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Items: 43


Prevalence of Virulence Genes in Enteroaggregative Escherichia coli Isolates from Young Children from Rural South Africa.

Tanih NF, Bolick DT, Samie A, Nyathi E, Dillingham R, Pinkerton RC, Guerrant RL, Bessong PO.

Am J Trop Med Hyg. 2019 Sep 16. doi: 10.4269/ajtmh.19-0192. [Epub ahead of print]


Understanding & ameliorating enteropathy and malnutrition in impoverished areas.

Bolick DT, Guerrant RL.

EBioMedicine. 2019 Jul;45:7-8. doi: 10.1016/j.ebiom.2019.06.054. Epub 2019 Jul 11. No abstract available.


Intestinal parasitic infection alters bone marrow derived dendritic cell inflammatory cytokine production in response to bacterial endotoxin in a diet-dependent manner.

Burgess SL, Oka A, Liu B, Bolick DT, Oakland DN, Guerrant RL, Bartelt L.

PLoS Negl Trop Dis. 2019 Jul 1;13(7):e0007515. doi: 10.1371/journal.pntd.0007515. eCollection 2019 Jul.


A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency.

Q S Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DVS, Oriá RB, Barry EM, Swann JR, Lima AÂM, Agaisse H, Guerrant RL.

Gut Microbes. 2019;10(5):615-630. doi: 10.1080/19490976.2018.1564430. Epub 2019 Feb 3.


5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFκB-Dependent Pathway.

Costa DVS, Bon-Frauches AC, Silva AMHP, Lima-Júnior RCP, Martins CS, Leitão RFC, Freitas GB, Castelucci P, Bolick DT, Guerrant RL, Warren CA, Moura-Neto V, Brito GAC.

Sci Rep. 2019 Jan 24;9(1):665. doi: 10.1038/s41598-018-36878-z.


Disentangling Microbial Mediators of Malnutrition: Modeling Environmental Enteric Dysfunction.

Bartelt LA, Bolick DT, Guerrant RL.

Cell Mol Gastroenterol Hepatol. 2019;7(3):692-707. doi: 10.1016/j.jcmgh.2018.12.006. Epub 2019 Jan 7. Review.


Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium.

Bartelt LA, Bolick DT, Kolling GL, Stebbins E, Huston CD, Guerrant RL, Hoffman PS.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00718-18. doi: 10.1128/AAC.00718-18. Print 2018 Dec.


Revisiting Inbred Mouse Models to Study the Developing Brain: The Potential Role of Intestinal Microbiota.

Oriá RB, Malva JO, Foley PL, Freitas RS, Bolick DT, Guerrant RL.

Front Hum Neurosci. 2018 Sep 19;12:358. doi: 10.3389/fnhum.2018.00358. eCollection 2018. No abstract available.


Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children.

de Medeiros PHQS, Pinto DV, de Almeida JZ, Rêgo JMC, Rodrigues FAP, Lima AÂM, Bolick DT, Guerrant RL, Oriá RB.

Nutrients. 2018 Aug 21;10(9). pii: E1128. doi: 10.3390/nu10091128. Review.


A novel mouse model of Campylobacter jejuni enteropathy and diarrhea.

Giallourou N, Medlock GL, Bolick DT, Medeiros PH, Ledwaba SE, Kolling GL, Tung K, Guerry P, Swann JR, Guerrant RL.

PLoS Pathog. 2018 May 23;14(3):e1007083. doi: 10.1371/journal.ppat.1007083. eCollection 2018 Mar.


Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea.

Bolick DT, Medeiros PHQS, Ledwaba SE, Lima AAM, Nataro JP, Barry EM, Guerrant RL.

Infect Immun. 2018 Jun 21;86(7). pii: e00183-18. doi: 10.1128/IAI.00183-18. Print 2018 Jul.


Abundant production of exopolysaccharide by EAEC strains enhances the formation of bacterial biofilms in contaminated sprouts.

Borgersen Q, Bolick DT, Kolling GL, Aijuka M, Ruiz-Perez F, Guerrant RL, Nataro JP, Santiago AE.

Gut Microbes. 2018;9(3):264-278. doi: 10.1080/19490976.2018.1429877. Epub 2018 Apr 19.


Innate Immune Response and Outcome of Clostridium difficile Infection Are Dependent on Fecal Bacterial Composition in the Aged Host.

