L, Giglio F, Assanelli A, Carbone MR, Magnani Z, Crippa F, Corti C, Bernardi M, Peccatori J, Bordignon C, Ciceri F, Bonini C, Bondanza A.

Bone Marrow Transplant. 2015 Sep;50(9):1262-4. doi: 10.1038/bmt.2015.132. Epub 2015 Jun 15. No abstract available.

PMID:
26076126
20.

Haploidentical HSCT: a 15-year experience at San Raffaele.

Bonini C, Peccatori J, Stanghellini MT, Vago L, Bondanza A, Cieri N, Greco R, Bernardi M, Corti C, Oliveira G, Zappone E, Traversari C, Bordignon C, Ciceri F.

Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S67-71. doi: 10.1038/bmt.2015.99.

PMID:
26039212
21.

Improving the safety of cell therapy with the TK-suicide gene.

Greco R, Oliveira G, Stanghellini MT, Vago L, Bondanza A, Peccatori J, Cieri N, Marktel S, Mastaglio S, Bordignon C, Bonini C, Ciceri F.

Front Pharmacol. 2015 May 5;6:95. doi: 10.3389/fphar.2015.00095. eCollection 2015. Review.

22.

Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation.

Cieri N, Oliveira G, Greco R, Forcato M, Taccioli C, Cianciotti B, Valtolina V, Noviello M, Vago L, Bondanza A, Lunghi F, Marktel S, Bellio L, Bordignon C, Bicciato S, Peccatori J, Ciceri F, Bonini C.

Blood. 2015 Apr 30;125(18):2865-74. doi: 10.1182/blood-2014-11-608539. Epub 2015 Mar 3.

23.

Overcoming the toxicity hurdles of genetically targeted T cells.

Casucci M, Hawkins RE, Dotti G, Bondanza A.

Cancer Immunol Immunother. 2015 Jan;64(1):123-30. doi: 10.1007/s00262-014-1641-9. Epub 2014 Dec 9. Review.

PMID:
25488419
24.

SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking.

Alexander T, Bondanza A, Muraro PA, Greco R, Saccardi R, Daikeler T, Kazmi M, Hawkey C, Simoes BP, Leblanc K, Fibbe WE, Moore J, Snarski E, Martin T, Hiepe F, Velardi A, Toubert A, Snowden JA, Farge D.

Bone Marrow Transplant. 2015 Feb;50(2):173-80. doi: 10.1038/bmt.2014.251. Epub 2014 Nov 10. Review.

25.

Autologous hematopoietic stem cell transplantation in neuromyelitis optica: a registry study of the EBMT Autoimmune Diseases Working Party.

Greco R, Bondanza A, Oliveira MC, Badoglio M, Burman J, Piehl F, Hagglund H, Krasulova E, Simões BP, Carlson K, Pohlreich D, Labopin M, Saccardi R, Comi G, Mancardi GL, Bacigalupo A, Ciceri F, Farge D.

Mult Scler. 2015 Feb;21(2):189-97. doi: 10.1177/1352458514541978. Epub 2014 Jul 30.

PMID:
25078274
26.

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.

Lepore M, de Lalla C, Gundimeda SR, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Häussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jenö P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G.

J Exp Med. 2014 Jun 30;211(7):1363-77. doi: 10.1084/jem.20140410. Epub 2014 Jun 16.

27.

Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors.

Peccatori J, Forcina A, Clerici D, Crocchiolo R, Vago L, Stanghellini MT, Noviello M, Messina C, Crotta A, Assanelli A, Marktel S, Olek S, Mastaglio S, Giglio F, Crucitti L, Lorusso A, Guggiari E, Lunghi F, Carrabba M, Tassara M, Battaglia M, Ferraro A, Carbone MR, Oliveira G, Roncarolo MG, Rossini S, Bernardi M, Corti C, Marcatti M, Patriarca F, Zecca M, Locatelli F, Bordignon C, Fleischhauer K, Bondanza A, Bonini C, Ciceri F.

Leukemia. 2015 Feb;29(2):396-405. doi: 10.1038/leu.2014.180. Epub 2014 Jun 4.

PMID:
24897508
28.

Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD.

Noviello M, Tedesco FS, Bondanza A, Tonlorenzi R, Rosaria Carbone M, Gerli MFM, Marktel S, Napolitano S, Cicalese MP, Ciceri F, Peretti G, Cossu G, Bonini C.

