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Breast Cancer Metastasis to Bone: from Epithelial to Mesenchymal Transition to Breast Osteoblast-Like Cells.

Scimeca M, Trivigno D, Bonfiglio R, Ciuffa S, Urbano N, Schillaci O, Bonanno E.

Semin Cancer Biol. 2020 Feb 8. pii: S1044-579X(20)30005-5. doi: 10.1016/j.semcancer.2020.01.004. [Epub ahead of print] Review.


99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives.

Urbano N, Scimeca M, Tancredi V, Bonanno E, Schillaci O.

Semin Cancer Biol. 2020 Jan 23. pii: S1044-579X(20)30008-0. doi: 10.1016/j.semcancer.2020.01.007. [Epub ahead of print] Review.


A random initialization deep neural network for discriminating malignant breast cancer lesions.

Duggento A, Guerrisi M, Toschi N, Scimeca M, Urbano N, Bonanno E, Aiello M, Cavaliere C, Cascella GL, Cascella D, Conte G.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:912-915. doi: 10.1109/EMBC.2019.8856740.


A Novel Prostate Cell Type-Specific Gene Signature to Interrogate Prostate Tumor Differentiation Status and Monitor Therapeutic Response (Running Title: Phenotypic Classification of Prostate Tumors).

Mapelli SN, Albino D, Mello-Grand M, Shinde D, Scimeca M, Bonfiglio R, Bonanno E, Chiorino G, Garcia-Escudero R, Catapano CV, Carbone GM.

Cancers (Basel). 2020 Jan 10;12(1). pii: E176. doi: 10.3390/cancers12010176.


Effects of short-term aerobic exercise in a mouse model of Niemann-Pick type C disease on synaptic and muscle plasticity.

Palmieri M, Cariati I, Scimeca M, Pallone G, Bonanno E, Tancredi V, D'Arcangelo G, Frank C.

Ann Ist Super Sanita. 2019 Oct-Dec;55(4):330-337. doi: 10.4415/ANN_19_04_05.


Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition.

Scimeca M, Bonfiglio R, Menichini E, Albonici L, Urbano N, De Caro MT, Mauriello A, Schillaci O, Gambacurta A, Bonanno E.

Int J Mol Sci. 2019 Nov 11;20(22). pii: E5633. doi: 10.3390/ijms20225633.


Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors.

Scimeca M, Anemona L, Granaglia A, Bonfiglio R, Urbano N, Toschi N, Santeusanio G, Schiaroli S, Mauriello S, Tancredi V, Schillaci O, Bonanno E, Mauriello A.

Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1330-1336. doi: 10.1016/j.numecd.2019.08.009. Epub 2019 Aug 23.


18F-Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers.

Urbano N, Scimeca M, Crocco A, Mauriello A, Bonanno E, Schillaci O.

J Clin Med. 2019 Oct 11;8(10). pii: E1657. doi: 10.3390/jcm8101657.


Negative prognostic value of intra-ductal fat infiltrate in breast cancer.

Bonfiglio R, Milano F, Cranga A, De Caro MT, Kaur Lamsira H, Trivigno D, Urso S, Scimeca M, Bonanno E.

Pathol Res Pract. 2019 Nov;215(11):152634. doi: 10.1016/j.prp.2019.152634. Epub 2019 Sep 13.


Combining Diagnostic Imaging and Pathology for Improving Diagnosis and Prognosis of Cancer.

Schillaci O, Scimeca M, Toschi N, Bonfiglio R, Urbano N, Bonanno E.

Contrast Media Mol Imaging. 2019 Jul 1;2019:9429761. doi: 10.1155/2019/9429761. eCollection 2019. Review.


Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology.

Scimeca M, Urbano N, Bonfiglio R, Duggento A, Toschi N, Schillaci O, Bonanno E.

Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):138-148. doi: 10.1016/j.bbcan.2019.07.002. Epub 2019 Jul 23. Review.


New advance in breast cancer pathology and imaging.

Urbano N, Scimeca M, Bonfiglio R, Bonanno E, Schillaci O.

Future Oncol. 2019 Aug;15(23):2707-2722. doi: 10.2217/fon-2019-0017. Epub 2019 Jul 24. Review.


Imaging Diagnostic and Pathology in the Management of Oncological-Patients.

Bonanno E, Toschi N, Bombonati A, Muto P, Schillaci O.

Contrast Media Mol Imaging. 2019 Jun 16;2019:2513680. doi: 10.1155/2019/2513680. eCollection 2019. No abstract available.


Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease.

Rovella V, Scimeca M, Giannini E, D'Ercole A, Giacobbi E, Noce A, D'Urso G, Anselmo A, Bove P, Santeusanio G, Bonanno E, Casasco M, Mauriello S, Di Daniele N, Mauriello A, Anemona L.

J Nephrol. 2020 Feb;33(1):83-89. doi: 10.1007/s40620-019-00612-3. Epub 2019 Apr 25.


Erratum to "Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients".

Scimeca M, Urbano N, Bonfiglio R, Mapelli SN, Catapano CV, Carbone GM, Ciuffa S, Tavolozza M, Schillaci O, Mauriello A, Bonanno E.

Contrast Media Mol Imaging. 2019 Mar 11;2019:7843735. doi: 10.1155/2019/7843735. eCollection 2019.


Role of physical activity in onset, prevention and treatment of human neoplasms.

Scimeca M, Pietrolungo F, Bonfiglio R, Bonanno E, Tancredi V.

Future Oncol. 2019 Apr;15(11):1181-1183. doi: 10.2217/fon-2018-0963. Epub 2019 Mar 18. No abstract available.


Programmed death ligand 1 expression in prostate cancer cells is associated with deep changes of the tumor inflammatory infiltrate composition.

Scimeca M, Bonfiglio R, Urbano N, Cerroni C, Anemona L, Montanaro M, Fazi S, Schillaci O, Mauriello A, Bonanno E.

Urol Oncol. 2019 May;37(5):297.e19-297.e31. doi: 10.1016/j.urolonc.2019.02.013. Epub 2019 Feb 28.


Prostate cancer and inflammation: A new molecular imaging challenge in the era of personalized medicine.

Schillaci O, Scimeca M, Trivigno D, Chiaravalloti A, Facchetti S, Anemona L, Bonfiglio R, Santeusanio G, Tancredi V, Bonanno E, Urbano N, Mauriello A.

Nucl Med Biol. 2019 Jan - Feb;68-69:66-79. doi: 10.1016/j.nucmedbio.2019.01.003. Epub 2019 Jan 19. Review.


Electron microscopy in human diseases: diagnostic and research perspectives.

Scimeca M, Montanaro M, Bonfiglio R, Anemona L, Bonanno E.

Nanomedicine (Lond). 2019 Feb;14(4):371-373. doi: 10.2217/nnm-2018-0407. Epub 2019 Jan 18. No abstract available.


Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation.

Cardellini M, Rovella V, Scimeca M, Anemona L, Bischetti S, Casella S, Saggini A, Bonanno E, Ballanti M, Davato F, Menghini R, Ippoliti A, Santeusanio G, Di Daniele N, Federici M, Mauriello A.

Aging Dis. 2019 Feb 1;10(1):71-81. doi: 10.14336/AD.2018.0117. eCollection 2019 Feb.


Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients.

Scimeca M, Urbano N, Bonfiglio R, Mapelli SN, Catapano CV, Carbone GM, Ciuffa S, Tavolozza M, Schillaci O, Mauriello A, Bonanno E.

Contrast Media Mol Imaging. 2018 Dec 9;2018:9840962. doi: 10.1155/2018/9840962. eCollection 2018. Erratum in: Contrast Media Mol Imaging. 2019 Mar 11;2019:7843735.


99mTc sestamibi SPECT: a possible tool for early detection of breast cancer lesions with high bone metastatic potential.

Urbano N, Scimeca M, Bonanno E, Schillaci O.

Future Oncol. 2019 Feb;15(5):455-457. doi: 10.2217/fon-2018-0735. Epub 2019 Jan 8. No abstract available.


New highlight in breast cancer development: the key role of hepcidin and iron metabolism.

Scimeca M, Bonanno E.

Ann Transl Med. 2018 Nov;6(Suppl 1):S56. doi: 10.21037/atm.2018.10.30. No abstract available.


Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction.

Bruni E, Reichle A, Scimeca M, Bonanno E, Ghibelli L.

Front Pharmacol. 2018 Nov 13;9:1307. doi: 10.3389/fphar.2018.01307. eCollection 2018.


Breast microcalcifications: biological and diagnostic perspectives.

Bonfiglio R, Scimeca M, Urbano N, Bonanno E, Schillaci O.

Future Oncol. 2018 Dec;14(30):3097-3099. doi: 10.2217/fon-2018-0624. Epub 2018 Nov 9. No abstract available.


