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Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.

Fermont JM, Bolton CE, Fisk M, Mohan D, Macnee W, Cockcroft JR, McEniery C, Fuld J, Cheriyan J, Tal-Singer R, Wilkinson IB, Wood AM, Polkey MI, Müllerova H.

PLoS One. 2020 Feb 10;15(2):e0228940. doi: 10.1371/journal.pone.0228940. eCollection 2020.


Short Physical Performance Battery: What Does Each Sub-Test Measure in Patients with Chronic Obstructive Pulmonary Disease?

Mohan D, Benson VS, Allinder M, Galwey N, Bolton CE, Cockcroft JR, MacNee W, Wilkinson IB, Tal-Singer R, Polkey MI; ERICA Consortium.

Chronic Obstr Pulm Dis. 2020 Jan;7(1):13-25. doi: 10.15326/jcopdf.7.1.2019.0144.


European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia.

Duijts L, van Meel ER, Moschino L, Baraldi E, Barnhoorn M, Bramer WM, Bolton CE, Boyd J, Buchvald F, Del Cerro MJ, Colin AA, Ersu R, Greenough A, Gremmen C, Halvorsen T, Kamphuis J, Kotecha S, Rooney-Otero K, Schulzke S, Wilson A, Rigau D, Morgan RL, Tonia T, Roehr CC, Pijnenburg MW.

Eur Respir J. 2020 Jan 2;55(1). pii: 1900788. doi: 10.1183/13993003.00788-2019. Print 2020 Jan.


Is targeted lung cancer screening an opportune time to address cardiovascular risk?

Fisk M, Bolton CE.

Thorax. 2019 Dec;74(12):1107-1108. doi: 10.1136/thoraxjnl-2019-213790. Epub 2019 Sep 26. No abstract available.


Outcome measures in a combined exercise rehabilitation programme for adults with COPD and chronic heart failure: A preliminary stakeholder consensus event.

Jones AV, Evans RA, Man WD, Bolton CE, Breen S, Doherty PJ, Gardiner N, Houchen-Wolloff L, Hurst JR, Jolly K, Maddocks M, Quint JK, Revitt O, Sherar LB, Taylor RS, Watt A, Wingham J, Yorke J, Singh SJ.

Chron Respir Dis. 2019 Jan-Dec;16:1479973119867952. doi: 10.1177/1479973119867952.


A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.


Building toolkits for COPD exacerbations: lessons from the past and present.

Sapey E, Bafadhel M, Bolton CE, Wilkinson T, Hurst JR, Quint JK.

Thorax. 2019 Sep;74(9):898-905. doi: 10.1136/thoraxjnl-2018-213035. Epub 2019 Jul 3.


Predicting fracture risk in patients with chronic obstructive pulmonary disease: a UK-based population-based cohort study.

Akyea RK, McKeever TM, Gibson J, Scullion JE, Bolton CE.

BMJ Open. 2019 Apr 3;9(4):e024951. doi: 10.1136/bmjopen-2018-024951.


Challenges of chronic obstructive pulmonary disease in rural Nepal.

Bolton CE, Kc B, Koju R, Hall IP.

Lancet Respir Med. 2019 Jun;7(6):476-478. doi: 10.1016/S2213-2600(19)30079-7. Epub 2019 Mar 14. No abstract available.


Patient-reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.

Pick HJ, Bolton CE, Lim WS, McKeever TM.

Eur Respir J. 2019 Mar 18;53(3). pii: 1802165. doi: 10.1183/13993003.02165-2018. Print 2019 Mar.


Hip fracture outcomes in patients with chronic obstructive pulmonary disease.

Buss L, McKeever TM, Nightingale J, Akyea R, Ollivere B, Moppett IK, Bolton CE.

Br J Anaesth. 2018 Dec;121(6):1377-1379. doi: 10.1016/j.bja.2018.09.008. Epub 2018 Oct 15. No abstract available.


TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.

Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro S, Overall CM, Johnson SR.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L1003-L1014. doi: 10.1152/ajplung.00175.2018. Epub 2018 Oct 4.


Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Mohan D, Forman JR, Allinder M, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Marchong M, Gale NS, Fisk M, Nagarajan S, Cheriyan J, Lomas DA, Calverley PMA, Miller BE, Tal-Singer R, Wilkinson IB, Polkey MI; ERICA Consortium.