Mol Ther. 2014 Jul;22(7):1342-1352. doi: 10.1038/mt.2014.62. Epub 2014 Apr 16.

29.

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Escobar G, Moi D, Ranghetti A, Ozkal-Baydin P, Squadrito ML, Kajaste-Rudnitski A, Bondanza A, Gentner B, De Palma M, Mazzieri R, Naldini L.

Sci Transl Med. 2014 Jan 1;6(217):217ra3. doi: 10.1126/scitranslmed.3006353.

30.

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.

Passerini L, Rossi Mel E, Sartirana C, Fousteri G, Bondanza A, Naldini L, Roncarolo MG, Bacchetta R.

Sci Transl Med. 2013 Dec 11;5(215):215ra174. doi: 10.1126/scitranslmed.3007320.

31.

Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation.

Cieri N, Mastaglio S, Oliveira G, Casucci M, Bondanza A, Bonini C.

Immunol Rev. 2014 Jan;257(1):165-80. doi: 10.1111/imr.12130. Review.

PMID:
24329796
32.

Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica.

Greco R, Bondanza A, Vago L, Moiola L, Rossi P, Furlan R, Martino G, Radaelli M, Martinelli V, Carbone MR, Lupo Stanghellini MT, Assanelli A, Bernardi M, Corti C, Peccatori J, Bonini C, Vezzulli P, Falini A, Ciceri F, Comi G.

Ann Neurol. 2014 Mar;75(3):447-53. doi: 10.1002/ana.24079. Epub 2014 Mar 7.

PMID:
24318127
33.

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Casucci M, Nicolis di Robilant B, Falcone L, Camisa B, Norelli M, Genovese P, Gentner B, Gullotta F, Ponzoni M, Bernardi M, Marcatti M, Saudemont A, Bordignon C, Savoldo B, Ciceri F, Naldini L, Dotti G, Bonini C, Bondanza A.

Blood. 2013 Nov 14;122(20):3461-72. doi: 10.1182/blood-2013-04-493361. Epub 2013 Sep 9.

34.

Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers.

Forcina A, Noviello M, Carbone MR, Bonini C, Bondanza A.

Front Immunol. 2013 Mar 25;4:71. doi: 10.3389/fimmu.2013.00071. eCollection 2013.

35.

Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.

Casucci M, Perna SK, Falcone L, Camisa B, Magnani Z, Bernardi M, Crotta A, Tresoldi C, Fleischhauer K, Ponzoni M, Gregori S, Caligaris Cappio F, Ciceri F, Bordignon C, Cignetti A, Bondanza A, Bonini C.

Mol Ther. 2013 Feb;21(2):466-75. doi: 10.1038/mt.2012.227. Epub 2012 Nov 13.

36.

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

Cieri N, Camisa B, Cocchiarella F, Forcato M, Oliveira G, Provasi E, Bondanza A, Bordignon C, Peccatori J, Ciceri F, Lupo-Stanghellini MT, Mavilio F, Mondino A, Bicciato S, Recchia A, Bonini C.

Blood. 2013 Jan 24;121(4):573-84. doi: 10.1182/blood-2012-05-431718. Epub 2012 Nov 15.

37.

T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation.

Vago L, Oliveira G, Bondanza A, Noviello M, Soldati C, Ghio D, Brigida I, Greco R, Lupo Stanghellini MT, Peccatori J, Fracchia S, Del Fiacco M, Traversari C, Aiuti A, Del Maschio A, Bordignon C, Ciceri F, Bonini C.

Blood. 2012 Aug 30;120(9):1820-30. doi: 10.1182/blood-2012-01-405670. Epub 2012 Jun 18.

38.

Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells.

Andolfi G, Fousteri G, Rossetti M, Magnani CF, Jofra T, Locafaro G, Bondanza A, Gregori S, Roncarolo MG.

Mol Ther. 2012 Sep;20(9):1778-90. doi: 10.1038/mt.2012.71. Epub 2012 Jun 12.

39.

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer.

Provasi E, Genovese P, Lombardo A, Magnani Z, Liu PQ, Reik A, Chu V, Paschon DE, Zhang L, Kuball J, Camisa B, Bondanza A, Casorati G, Ponzoni M, Ciceri F, Bordignon C, Greenberg PD, Holmes MC, Gregory PD, Naldini L, Bonini C.

