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Items: 1 to 50 of 109

1.

Corrigendum to "Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1" [J Mol Cell Cardiol 125 (2018) 195-204].

Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Müller FU, Neumann J, Schulte JS, Schulte K, Seidl MD, Boknik P.

J Mol Cell Cardiol. 2019 Nov 9. pii: S0022-2828(19)30214-7. doi: 10.1016/j.yjmcc.2019.10.007. [Epub ahead of print] No abstract available.

PMID:
31718792
2.

Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors.

Boknik P, Drzewiecki K, Eskandar J, Gergs U, Hofmann B, Treede H, Grote-Wessels S, Fabritz L, Kirchhof P, Fortmüller L, Müller FU, Schmitz W, Zimmermann N, Kirchhefer U, Neumann J.

Front Pharmacol. 2019 Sep 18;10:1051. doi: 10.3389/fphar.2019.01051. eCollection 2019.

3.

Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1.

Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Müller FU, Neumann J, Schulte K, Seidl MD, Boknik P, Schulte JS.

J Mol Cell Cardiol. 2018 Dec;125:195-204. doi: 10.1016/j.yjmcc.2018.10.022. Epub 2018 Oct 31. Erratum in: J Mol Cell Cardiol. 2019 Nov 9;:.

PMID:
30389400
4.

Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.

Puhl SL, Weeks KL, Güran A, Ranieri A, Boknik P, Kirchhefer U, Müller FU, Avkiran M.

Cardiovasc Res. 2019 Mar 1;115(3):519-529. doi: 10.1093/cvr/cvy230.

5.

Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy.

Bögeholz N, Pauls P, Bauer BK, Schulte JS, Frommeyer G, Dechering DG, Boknik P, Kirchhefer U, Müller FU, Pott C, Eckardt L.

Fundam Clin Pharmacol. 2019 Feb;33(1):43-51. doi: 10.1111/fcp.12404. Epub 2018 Aug 30.

PMID:
30092622
6.

Corrigendum to 'Impaired Ca2+ cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction' [J. Mol. Cell. Cardiol. 119 (2018) 28-39].

Kronenbitter A, Funk F, Hackert K, Gorreßen S, Glaser D, Boknik P, Poschmann G, Stühler K, Isić M, Krüger M, Schmitt JP.

J Mol Cell Cardiol. 2018 Aug;121:304. doi: 10.1016/j.yjmcc.2018.06.004. Epub 2018 Jun 12. No abstract available.

PMID:
29907408
7.

Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells.

Krause T, Grote-Wessels S, Balzer F, Boknik P, Gergs U, Kirchhefer U, Buchwalow IB, Müller FU, Schmitz W, Neumann J.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):859-873. doi: 10.1007/s00210-018-1515-3. Epub 2018 May 24.

PMID:
29797049
8.

Impaired Ca2+ cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction.

Kronenbitter A, Funk F, Hackert K, Gorreßen S, Glaser D, Boknik P, Poschmann G, Stühler K, Isić M, Krüger M, Schmitt JP.

J Mol Cell Cardiol. 2018 Jun;119:28-39. doi: 10.1016/j.yjmcc.2018.04.004. Epub 2018 Apr 16. Erratum in: J Mol Cell Cardiol. 2018 Aug;121:304.

PMID:
29674140
9.

Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors.

Boknik P, Drzewiecki K, Eskandar J, Gergs U, Grote-Wessels S, Fabritz L, Kirchhof P, Müller FU, Stümpel F, Schmitz W, Zimmermann N, Kirchhefer U, Neumann J.

Front Pharmacol. 2018 Jan 22;9:13. doi: 10.3389/fphar.2018.00013. eCollection 2018.

10.

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.

Krysiak J, Unger A, Beckendorf L, Hamdani N, von Frieling-Salewsky M, Redfield MM, Dos Remedios CG, Sheikh F, Gergs U, Boknik P, Linke WA.

