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CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.

Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K.

Stem Cells. 2019 Jul;37(7):958-972. doi: 10.1002/stem.3012. Epub 2019 Apr 23.


AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.

Pollard AE, Martins L, Muckett PJ, Khadayate S, Bornot A, Clausen M, Admyre T, Bjursell M, Fiadeiro R, Wilson L, Whilding C, Kotiadis VN, Duchen MR, Sutton D, Penfold L, Sardini A, Bohlooly-Y M, Smith DM, Read JA, Snowden MA, Woods A, Carling D.

Nat Metab. 2019 Mar;1(3):340-349. doi: 10.1038/s42255-019-0036-9. Epub 2019 Feb 25. No abstract available.


Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.

Johanns M, Kviklyte S, Chuang SJ, Corbeels K, Jacobs R, Herinckx G, Vertommen D, Schakman O, Duparc T, Cani PD, Bouzin C, Andersén H, Bohlooly-Y M, Van der Schueren B, Oscarsson J, Rider MH.

Mol Genet Metab. 2019 Apr;126(4):377-387. doi: 10.1016/j.ymgme.2019.01.017. Epub 2019 Feb 14.


Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.

Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad P, Romeo S.

Mol Metab. 2019 Apr;22:49-61. doi: 10.1016/j.molmet.2019.01.013. Epub 2019 Feb 5.


In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.

Carreras A, Pane LS, Nitsch R, Madeyski-Bengtson K, Porritt M, Akcakaya P, Taheri-Ghahfarokhi A, Ericson E, Bjursell M, Perez-Alcazar M, Seeliger F, Althage M, Knöll R, Hicks R, Mayr LM, Perkins R, Lindén D, Borén J, Bohlooly-Y M, Maresca M.

BMC Biol. 2019 Jan 15;17(1):4. doi: 10.1186/s12915-018-0624-2.


In vivo CRISPR editing with no detectable genome-wide off-target mutations.

Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK.

Nature. 2018 Sep;561(7723):416-419. doi: 10.1038/s41586-018-0500-9. Epub 2018 Sep 12.


Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons.

Robbins JP, Perfect L, Ribe EM, Maresca M, Dangla-Valls A, Foster EM, Killick R, Nowosiad P, Reid MJ, Polit LD, Nevado AJ, Ebner D, Bohlooly-Y M, Buckley N, Pangalos MN, Price J, Lovestone S.

Front Neurosci. 2018 Jul 25;12:504. doi: 10.3389/fnins.2018.00504. eCollection 2018.


Decoding non-random mutational signatures at Cas9 targeted sites.

Taheri-Ghahfarokhi A, Taylor BJM, Nitsch R, Lundin A, Cavallo AL, Madeyski-Bengtson K, Karlsson F, Clausen M, Hicks R, Mayr LM, Bohlooly-Y M, Maresca M.

Nucleic Acids Res. 2018 Sep 19;46(16):8417-8434. doi: 10.1093/nar/gky653.


Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice.

Jung C, Wernly B, Bjursell M, Wiseman J, Admyre T, Wikström J, Palmér M, Seeliger F, Lichtenauer M, Franz M, Frick C, Andersson AK, Elg M, Pernow J, Sjöquist PO, Bohlooly-Y M, Wang QD.

J Card Fail. 2018 Jul;24(7):470-478. doi: 10.1016/j.cardfail.2018.05.004. Epub 2018 May 23.


Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype.

Bjursell M, Porritt MJ, Ericson E, Taheri-Ghahfarokhi A, Clausen M, Magnusson L, Admyre T, Nitsch R, Mayr L, Aasehaug L, Seeliger F, Maresca M, Bohlooly-Y M, Wiseman J.

EBioMedicine. 2018 Mar;29:104-111. doi: 10.1016/j.ebiom.2018.02.015. Epub 2018 Feb 19.


ADAMTS-1 in abdominal aortic aneurysm.

Vorkapic E, Folkesson M, Magnell K, Bohlooly-Y M, Länne T, