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ArgBP2γ interacts with Akt and p21-activated kinase-1 and promotes cell survival.

Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22845. No abstract available.


A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.

Huang TY, Michael S, Xu T, Sarkeshik A, Moresco JJ, Yates JR 3rd, Masliah E, Bokoch GM, DerMardirossian C.

Mol Biol Cell. 2013 Feb;24(3):194-209. doi: 10.1091/mbc.E12-07-0565. Epub 2012 Dec 5.


The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic.

Pathak R, Delorme-Walker VD, Howell MC, Anselmo AN, White MA, Bokoch GM, Dermardirossian C.

Dev Cell. 2012 Aug 14;23(2):397-411. doi: 10.1016/j.devcel.2012.06.014.


Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1).

Gianni D, Nicolas N, Zhang H, Der Mardirossian C, Kister J, Martinez L, Ferguson J, Roush WR, Brown SJ, Bokoch GM, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 13 [updated 2011 Dec 12].


Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.

Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.

J Cell Biol. 2011 Jun 27;193(7):1289-303. doi: 10.1083/jcb.201010059.


c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.

Gianni D, Taulet N, DerMardirossian C, Bokoch GM.

Mol Biol Cell. 2010 Dec;21(23):4287-98. doi: 10.1091/mbc.E10-08-0685. Epub 2010 Oct 13.


A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.

Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H.

ACS Chem Biol. 2010 Oct 15;5(10):981-93. doi: 10.1021/cb100219n.


Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.

Gianni D, DerMardirossian C, Bokoch GM.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):164-71. doi: 10.1016/j.ejcb.2010.05.007. Epub 2010 Jul 6.


NADPH oxidases in innate immunity.

Bokoch GM.

J Innate Immun. 2009;1(6):507-8. doi: 10.1159/000235859. Epub 2009 Aug 27. No abstract available.


Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells.

Kim JS, Bokoch GM.

J Innate Immun. 2009;1(2):145-52. doi: 10.1159/000151481. Epub 2008 Aug 18.


Isolation and characterization of cytoplasmic cofilin-actin rods.

Minamide LS, Maiti S, Boyle JA, Davis RC, Coppinger JA, Bao Y, Huang TY, Yates J, Bokoch GM, Bamburg JR.

J Biol Chem. 2010 Feb 19;285(8):5450-60. doi: 10.1074/jbc.M109.063768. Epub 2009 Dec 17.


Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.

Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM.

Sci Signal. 2009 Sep 15;2(88):ra54. doi: 10.1126/scisignal.2000370.


p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.

Chang YC, Tien SC, Tien HF, Zhang H, Bokoch GM, Chang ZF.

Oncogene. 2009 Nov 19;28(46):4105-15. doi: 10.1038/onc.2009.260. Epub 2009 Aug 31.


Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2.

Zhang H, Sun C, Glogauer M, Bokoch GM.

J Immunol. 2009 Aug 15;183(4):2718-28. doi: 10.4049/jimmunol.0900849. Epub 2009 Jul 22.


Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2009 Sep;20(18):4070-82. doi: 10.1091/mbc.E09-01-0041. Epub 2009 Jul 22.


Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.

Bokoch GM, Diebold B, Kim JS, Gianni D.

Antioxid Redox Signal. 2009 Oct;11(10):2429-41. doi: 10.1089/ARS.2009.2590. Review.


Reactive oxygen species regulate a slingshot-cofilin activation pathway.

Kim JS, Huang TY, Bokoch GM.

Mol Biol Cell. 2009 Jun;20(11):2650-60. doi: 10.1091/mbc.E09-02-0131. Epub 2009 Apr 1.


Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.

Huang TY, Minamide LS, Bamburg JR, Bokoch GM.

Dev Cell. 2008 Nov;15(5):691-703. doi: 10.1016/j.devcel.2008.09.017.


Inactivation of rho GTPases by statins attenuates anthrax lethal toxin activity.

deCathelineau AM, Bokoch GM.

Infect Immun. 2009 Jan;77(1):348-59. doi: 10.1128/IAI.01005-08. Epub 2008 Oct 20.


FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.

Huber C, Mårtensson A, Bokoch GM, Nemazee D, Gavin AL.

J Biol Chem. 2008 Dec 5;283(49):34002-12. doi: 10.1074/jbc.M803957200. Epub 2008 Oct 6.


Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.

Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P.

J Mol Biol. 2008 Jul 25;380(5):828-43. doi: 10.1016/j.jmb.2008.05.024. Epub 2008 May 17.


The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.

Gianni D, Bohl B, Courtneidge SA, Bokoch GM.

