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Items: 1 to 50 of 529

1.

Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation.

Okur MN, Lee JH, Osmani W, Kimura R, Demarest TG, Croteau DL, Bohr VA.

Nucleic Acids Res. 2020 Jan 23. pii: gkz1242. doi: 10.1093/nar/gkz1242. [Epub ahead of print]

PMID:
31970402
2.

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome.

Okur MN, Mao B, Kimura R, Haraczy S, Fitzgerald T, Edwards-Hollingsworth K, Tian J, Osmani W, Croteau DL, Kelley MW, Bohr VA.

NPJ Aging Mech Dis. 2020 Jan 7;6:1. doi: 10.1038/s41514-019-0040-z. eCollection 2020.

3.

Mitophagy and DNA damage signaling in human aging.

Babbar M, Basu S, Yang B, Croteau DL, Bohr VA.

Mech Ageing Dev. 2020 Jan 7;186:111207. doi: 10.1016/j.mad.2020.111207. [Epub ahead of print]

PMID:
31923475
4.

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications.

Aman Y, Frank J, Lautrup SH, Matysek A, Niu Z, Yang G, Shi L, Bergersen LH, Storm-Mathisen J, Rasmussen LJ, Bohr VA, Nilsen H, Fang EF.

Mech Ageing Dev. 2020 Jan;185:111194. doi: 10.1016/j.mad.2019.111194. Epub 2019 Dec 5.

PMID:
31812486
5.

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.

Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA.

Nat Commun. 2019 Nov 21;10(1):5284. doi: 10.1038/s41467-019-13172-8.

6.

Lamin A/C promotes DNA base excision repair.

Maynard S, Keijzers G, Akbari M, Ezra MB, Hall A, Morevati M, Scheibye-Knudsen M, Gonzalo S, Bartek J, Bohr VA.

Nucleic Acids Res. 2019 Dec 16;47(22):11709-11728. doi: 10.1093/nar/gkz912.

PMID:
31647095
7.

Ageing as a risk factor for neurodegenerative disease.

Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA.

Nat Rev Neurol. 2019 Oct;15(10):565-581. doi: 10.1038/s41582-019-0244-7. Epub 2019 Sep 9. Review.

PMID:
31501588
8.

Mitochondria in the signaling pathways that control longevity and health span.

Akbari M, Kirkwood TBL, Bohr VA.

Ageing Res Rev. 2019 Sep;54:100940. doi: 10.1016/j.arr.2019.100940. Epub 2019 Aug 12. Review.

9.

Corrigendum to "Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair" [DNA Repair 79 (2019) 22-31].

Ghosh D, Bohr VA, Karmakar P.

DNA Repair (Amst). 2019 Nov;83:102671. doi: 10.1016/j.dnarep.2019.102671. Epub 2019 Jul 18. No abstract available.

PMID:
31327581
10.

Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions.

Chimienti G, Pesce V, Fracasso F, Russo F, de Souza-Pinto NC, Bohr VA, Lezza AMS.

Int J Mol Sci. 2019 Jul 5;20(13). pii: E3302. doi: 10.3390/ijms20133302.

11.

Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging.

Lee JH, Demarest TG, Babbar M, Kim EW, Okur MN, De S, Croteau DL, Bohr VA.

Nucleic Acids Res. 2019 Sep 19;47(16):8548-8562. doi: 10.1093/nar/gkz568.

12.

Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy.

Park Y, Chui MH, Suryo Rahmanto Y, Yu ZC, Shamanna RA, Bellani MA, Gaillard S, Ayhan A, Viswanathan A, Seidman MM, Franco S, Leung AKL, Bohr VA, Shih IM, Wang TL.

Clin Cancer Res. 2019 Sep 15;25(18):5584-5594. doi: 10.1158/1078-0432.CCR-18-4222. Epub 2019 Jun 13.

PMID:
31196855
13.

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.

Yang B, Figueroa DM, Hou Y, Babbar M, Baringer SL, Croteau DL, Bohr VA.

