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Items: 22

1.

Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis.

Schuster S, Bohnert JA, Vavra M, Rossen JW, Kern WV.

Molecules. 2019 Jan 29;24(3). pii: E470. doi: 10.3390/molecules24030470.

2.

Impact of antibiotic administration on blood culture positivity at the beginning of sepsis: a prospective clinical cohort study.

Scheer CS, Fuchs C, Gründling M, Vollmer M, Bast J, Bohnert JA, Zimmermann K, Hahnenkamp K, Rehberg S, Kuhn SO.

Clin Microbiol Infect. 2019 Mar;25(3):326-331. doi: 10.1016/j.cmi.2018.05.016. Epub 2018 Jun 4.

PMID:
29879482
3.

Simple Ciprofloxacin Resistance Test and Determination of Minimal Inhibitory Concentration within 2 h Using Raman Spectroscopy.

Kirchhoff J, Glaser U, Bohnert JA, Pletz MW, Popp J, Neugebauer U.

Anal Chem. 2018 Feb 6;90(3):1811-1818. doi: 10.1021/acs.analchem.7b03800. Epub 2018 Jan 11.

PMID:
29260541
4.

Optimized efflux assay for the NorA multidrug efflux pump in Staphylococcus aureus.

Zimmermann S, Tuchscherr L, Rödel J, Löffler B, Bohnert JA.

J Microbiol Methods. 2017 Nov;142:39-40. doi: 10.1016/j.mimet.2017.09.001. Epub 2017 Sep 5.

PMID:
28887002
5.

Evaluation of loop-mediated isothermal amplification for the rapid identification of bacteria and resistance determinants in positive blood cultures.

Rödel J, Bohnert JA, Stoll S, Wassill L, Edel B, Karrasch M, Löffler B, Pfister W.

Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):1033-1040. doi: 10.1007/s10096-016-2888-1. Epub 2017 Jan 6.

PMID:
28063000
6.

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay.

Bohnert JA, Schuster S, Kern WV, Karcz T, Olejarz A, Kaczor A, Handzlik J, Kieć-Kononowicz K.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):1974-83. doi: 10.1128/AAC.01995-15. Print 2016 Apr.

7.
8.

Three Dimensional Checkerboard Synergy Analysis of Colistin, Meropenem, Tigecycline against Multidrug-Resistant Clinical Klebsiella pneumonia Isolates.

Stein C, Makarewicz O, Bohnert JA, Pfeifer Y, Kesselmeier M, Hagel S, Pletz MW.

PLoS One. 2015 Jun 11;10(6):e0126479. doi: 10.1371/journal.pone.0126479. eCollection 2015.

9.

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors.

Schuster S, Kohler S, Buck A, Dambacher C, König A, Bohnert JA, Kern WV.

Antimicrob Agents Chemother. 2014 Nov;58(11):6870-8. doi: 10.1128/AAC.03775-14. Epub 2014 Sep 2.

10.

Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli.

Bohnert JA, Schuster S, Kern WV.

Open Microbiol J. 2013;7:83-6. doi: 10.2174/1874285801307010083. Epub 2013 Mar 22.

11.

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.

Eicher T, Cha HJ, Seeger MA, Brandstätter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grütter MG, Diederichs K, Pos KM.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5687-92. doi: 10.1073/pnas.1114944109. Epub 2012 Mar 26.

12.

Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli.

Bohnert JA, Szymaniak-Vits M, Schuster S, Kern WV.

J Antimicrob Chemother. 2011 Sep;66(9):2057-60. doi: 10.1093/jac/dkr258. Epub 2011 Jun 23.

PMID:
21700628
13.

Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2'-dinaphthylamine efflux assay.

Bohnert JA, Schuster S, Szymaniak-Vits M, Kern WV.

PLoS One. 2011;6(6):e21196. doi: 10.1371/journal.pone.0021196. Epub 2011 Jun 15.

14.

Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates.

Bohnert JA, Karamian B, Nikaido H.

Antimicrob Agents Chemother. 2010 Sep;54(9):3770-5. doi: 10.1128/AAC.00620-10. Epub 2010 Jul 6.

15.

Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.

Wehmeier C, Schuster S, Fähnrich E, Kern WV, Bohnert JA.

Antimicrob Agents Chemother. 2009 Jan;53(1):329-30. doi: 10.1128/AAC.00921-08. Epub 2008 Oct 20. No abstract available.

16.

Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

Bohnert JA, Schuster S, Seeger MA, Fähnrich E, Pos KM, Kern WV.

J Bacteriol. 2008 Dec;190(24):8225-9. doi: 10.1128/JB.00912-08. Epub 2008 Oct 10.

17.

Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).

Bohnert JA, Schuster S, Fähnrich E, Trittler R, Kern WV.

J Antimicrob Chemother. 2007 Jun;59(6):1216-22. Epub 2006 Oct 24.

PMID:
17062614
18.

Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation.

Schumacher A, Trittler R, Bohnert JA, Kümmerer K, Pagès JM, Kern WV.

J Antimicrob Chemother. 2007 Jun;59(6):1261-4. Epub 2006 Sep 13.

PMID:
16971414
19.

Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide.

Pannek S, Higgins PG, Steinke P, Jonas D, Akova M, Bohnert JA, Seifert H, Kern WV.

J Antimicrob Chemother. 2006 May;57(5):970-4. Epub 2006 Mar 10.

PMID:
16531429
20.

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli.

Kern WV, Steinke P, Schumacher A, Schuster S, von Baum H, Bohnert JA.

J Antimicrob Chemother. 2006 Feb;57(2):339-43. Epub 2005 Dec 14.

PMID:
16354747
21.

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli.

Schumacher A, Steinke P, Bohnert JA, Akova M, Jonas D, Kern WV.

J Antimicrob Chemother. 2006 Feb;57(2):344-8. Epub 2005 Dec 14.

PMID:
16354746
22.

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