Mol Biol Cell. 2008 Jul;19(7):2984-94. doi: 10.1091/mbc.E08-02-0138. Epub 2008 May 7.


Transduction of proteins into intact neutrophils.

Zhao T, Bokoch GM.

Methods Mol Biol. 2007;412:115-23. doi: 10.1007/978-1-59745-467-4_9.


Rac and Rap GTPase activation assays.

Knaus UG, Bamberg A, Bokoch GM.

Methods Mol Biol. 2007;412:59-67. doi: 10.1007/978-1-59745-467-4_5.


Neutrophil methods and protocols. Preface.

Quinn MT, DeLeo FR, Bokoch GM.

Methods Mol Biol. 2007;412:vii-viii. No abstract available.


PAK'n it in: identification of a selective PAK inhibitor.

Bokoch GM.

Chem Biol. 2008 Apr;15(4):305-6. doi: 10.1016/j.chembiol.2008.03.011.


Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

Birkenfeld J, Nalbant P, Yoon SH, Bokoch GM.

Trends Cell Biol. 2008 May;18(5):210-9. doi: 10.1016/j.tcb.2008.02.006. Epub 2008 Apr 3. Review.


Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism.

Kao YY, Gianni D, Bohl B, Taylor RM, Bokoch GM.

J Biol Chem. 2008 May 9;283(19):12736-46. doi: 10.1074/jbc.M801010200. Epub 2008 Mar 17.


GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.

Chang YC, Nalbant P, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2008 May;19(5):2147-53. doi: 10.1091/mbc.E07-12-1269. Epub 2008 Feb 20.


Regulation of hypoxic neuronal death signaling by neuroglobin.

Khan AA, Mao XO, Banwait S, DerMardirossian CM, Bokoch GM, Jin K, Greenberg DA.

FASEB J. 2008 Jun;22(6):1737-47. doi: 10.1096/fj.07-100784. Epub 2008 Jan 15.


Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.

Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG.

J Cell Physiol. 2008 Jun;215(3):715-24.


Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.

Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM.

Dev Cell. 2007 Nov;13(5):646-62.


Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.

Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM.

J Biol Chem. 2007 Nov 30;282(48):34787-800. Epub 2007 Oct 3.


Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.

Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA.

J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11.


GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.

Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM.

Dev Cell. 2007 May;12(5):699-712. Erratum in: Dev Cell. 2007 Jun;12(6):1007.


Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.

Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM.

J Leukoc Biol. 2007 Apr;81(4):1127-36. Epub 2007 Jan 16.


Regulation of the phagocyte NADPH oxidase by Rac GTPase.

Bokoch GM, Zhao T.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1533-48. Review.


Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.

DerMardirossian C, Rocklin G, Seo JY, Bokoch GM.

Mol Biol Cell. 2006 Nov;17(11):4760-8. Epub 2006 Aug 30.


Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development.

Belvindrah R, Nalbant P, Ding S, Wu C, Bokoch GM, Müller U.

Mol Cell Neurosci. 2006 Oct;33(2):109-25. Epub 2006 Aug 17.


Affinity-based assay of Rho guanosine triphosphatase activation.

Stofega M, DerMardirossian C, Bokoch GM.

Methods Mol Biol. 2006;332:269-79.


Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis.

Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M.

Blood. 2006 Oct 15;108(8):2814-20. Epub 2006 Jun 29.


Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity.

Crawford MA, Aylott CV, Bourdeau RW, Bokoch GM.

J Immunol. 2006 Jun 15;176(12):7557-65.


Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis.

Chang YC, Lee HH, Chen YJ, Bokoch GM, Chang ZF.

Cell Death Differ. 2006 Dec;13(12):2023-32. Epub 2006 Apr 7.


Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.

DeCathelineau AM, Bokoch GM.

Biochem J. 2006 Apr 1;395(1):e1-3.


Phosphorylation of RhoGDI by p21-activated kinase 1.

DerMardirossian CM, Bokoch GM.

Methods Enzymol. 2006;406:80-90.


Cofilin phosphatases and regulation of actin dynamics.

Huang TY, DerMardirossian C, Bokoch GM.

Curr Opin Cell Biol. 2006 Feb;18(1):26-31. Epub 2005 Dec 7. Review.


GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction.

Birukova AA, Adyshev D, Gorshkov B, Bokoch GM, Birukov KG, Verin AD.

Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L540-8. Epub 2005 Oct 28.


Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes.

Diebold BA, Bokoch GM.

Curr Top Microbiol Immunol. 2005;291:91-111. Review.


GDIs: central regulatory molecules in Rho GTPase activation.

DerMardirossian C, Bokoch GM.

Trends Cell Biol. 2005 Jul;15(7):356-63. Review.


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