Nat Commun. 2018 Jan 17;9(1):262. doi: 10.1038/s41467-017-02483-3.

11.

Unbalanced upregulation of ryanodine receptor 2 plays a particular role in early development of daunorubicin cardiomyopathy.

Kucerova D, Doka G, Kruzliak P, Turcekova K, Kmecova J, Brnoliakova Z, Kyselovic J, Kirchhefer U, Müller FU, Krenek P, Boknik P, Klimas J.

Am J Transl Res. 2015 Jul 15;7(7):1280-94. eCollection 2015.

12.

Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat.

Matus M, Kucerova D, Kruzliak P, Adameova A, Doka G, Turcekova K, Kmecova J, Kyselovic J, Krenek P, Kirchhefer U, Mueller FU, Boknik P, Klimas J.

Mol Cell Biochem. 2015 May;403(1-2):199-208. doi: 10.1007/s11010-015-2350-1. Epub 2015 Feb 8.

PMID:
25663023
13.

Overexpression of protein phosphatase 2A in a murine model of chronic myocardial infarction leads to increased adverse remodeling but restores the regulation of β-catenin by glycogen synthase kinase 3β.

Hoehn M, Zhang Y, Xu J, Gergs U, Boknik P, Werdan K, Neumann J, Ebelt H.

Int J Cardiol. 2015 Mar 15;183:39-46. doi: 10.1016/j.ijcard.2015.01.087. Epub 2015 Jan 29.

PMID:
25662052
14.

Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.

Kirchhefer U, Brekle C, Eskandar J, Isensee G, Kučerová D, Müller FU, Pinet F, Schulte JS, Seidl MD, Boknik P.

J Biol Chem. 2014 Dec 5;289(49):33862-73. doi: 10.1074/jbc.M114.598938. Epub 2014 Oct 15.

15.

Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.

Kirchhefer U, Heinick A, König S, Kristensen T, Müller FU, Seidl MD, Boknik P.

J Biol Chem. 2014 Jan 3;289(1):163-76. doi: 10.1074/jbc.M113.507996. Epub 2013 Nov 13.

16.

Autonomic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: biochemical evidence of altered signaling pathways.

Paul M, Meyborg M, Boknik P, Gergs U, Gerss J, Schmitz W, Breithardt G, Wichter T, Neumann J.

Pacing Clin Electrophysiol. 2014 Feb;37(2):173-8. doi: 10.1111/pace.12237. Epub 2013 Sep 11.

PMID:
24025189
17.

Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches.

Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, Kattner L, El-Armouche A, Eschenhagen T.

J Biomol Screen. 2013 Sep;18(8):899-909. doi: 10.1177/1087057113486000. Epub 2013 Apr 19.

PMID:
23606651
18.

Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2008-17. doi: 10.1152/ajpheart.00457.2011. Epub 2012 Mar 16.

19.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.

Wijnker PJ, Boknik P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJ, van der Velden J, Kirchhefer U.

J Muscle Res Cell Motil. 2011 Nov;32(3):221-33. doi: 10.1007/s10974-011-9261-x. Epub 2011 Sep 30.

20.

Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways.

Paul M, Meyborg M, Boknik P, Gergs U, Schmitz W, Breithardt G, Wichter T, Neumann J.

Pacing Clin Electrophysiol. 2011 Sep;34(9):1147-53. doi: 10.1111/j.1540-8159.2011.03127.x. Epub 2011 May 23.

PMID:
21605134
21.

Modulation of cardiac contractility by serine/threonine protein phosphatase type 5.

Gergs U, Boknik P, Buchwalow IB, Fabritz L, Gründker N, Kucerova D, Matus M, Werner F, Schmitz W, Neumann J.

Int J Cardiol. 2012 Jan 26;154(2):116-21. doi: 10.1016/j.ijcard.2010.09.009. Epub 2010 Sep 28.

PMID:
20875921
22.

Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.

Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S.

Circ Arrhythm Electrophysiol. 2010 Oct;3(5):530-41. doi: 10.1161/CIRCEP.109.933036. Epub 2010 Jul 26.

PMID:
20660541
23.

Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium.

Boknik P, Grote-Wessels S, Barteska G, Jiang M, Müller FU, Schmitz W, Neumann J, Birnbaumer L.

Br J Pharmacol. 2009 Nov;158(6):1557-64. doi: 10.1111/j.1476-5381.2009.00441.x.

24.

Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.

Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U.

J Mol Cell Cardiol. 2009 Mar;46(3):385-94. doi: 10.1016/j.yjmcc.2008.11.012. Epub 2008 Nov 27.

PMID:
19100271
25.

A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts.

Gergs U, Boknik P, Schmitz W, Simm A, Silber RE, Neumann J.

Naunyn Schmiedebergs Arch Pharmacol. 2009 May;379(5):533-40. doi: 10.1007/s00210-008-0374-8. Epub 2008 Nov 27.

PMID:
19037631
26.

Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.

Schwoerer AP, Neuber C, Schmechel A, Melnychenko I, Mearini G, Boknik P, Kirchhefer U, Schmitz W, Ehmke H, Eschenhagen T, El-Armouche A.

J Mol Cell Cardiol. 2008 Dec;45(6):846-52. doi: 10.1016/j.yjmcc.2008.09.003. Epub 2008 Sep 20.

PMID:
18848565
27.

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.

Brüchert N, Mavila N, Boknik P, Baba HA, Fabritz L, Gergs U, Kirchhefer U, Kirchhof P, Matus M, Schmitz W, DePaoli-Roach AA, Neumann J.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1539-46. doi: 10.1152/ajpheart.00515.2008. Epub 2008 Aug 8.

28.

Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure.

Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S.

Circ Arrhythm Electrophysiol. 2008 Jun 1;1(2):93-102. doi: 10.1161/CIRCEP.107.754788. Epub 2008 Apr 30.

PMID:
19808399
29.

Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.

Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U.

Cardiovasc Res. 2008 Aug 1;79(3):464-71. doi: 10.1093/cvr/cvn113. Epub 2008 May 3.

PMID:
18453636
30.

A positive inotropic effect of ATP in the human cardiac atrium.

Gergs U, Boknik P, Schmitz W, Simm A, Silber RE, Neumann J.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1716-23. doi: 10.1152/ajpheart.00945.2007. Epub 2008 Feb 8.

31.

Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation.

Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug;375(6):383-92. Epub 2007 Jun 26.

PMID:
17593353
32.

Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin.

Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schäfers M, Hermann S, Boknik P, Schmitz W, Breithardt G, Kirchhefer U, Neumann J.

J Mol Cell Cardiol. 2007 May;42(5):962-71. Epub 2007 Mar 7.

PMID:
17408688
33.

Reduced expression of Ca2+-regulating proteins in the upper gastrointestinal tract of patients with achalasia.

Fischer H, Fischer J, Boknik P, Gergs U, Schmitz W, Domschke W, Konturek JW, Neumann J.

World J Gastroenterol. 2006 Oct 7;12(37):6002-7.

34.

Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.

El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D.

Circulation. 2006 Aug 15;114(7):670-80. Epub 2006 Aug 7.

PMID:
16894034
35.

Reduced serine-16 and threonine-17 phospholamban phosphorylation in stunning of conscious dogs: no evidence for any involvement of protein kinase A or protein phosphatases.

Weber T, Neumann J, Meissner A, Grosse Hartlage M, Van Aken H, Hanske G, Schmitz W, Boknik P.

Basic Res Cardiol. 2006 May;101(3):253-60. Epub 2005 Dec 23.

PMID:
16369730
36.

Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.

Kirchhefer U, Baba HA, Bokník P, Breeden KM, Mavila N, Brüchert N, Justus I, Matus M, Schmitz W, Depaoli-Roach AA, Neumann J.