Shin JH, Gao Y, Moore JH 2nd, Bolick DT, Kolling GL, Wu M, Warren CA.

J Infect Dis. 2018 Jan 4;217(2):188-197. doi: 10.1093/infdis/jix414.


Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli.

Bartelt LA, Bolick DT, Mayneris-Perxachs J, Kolling GL, Medlock GL, Zaenker EI, Donowitz J, Thomas-Beckett RV, Rogala A, Carroll IM, Singer SM, Papin J, Swann JR, Guerrant RL.

PLoS Pathog. 2017 Jul 27;13(7):e1006471. doi: 10.1371/journal.ppat.1006471. eCollection 2017 Jul.


Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects.

Bolick DT, Mayneris-Perxachs J, Medlock GL, Kolling GL, Papin JA, Swann JR, Guerrant RL.

J Infect Dis. 2017 Jul 1;216(1):64-71. doi: 10.1093/infdis/jix234. Erratum in: J Infect Dis. 2018 Apr 23;217(10):1673.


Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype.

Mayneris-Perxachs J, Bolick DT, Leng J, Medlock GL, Kolling GL, Papin JA, Swann JR, Guerrant RL.

Am J Clin Nutr. 2016 Nov;104(5):1253-1262. Epub 2016 Oct 12.


Protein Malnutrition Impairs Intestinal Epithelial Cell Turnover, a Potential Mechanism of Increased Cryptosporidiosis in a Murine Model.

Liu J, Bolick DT, Kolling GL, Fu Z, Guerrant RL.

Infect Immun. 2016 Nov 18;84(12):3542-3549. Print 2016 Dec.


Comparisons between myeloperoxidase, lactoferrin, calprotectin and lipocalin-2, as fecal biomarkers of intestinal inflammation in malnourished children.

Prata MM, Havt A, Bolick DT, Pinkerton R, Lima A, Guerrant RL.

J Transl Sci. 2016;2(2):134-139. Epub 2016 Mar 25.


Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.

Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, Guedes MM, Moore SR, Petri WA, Havt A, Lima IF, Prata MM, Michaleckyj JC, Scharf RJ, Sturgeon C, Fasano A, Lima AA.

PLoS One. 2016 Sep 30;11(9):e0158772. doi: 10.1371/journal.pone.0158772. eCollection 2016.


Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model.

Bartelt LA, Bolick DT, Kolling GL, Roche JK, Zaenker EI, Lara AM, Noronha FJ, Cowardin CA, Moore JH, Turner JR, Warren CA, Buck GA, Guerrant RL.

PLoS Negl Trop Dis. 2016 Jul 28;10(7):e0004820. doi: 10.1371/journal.pntd.0004820. eCollection 2016 Jul.


Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of Clostridium difficile Infection.

van Opstal E, Kolling GL, Moore JH 2nd, Coquery CM, Wade NS, Loo WM, Bolick DT, Shin JH, Erickson LD, Warren CA.

J Infect Dis. 2016 Jul 1;214(1):130-9. doi: 10.1093/infdis/jiw071. Epub 2016 Feb 24.


Correction: Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model.

Moore JH, Pinheiro CC, Zaenker EI, Bolick DT, Kolling GL, van Opstal E, Noronha FJ, De Medeiros PH, Rodriguez RS, Lima AA, Guerrant RL, Warren CA.

PLoS One. 2015 Sep 15;10(9):e0137037. doi: 10.1371/journal.pone.0137037. eCollection 2015. No abstract available.


Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model.

Moore JH, Pinheiro CC, Zaenker EI, Bolick DT, Kolling GL, van Opstal E, Noronha FJ, De Medeiros PH, Rodriguez RS, Lima AA, Guerrant RL, Warren CA.

PLoS One. 2015 Jul 16;10(7):e0131829. doi: 10.1371/journal.pone.0131829. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0137037.


Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea.

Bolick DT, Kolling GL, Moore JH 2nd, de Oliveira LA, Tung K, Philipson C, Viladomiu M, Hontecillas R, Bassaganya-Riera J, Guerrant RL.

Gut Microbes. 2014;5(5):618-27. doi: 10.4161/19490976.2014.969642.


Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.

Bolick DT, Chen T, Alves LA, Tong Y, Wu D, Joyner LT 2nd, Oriá RB, Guerrant RL, Fu Z.

