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Items: 1 to 50 of 95

1.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.

PMID:
31002797
2.

BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.

Chatterjee N, Bohmann D.

Bioessays. 2018 May;40(5):e1800007. doi: 10.1002/bies.201800007. Epub 2018 Mar 30. Review.

PMID:
29603290
3.

Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.

Li X, Eberhardt A, Hansen JN, Bohmann D, Li H, Schor NF.

FASEB J. 2017 Jun;31(6):2327-2339. doi: 10.1096/fj.201601050RR. Epub 2017 Feb 17.

PMID:
28213359
4.

An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lep(ob) /Lep(ob) mouse.

Bhaskar V, Goldfine ID, Gerstner R, Michelson K, Tran C, Nonet G, Bohmann D, Pongo E, Zhao J, Horwitz AH, Takeuchi T, White M, Corbin JA.

Obesity (Silver Spring). 2016 Aug;24(8):1687-94. doi: 10.1002/oby.21539. Epub 2016 Jun 21.

5.

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D.

PLoS Genet. 2016 May 27;12(5):e1006072. doi: 10.1371/journal.pgen.1006072. eCollection 2016 May.

6.

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.

Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D.

Sci Rep. 2016 Feb 25;6:21455. doi: 10.1038/srep21455.

7.

Mechanisms and functions of Nrf2 signaling in Drosophila.

Pitoniak A, Bohmann D.

Free Radic Biol Med. 2015 Nov;88(Pt B):302-313. doi: 10.1016/j.freeradbiomed.2015.06.020. Epub 2015 Jun 25. Review.

8.

Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann.

Bohmann D, Dhillon P.

Dis Model Mech. 2014 May;7(5):499-502. doi: 10.1242/dmm.016329. No abstract available.

9.

Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.

Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP.

Aging Cell. 2013 Oct;12(5):802-13. doi: 10.1111/acel.12111. Epub 2013 Jun 28.

10.
11.

Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm.

Levy R, Ahluwalia K, Bohmann DJ, Giang HM, Schwimmer LJ, Issafras H, Reddy NB, Chan C, Horwitz AH, Takeuchi T.

J Immunol Methods. 2013 Aug 30;394(1-2):10-21. doi: 10.1016/j.jim.2013.04.010. Epub 2013 Apr 23.

12.

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D.

Aging Cell. 2013 Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.

13.

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Tsakiri EN, Sykiotis GP, Papassideri IS, Gorgoulis VG, Bohmann D, Trougakos IP.

FASEB J. 2013 Jun;27(6):2407-20. doi: 10.1096/fj.12-221408. Epub 2013 Mar 1.

14.

Discovery of diverse and functional antibodies from large human repertoire antibody libraries.

Schwimmer LJ, Huang B, Giang H, Cotter RL, Chemla-Vogel DS, Dy FV, Tam EM, Zhang F, Toy P, Bohmann DJ, Watson SR, Beaber JW, Reddy N, Kuan HF, Bedinger DH, Rondon IJ.

J Immunol Methods. 2013 May 31;391(1-2):60-71. doi: 10.1016/j.jim.2013.02.010. Epub 2013 Feb 27.

15.

A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.

Chatterjee N, Bohmann D.

PLoS One. 2012;7(4):e34063. doi: 10.1371/journal.pone.0034063. Epub 2012 Apr 11.

16.

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

Barone MC, Sykiotis GP, Bohmann D.

Dis Model Mech. 2011 Sep;4(5):701-7. doi: 10.1242/dmm.007575. Epub 2011 Jun 30.

17.

c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.

Schreck I, Al-Rawi M, Mingot JM, Scholl C, Diefenbacher ME, O'Donnell P, Bohmann D, Weiss C.

Biochem Biophys Res Commun. 2011 Apr 22;407(4):735-40. doi: 10.1016/j.bbrc.2011.03.092. Epub 2011 Mar 31.

PMID:
21439937
18.

Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.

Hochmuth CE, Biteau B, Bohmann D, Jasper H.

Cell Stem Cell. 2011 Feb 4;8(2):188-99. doi: 10.1016/j.stem.2010.12.006.

19.

Computational systems biology of aging.

Kriete A, Lechner M, Clearfield D, Bohmann D.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):414-28. doi: 10.1002/wsbm.126. Epub 2010 Dec 31. Review.

PMID:
21197651
20.

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.

Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D.

Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):41-8. doi: 10.1097/MCO.0b013e32834136f2. Review.

21.

Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

Roell MK, Issafras H, Bauer RJ, Michelson KS, Mendoza N, Vanegas SI, Gross LM, Larsen PD, Bedinger DH, Bohmann DJ, Nonet GH, Liu N, Lee SR, Handa M, Kantak SS, Horwitz AH, Hunter JJ, Owyang AM, Mirza AM, Corbin JA, White ML.

J Biol Chem. 2010 Jul 2;285(27):20607-14. doi: 10.1074/jbc.M110.115790. Epub 2010 Apr 21.

22.

Stress-activated cap'n'collar transcription factors in aging and human disease.

Sykiotis GP, Bohmann D.

Sci Signal. 2010 Mar 9;3(112):re3. doi: 10.1126/scisignal.3112re3. Review.

23.

Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.

