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Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.

Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, Nikolova M, Cora V, Antkowiak L, Haq W, Shen N, Schenke-Layland K, Ueffing M, Liebau S, Loskill P.

Elife. 2019 Aug 27;8. pii: e46188. doi: 10.7554/eLife.46188.


Metastatic Merkel cell carcinoma and myasthenia gravis: contraindication for therapy with immune checkpoint inhibitors?

Zaremba A, Chorti E, Jockenhöfer F, Bolz S, Sirin S, Glas M, Becker JC, Ugurel S, Roesch A, Schadendorf D, Livingstone E, Hagenacker T, Zimmer L.

J Immunother Cancer. 2019 May 29;7(1):141. doi: 10.1186/s40425-019-0626-9.


A Cleared View on Retinal Organoids.

Cora V, Haderspeck J, Antkowiak L, Mattheus U, Neckel PH, Mack AF, Bolz S, Ueffing M, Pashkovskaia N, Achberger K, Liebau S.

Cells. 2019 Apr 28;8(5). pii: E391. doi: 10.3390/cells8050391.


Discovery of Novel Antibiotic Resistance Determinants in Forest and Grassland Soil Metagenomes.

Willms IM, Kamran A, Aßmann NF, Krone D, Bolz SH, Fiedler F, Nacke H.

Front Microbiol. 2019 Mar 7;10:460. doi: 10.3389/fmicb.2019.00460. eCollection 2019.


The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock∆19/∆19 Mice With Implications for Circadian Medicine.

Duong ATH, Reitz CJ, Louth EL, Creighton SD, Rasouli M, Zwaiman A, Kroetsch JT, Bolz SS, Winters BD, Bailey CDC, Martino TA.

Sci Rep. 2019 Mar 21;9(1):4994. doi: 10.1038/s41598-019-41469-7.


A retinal model of cerebral malaria.

Paquet-Durand F, Beck SC, Das S, Huber G, Le Chang, Schubert T, Tanimoto N, Garcia-Garrido M, Mühlfriedel R, Bolz S, Hoffmann W, Schraermeyer U, Mordmüller B, Seeliger MW.

Sci Rep. 2019 Mar 5;9(1):3470. doi: 10.1038/s41598-019-39143-z.


B-Cell Deficiency Lowers Blood Pressure in Mice.

Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M.

Hypertension. 2019 Mar;73(3):561-570. doi: 10.1161/HYPERTENSIONAHA.118.11828.


Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophy.

Stolte B, Totzeck A, Kizina K, Bolz S, Pietruck L, Mönninghoff C, Guberina N, Oldenburg D, Forsting M, Kleinschnitz C, Hagenacker T.

Ther Adv Neurol Disord. 2018 Oct 5;11:1756286418803246. doi: 10.1177/1756286418803246. eCollection 2018.


CIDP, myasthenia gravis, and membranous glomerulonephritis - three autoimmune disorders in one patient: a case report.

Bolz S, Totzeck A, Amann K, Stettner M, Kleinschnitz C, Hagenacker T.

BMC Neurol. 2018 Aug 14;18(1):113. doi: 10.1186/s12883-018-1120-6.


First Insight into the Genome Sequence of Clostridium vincentii DSM 10228, Isolated from Sediment of the McMurdo Ice Shelf, Antarctica.

Poehlein A, Bolz S, Fischer B, Daniel R.

Genome Announc. 2018 Apr 12;6(15). pii: e00334-18. doi: 10.1128/genomeA.00334-18.


CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, Ueffing M, Boldt K.

Mol Cell Proteomics. 2018 Jul;17(7):1285-1294. doi: 10.1074/mcp.RA117.000487. Epub 2018 Apr 3.


The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia.

Schliffke S, Buhs S, Bolz S, Gerull H, von Wenserski L, Riecken K, Fehse B, Nollau P, Binder M.

Blood. 2018 Apr 12;131(15):1755-1758. doi: 10.1182/blood-2017-06-788166. Epub 2018 Feb 23. No abstract available.


Cerebral artery myogenic reactivity: The next frontier in developing effective interventions for subarachnoid hemorrhage.

Lidington D, Kroetsch JT, Bolz SS.

J Cereb Blood Flow Metab. 2018 Jan;38(1):17-37. doi: 10.1177/0271678X17742548. Epub 2017 Nov 14. Review.


Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure.

Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS.

Nat Commun. 2017 Apr 5;8:14805. doi: 10.1038/ncomms14805.


Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.

Alibhai FJ, LaMarre J, Reitz CJ, Tsimakouridze EV, Kroetsch JT, Bolz SS, Shulman A, Steinberg S, Burris TP, Oudit GY, Martino TA.

J Mol Cell Cardiol. 2017 Apr;105:24-37. doi: 10.1016/j.yjmcc.2017.01.008. Epub 2017 Feb 20.


Evaluation of polyesteramide (PEA) and polyester (PLGA) microspheres as intravitreal drug delivery systems in albino rats.

Peters T, Kim SW, Castro V, Stingl K, Strasser T, Bolz S, Schraermeyer U, Mihov G, Zong M, Andres-Guerrero V, Herrero Vanrell R, Dias AA, Cameron NR, Zrenner E.

Biomaterials. 2017 Apr;124:157-168. doi: 10.1016/j.biomaterials.2017.02.006. Epub 2017 Feb 7.


Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes.

Sauvé M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, Offermanns S, Husain M, Kroetsch JT, Lidington D, Bolz SS.

Diabetes. 2016 Jul;65(7):1916-28. doi: 10.2337/db15-1450. Epub 2016 Apr 5.


Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries.

Hui S, Levy AS, Slack DL, Burnstein MJ, Errett L, Bonneau D, Latter D, Rotstein OD, Bolz SS, Lidington D, Voigtlaender-Bolz J.

PLoS One. 2015 Sep 14;10(9):e0138142. doi: 10.1371/journal.pone.0138142. eCollection 2015.


A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL.

Cardiovasc Res. 2015 Nov 1;108(2):268-77. doi: 10.1093/cvr/cvv218. Epub 2015 Sep 2.


Chronic Exposure to TNFα Impairs Secretion of Glucagon-Like Peptide-1.

Gagnon J, Sauvé M, Zhao W, Stacey HM, Wiber SC, Bolz SS, Brubaker PL.

Endocrinology. 2015 Nov;156(11):3950-60. doi: 10.1210/en.2015-1361. Epub 2015 Aug 13.


Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort.

Goligher EC, Fan E, Herridge MS, Murray A, Vorona S, Brace D, Rittayamai N, Lanys A, Tomlinson G, Singh JM, Bolz SS, Rubenfeld GD, Kavanagh BP, Brochard LJ, Ferguson ND.

Am J Respir Crit Care Med. 2015 Nov 1;192(9):1080-8. doi: 10.1164/rccm.201503-0620OC.


Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage.

Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS.

Stroke. 2015 Aug;46(8):2260-70. doi: 10.1161/STROKEAHA.114.006365. Epub 2015 Jul 2.


Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.

Malik FA, Meissner A, Semenkov I, Molinski S, Pasyk S, Ahmadi S, Bui HH, Bear CE, Lidington D, Bolz SS.

PLoS One. 2015 Jun 16;10(6):e0130313. doi: 10.1371/journal.pone.0130313. eCollection 2015.


Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function.

Yasotharan S, Pinto S, Sled JG, Bolz SS, Günther A.

Lab Chip. 2015 Jun 21;15(12):2660-9. doi: 10.1039/c5lc00021a.


The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction.

Zhang JN, Zhao Y, Liu C, Han ES, Yu X, Lidington D, Bolz SS, You L.

Bone. 2015 Oct;79:71-8. doi: 10.1016/j.bone.2015.05.017. Epub 2015 May 16.


Tumor Necrosis Factor-α Underlies Loss of Cortical Dendritic Spine Density in a Mouse Model of Congestive Heart Failure.

