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BMJ Case Rep. 2019 Feb 11;12(2). pii: bcr-2017-223415. doi: 10.1136/bcr-2017-223415.

Posterior reversible encephalopathy syndrome due to hypercalcaemia: a rare cause.

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Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.


Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey et al in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism. She had seizures and visual defects on presentation which recovered completely with treatment of hypercalcemia.


calcium and bone; epilepsy and seizures; hypertension; neurological injury; unwanted effects / adverse reactions

[Indexed for MEDLINE]

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