Free Radic Biol Med. 2019 Sep;141:47-58. doi: 10.1016/j.freeradbiomed.2019.05.037. Epub 2019 Jun 5.

PMID:
31175982
14.

Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair.

Ghosh D, Bohr VA, Karmakar P.

DNA Repair (Amst). 2019 Jul;79:22-31. doi: 10.1016/j.dnarep.2019.04.010. Epub 2019 May 3. Erratum in: DNA Repair (Amst). 2019 Jul 18;:102671.

PMID:
31085421
15.

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells.

Zheng J, Croteau DL, Bohr VA, Akbari M.

Nucleic Acids Res. 2019 May 7;47(8):4086-4110. doi: 10.1093/nar/gkz083.

16.

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.

Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP.

Nat Neurosci. 2019 May;22(5):719-728. doi: 10.1038/s41593-019-0372-9. Epub 2019 Apr 1.

17.

Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.

PMID:
30822397
18.

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA.

Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11.

19.

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).

Sommers JA, Kulikowicz T, Croteau DL, Dexheimer T, Dorjsuren D, Jadhav A, Maloney DJ, Simeonov A, Bohr VA, Brosh RM Jr.

PLoS One. 2019 Jan 9;14(1):e0210525. doi: 10.1371/journal.pone.0210525. eCollection 2019.

20.

Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins.

Iyama T, Okur MN, Golato T, McNeill DR, Lu H, Hamilton R, Raja A, Bohr VA, Wilson DM 3rd.

Sci Rep. 2018 Nov 30;8(1):17490. doi: 10.1038/s41598-018-36027-6.

21.

Toward understanding genomic instability, mitochondrial dysfunction and aging.

Fakouri NB, Hou Y, Demarest TG, Christiansen LS, Okur MN, Mohanty JG, Croteau DL, Bohr VA.

FEBS J. 2019 Mar;286(6):1058-1073. doi: 10.1111/febs.14663. Epub 2018 Oct 8. Review.

PMID:
30238623
22.

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia).

Fang EF, Froetscher L, Scheibye-Knudsen M, Bohr VA, Wong JH, Ng TB.

Curr Protein Pept Sci. 2019;20(3):296-301. doi: 10.2174/1389203719666180622095800. Review.

23.

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.

Baptiste BA, Katchur SR, Fivenson EM, Croteau DL, Rumsey WL, Bohr VA.

Free Radic Biol Med. 2018 Aug 20;124:149-162. doi: 10.1016/j.freeradbiomed.2018.05.094. Epub 2018 Jun 5.

24.

Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.

Maity J, Das B, Bohr VA, Karmakar P.

DNA Repair (Amst). 2018 Aug;68:1-11. doi: 10.1016/j.dnarep.2018.05.003. Epub 2018 May 18.

25.

Multiple RPAs make WRN syndrome protein a superhelicase.

Lee M, Shin S, Uhm H, Hong H, Kirk J, Hyun K, Kulikowicz T, Kim J, Ahn B, Bohr VA, Hohng S.

Nucleic Acids Res. 2018 May 18;46(9):4689-4698. doi: 10.1093/nar/gky272.

26.

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.

27.

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ.

Sci Rep. 2018 Mar 6;8(1):4245. doi: 10.1038/s41598-018-20586-9.

28.

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.

29.

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.

Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA.

J Vis Exp. 2017 Nov 22;(129). doi: 10.3791/56301.

30.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

Lu H, Shamanna RA, de Freitas JK, Okur M, Khadka P, Kulikowicz T, Holland PP, Tian J, Croteau DL, Davis AJ, Bohr VA.

Nat Commun. 2017 Dec 11;8(1):2039. doi: 10.1038/s41467-017-02146-3.

31.

Recent Advances in Understanding Werner Syndrome.

Shamanna RA, Croteau DL, Lee JH, Bohr VA.

F1000Res. 2017 Sep 28;6:1779. doi: 10.12688/f1000research.12110.1. eCollection 2017. Review.

