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Items: 24

1.

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.

Bornholdt ZA, Herbert AS, Mire CE, He S, Cross RW, Wec AZ, Abelson DM, Geisbert JB, James RM, Rahim MN, Zhu W, Borisevich V, Banadyga L, Gunn BM, Agans KN, Wirchnianski AS, Goodwin E, Tierney K, Shestowsky WS, Bohorov O, Bohorova N, Velasco J, Ailor E, Kim D, Pauly MH, Whaley KJ, Alter G, Walker LM, Chandran K, Zeitlin L, Qiu X, Geisbert TW, Dye JM.

Cell Host Microbe. 2019 Jan 9;25(1):49-58.e5. doi: 10.1016/j.chom.2018.12.005.

PMID:
30629918
2.

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.

Wec AZ, Bornholdt ZA, He S, Herbert AS, Goodwin E, Wirchnianski AS, Gunn BM, Zhang Z, Zhu W, Liu G, Abelson DM, Moyer CL, Jangra RK, James RM, Bakken RR, Bohorova N, Bohorov O, Kim DH, Pauly MH, Velasco J, Bortz RH 3rd, Whaley KJ, Goldstein T, Anthony SJ, Alter G, Walker LM, Dye JM, Zeitlin L, Qiu X, Chandran K.

Cell Host Microbe. 2019 Jan 9;25(1):39-48.e5. doi: 10.1016/j.chom.2018.12.004.

PMID:
30629917
3.

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin.

Roy CJ, Ehrbar DJ, Bohorova N, Bohorov O, Kim D, Pauly M, Whaley K, Rong Y, Torres-Velez FJ, Vitetta ES, Didier PJ, Doyle-Meyers L, Zeitlin L, Mantis NJ.

JCI Insight. 2019 Jan 10;4(1). pii: 124771. doi: 10.1172/jci.insight.124771. [Epub ahead of print]

4.

Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.

Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE Jr, Zeitlin L, Geisbert TW.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8711. doi: 10.1126/scitranslmed.aai8711.

5.

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Van Slyke G, Sully EK, Bohorova N, Bohorov O, Kim D, Pauly MH, Whaley KJ, Zeitlin L, Mantis NJ.

Clin Vaccine Immunol. 2016 Sep 6;23(9):795-9. doi: 10.1128/CVI.00088-16. Print 2016 Sep.

6.

Monoclonal antibody therapy for Junin virus infection.

Zeitlin L, Geisbert JB, Deer DJ, Fenton KA, Bohorov O, Bohorova N, Goodman C, Kim D, Hiatt A, Pauly MH, Velasco J, Whaley KJ, Altmann F, Gruber C, Steinkellner H, Honko AN, Kuehne AI, Aman MJ, Sahandi S, Enterlein S, Zhan X, Enria D, Geisbert TW.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4458-63. doi: 10.1073/pnas.1600996113. Epub 2016 Apr 4.

7.

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.

Johnson RF, Bagci U, Keith L, Tang X, Mollura DJ, Zeitlin L, Qin J, Huzella L, Bartos CJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Paulty MH, Velasco J, Whaley KJ, Johnson JC, Pettitt J, Ork BL, Solomon J, Oberlander N, Zhu Q, Sun J, Holbrook MR, Olinger GG, Baric RS, Hensley LE, Jahrling PB, Marasco WA.

Virology. 2016 Mar;490:49-58. doi: 10.1016/j.virol.2016.01.004. Epub 2016 Jan 30.

8.

Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

Levinson KJ, Giffen SR, Pauly MH, Kim DH, Bohorov O, Bohorova N, Whaley KJ, Zeitlin L, Mantis NJ.

J Immunol Methods. 2015 Jul;422:111-7. doi: 10.1016/j.jim.2015.04.001. Epub 2015 Apr 9.

9.

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Sully EK, Whaley K, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly M, Velasco J, Holtsberg FW, Stavale E, Aman MJ, Tangudu C, Uzal FA, Mantis NJ, Zeitlin L.