Nuclear medicine and anatomic pathology in personalized medicine: a challenging alliance.

Urbano N, Scimeca M, Bonanno E, Schillaci O.

Per Med. 2018 Nov;15(6):457-459. doi: 10.2217/pme-2018-0050. Epub 2018 Nov 6. No abstract available.


Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53.

Di Leo L, Vegliante R, Ciccarone F, Salvatori I, Scimeca M, Bonanno E, Sagnotta A, Grazi GL, Aquilano K, Ciriolo MR.

Oncogene. 2019 Mar;38(11):1860-1875. doi: 10.1038/s41388-018-0545-0. Epub 2018 Oct 26.


Breast osteoblast-like cells: a new biomarker for the management of breast cancer.

Scimeca M, Urbano N, Bonfiglio R, Schillaci O, Bonanno E.

Br J Cancer. 2018 Oct;119(9):1129-1132. doi: 10.1038/s41416-018-0255-y. Epub 2018 Oct 17.


In vivo biological fate of poly(vinylalcohol) microbubbles in mice.

Cerroni B, Cicconi R, Oddo L, Scimeca M, Bonfiglio R, Bernardini R, Palmieri G, Domenici F, Bonanno E, Mattei M, Paradossi G.

Heliyon. 2018 Sep 17;4(9):e00770. doi: 10.1016/j.heliyon.2018.e00770. eCollection 2018 Sep.


Radiological, Histological and Chemical Analysis of Breast Microcalcifications: Diagnostic Value and Biological Significance.

Bonfiglio R, Scimeca M, Toschi N, Pistolese CA, Giannini E, Antonacci C, Ciuffa S, Tancredi V, Tarantino U, Albonici L, Bonanno E.

J Mammary Gland Biol Neoplasia. 2018 Jun;23(1-2):89-99. doi: 10.1007/s10911-018-9396-0. Epub 2018 May 9.


Calcifications in prostate cancer: An active phenomenon mediated by epithelial cells with osteoblast-phenotype.

Scimeca M, Bonfiglio R, Varone F, Ciuffa S, Mauriello A, Bonanno E.

Microsc Res Tech. 2018 Jul;81(7):745-748. doi: 10.1002/jemt.23031. Epub 2018 Apr 6.


Management of oncological patients in the digital era: anatomic pathology and nuclear medicine teamwork.

Scimeca M, Urbano N, Bonfiglio R, Schillaci O, Bonanno E.

Future Oncol. 2018 May;14(11):1013-1015. doi: 10.2217/fon-2017-0698. Epub 2018 Apr 6. No abstract available.


The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors.

Rovella V, Anemona L, Cardellini M, Scimeca M, Saggini A, Santeusanio G, Bonanno E, Montanaro M, Legramante IM, Ippoliti A, Di Daniele N, Federici M, Mauriello A.

Cardiovasc Diabetol. 2018 Mar 29;17(1):46. doi: 10.1186/s12933-018-0685-0.


Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis.

Scimeca M, Bischetti S, Lamsira HK, Bonfiglio R, Bonanno E.

Eur J Histochem. 2018 Mar 15;62(1):2841. doi: 10.4081/ejh.2018.2841.


H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells.

Testa E, Nardozi D, Antinozzi C, Faieta M, Di Cecca S, Caggiano C, Fukuda T, Bonanno E, Zhenkun L, Maldonado A, Roig I, Di Giacomo M, Barchi M.

J Cell Sci. 2018 Mar 20;131(6). pii: jcs214411. doi: 10.1242/jcs.214411.


Breast Osteoblast-like Cells: A Reliable Early Marker for Bone Metastases From Breast Cancer.

Scimeca M, Antonacci C, Toschi N, Giannini E, Bonfiglio R, Buonomo CO, Pistolese CA, Tarantino U, Bonanno E.

Clin Breast Cancer. 2018 Aug;18(4):e659-e669. doi: 10.1016/j.clbc.2017.11.020. Epub 2017 Dec 5.


Osteoblast-like cells in human cancers: new cell type and reliable markers for bone metastasis.

Scimeca M, Bonfiglio R, Montanaro M, Bonanno E.

Future Oncol. 2018 Jan;14(1):9-11. doi: 10.2217/fon-2017-0472. Epub 2017 Dec 8. No abstract available.


Animal models for the study of inflammatory bowel diseases: a meta-analysis on modalities for imaging inflammatory lesions.

Auletta S, Bonfiglio R, Wunder A, Varani M, Galli F, Borri F, Scimeca M, Niessen HG, Schönberger T, Bonanno E.