Cardiovasc Res. 2005 Oct 1;68(1):98-108.

PMID:
15975567
37.

Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.

Müller FU, Lewin G, Baba HA, Bokník P, Fabritz L, Kirchhefer U, Kirchhof P, Loser K, Matus M, Neumann J, Riemann B, Schmitz W.

J Biol Chem. 2005 Feb 25;280(8):6906-14. Epub 2004 Nov 29.

38.

L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases.

Christ T, Boknik P, Wöhrl S, Wettwer E, Graf EM, Bosch RF, Knaut M, Schmitz W, Ravens U, Dobrev D.

Circulation. 2004 Oct 26;110(17):2651-7. Epub 2004 Oct 18.

PMID:
15492323
39.

Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function.

Gergs U, Boknik P, Buchwalow I, Fabritz L, Matus M, Justus I, Hanske G, Schmitz W, Neumann J.

J Biol Chem. 2004 Sep 24;279(39):40827-34. Epub 2004 Jul 6.

40.

Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors.

Fabritz L, Kirchhof P, Fortmüller L, Auchampach JA, Baba HA, Breithardt G, Neumann J, Boknik P, Schmitz W.

Cardiovasc Res. 2004 Jun 1;62(3):500-8.

41.

Expression and functional role of serine/threonine phosphatases in rat esophagus.

van der Voort IR, Knapp J, Konturek JW, Boknik P, Domschke W, Schmitz W, Neumann J.

Med Sci Monit. 2004 May;10(5):BR123-9. Epub 2004 Apr 28.

PMID:
15114259
42.

Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts.

El-Armouche A, Jaeckel E, Boheler KR, Boknik P, Hertle B, Neumann J, Eschenhagen T.

Biochem Biophys Res Commun. 2004 May 21;318(1):219-26.

PMID:
15110776
43.

Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists.

Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B, Schmitz W, Stypmann J, Neumann J.

Cardiovasc Res. 2004 Apr 1;62(1):122-34.

PMID:
15023559
44.

Altered signal transduction in cardiac ventricle overexpressing A(1)-adenosine receptors.

Neumann J, Boknik P, Begrow F, Hanske G, Justus I, Mát'us M, Reinke U, Matherne GP, Schmitz W.

Cardiovasc Res. 2003 Dec 1;60(3):529-37.

PMID:
14659798
45.

Gastroprotection by vitamin C--a heme oxygenase-1-dependent mechanism?

Becker JC, Grosser N, Boknik P, Schröder H, Domschke W, Pohle T.

Biochem Biophys Res Commun. 2003 Dec 12;312(2):507-12.

PMID:
14637166
46.

Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor.

Kirchhof P, Fabritz L, Fortmuller L, Matherne GP, Lankford A, Baba HA, Schmitz W, Breithardt G, Neumann J, Boknik P.

Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H145-53. Epub 2003 Mar 13.

47.

Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors.

Neumann J, Boknik P, Matherne GP, Lankford A, Schmitz W.

Br J Pharmacol. 2003 Jan;138(1):209-17.

48.

Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes.

El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann WH, Jäckel E, Harding SE, Boknik P, Neumann J, Eschenhagen T.

FASEB J. 2003 Mar;17(3):437-9. Epub 2003 Jan 2.

PMID:
12514122
49.

Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice.

Pierkes M, Gambaryan S, Bokník P, Lohmann SM, Schmitz W, Potthast R, Holtwick R, Kuhn M.

Cardiovasc Res. 2002 Mar;53(4):852-61.

PMID:
11922895
50.

Functional properties of the rat phosphatase 1alpha promoter.

Linck B, Boknik P, Knapp J, Kikuchi K, Lüss H, Müller FU, Nomoto K, Neumann J, Schmitz W.

Mol Cell Biochem. 2001 Jul;223(1-2):123-9.

PMID:
11681713

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