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PKA facilitates relaxation of mouse ileum via phosphorylation of neuronal NO synthase.

Guerra DD, Bok R, Lorca RA, Hurt KJ.

Br J Pharmacol. 2020 Jan 23. doi: 10.1111/bph.15001. [Epub ahead of print]


Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.

Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR.

Oncotarget. 2019 Oct 22;10(58):6096-6110. doi: 10.18632/oncotarget.27225. eCollection 2019 Oct 22.


Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.

Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB.

Prostate Cancer Prostatic Dis. 2019 Nov 4. doi: 10.1038/s41391-019-0180-z. [Epub ahead of print]


Adiponectin links maternal metabolism to uterine contractility.

Vyas V, Guerra DD, Bok R, Powell T, Jansson T, Hurt KJ.

FASEB J. 2019 Dec;33(12):14588-14601. doi: 10.1096/fj.201901646R. Epub 2019 Oct 30.


First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.

Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB.

J Magn Reson. 2019 Dec;309:106617. doi: 10.1016/j.jmr.2019.106617. Epub 2019 Oct 8.


Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum.

Guerra DD, Bok R, Vyas V, Orlicky DJ, Lorca RA, Hurt KJ.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17541-17546. doi: 10.1073/pnas.1905902116. Epub 2019 Aug 12.


Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.

Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR.

Chemistry. 2019 Sep 12;25(51):11842-11846. doi: 10.1002/chem.201902771. Epub 2019 Aug 20.


Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.

Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB.

IEEE Trans Med Imaging. 2019 Jul 2. doi: 10.1109/TMI.2019.2926437. [Epub ahead of print]


Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.

Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR.

Magn Reson Med. 2019 Sep;82(3):959-972. doi: 10.1002/mrm.27780. Epub 2019 May 3.


Hyperpolarized 13C MRI: State of the Art and Future Directions.

Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB.

Radiology. 2019 May;291(2):273-284. doi: 10.1148/radiol.2019182391. Epub 2019 Mar 5.


The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.

Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P.

Cancers (Basel). 2019 Feb 22;11(2). pii: E257. doi: 10.3390/cancers11020257.


Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging.

Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ.

NMR Biomed. 2019 Mar;32(3):e4052. doi: 10.1002/nbm.4052. Epub 2019 Jan 21.


Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.

Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB.

Magn Reson Med. 2019 Apr;81(4):2702-2709. doi: 10.1002/mrm.27549. Epub 2018 Oct 30.


Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport.

Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ.

Magn Reson Med. 2019 Mar;81(3):2001-2010. doi: 10.1002/mrm.27501. Epub 2018 Oct 28.


A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13 C MRI.

Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ.

Magn Reson Med. 2019 Feb;81(2):839-851. doi: 10.1002/mrm.27391. Epub 2018 Sep 18.


Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients.

Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB.

NMR Biomed. 2018 Nov;31(11):e3997. doi: 10.1002/nbm.3997. Epub 2018 Sep 19.


Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI.

Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ.

Cancers (Basel). 2018 Sep 5;10(9). pii: E313. doi: 10.3390/cancers10090313.


Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.

Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J.

NMR Biomed. 2019 Oct;32(10):e3962. doi: 10.1002/nbm.3962. Epub 2018 Jul 18.


Na+-Leak Channel, Non-Selective (NALCN) Regulates Myometrial Excitability and Facilitates Successful Parturition.

Reinl EL, Zhao P, Wu W, Ma X, Amazu C, Bok R, Hurt KJ, Wang Y, England SK.

Cell Physiol Biochem. 2018;48(2):503-515. doi: 10.1159/000491805. Epub 2018 Jul 18.


Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models.

Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ.

IEEE Trans Med Imaging. 2018 Dec;37(12):2603-2612. doi: 10.1109/TMI.2018.2844246. Epub 2018 Jun 5.


Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.

Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR.

Chem Commun (Camb). 2018 May 17;54(41):5233-5236. doi: 10.1039/c8cc02246a.


Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer.

Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB.

Magn Reson Med. 2018 Nov;80(5):2062-2072. doi: 10.1002/mrm.27179. Epub 2018 Mar 25.


Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ.

Magn Reson Med. 2018 Sep;80(3):864-873. doi: 10.1002/mrm.27077. Epub 2018 Jan 10. No abstract available.


Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.

Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB.

Magn Reson Imaging. 2017 Nov;43:105-109. doi: 10.1016/j.mri.2017.07.014. Epub 2017 Jul 15.


Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion.

Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB.

Cancer Res. 2017 Jun 15;77(12):3207-3216. doi: 10.1158/0008-5472.CAN-16-2083. Epub 2017 Apr 20.


Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis.

Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR.

Sci Rep. 2017 Apr 20;7:46014. doi: 10.1038/srep46014.


Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver.

Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA.

J Magn Reson Imaging. 2018 Jan;47(1):141-151. doi: 10.1002/jmri.25721. Epub 2017 Apr 17.


Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.

Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB.

Magn Reson Imaging. 2017 May;38:152-162. doi: 10.1016/j.mri.2017.01.003. Epub 2017 Jan 7.


Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.

Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M.

Magn Reson Med. 2017 Jan;77(1):65-73. doi: 10.1002/mrm.26525. Epub 2016 Nov 17.


Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.

Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB.

Magn Reson Med. 2017 Sep;78(3):963-975. doi: 10.1002/mrm.26480. Epub 2016 Oct 21.


Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB.

Tomography. 2016 Jun;2(2):125-135.


Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism.

Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D.

Magn Reson Med. 2017 Jun;77(6):2356-2363. doi: 10.1002/mrm.26296. Epub 2016 Jun 14.


Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NFκB-Dependent Mechanism.

McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ.

J Innate Immun. 2016;8(4):386-99. doi: 10.1159/000445541. Epub 2016 Apr 29.


Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.

von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB.

Magn Reson Med. 2017 Apr;77(4):1429-1437. doi: 10.1002/mrm.26245. Epub 2016 Apr 21.


Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain.

Chen Y, Kim H, Bok R, Sukumar S, Mu X, Sheldon RA, Barkovich AJ, Ferriero DM, Xu D.

Dev Neurosci. 2016;38(1):34-40. doi: 10.1159/000439271. Epub 2015 Nov 10.


Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.

Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM.

Chem Commun (Camb). 2015 Sep 25;51(74):14119-22. doi: 10.1039/c5cc05348j.


Hyperpolarized [(13)C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms.

von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J.

Magn Reson Med. 2016 May;75(5):1894-900. doi: 10.1002/mrm.25716. Epub 2015 Jun 8.


Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.

Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ.

Magn Reson Med. 2015 Sep;74(3):622-633. doi: 10.1002/mrm.25422. Epub 2014 Sep 11.


Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.

Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ.

Diabetes. 2015 Feb;64(2):344-52. doi: 10.2337/db13-1829. Epub 2014 Sep 3.


A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging.

Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE.

Magn Reson Med. 2015 Aug;74(2):506-12. doi: 10.1002/mrm.25427. Epub 2014 Aug 22.


Simultaneous multiagent hyperpolarized (13)C perfusion imaging.

von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB.

Magn Reson Med. 2014 Dec;72(6):1599-609. doi: 10.1002/mrm.25071. Epub 2013 Dec 31.


Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.

Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ.

Magn Reson Med. 2014 Jan;71(1):19-25. doi: 10.1002/mrm.25003. Epub 2013 Nov 11.


High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects.

Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Hong Shang, Larson PE, Kurhanewicz J, Vigneron DB.

IEEE Trans Med Imaging. 2014 Feb;33(2):362-71. doi: 10.1109/TMI.2013.2285120. Epub 2013 Oct 25.


Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.

Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA.

Sci Transl Med. 2013 Aug 14;5(198):198ra108. doi: 10.1126/scitranslmed.3006070.


Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.

Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB.

Magn Reson Med. 2014 Jan;71(1):1-11. doi: 10.1002/mrm.24634. Epub 2013 Feb 14.


Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI).

Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB.

J Magn Reson Imaging. 2013 Sep;38(3):701-13. doi: 10.1002/jmri.23989. Epub 2013 Jan 4.


Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer.

Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB.

Magn Reson Imaging. 2013 Jun;31(5):635-42. doi: 10.1016/j.mri.2012.10.020. Epub 2012 Dec 21.


Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer.

Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB.

Magn Reson Imaging. 2013 May;31(4):490-6. doi: 10.1016/j.mri.2012.09.002. Epub 2012 Oct 27.


Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T.

von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB.

Magn Reson Imaging. 2013 Feb;31(2):163-70. doi: 10.1016/j.mri.2012.06.037. Epub 2012 Aug 13.


Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.

Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ.

Magn Reson Med. 2013 Jul;70(1):33-9. doi: 10.1002/mrm.24434. Epub 2012 Jul 31.

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