Q J Nucl Med Mol Imaging. 2018 Mar;62(1):78-100. doi: 10.23736/S1824-4785.17.03050-3. Epub 2017 Nov 30.


The Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo.

Atzori MG, Tentori L, Ruffini F, Ceci C, Bonanno E, Scimeca M, Lacal PM, Graziani G.

J Pharmacol Exp Ther. 2018 Jan;364(1):77-86. doi: 10.1124/jpet.117.244434. Epub 2017 Oct 12.


Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis.

Scimeca M, Salustri A, Bonanno E, Nardozi D, Rao C, Piccirilli E, Feola M, Tancredi V, Rinaldi A, Iolascon G, Orlandi A, Gasbarra E, Maffulli N, Brandi ML, Tarantino U.

Cell Death Dis. 2017 Oct 12;8(10):e3125. doi: 10.1038/cddis.2017.514.


PD-L1 in immune-escape of breast and prostate cancers: from biology to therapy.

Bonfiglio R, Nardozi D, Scimeca M, Cerroni C, Mauriello A, Bonanno E.

Future Oncol. 2017 Oct;13(24):2129-2131. doi: 10.2217/fon-2017-0278. Epub 2017 Oct 6. No abstract available.


The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells.

Atzori MG, Tentori L, Ruffini F, Ceci C, Lisi L, Bonanno E, Scimeca M, Eskilsson E, Daubon T, Miletic H, Ricci Vitiani L, Pallini R, Navarra P, Bjerkvig R, D'Atri S, Lacal PM, Graziani G.

J Exp Clin Cancer Res. 2017 Aug 10;36(1):106. doi: 10.1186/s13046-017-0577-2.


Carotid plaque instability is not related to quantity but to elemental composition of calcification.

Bischetti S, Scimeca M, Bonanno E, Federici M, Anemona L, Menghini R, Casella S, Cardellini M, Ippoliti A, Mauriello A.

Nutr Metab Cardiovasc Dis. 2017 Sep;27(9):768-774. doi: 10.1016/j.numecd.2017.05.006. Epub 2017 May 31.


Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus.

Campagnolo L, Massimiani M, Vecchione L, Piccirilli D, Toschi N, Magrini A, Bonanno E, Scimeca M, Castagnozzi L, Buonanno G, Stabile L, Cubadda F, Aureli F, Fokkens PH, Kreyling WG, Cassee FR, Pietroiusti A.

Nanotoxicology. 2017 Jun;11(5):687-698. doi: 10.1080/17435390.2017.1343875. Epub 2017 Jul 7.


Mandibular regeneration after immediate load dental implant in a periodontitis patient: A clinical and ultrastructural case report.

Catinari M, Scimeca M, Amorosino M, Marini M, Bonanno E, Tancredi V.

Medicine (Baltimore). 2017 Apr;96(15):e6600. doi: 10.1097/MD.0000000000006600.


Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia.

Scimeca M, Piccirilli E, Mastrangeli F, Rao C, Feola M, Orlandi A, Gasbarra E, Bonanno E, Tarantino U.

J Transl Med. 2017 Feb 15;15(1):34. doi: 10.1186/s12967-017-1143-6.


Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth.

Ceci C, Tentori L, Atzori MG, Lacal PM, Bonanno E, Scimeca M, Cicconi R, Mattei M, de Martino MG, Vespasiani G, Miano R, Graziani G.

Nutrients. 2016 Nov 22;8(11). pii: E744.


Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding.

Graziani G, Ruffini F, Tentori L, Scimeca M, Dorio AS, Atzori MG, Failla CM, Morea V, Bonanno E, D'Atri S, Lacal PM.

Oncotarget. 2016 Nov 8;7(45):72868-72885. doi: 10.18632/oncotarget.12108.


The role of sarcopenia with and without fracture.

Tarantino U, Baldi J, Scimeca M, Piccirilli E, Piccioli A, Bonanno E, Gasbarra E.

Injury. 2016 Oct;47 Suppl 4:S3-S10. doi: 10.1016/j.injury.2016.07.057. Epub 2016 Aug 3.


Heavy metals accumulation affects bone microarchitecture in osteoporotic patients.

Scimeca M, Feola M, Romano L, Rao C, Gasbarra E, Bonanno E, Brandi ML, Tarantino U.

Environ Toxicol. 2017 Apr;32(4):1333-1342. doi: 10.1002/tox.22327. Epub 2016 Jul 27.


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