Toxicon. 2014 Dec 15;92:36-41. doi: 10.1016/j.toxicon.2014.09.006. Epub 2014 Sep 28.

10.

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.

Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J, Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L, Kobinger GP.

Nature. 2014 Oct 2;514(7520):47-53. doi: 10.1038/nature13777. Epub 2014 Aug 29.

11.

Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana.

Garcia JP, Beingesser J, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Roy CJ, Uzal FA.

Toxicon. 2014 Sep;88:93-8. doi: 10.1016/j.toxicon.2014.06.012. Epub 2014 Jun 17.

12.

Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy.

Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ, Piedra PA, Gilbert BE, Zeitlin L.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5992-7. doi: 10.1073/pnas.1402458111. Epub 2014 Apr 7.

13.

Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ.

Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.

14.

Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model.

Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE Jr, Piedra PA, Gilbert BE.

MAbs. 2013 Mar-Apr;5(2):263-9. doi: 10.4161/mabs.23281. Epub 2013 Feb 8.

15.

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant.

Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ, Olinger GG.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20690-4. doi: 10.1073/pnas.1108360108. Epub 2011 Dec 5.

16.

Rapid high yield production of different glycoforms of Ebola virus monoclonal antibody.

Castilho A, Bohorova N, Grass J, Bohorov O, Zeitlin L, Whaley K, Altmann F, Steinkellner H.

PLoS One. 2011;6(10):e26040. doi: 10.1371/journal.pone.0026040. Epub 2011 Oct 24.

17.

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems.

Pogue GP, Vojdani F, Palmer KE, Hiatt E, Hume S, Phelps J, Long L, Bohorova N, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Garger SJ, White E, Bai Y, Haydon H, Bratcher B.

Plant Biotechnol J. 2010 Jun;8(5):638-54. Review.

18.
19.

Accumulation, assembly, and digestibility of amarantin expressed in transgenic tropical maize.

Rascón-Cruz Q, Sinagawa-García S, Osuna-Castro JA, Bohorova N, Paredes-López O.

Theor Appl Genet. 2004 Jan;108(2):335-42. Epub 2003 Oct 2.

PMID:
14523523
20.

Production of transgenic tropical maize with cryIAb and cryIAc genes via microprojectile bombardment of immature embryos.

Bohorova N, Zhang W, Julstrom P, McLean S, Luna B, Brito RM, Diaz L, Ramos ME, Estanol P, Pacheco M, Salgado M, Hoisington D.

Theor Appl Genet. 1999 Aug;99(3-4):437-44. doi: 10.1007/s001220051255. Erratum in: Theor Appl Genet. 2012 Jun;125(1):197.

PMID:
22665176
21.

Type II callus production and plant regeneration in tropical maize genotypes.

Carvalho CHS, Bohorova N, Bordallo PN, Abreu LL, Valicente FH, Bressan W, Paiva E.

Plant Cell Rep. 1997 Nov;17(1):73-76. doi: 10.1007/s002990050355.

PMID:
30732424
22.

Plant regeneration from immature embryos of 48 elite CIMMYT bread wheats.

Fennell S, Bohorova N, van Ginkel M, Crossa J, Hoisington D.

Theor Appl Genet. 1996 Feb;92(2):163-9. doi: 10.1007/BF00223371.

PMID:
24166163
23.

Molecular analysis of a new cytoplasmic male sterile genotype in sunflower.

Spassova M, Christov M, Bohorova N, Petrov P, Dudov K, Atanassov A, Nijkamp HJ, Hille J.

FEBS Lett. 1992 Feb 3;297(1-2):159-63.

24.

Isolation, culture and callus regeneration of protoplasts of wild and cultivated Helianthus species.

Bohorova NE, Cocking EC, Power JB.

Plant Cell Rep. 1986 Aug;5(4):256-8. doi: 10.1007/BF00269815.

PMID:
24248240

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