PLoS One. 2014 Sep 3;9(9):e106902. doi: 10.1371/journal.pone.0106902. eCollection 2014.


Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.

Azevedo OG, Bolick DT, Roche JK, Pinkerton RF, Lima AA, Vitek MP, Warren CA, Oriá RB, Guerrant RL.

PLoS One. 2014 Feb 28;9(2):e89562. doi: 10.1371/journal.pone.0089562. eCollection 2014.


The micronutrient zinc inhibits EAEC strain 042 adherence, biofilm formation, virulence gene expression, and epithelial cytokine responses benefiting the infected host.

Medeiros P, Bolick DT, Roche JK, Noronha F, Pinheiro C, Kolling GL, Lima A, Guerrant RL.

Virulence. 2013 Oct 1;4(7):624-33. doi: 10.4161/viru.26120. Epub 2013 Aug 19.


Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide.

Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL.

J Med Microbiol. 2013 Jun;62(Pt 6):896-905. doi: 10.1099/jmm.0.046300-0. Epub 2013 Mar 8.


ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions.

Whetzel AM, Sturek JM, Nagelin MH, Bolick DT, Gebre AK, Parks JS, Bruce AC, Skaflen MD, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):809-17. doi: 10.1161/ATVBAHA.109.199166. Epub 2010 Jan 28.


G2A deficiency in mice promotes macrophage activation and atherosclerosis.

Bolick DT, Skaflen MD, Johnson LE, Kwon SC, Howatt D, Daugherty A, Ravichandran KS, Hedrick CC.

Circ Res. 2009 Feb 13;104(3):318-27. doi: 10.1161/CIRCRESAHA.108.181131. Epub 2008 Dec 23.


Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3.

Whetzel AM, Bolick DT, Hedrick CC.

Am J Physiol Cell Physiol. 2009 Feb;296(2):C339-45. doi: 10.1152/ajpcell.00293.2008. Epub 2008 Dec 17.


The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice.

Johnson LE, Elias MS, Bolick DT, Skaflen MD, Green RM, Hedrick CC.

Hepatology. 2008 Oct;48(4):1138-48. doi: 10.1002/hep.22433.


Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69.

Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC.

Diabetes. 2008 Feb;57(2):484-93. Epub 2007 Nov 14.


Absence of the G protein-coupled receptor G2A in mice promotes monocyte/endothelial interactions in aorta.

Bolick DT, Whetzel AM, Skaflen M, Deem TL, Lee J, Hedrick CC.

Circ Res. 2007 Mar 2;100(4):572-80. Epub 2007 Jan 25.


Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.

Whetzel AM, Bolick DT, Srinivasan S, Macdonald TL, Morris MA, Ley K, Hedrick CC.

Circ Res. 2006 Sep 29;99(7):731-9. Epub 2006 Sep 7.


12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kappaB.

Bolick DT, Srinivasan S, Whetzel A, Fuller LC, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1260-6. Epub 2006 Mar 16.


12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB.

Bolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2301-7. Epub 2005 Sep 15.


Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.

Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):976-81. Epub 2005 Mar 10.


Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells.

Srinivasan S, Hatley ME, Bolick DT, Palmer LA, Edelstein D, Brownlee M, Hedrick CC.

Diabetologia. 2004 Oct;47(10):1727-34. Epub 2004 Oct 13.


Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes.

Srinivasan S, Bolick DT, Hatley ME, Natarajan R, Reilly KB, Yeh M, Chrestensen C, Sturgill TW, Hedrick CC.

J Biol Chem. 2004 Jul 23;279(30):31930-6. Epub 2004 May 15.


12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo.

Reilly KB, Srinivasan S, Hatley ME, Patricia MK, Lannigan J, Bolick DT, Vandenhoff G, Pei H, Natarajan R, Nadler JL, Hedrick CC.

J Biol Chem. 2004 Mar 5;279(10):9440-50. Epub 2003 Dec 15.


Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition.

Bolick DT, Hatley ME, Srinivasan S, Hedrick CC, Nadler JL.

Endocrinology. 2003 Dec;144(12):5227-31. Epub 2003 Aug 28.


Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice.

Hatley ME, Srinivasan S, Reilly KB, Bolick DT, Hedrick CC.

J Biol Chem. 2003 Jul 11;278(28):25369-75. Epub 2003 May 6. Erratum in: J Biol Chem. 2003 Dec 12;278(50):50818.

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