Thorax. 2018 Dec;73(12):1182-1185. doi: 10.1136/thoraxjnl-2018-211556. Epub 2018 Apr 4.


Risk of fall in patients with COPD.

Hakamy A, Bolton CE, Gibson JE, McKeever TM.

Thorax. 2018 Nov;73(11):1079-1080. doi: 10.1136/thoraxjnl-2017-211008. Epub 2018 Mar 21.


Variation in lung function and alterations in cardiac structure and function-Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy.

Thomson RJ, Aung N, Sanghvi MM, Paiva JM, Lee AM, Zemrak F, Fung K, Pfeffer PE, Mackay AJ, McKeever TM, Lukaschuk E, Carapella V, Kim YJ, Bolton CE, Piechnik SK, Neubauer S, Petersen SE.

PLoS One. 2018 Mar 20;13(3):e0194434. doi: 10.1371/journal.pone.0194434. eCollection 2018.


COPD exacerbations: transforming outcomes through research.

Hurst JR, Bafadhel M, Bolton CE, Quint JK, Sapey E, Wilkinson TMA.

Lancet Respir Med. 2018 Mar;6(3):172-174. doi: 10.1016/S2213-2600(18)30049-3. Epub 2018 Feb 9. No abstract available.


The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database.

Hakamy A, McKeever TM, Gibson JE, Bolton CE.

NPJ Prim Care Respir Med. 2017 Oct 11;27(1):58. doi: 10.1038/s41533-017-0058-2.


Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

Shindi R, Almehairi A, Negm OH, Kalsheker N, Gale NS, Shale DJ, Harrison TW, Bolton CE, John M, Todd I, Tighe PJ, Fairclough LC.

Clin Immunol. 2017 Oct;183:344-353. doi: 10.1016/j.clim.2017.09.020. Epub 2017 Sep 23.


The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream.

Hakamy A, McKeever TM, Steiner MC, Roberts CM, Singh SJ, Bolton CE.

Int J Chron Obstruct Pulmon Dis. 2017 Sep 8;12:2681-2686. doi: 10.2147/COPD.S141620. eCollection 2017.


Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales.

Steiner MC, Lowe D, Beckford K, Blakey J, Bolton CE, Elkin S, Man WD, Roberts CM, Sewell L, Walker P, Singh SJ.

Thorax. 2017 Jun;72(6):530-537. doi: 10.1136/thoraxjnl-2016-209376. Epub 2017 Jan 11.


The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

Miller S, Henry AP, Hodge E, Kheirallah AK, Billington CK, Rimington TL, Bhaker SK, Obeidat M, Melén E, Merid SK, Swan C, Gowland C, Nelson CP, Stewart CE, Bolton CE, Kilty I, Malarstig A, Parker SG, Moffatt MF, Wardlaw AJ, Hall IP, Sayers I.

PLoS One. 2016 Oct 18;11(10):e0164041. doi: 10.1371/journal.pone.0164041. eCollection 2016.


Cardiovascular disease in COPD: time to quash a silent killer.

Bolton CE, Quint JK, Dransfield MT.

Lancet Respir Med. 2016 Sep;4(9):687-689. doi: 10.1016/S2213-2600(16)30243-0. No abstract available.


Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease.

Huang JT, Bolton CE, Miller BE, Tal-Singer R, Rabinovich RA, Palmer CN, Thomson NC, MacNee W; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators.

Eur Respir J. 2016 Oct;48(4):1215-1218. doi: 10.1183/13993003.01125-2016. Epub 2016 Sep 1. No abstract available.


Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Selvarajah S, Todd I, Tighe PJ, John M, Bolton CE, Harrison T, Fairclough LC.

Mediators Inflamm. 2016;2016:3604842. doi: 10.1155/2016/3604842. Epub 2016 Jul 25.


The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease.

Hakamy A, Bolton CE, McKeever TM.

Chron Respir Dis. 2017 Feb;14(1):54-62. doi: 10.1177/1479972316661925. Epub 2016 Jan 1. Review.


Optimising prescription and titration of oxygen for adult inpatients using novel silicone wristbands: results of a pilot project at three centres.

Forster S, Smith S, Daniel P, Binnion A, Briggs L, Evans R, Ryanna K, Woltmann G, Bajammal O, Hodgson D, Saini G, Scullion J, Bolton CE, Lowrey G.

Clin Med (Lond). 2016 Aug;16(4):330-4. doi: 10.7861/clinmedicine.16-4-330.


Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD.

Rabinovich RA, Miller BE, Wrobel K, Ranjit K, Williams MC, Drost E, Edwards LD, Lomas DA, Rennard SI, Agustí A, Tal-Singer R, Vestbo J, Wouters EF, John M, van Beek EJ, Murchison JT, Bolton CE, MacNee W, Huang JT; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators.

Eur Respir J. 2016 May;47(5):1365-73. doi: 10.1183/13993003.01824-2015. Epub 2016 Mar 23.


Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

John M, McKeever TM, Haddad MA, Hall IP, Sayers I, Cockcroft JR, Bolton CE.

Chron Respir Dis. 2016 Aug;13(3):247-55. doi: 10.1177/1479972316636995. Epub 2016 Mar 10.


Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Jackson VE, Ntalla I, Sayers I, Morris R, Whincup P, Casas JP, Amuzu A, Choi M, Dale C, Kumari M, Engmann J, Kalsheker N, Chappell S, Guetta-Baranes T, McKeever TM, Palmer CN, Tavendale R, Holloway JW, Sayer AA, Dennison EM, Cooper C, Bafadhel M, Barker B, Brightling C, Bolton CE, John ME, Parker SG, Moffat MF, Wardlaw AJ, Connolly MJ, Porteous DJ, Smith BH, Padmanabhan S, Hocking L, Stirrups KE, Deloukas P, Strachan DP, Hall IP, Tobin MD, Wain LV.

Thorax. 2016 Jun;71(6):501-9. doi: 10.1136/thoraxjnl-2015-207876. Epub 2016 Feb 25.


Lung consequences in adults born prematurely.

Bolton CE, Bush A, Hurst JR, Kotecha S, McGarvey L.

Postgrad Med J. 2015 Dec;91(1082):712-8. doi: 10.1136/postgradmedj-2014-206590rep. Review.


Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity.

Poon CY, Watkins WJ, Evans CJ, Tsai-Goodman B, Bolton CE, Cockcroft JR, Wise RG, Kotecha S.

Arch Dis Child Fetal Neonatal Ed. 2016 Jul;101(4):F309-13. doi: 10.1136/archdischild-2015-309015. Epub 2015 Oct 21.


Matrix metalloproteinases -8 and -9 in the Airways, Blood and Urine During Exacerbations of COPD.

Cane JL, Mallia-Millanes B, Forrester DL, Knox AJ, Bolton CE, Johnson SR.

COPD. 2016;13(1):26-34. doi: 10.3109/15412555.2015.1043522. Epub 2015 Sep 29.


Role of the Timed Up and Go Test in Patients With Chronic Obstructive Pulmonary Disease.

Al Haddad MA, John M, Hussain S, Bolton CE.

J Cardiopulm Rehabil Prev. 2016 Jan-Feb;36(1):49-55. doi: 10.1097/HCR.0000000000000143.


Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders.

Kristensen JH, Larsen L, Dasgupta B, Brodmerkel C, Curran M, Karsdal MA, Sand JM, Willumsen N, Knox AJ, Bolton CE, Johnson SR, Hägglund P, Svensson B, Leeming DJ.

Clin Biochem. 2015 Nov;48(16-17):1083-8. doi: 10.1016/j.clinbiochem.2015.07.009. Epub 2015 Jul 9.


Accelerated extracellular matrix turnover during exacerbations of COPD.

Sand JM, Knox AJ, Lange P, Sun S, Kristensen JH, Leeming DJ, Karsdal MA, Bolton CE, Johnson SR.

Respir Res. 2015 Jun 11;16:69. doi: 10.1186/s12931-015-0225-3.


Lung consequences in adults born prematurely.

Bolton CE, Bush A, Hurst JR, Kotecha S, McGarvey L.

Thorax. 2015 Jun;70(6):574-80. doi: 10.1136/thoraxjnl-2014-206590. Epub 2015 Mar 30. Review.


Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial.

John ME, Cockcroft JR, McKeever TM, Coward WR, Shale DJ, Johnson SR, Thornton JG, Harrison TW, Knox AJ, Bolton CE.

Int J Chron Obstruct Pulmon Dis. 2015 Jan 29;10:211-21. doi: 10.2147/COPD.S76061. eCollection 2015.


Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE): Protocol and preliminary data.

Gale NS, Albarrati AM, Munnery MM, Munnery IC, Irfan M, Bolton CE, Rambaran CN, Singer RM, Cockcroft JR, Shale DJ.