Meissner A, Visanji NP, Momen MA, Feng R, Francis BM, Bolz SS, Hazrati LN.

J Am Heart Assoc. 2015 May 6;4(5). pii: e001920. doi: 10.1161/JAHA.115.001920.


Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity.

Goligher EC, Laghi F, Detsky ME, Farias P, Murray A, Brace D, Brochard LJ, Bolz SS, Rubenfeld GD, Kavanagh BP, Ferguson ND.

Intensive Care Med. 2015 Apr;41(4):734. doi: 10.1007/s00134-015-3724-2. No abstract available.


Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory.

Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R.

J Biol Chem. 2015 Apr 17;290(16):10242-55. doi: 10.1074/jbc.M114.611921. Epub 2015 Mar 4.


Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity.

Goligher EC, Laghi F, Detsky ME, Farias P, Murray A, Brace D, Brochard LJ, Bolz SS, Rubenfeld GD, Kavanagh BP, Ferguson ND.

Intensive Care Med. 2015 Apr;41(4):642-9. doi: 10.1007/s00134-015-3687-3. Epub 2015 Feb 19. Erratum in: Intensive Care Med. 2015 Apr;41(4):734. Sebastien-Bolz, Steffen [corrected to Bolz, Steffen-Sebastien].


Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells.

Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz SS, Heit B, Klip A, Lee WL.

Mol Biol Cell. 2015 Feb 15;26(4):740-50. doi: 10.1091/mbc.E14-08-1307. Epub 2014 Dec 24.


Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.

Sahaboglu A, Tanimoto N, Bolz S, Garrido MG, Ueffing M, Seeliger MW, Löwenheim H, Ekström P, Paquet-Durand F.

Cell Death Dis. 2014 May 22;5:e1234. doi: 10.1038/cddis.2014.208.


Expression of poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.

Sahaboglu A, Bolz S, Löwenheim H, Paquet-Durand F.

Adv Exp Med Biol. 2014;801:463-9. doi: 10.1007/978-1-4614-3209-8_59.


RecD2 helicase limits replication fork stress in Bacillus subtilis.

Walsh BW, Bolz SA, Wessel SR, Schroeder JW, Keck JL, Simmons LA.

J Bacteriol. 2014 Apr;196(7):1359-68. doi: 10.1128/JB.01475-13. Epub 2014 Jan 17.


The TNF-α/sphingosine-1-phosphate signaling axis drives myogenic responsiveness in heart failure.

Kroetsch JT, Bolz SS.

J Vasc Res. 2013;50(3):177-85. doi: 10.1159/000350528. Epub 2013 Apr 16. Review.


Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness.

Lidington D, Schubert R, Bolz SS.

Cardiovasc Res. 2013 Mar 1;97(3):404-12. doi: 10.1093/cvr/cvs345. Epub 2012 Nov 23. Review.


A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.

Zhang L, Orban M, Lorenz M, Barocke V, Braun D, Urtz N, Schulz C, von Brühl ML, Tirniceriu A, Gaertner F, Proia RL, Graf T, Bolz SS, Montanez E, Prinz M, Müller A, von Baumgarten L, Billich A, Sixt M, Fässler R, von Andrian UH, Junt T, Massberg S.

J Exp Med. 2012 Nov 19;209(12):2165-81. doi: 10.1084/jem.20121090. Epub 2012 Nov 12.


A nonsense mutation in PDE6H causes autosomal-recessive incomplete achromatopsia.

Kohl S, Coppieters F, Meire F, Schaich S, Roosing S, Brennenstuhl C, Bolz S, van Genderen MM, Riemslag FC; European Retinal Disease Consortium, Lukowski R, den Hollander AI, Cremers FP, De Baere E, Hoyng CB, Wissinger B.

Am J Hum Genet. 2012 Sep 7;91(3):527-32. Epub 2012 Aug 16.


Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats.

Schatz A, Arango-Gonzalez B, Fischer D, Enderle H, Bolz S, Röck T, Naycheva L, Grimm C, Messias A, Zrenner E, Bartz-Schmidt KU, Willmann G, Gekeler F.

