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Items: 8

1.

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.

Puyang X, Furman C, Zheng GZ, Wu ZJ, Banka D, Aithal K, Agoulnik S, Bolduc DM, Buonamici S, Caleb B, Das S, Eckley S, Fekkes P, Hao MH, Hart A, Houtman R, Irwin S, Joshi JJ, Karr C, Kim A, Kumar N, Kumar P, Kuznetsov G, Lai WG, Larsen N, Mackenzie C, Martin LA, Melchers D, Moriarty A, Nguyen TV, Norris J, O'Shea M, Pancholi S, Prajapati S, Rajagopalan S, Reynolds DJ, Rimkunas V, Rioux N, Ribas R, Siu A, Sivakumar S, Subramanian V, Thomas M, Vaillancourt FH, Wang J, Wardell S, Wick MJ, Yao S, Yu L, Warmuth M, Smith PG, Zhu P, Korpal M.

Cancer Discov. 2018 Sep;8(9):1176-1193. doi: 10.1158/2159-8290.CD-17-1229. Epub 2018 Jul 10.

PMID:
29991605
2.

Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.

3.

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ.

Elife. 2016 Aug 31;5. pii: e17578. doi: 10.7554/eLife.17578.

4.

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA.

Biochemistry. 2016 Jul 5;55(26):3658-66. doi: 10.1021/acs.biochem.6b00448. Epub 2016 Jun 22.

5.

Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.

Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA.

J Biol Chem. 2016 Jul 1;291(27):14160-9. doi: 10.1074/jbc.M116.728980. Epub 2016 May 11.

6.

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.

7.

Structure of nicastrin unveils secrets of γ-secretase.

Bolduc DM, Wolfe MS.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14643-4. doi: 10.1073/pnas.1416637111. Epub 2014 Sep 29. No abstract available.

8.

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB.

Oncotarget. 2014 Jul 30;5(14):5198-208.

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