Nat Med. 2012 May;18(5):807-815. doi: 10.1038/nm.2700.

40.

A dual role for genetically modified lymphocytes in cancer immunotherapy.

Russo V, Bondanza A, Ciceri F, Bregni M, Bordignon C, Traversari C, Bonini C.

Trends Mol Med. 2012 Apr;18(4):193-200. doi: 10.1016/j.molmed.2011.12.003. Epub 2012 Jan 7. Review.

PMID:
22230382
41.

Genetic engineering of T cells for the immunotherapy of haematological malignancies.

Casucci M, Bondanza A, Falcone L, Provasi E, Magnani Z, Bonini C.

Tissue Antigens. 2012 Jan;79(1):4-14. doi: 10.1111/j.1399-0039.2011.01799.x. Review.

PMID:
22150366
42.
43.

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells.

Tresoldi E, Dell'Albani I, Stabilini A, Jofra T, Valle A, Gagliani N, Bondanza A, Roncarolo MG, Battaglia M.

Haematologica. 2011 Sep;96(9):1357-65. doi: 10.3324/haematol.2011.041483. Epub 2011 May 12.

44.

IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.

Bondanza A, Hambach L, Aghai Z, Nijmeijer B, Kaneko S, Mastaglio S, Radrizzani M, Fleischhauer K, Ciceri F, Bordignon C, Bonini C, Goulmy E.

Blood. 2011 Jun 16;117(24):6469-78. doi: 10.1182/blood-2010-11-320366. Epub 2011 Apr 29.

45.

Progress and prospects: graft-versus-host disease.

Mastaglio S, Stanghellini MT, Bordignon C, Bondanza A, Ciceri F, Bonini C.

Gene Ther. 2010 Nov;17(11):1309-17. doi: 10.1038/gt.2010.83. Epub 2010 May 27. Review.

PMID:
20508597
46.

Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation.

Lupo-Stanghellini MT, Provasi E, Bondanza A, Ciceri F, Bordignon C, Bonini C.

Hum Gene Ther. 2010 Mar;21(3):241-50. doi: 10.1089/hum.2010.014. Review.

PMID:
20121594
47.

Loss of mismatched HLA in leukemia after stem-cell transplantation.

Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Stanghellini MT, Perrelli NF, Cosentino C, Torri F, Angius A, Forno B, Casucci M, Bernardi M, Peccatori J, Corti C, Bondanza A, Ferrari M, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K.

N Engl J Med. 2009 Jul 30;361(5):478-88. doi: 10.1056/NEJMoa0811036.

48.

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.

Ciceri F, Bonini C, Stanghellini MT, Bondanza A, Traversari C, Salomoni M, Turchetto L, Colombi S, Bernardi M, Peccatori J, Pescarollo A, Servida P, Magnani Z, Perna SK, Valtolina V, Crippa F, Callegaro L, Spoldi E, Crocchiolo R, Fleischhauer K, Ponzoni M, Vago L, Rossini S, Santoro A, Todisco E, Apperley J, Olavarria E, Slavin S, Weissinger EM, Ganser A, Stadler M, Yannaki E, Fassas A, Anagnostopoulos A, Bregni M, Stampino CG, Bruzzi P, Bordignon C.

Lancet Oncol. 2009 May;10(5):489-500. doi: 10.1016/S1470-2045(09)70074-9. Epub 2009 Apr 1.

PMID:
19345145
49.

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Kaneko S, Mastaglio S, Bondanza A, Ponzoni M, Sanvito F, Aldrighetti L, Radrizzani M, La Seta-Catamancio S, Provasi E, Mondino A, Nagasawa T, Fleischhauer K, Russo V, Traversari C, Ciceri F, Bordignon C, Bonini C.

Blood. 2009 Jan 29;113(5):1006-15. doi: 10.1182/blood-2008-05-156059. Epub 2008 Oct 31.

50.

Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation.

Vago L, Forno B, Sormani MP, Crocchiolo R, Zino E, Di Terlizzi S, Lupo Stanghellini MT, Mazzi B, Perna SK, Bondanza A, Middleton D, Palini A, Bernardi M, Bacchetta R, Peccatori J, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K.

Blood. 2008 Oct 15;112(8):3488-99. doi: 10.1182/blood-2007-07-103325. Epub 2008 Jul 21.

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