Invest Ophthalmol Vis Sci. 2012 Aug 15;53(9):5552-61. doi: 10.1167/iovs.12-10037.


In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition.

Zhour A, Bolz S, Grimm C, Willmann G, Schatz A, Weber BH, Zrenner E, Fischer MD.

Vet Ophthalmol. 2012 Sep;15 Suppl 2:123-33. doi: 10.1111/j.1463-5224.2012.01039.x. Epub 2012 Jun 4.


Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.

Yang J, Noyan-Ashraf MH, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS.

Circulation. 2012 Jul 10;126(2):196-206. doi: 10.1161/CIRCULATIONAHA.111.039644. Epub 2012 Jun 5.


Effects of combined ketamine/xylazine anesthesia on light induced retinal degeneration in rats.

Arango-Gonzalez B, Schatz A, Bolz S, Eslava-Schmalbach J, Willmann G, Zhour A, Zrenner E, Fischer MD, Gekeler F.

PLoS One. 2012;7(4):e35687. doi: 10.1371/journal.pone.0035687. Epub 2012 Apr 25. Erratum in: PLoS One. 2012;7(8). doi:10.1371/annotation/d52a610e-6a56-4158-90bf-45e37f053567.


Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.

Meissner A, Yang J, Kroetsch JT, Sauvé M, Dax H, Momen A, Noyan-Ashraf MH, Heximer S, Husain M, Lidington D, Bolz SS.

Circulation. 2012 Jun 5;125(22):2739-50. doi: 10.1161/CIRCULATIONAHA.111.047316. Epub 2012 Apr 25.


Structural and functional protein network analyses predict novel signaling functions for rhodopsin.

Kiel C, Vogt A, Campagna A, Chatr-aryamontri A, Swiatek-de Lange M, Beer M, Bolz S, Mack AF, Kinkl N, Cesareni G, Serrano L, Ueffing M.

Mol Syst Biol. 2011 Nov 22;7:551. doi: 10.1038/msb.2011.83.


Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.

Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17544-9. doi: 10.1073/pnas.1114026108. Epub 2011 Oct 5.


Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

Willmann G, Schäferhoff K, Fischer MD, Arango-Gonzalez B, Bolz S, Naycheva L, Röck T, Bonin M, Bartz-Schmidt KU, Zrenner E, Schatz A, Gekeler F.

Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7529-37. doi: 10.1167/iovs.11-7838.


Metoprolol impairs resistance artery function in mice.

El Beheiry MH, Heximer SP, Voigtlaender-Bolz J, Mazer CD, Connelly KA, Wilson DF, Beattie WS, Tsui AK, Zhang H, Golam K, Hu T, Liu E, Lidington D, Bolz SS, Hare GM.

J Appl Physiol (1985). 2011 Oct;111(4):1125-33. doi: 10.1152/japplphysiol.01340.2010. Epub 2011 Jul 28.


Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.

Panama BK, Latour-Villamil D, Farman GP, Zhao D, Bolz SS, Kirshenbaum LA, Backx PH.

Circ Res. 2011 Mar 4;108(5):537-43. doi: 10.1161/CIRCRESAHA.110.229112. Epub 2011 Jan 20.


Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death.

Schuettauf F, Stein T, Choragiewicz TJ, Rejdak R, Bolz S, Zurakowski D, Varde MA, Laties AM, Thaler S.

Clin Exp Ophthalmol. 2011 Aug;39(6):545-54. doi: 10.1111/j.1442-9071.2010.02486.x. Epub 2011 Feb 23.


Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.

Scherer EQ, Yang J, Canis M, Reimann K, Ivanov K, Diehl CD, Backx PH, Wier WG, Strieth S, Wangemann P, Voigtlaender-Bolz J, Lidington D, Bolz SS.

Stroke. 2010 Nov;41(11):2618-24. doi: 10.1161/STROKEAHA.110.593327. Epub 2010 Oct 7.

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