Wang Q, Uhlirova M, Bohmann D.

Dev Cell. 2010 Jan 19;18(1):157-64. doi: 10.1016/j.devcel.2009.11.004.

24.

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.

Sekyrova P, Bohmann D, Jindra M, Uhlirova M.

Development. 2010 Jan;137(1):141-50. doi: 10.1242/dev.037861.

25.

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy.

Wu H, Wang MC, Bohmann D.

Mech Dev. 2009 Aug-Sep;126(8-9):624-37. doi: 10.1016/j.mod.2009.06.1082. Epub 2009 Jun 18.

26.

Development of XPA067.06, a potent high affinity human anti-gastrin monoclonal antibody.

Hsu SJ, Patel A, Larsen PD, Bohmann DJ, Bauer RJ, Ma JK, Masat L, Roell M, Babuka SJ, Hansen RK, White M, Haak-Frendscho M.

Biochem Pharmacol. 2008 Aug 1;76(3):340-52. doi: 10.1016/j.bcp.2008.05.015. Epub 2008 May 24.

PMID:
18589401
27.

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila.

Sykiotis GP, Bohmann D.

Dev Cell. 2008 Jan;14(1):76-85. doi: 10.1016/j.devcel.2007.12.002.

28.

Connecting up the pathways in Drosophila development.

Riesgo-Escovar JR, Hafen E, Hou XS, Goldstein ES, Perrimon N, Glise B, Noselli S, Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D.

Trends Cell Biol. 1997 Nov;7(11):421-2. No abstract available.

PMID:
17708993
29.

Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.

Luo X, Puig O, Hyun J, Bohmann D, Jasper H.

EMBO J. 2007 Jan 24;26(2):380-90. Epub 2006 Dec 21.

30.

JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.

Uhlirova M, Bohmann D.

EMBO J. 2006 Nov 15;25(22):5294-304. Epub 2006 Nov 2.

31.

Control of G2/M transition by Drosophila Fos.

Hyun J, Bécam I, Yanicostas C, Bohmann D.

Mol Cell Biol. 2006 Nov;26(22):8293-302. Epub 2006 Sep 11.

32.

Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users.

Katsamba PS, Navratilova I, Calderon-Cacia M, Fan L, Thornton K, Zhu M, Bos TV, Forte C, Friend D, Laird-Offringa I, Tavares G, Whatley J, Shi E, Widom A, Lindquist KC, Klakamp S, Drake A, Bohmann D, Roell M, Rose L, Dorocke J, Roth B, Luginbühl B, Myszka DG.

Anal Biochem. 2006 May 15;352(2):208-21. Epub 2006 Feb 23.

PMID:
16564019
33.

Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.

Miotto B, Sagnier T, Berenger H, Bohmann D, Pradel J, Graba Y.

Genes Dev. 2006 Jan 1;20(1):101-12.

34.

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.

Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D.

Dev Dyn. 2006 Feb;235(2):427-34.

35.

Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.

Uhlirova M, Jasper H, Bohmann D.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13123-8. Epub 2005 Sep 6.

36.
37.

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons.

Etter PD, Narayanan R, Navratilova Z, Patel C, Bohmann D, Jasper H, Ramaswami M.

BMC Neurosci. 2005 Jun 2;6:39.

38.
39.

Small flies--big discoveries: nearly a century of Drosophila genetics and development.

Letsou A, Bohmann D.

Dev Dyn. 2005 Mar;232(3):526-8. Review. No abstract available.

40.

Toward the computable transcriptome.

Portman DS, Bohmann D.

Mol Cell. 2004 Jun 18;14(6):693-4. Review.

41.

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.

Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J.

EMBO J. 2004 Mar 10;23(5):1133-43. Epub 2004 Feb 19.

42.

Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis.

Weiss C, Bohmann D.

Cell Cycle. 2004 Feb;3(2):111-3. Review.

PMID:
14712066
43.
44.

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.

Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D.

EMBO J. 2003 Jul 15;22(14):3686-95.

45.

Drosophila innate immunity: a genomic view of pathogen defense.

Jasper H, Bohmann D.

Mol Cell. 2002 Nov;10(5):967-9. Review. No abstract available.

46.

A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.

Jasper H, Benes V, Atzberger A, Sauer S, Ansorge W, Bohmann D.

Dev Cell. 2002 Oct;3(4):511-21.

47.

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation.

Gallo A, Cuozzo C, Esposito I, Maggiolini M, Bonofiglio D, Vivacqua A, Garramone M, Weiss C, Bohmann D, Musti AM.

Oncogene. 2002 Sep 19;21(42):6434-45.

48.

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

Lafarga M, Berciano MT, Pena E, Mayo I, Castaño JG, Bohmann D, Rodrigues JP, Tavanez JP, Carmo-Fonseca M.

Mol Biol Cell. 2002 Aug;13(8):2771-82.

49.

Transrepression of AP-1 by nuclear receptors in Drosophila.

Gritzan U, Weiss C, Brennecke J, Bohmann D.

Mech Dev. 2002 Jul;115(1-2):91-100.

50.

An essential function of AP-1 heterodimers in Drosophila development.

Ciapponi L, Bohmann D.

Mech Dev. 2002 Jul;115(1-2):35-40.

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