Chron Respir Dis. 2014 Nov;11(4):199-207. doi: 10.1177/1479972314546765. Epub 2014 Aug 26.


Exercise and cardiovascular benefit in subjects with COPD: the need for randomised trials.

Bolton CE, Gale NS, Cockcroft JR.

Eur Respir J. 2014 Jul;44(1):263-4. doi: 10.1183/09031936.00009714. No abstract available.


Role of IGF-I, IGF-II and IGFBP-3 in lung function of males: the Caerphilly Prospective Study.

Green CJ, Holly JM, Bolton CE, Bayer A, Ebrahim S, Gallacher J, Ben-Shlomo Y.

Int J Mol Epidemiol Genet. 2014 May 29;5(2):112-9. eCollection 2014.


Evaluating the role of inflammation in chronic airways disease: the ERICA study.

Mohan D, Gale NS, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Lomas DA, Calverley PM, Shale DJ, Miller BE, Wilkinson IB, Tal-Singer R, Polkey MI; ERICA Consortium.

COPD. 2014 Sep;11(5):552-9. doi: 10.3109/15412555.2014.898031. Epub 2014 May 15.


The British Thoracic Society guideline on pulmonary rehabilitation in adults: your opinion is noted.

Bolton CE, Blakey JD, Morgan MD; BTS Pulmonary Rehabilitation Guideline Development Group for the Standards of Care Committee for the BTS.

Thorax. 2014 Apr;69(4):388-9. doi: 10.1136/thoraxjnl-2013-204754. Epub 2014 Jan 15. No abstract available.


Chronic disease influences over 40 major life-changing decisions (MLCDs): a qualitative study in dermatology and general medicine.

Bhatti ZU, Finlay AY, Bolton CE, George L, Halcox JP, Jones SM, Ketchell RI, Moore RH, Salek MS.

J Eur Acad Dermatol Venereol. 2014 Oct;28(10):1344-55. doi: 10.1111/jdv.12289. Epub 2013 Oct 18.


Assessment of pulmonary artery pulse wave velocity in children: an MRI pilot study.

Poon CY, Edwards JM, Evans CJ, Harris AD, Tsai-Goodman B, Bolton CE, Cockcroft JR, Wise RG, Kotecha S.

Magn Reson Imaging. 2013 Dec;31(10):1690-4. doi: 10.1016/j.mri.2013.08.006. Epub 2013 Oct 4.


Commentary: the British Thoracic Society guideline on pulmonary rehabilitation in adults.

Bolton CE, Singh SJ, Walker PP; British Thoracic Society Pulmonary Rehabilitation Guideline Group.

Thorax. 2013 Sep;68(9):887-8. doi: 10.1136/thoraxjnl-2013-203809.


British Thoracic Society guideline on pulmonary rehabilitation in adults.

Bolton CE, Bevan-Smith EF, Blakey JD, Crowe P, Elkin SL, Garrod R, Greening NJ, Heslop K, Hull JH, Man WD, Morgan MD, Proud D, Roberts CM, Sewell L, Singh SJ, Walker PP, Walmsley S; British Thoracic Society Pulmonary Rehabilitation Guideline Development Group; British Thoracic Society Standards of Care Committee.

Thorax. 2013 Sep;68 Suppl 2:ii1-30. doi: 10.1136/thoraxjnl-2013-203808. No abstract available.


Coming now to a chest clinic near you.

Bolton CE, Bush A.

Thorax. 2013 Aug;68(8):707-8. doi: 10.1136/thoraxjnl-2013-203836. No abstract available.


The development and validation of the major life changing decision profile (MLCDP).

Bhatti ZU, Salek SS, Bolton CE, George L, Halcox JP, Jones SM, Ketchell IR, Moore RH, Sabit R, Piguet V, Finlay AY.

Health Qual Life Outcomes. 2013 May 8;11:78. doi: 10.1186/1477-7525-11-78.


Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD.

John M, Hussain S, Prayle A, Simms R, Cockcroft JR, Bolton CE.

Respir Res. 2013 Mar 5;14:31. doi: 10.1186/1465-9921-14-31.


Systemic comorbidities in bronchiectasis.

Gale NS, Bolton CE, Duckers JM, Enright S, Cockcroft JR, Shale DJ.

Chron Respir Dis. 2012;9(4):231-8. doi: 10.1177/1479972312459973.


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