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Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation.

Pázmándi K, Sütő M, Fekete T, Varga A, Boldizsár E, Boldogh I, Bácsi A.

Free Radic Biol Med. 2019 Aug 10;143:209-220. doi: 10.1016/j.freeradbiomed.2019.08.010. [Epub ahead of print]


c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes.

Bohio AA, Sattout A, Wang R, Wang K, Sah RK, Guo X, Zeng X, Ke Y, Boldogh I, Ba X.

J Immunol. 2019 Sep 15;203(6):1521-1531. doi: 10.4049/jimmunol.1801616. Epub 2019 Aug 9.


Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.

Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, Gao J, Pandey A, Taylor JP, Kraemer BC, Wu P, Boldogh I, Garruto RM, Mitra S, Rao KS, Hegde ML.

Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201818415. doi: 10.1073/pnas.1818415116. [Epub ahead of print]


Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome.

Abraham D, Feher J, Scuderi GL, Szabo D, Dobolyi A, Cservenak M, Juhasz J, Ligeti B, Pongor S, Gomez-Cabrera MC, Vina J, Higuchi M, Suzuki K, Boldogh I, Radak Z.

Exp Gerontol. 2019 Jan;115:122-131. doi: 10.1016/j.exger.2018.12.005. Epub 2018 Dec 6.


Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T.

Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048.


Exercise effects on physiological function during aging.

Radak Z, Torma F, Berkes I, Goto S, Mimura T, Posa A, Balogh L, Boldogh I, Suzuki K, Higuchi M, Koltai E.

Free Radic Biol Med. 2019 Feb 20;132:33-41. doi: 10.1016/j.freeradbiomed.2018.10.444. Epub 2018 Oct 30. Review.


Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation.

Hosoki K, Jaruga P, Itazawa T, Aguilera-Aguirre L, Coskun E, Hazra TK, Boldogh I, Dizdaroglu M, Sur S.

Clin Exp Allergy. 2018 Dec;48(12):1676-1687. doi: 10.1111/cea.13284. Epub 2018 Nov 5.


Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer.

Vlahopoulos S, Adamaki M, Khoury N, Zoumpourlis V, Boldogh I.

Pharmacol Ther. 2019 Feb;194:59-72. doi: 10.1016/j.pharmthera.2018.09.004. Epub 2018 Sep 19. Review.


Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls.

Koltai E, Bori Z, Osvath P, Ihasz F, Peter S, Toth G, Degens H, Rittweger J, Boldogh I, Radak Z.

Redox Biol. 2018 Oct;19:46-51. doi: 10.1016/j.redox.2018.07.022. Epub 2018 Aug 7.


The roles of base excision repair enzyme OGG1 in gene expression.

Wang R, Hao W, Pan L, Boldogh I, Ba X.

Cell Mol Life Sci. 2018 Oct;75(20):3741-3750. doi: 10.1007/s00018-018-2887-8. Epub 2018 Jul 24. Review.


Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA.

Hao W, Qi T, Pan L, Wang R, Zhu B, Aguilera-Aguirre L, Radak Z, Hazra TK, Vlahopoulos SA, Bacsi A, Brasier AR, Ba X, Boldogh I.

Redox Biol. 2018 Sep;18:43-53. doi: 10.1016/j.redox.2018.06.002. Epub 2018 Jun 12.


OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.

Wang R, Li C, Qiao P, Xue Y, Zheng X, Chen H, Zeng X, Liu W, Boldogh I, Ba X.

Cell Death Dis. 2018 May 24;9(6):628. doi: 10.1038/s41419-018-0680-0.


Isolation of mitochondria from Saccharomyces cerevisiae using magnetic bead affinity purification.

Liao PC, Boldogh IR, Siegmund SE, Freyberg Z, Pon LA.

PLoS One. 2018 Apr 26;13(4):e0196632. doi: 10.1371/journal.pone.0196632. eCollection 2018.


The establishment of methods for free PAR generation and PAR reader detection.

Ke Y, Wang K, Xu H, Wang C, Zhang J, Zeng X, Wang R, Boldogh I, Ba X.

Mol Cell Probes. 2018 Jun;39:57-60. doi: 10.1016/j.mcp.2018.04.002. Epub 2018 Apr 5.


A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.

Area-Gomez E, de Groof A, Bonilla E, Montesinos J, Tanji K, Boldogh I, Pon L, Schon EA.

Cell Death Dis. 2018 Feb 28;9(3):335. doi: 10.1038/s41419-017-0215-0. Review.


Mitochondrial Tethers and Their Impact on Lifespan in Budding Yeast.

Pernice WM, Swayne TC, Boldogh IR, Pon LA.

Front Cell Dev Biol. 2018 Jan 8;5:120. doi: 10.3389/fcell.2017.00120. eCollection 2017. Review.


8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions.

Ba X, Boldogh I.

Redox Biol. 2018 Apr;14:669-678. doi: 10.1016/j.redox.2017.11.008. Epub 2017 Nov 10. Review.


Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells.

Agod Z, Fekete T, Budai MM, Varga A, Szabo A, Moon H, Boldogh I, Biro T, Lanyi A, Bacsi A, Pazmandi K.

Redox Biol. 2017 Oct;13:633-645. doi: 10.1016/j.redox.2017.07.016. Epub 2017 Jul 29.


Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation.

Aguilera-Aguirre L, Hao W, Pan L, Li X, Saavedra-Molina A, Bacsi A, Radak Z, Sur S, Brasier AR, Ba X, Boldogh I.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1058-L1068. doi: 10.1152/ajplung.00141.2017. Epub 2017 Aug 10.


Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways.

Hosoki K, Redding D, Itazawa T, Chakraborty A, Tapryal N, Qian S, Qi H, Aguilera-Aguirre L, Brasier AR, Phani VS, Hazra TK, Boldogh I, Sur S.

J Allergy Clin Immunol. 2017 Nov;140(5):1436-1439.e5. doi: 10.1016/j.jaci.2017.04.044. Epub 2017 Jun 2. No abstract available.


Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats.

Pajk M, Cselko A, Varga C, Posa A, Tokodi M, Boldogh I, Goto S, Radak Z.

Biogerontology. 2017 Aug;18(4):593-600. doi: 10.1007/s10522-017-9705-9. Epub 2017 May 5.


Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR.

Ke Y, Han Y, Guo X, Wen J, Wang K, Jiang X, Tian X, Ba X, Boldogh I, Zeng X.

Nat Commun. 2017 Mar 31;8:15191. doi: 10.1038/ncomms15191. No abstract available.


Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve.

Radak Z, Ishihara K, Tekus E, Varga C, Posa A, Balogh L, Boldogh I, Koltai E.

Redox Biol. 2017 Aug;12:285-290. doi: 10.1016/j.redox.2017.02.015. Epub 2017 Mar 3.


PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.

Ke Y, Han Y, Guo X, Wen J, Wang K, Jiang X, Tian X, Ba X, Boldogh I, Zeng X.

Nat Commun. 2017 Mar 8;8:14632. doi: 10.1038/ncomms14632.


OGG1-DNA interactions facilitate NF-κB binding to DNA targets.

Pan L, Hao W, Zheng X, Zeng X, Ahmed Abbasi A, Boldogh I, Ba X.

Sci Rep. 2017 Mar 7;7:43297. doi: 10.1038/srep43297.


SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle.

Koltai E, Bori Z, Chabert C, Dubouchaud H, Naito H, Machida S, Davies KJ, Murlasits Z, Fry AC, Boldogh I, Radak Z.

J Physiol. 2017 Jun 1;595(11):3361-3376. doi: 10.1113/JP273774. Epub 2017 Apr 28.


Reply: Protease Plays a Role in Ragweed Pollen-Induced Neutrophil Recruitment and Epithelial Barrier Disruption.

Hosoki K, Brasier AR, Kurosky A, Boldogh I, Sur S.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):272-273. doi: 10.1165/rcmb.2016-0281LE. No abstract available.


NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns.

Tian B, Patrikeev I, Ochoa L, Vargas G, Belanger KK, Litvinov J, Boldogh I, Ameredes BT, Motamedi M, Brasier AR.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):506-520. doi: 10.1165/rcmb.2016-0259OC.


Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos SA, Hazra TK, Hegde ML, Radak Z, Bacsi A, Brasier AR, Ba X, Boldogh I.

J Biol Chem. 2016 Dec 2;291(49):25553-25566. Epub 2016 Oct 18.


Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

Wang H, Dharmalingam P, Vasquez V, Mitra J, Boldogh I, Rao KS, Kent TA, Mitra S, Hegde ML.

Mech Ageing Dev. 2017 Jan;161(Pt A):163-176. doi: 10.1016/j.mad.2016.09.005. Epub 2016 Sep 20. Review.


The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma.

Belanger KK, Ameredes BT, Boldogh I, Aguilera-Aguirre L.

Mediators Inflamm. 2016;2016:3762561. doi: 10.1155/2016/3762561. Epub 2016 Jul 25. Review.


8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.

German P, Saenz D, Szaniszlo P, Aguilera-Aguirre L, Pan L, Hegde ML, Bacsi A, Hajas G, Radak Z, Ba X, Mitra S, Papaconstantinou J, Boldogh I.

Mech Ageing Dev. 2017 Jan;161(Pt A):51-65. doi: 10.1016/j.mad.2016.06.009. Epub 2016 Jun 21.


The rate of training response to aerobic exercise affects brain function of rats.

Marton O, Koltai E, Takeda M, Mimura T, Pajk M, Abraham D, Koch LG, Britton SL, Higuchi M, Boldogh I, Radak Z.

Neurochem Int. 2016 Oct;99:16-23. doi: 10.1016/j.neuint.2016.05.012. Epub 2016 Jun 1.


