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Items: 10

1.

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Londregan AT, Wei L, Xiao J, Lintner NG, Petersen D, Dullea RG, McClure KF, Bolt MW, Warmus JS, Coffey SB, Limberakis C, Genovino J, Thuma BA, Hesp KD, Aspnes GE, Reidich B, Salatto CT, Chabot JR, Cate JHD, Liras S, Piotrowski DW.

J Med Chem. 2018 Jul 12;61(13):5704-5718. doi: 10.1021/acs.jmedchem.8b00650. Epub 2018 Jun 25.

PMID:
29878763
2.

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

McClure KF, Piotrowski DW, Petersen D, Wei L, Xiao J, Londregan AT, Kamlet AS, Dechert-Schmitt AM, Raymer B, Ruggeri RB, Canterbury D, Limberakis C, Liras S, DaSilva-Jardine P, Dullea RG, Loria PM, Reidich B, Salatto CT, Eng H, Kimoto E, Atkinson K, King-Ahmad A, Scott D, Beaumont K, Chabot JR, Bolt MW, Maresca K, Dahl K, Arakawa R, Takano A, Halldin C.

Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222. doi: 10.1002/anie.201708744. Epub 2017 Nov 24.

PMID:
29073340
3.

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ.

Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8.

PMID:
28893587
4.

Nonclinical Evaluation of PF-06438179: A Potential Biosimilar to Remicade® (Infliximab).

Derzi M, Johnson TR, Shoieb AM, Conlon HD, Sharpe P, Saati A, Koob S, Bolt MW, Lorello LG, McNally J, Kirchhoff CF, Smolarek TA, Leach MW.

Adv Ther. 2016 Nov;33(11):1964-1982. Epub 2016 Sep 1.

5.

Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis.

David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR.

Sci Transl Med. 2016 Aug 24;8(353):353ra112. doi: 10.1126/scitranslmed.aaf4331.

PMID:
27559095
6.

Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells.

Bolt MW, Racz WJ, Brien JF, Massey TE.

Toxicology. 2001 Sep 25;166(3):109-18.

PMID:
11543907
7.
8.

Differential susceptibilities of isolated hamster lung cell types to amiodarone toxicity.

Bolt MW, Racz WJ, Brien JF, Bray TM, Massey TE.

Can J Physiol Pharmacol. 1998 Jul-Aug;76(7-8):721-7.

PMID:
10030452
9.
10.

Modulation of aflatoxin B1 biotransformation by beta-naphthoflavone in isolated rabbit lung cells.

Im SH, Bolt MW, Stewart RK, Massey TE.

Arch Toxicol. 1996;71(1-2):72-9.

PMID:
9010588

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