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Items: 19


Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.

Ting PY, Parker AE, Lee JS, Trussell C, Sharif O, Luna F, Federe G, Barnes SW, Walker JR, Vance J, Gao MY, Klock HE, Clarkson S, Russ C, Miraglia LJ, Cooke MP, Boitano AE, McNamara P, Lamb J, Schmedt C, Snead JL.

Nat Methods. 2018 Nov;15(11):941-946. doi: 10.1038/s41592-018-0149-1. Epub 2018 Oct 8.


A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery.

Joslin J, Gilligan J, Anderson P, Garcia C, Sharif O, Hampton J, Cohen S, King M, Zhou B, Jiang S, Trussell C, Dunn R, Fathman JW, Snead JL, Boitano AE, Nguyen T, Conner M, Cooke M, Harris J, Ainscow E, Zhou Y, Shaw C, Sipes D, Mainquist J, Lesley S.

SLAS Discov. 2018 Aug;23(7):697-707. doi: 10.1177/2472555218773086. Epub 2018 May 29.


Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft.

Wagner JE Jr, Brunstein CG, Boitano AE, DeFor TE, McKenna D, Sumstad D, Blazar BR, Tolar J, Le C, Jones J, Cooke MP, Bleul CC.

Cell Stem Cell. 2016 Jan 7;18(1):144-55. doi: 10.1016/j.stem.2015.10.004. Epub 2015 Dec 5.


Advances in umbilical cord blood manipulation-from niche to bedside.

Lund TC, Boitano AE, Delaney CS, Shpall EJ, Wagner JE.

Nat Rev Clin Oncol. 2015 Mar;12(3):163-74. doi: 10.1038/nrclinonc.2014.215. Epub 2014 Dec 16. Review.


Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells.

de Lichtervelde L, Boitano AE, Wang Y, Krastel P, Petersen F, Cooke MP, Schultz PG.

ACS Chem Biol. 2013 May 17;8(5):866-70. doi: 10.1021/cb4000234. Epub 2013 Mar 15.


Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.

de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG.

Chem Biol. 2012 Aug 24;19(8):994-1000. doi: 10.1016/j.chembiol.2012.06.010.


An image-based screen identifies a small molecule regulator of megakaryopoiesis.

Boitano AE, de Lichtervelde L, Snead JL, Cooke MP, Schultz PG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23. doi: 10.1073/pnas.1212545109. Epub 2012 Aug 13.


Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.

Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW.

Cell Stem Cell. 2012 Feb 3;10(2):218-29. doi: 10.1016/j.stem.2012.01.003.


Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.

Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson WH, Kolluri SK, Cooke MP, Perdew GH.

J Pharmacol Exp Ther. 2011 Jul;338(1):318-27. doi: 10.1124/jpet.110.178392. Epub 2011 Apr 14.


Small-molecule regulators of human stem cell self-renewal.

Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG.

Chembiochem. 2011 Apr 11;12(6):854-7. doi: 10.1002/cbic.201000734. Epub 2011 Mar 4. No abstract available.


Chemical control of stem cell fate and developmental potential.

Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jan 3;50(1):200-42. doi: 10.1002/anie.201004284. Review.


Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP.

Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664.


Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW Jr, Glick GD.

Biochem Pharmacol. 2009 Oct 15;78(8):966-73. doi: 10.1016/j.bcp.2009.05.025. Epub 2009 May 27.


Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax.

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW Jr, Glick GD.

Free Radic Biol Med. 2008 Nov 1;45(9):1232-42. doi: 10.1016/j.freeradbiomed.2008.07.022. Epub 2008 Aug 3.


A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin.

Varani J, Bhagavathula N, Nerusu KC, Sherzer H, Fay K, Boitano AE, Glick GD, Johnson K, Kang S, Opipari AW Jr.

J Pharmacol Exp Ther. 2005 Apr;313(1):56-63. Epub 2004 Dec 2.


A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.

Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW Jr.

J Biol Chem. 2004 Jul 9;279(28):29615-21. Epub 2004 May 3.


Resveratrol-induced autophagocytosis in ovarian cancer cells.

Opipari AW Jr, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR.

Cancer Res. 2004 Jan 15;64(2):696-703.


Constitutively active NFkappa B is required for the survival of S-type neuroblastoma.

Bian X, Opipari AW Jr, Ratanaproeksa AB, Boitano AE, Lucas PC, Castle VP.

J Biol Chem. 2002 Nov 1;277(44):42144-50. Epub 2002 Aug 26.


Use of kinetic isotope effects to delineate the role of phenylalanine 87 in P450(BM-3).

Rock DA, Boitano AE, Wahlstrom JL, Rock DA, Jones JP.

Bioorg Chem. 2002 Apr;30(2):107-18.


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