Physical exercise, reactive oxygen species and neuroprotection.

Radak Z, Suzuki K, Higuchi M, Balogh L, Boldogh I, Koltai E.

Free Radic Biol Med. 2016 Sep;98:187-196. doi: 10.1016/j.freeradbiomed.2016.01.024. Epub 2016 Jan 28. Review.


Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae.

Higuchi-Sanabria R, Charalel JK, Viana MP, Garcia EJ, Sing CN, Koenigsberg A, Swayne TC, Vevea JD, Boldogh IR, Rafelski SM, Pon LA.

Mol Biol Cell. 2016 Mar 1;27(5):776-87. doi: 10.1091/mbc.E15-07-0455. Epub 2016 Jan 13.


Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.

Choudhary S, Boldogh I, Brasier AR.

J Innate Immun. 2016;8(2):143-55. doi: 10.1159/000442254. Epub 2016 Jan 13. Review.


Pathophysiology of bronchoconstriction: role of oxidatively damaged DNA repair.

Bacsi A, Pan L, Ba X, Boldogh I.

Curr Opin Allergy Clin Immunol. 2016 Feb;16(1):59-67. doi: 10.1097/ACI.0000000000000232. Review.


Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation.

Hosoki K, Itazawa T, Boldogh I, Sur S.

Curr Opin Allergy Clin Immunol. 2016 Feb;16(1):45-50. doi: 10.1097/ACI.0000000000000231. Review.


Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes.

Dutta EH, Behnia F, Boldogh I, Saade GR, Taylor BD, Kacerovský M, Menon R.

Mol Hum Reprod. 2016 Feb;22(2):143-57. doi: 10.1093/molehr/gav074. Epub 2015 Dec 21.


Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.

Hosoki K, Boldogh I, Aguilera-Aguirre L, Sun Q, Itazawa T, Hazra T, Brasier AR, Kurosky A, Sur S.

J Allergy Clin Immunol. 2016 May;137(5):1506-1513.e2. doi: 10.1016/j.jaci.2015.09.036. Epub 2015 Nov 14.


Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development.

Zhang X, He N, Gu D, Wickliffe J, Salazar J, Boldogh I, Xie J.

J Genet Genomics. 2015 Oct 20;42(10):589-596. doi: 10.1016/j.jgg.2015.09.006. Epub 2015 Oct 17.


Imaging of the Actin Cytoskeleton and Mitochondria in Fixed Budding Yeast Cells.

Higuchi-Sanabria R, Swayne TC, Boldogh IR, Pon LA.

Methods Mol Biol. 2016;1365:63-81. doi: 10.1007/978-1-4939-3124-8_3.


Live-Cell Imaging of Mitochondria and the Actin Cytoskeleton in Budding Yeast.

Higuchi-Sanabria R, Swayne TC, Boldogh IR, Pon LA.

Methods Mol Biol. 2016;1365:25-62. doi: 10.1007/978-1-4939-3124-8_2.


Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.

Chakraborty A, Wakamiya M, Venkova-Canova T, Pandita RK, Aguilera-Aguirre L, Sarker AH, Singh DK, Hosoki K, Wood TG, Sharma G, Cardenas V, Sarkar PS, Sur S, Pandita TK, Boldogh I, Hazra TK.

J Biol Chem. 2015 Oct 9;290(41):24636-48. doi: 10.1074/jbc.M115.658146. Epub 2015 Aug 5.


Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling.

Aguilera-Aguirre L, Hosoki K, Bacsi A, Radák Z, Sur S, Hegde ML, Tian B, Saavedra-Molina A, Brasier AR, Ba X, Boldogh I.

Free Radic Biol Med. 2015 Dec;89:20-33. doi: 10.1016/j.freeradbiomed.2015.07.007. Epub 2015 Jul 15.


Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells.

Patel PR, Hegde ML, Theruvathu J, Mitra SA, Boldogh I, Sowers L.

J Bioanal Biomed. 2015;7(3):75-80.


The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.

Hegde PM, Dutta A, Sengupta S, Mitra J, Adhikari S, Tomkinson AE, Li GM, Boldogh I, Hazra TK, Mitra S, Hegde ML.

J Biol Chem. 2015 Aug 21;290(34):20919-33. doi: 10.1074/jbc.M115.642918. Epub 2015 Jul 1.


Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.

Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP.

Cytokine Growth Factor Rev. 2015 Aug;26(4):389-403. doi: 10.1016/j.cytogfr.2015.06.001. Epub 2015 Jun 20. Review.


Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment.

Hosoki K, Aguilera-Aguirre L, Brasier AR, Kurosky A, Boldogh I, Sur S.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):81-90. doi: 10.1165/rcmb.2015-0044OC.


Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1.

Hosoki K, Ying S, Corrigan C, Qi H, Kurosky A, Jennings K, Sun Q, Boldogh I, Sur S.

PLoS One. 2015 May 26;10(5):e0126035. doi: 10.1371/journal.pone.0126035. eCollection 2015.

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