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Items: 21

1.

Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds.

Charpentier J, Emter R, Koch H, Lelièvre D, Pannecoucke X, Couve-Bonnaire S, Natsch A, Bombrun A.

Chem Biodivers. 2018 Apr;15(4):e1800013. doi: 10.1002/cbdv.201800013. Epub 2018 Apr 19.

PMID:
29476591
2.

Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.

Quattropani A, Sauer WH, Crosignani S, Dorbais J, Gerber P, Gonzalez J, Marin D, Muzerelle M, Beltran F, Nichols A, Georgi K, Schneider M, Vitte PA, Eligert V, Novo-Perez L, Hantson J, Nock S, Carboni S, de Souza AL, Arrighi JF, Boschert U, Bombrun A.

ChemMedChem. 2015 Apr;10(4):688-714. doi: 10.1002/cmdc.201402557. Epub 2015 Mar 3.

PMID:
25735812
3.

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.

Molette J, Routier J, Abla N, Besson D, Bombrun A, Brun R, Burt H, Georgi K, Kaiser M, Nwaka S, Muzerelle M, Scheer A.

ACS Med Chem Lett. 2013 Sep 22;4(11):1037-41. doi: 10.1021/ml400015f. eCollection 2013 Nov 14.

4.

BAX channel activity mediates lysosomal disruption linked to Parkinson disease.

Bové J, Martínez-Vicente M, Dehay B, Perier C, Recasens A, Bombrun A, Antonsson B, Vila M.

Autophagy. 2014 May;10(5):889-900. doi: 10.4161/auto.28286. Epub 2014 Mar 26.

5.

Enantioselective synthesis and physicochemical properties of libraries of 3-amino- and 3-amidofluoropiperidines.

Orliac A, Routier J, Charvillon FB, Sauer WH, Bombrun A, Kulkarni SS, Pardo DG, Cossy J.

Chemistry. 2014 Mar 24;20(13):3813-24. doi: 10.1002/chem.201302423. Epub 2014 Feb 13.

PMID:
24532344
6.

Titanium mediated olefination of aldehydes with α-haloacetates: an exceptionally stereoselective and general approach to (Z)-α-haloacrylates.

Augustine JK, Bombrun A, Venkatachaliah S, Jothi A.

Org Biomol Chem. 2013 Dec 14;11(46):8065-72. doi: 10.1039/c3ob41592a.

PMID:
24145668
7.

XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids.

Orliac A, Gomez Pardo D, Bombrun A, Cossy J.

Org Lett. 2013 Feb 15;15(4):902-5. doi: 10.1021/ol400045d. Epub 2013 Feb 5.

PMID:
23383604
8.

Access and regioselective transformations of 6-substituted 4-aryl-2,8-dichloropyrido[3,2-d]pyrimidine compounds.

Bouscary-Desforges G, Bombrun A, Augustine JK, Bernardinelli G, Quattropani A.

J Org Chem. 2012 May 18;77(10):4586-95. doi: 10.1021/jo300189q. Epub 2012 May 2.

PMID:
22500580
9.

Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.

Crosignani S, Jorand-Lebrun C, Campbell G, Prêtre A, Grippi-Vallotton T, Quattropani A, Bouscary-Desforges G, Bombrun A, Missotten M, Humbert Y, Frémaux C, Pâquet M, El Harkani K, Bradshaw CG, Cleva C, Abla N, Daff H, Schott O, Pittet PA, Arrighi JF, Gaudet M, Johnson Z.

ACS Med Chem Lett. 2011 Oct 10;2(12):938-42. doi: 10.1021/ml200223s. eCollection 2011 Dec 8.

10.

Regioselective synthesis of 2,8-disubstituted 4-aminopyrido[3,2-d]pyrimidine-6-carboxylic acid methyl ester compounds.

Bouscary-Desforges G, Bombrun A, Augustine JK, Bernardinelli G, Quattropani A.

J Org Chem. 2012 Jan 6;77(1):243-52. doi: 10.1021/jo201834d. Epub 2011 Dec 19.

PMID:
22118529
11.

Discovery of a novel series of CXCR3 antagonists.