32.

Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ.

Sci Rep. 2017 Oct 2;7(1):12480. doi: 10.1038/s41598-017-12662-3. Erratum in: Sci Rep. 2018 Mar 6;8(1):4245.

33.

NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.

Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Review.

PMID:
28899755
34.

Sarcopenia, Aging and Prospective Interventional Strategies.

Waltz TB, Fivenson EM, Morevati M, Li C, Becker KG, Bohr VA, Fang EF.

Curr Med Chem. 2018;25(40):5588-5596. doi: 10.2174/0929867324666170801095850. Review.

35.

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.

Rahnasto-Rilla MK, McLoughlin P, Kulikowicz T, Doyle M, Bohr VA, Lahtela-Kakkonen M, Ferrucci L, Hayes M, Moaddel R.

Mar Drugs. 2017 Jun 21;15(6). pii: E190. doi: 10.3390/md15060190.

36.

DNA Polymerase Beta Participates in Mitochondrial DNA Repair.

Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00237-17. doi: 10.1128/MCB.00237-17. Print 2017 Aug 15.

37.

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG.

Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208.

38.

NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB.

Lee JY, Lake RJ, Kirk J, Bohr VA, Fan HY, Hohng S.

Nucleic Acids Res. 2017 May 5;45(8):4696-4707. doi: 10.1093/nar/gkx188.

39.

Mitophagy in neurodegeneration and aging.

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF.

Neurochem Int. 2017 Oct;109:202-209. doi: 10.1016/j.neuint.2017.02.007. Epub 2017 Feb 21. Review.

40.

DNA damage responses in central nervous system and age-associated neurodegeneration.

Hegde ML, Bohr VA, Mitra S.

Mech Ageing Dev. 2017 Jan;161(Pt A):1-3. doi: 10.1016/j.mad.2017.01.010. No abstract available.

41.

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF.

Trends Neurosci. 2017 Mar;40(3):151-166. doi: 10.1016/j.tins.2017.01.002. Epub 2017 Feb 9. Review.

42.

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.

Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA.

Nucleic Acids Res. 2017 Feb 17;45(3):1566. doi: 10.1093/nar/gkw1216.

43.

NAD+ in DNA repair and mitochondrial maintenance.

Croteau DL, Fang EF, Nilsen H, Bohr VA.

Cell Cycle. 2017 Mar 19;16(6):491-492. doi: 10.1080/15384101.2017.1285631. Epub 2017 Feb 1. No abstract available.

44.

NAD+: The convergence of DNA repair and mitophagy.

Fang EF, Bohr VA.

Autophagy. 2017 Feb;13(2):442-443. doi: 10.1080/15548627.2016.1257467. Epub 2016 Dec 8.

45.

Human RECQL1 participates in telomere maintenance.

Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA.

Nucleic Acids Res. 2017 Mar 17;45(5):2935. doi: 10.1093/nar/gkw1217. No abstract available.

46.

WRN regulates pathway choice between classical and alternative non-homologous end joining.

Shamanna RA, Lu H, de Freitas JK, Tian J, Croteau DL, Bohr VA.

Nat Commun. 2016 Dec 6;7:13785. doi: 10.1038/ncomms13785.

47.

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. Epub 2016 Oct 18.

48.

Cockayne syndrome: Clinical features, model systems and pathways.

Karikkineth AC, Scheibye-Knudsen M, Fivenson E, Croteau DL, Bohr VA.

Ageing Res Rev. 2017 Jan;33:3-17. doi: 10.1016/j.arr.2016.08.002. Epub 2016 Aug 6. Review.

49.

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.

50.

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.

Misiak M, Vergara Greeno R, Baptiste BA, Sykora P, Liu D, Cordonnier S, Fang EF, Croteau DL, Mattson MP, Bohr VA.

Aging Cell. 2017 Feb;16(1):162-172. doi: 10.1111/acel.12541. Epub 2016 Sep 30.

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