Crosignani S, Missotten M, Cleva C, Dondi R, Ratinaud Y, Humbert Y, Mandal AB, Bombrun A, Power C, Chollet A, Proudfoot A.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3614-7. doi: 10.1016/j.bmcl.2010.04.113. Epub 2010 Apr 28.

PMID:
20483605
12.

Discovery of a novel series of potent S1P1 agonists.

Crosignani S, Bombrun A, Covini D, Maio M, Marin D, Quattropani A, Swinnen D, Simpson D, Sauer W, Françon B, Martin T, Cambet Y, Nichols A, Martinou I, Burgat-Charvillon F, Rivron D, Donini C, Schott O, Eligert V, Novo-Perez L, Vitte PA, Arrighi JF.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1516-9. doi: 10.1016/j.bmcl.2010.01.102. Epub 2010 Jan 25.

PMID:
20149651
13.

MAC inhibitors suppress mitochondrial apoptosis.

Peixoto PM, Ryu SY, Bombrun A, Antonsson B, Kinnally KW.

Biochem J. 2009 Oct 12;423(3):381-7. doi: 10.1042/BJ20090664.

PMID:
19691447
14.

GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.

Gobert RP, van den Eijnden M, Szyndralewiez C, Jorand-Lebrun C, Swinnen D, Chen L, Gillieron C, Pixley F, Juillard P, Gerber P, Johnson-Léger C, Halazy S, Camps M, Bombrun A, Shipp M, Vitte PA, Ardissone V, Ferrandi C, Perrin D, Rommel C, Hooft van Huijsduijnen R.

J Biol Chem. 2009 Apr 24;284(17):11385-95. doi: 10.1074/jbc.M807241200. Epub 2009 Feb 20.

15.

Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits.

Gobert RP, Joubert L, Curchod ML, Salvat C, Foucault I, Jorand-Lebrun C, Lamarine M, Peixoto H, Vignaud C, Frémaux C, Jomotte T, Françon B, Alliod C, Bernasconi L, Abderrahim H, Perrin D, Bombrun A, Zanoguera F, Rommel C, Hooft van Huijsduijnen R.

Mol Cell Biol. 2009 Mar;29(6):1538-53. doi: 10.1128/MCB.01375-08. Epub 2009 Jan 12.

16.

An efficient and expeditious synthesis of di- and trisubstituted amino-phenyl and -benzyl derivatives of tetrazole and [1,3,4]oxadiazol-2-one.

Desforges G, Bombrun A, Quattropani A.

J Comb Chem. 2008 Sep-Oct;10(5):671-80. doi: 10.1021/cc800083h. Epub 2008 Aug 16.

PMID:
18707176
17.

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

Vercauteren M, Remy E, Devaux C, Dautreaux B, Henry JP, Bauer F, Mulder P, Hooft van Huijsduijnen R, Bombrun A, Thuillez C, Richard V.

Circulation. 2006 Dec 5;114(23):2498-507. Epub 2006 Nov 13.

PMID:
17101854
18.

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

Hetz C, Vitte PA, Bombrun A, Rostovtseva TK, Montessuit S, Hiver A, Schwarz MK, Church DJ, Korsmeyer SJ, Martinou JC, Antonsson B.

J Biol Chem. 2005 Dec 30;280(52):42960-70. Epub 2005 Oct 11. Erratum in: J Biol Chem. 2012 Dec 28;287(53):44108.

19.

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs.

Hooft van Huijsduijnen R, Sauer WH, Bombrun A, Swinnen D.

J Med Chem. 2004 Aug 12;47(17):4142-6. Review. No abstract available.

PMID:
15293983
20.

3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.

Bombrun A, Gerber P, Casi G, Terradillos O, Antonsson B, Halazy S.

J Med Chem. 2003 Oct 9;46(21):4365-8.

PMID:
14521400
21.

Selecting protein tyrosine phosphatases as drug targets.

Hooft van Huijsduijnen R, Bombrun A, Swinnen D.

Drug Discov Today. 2002 Oct 1;7(19):1013-9. Review.

PMID:
12546919

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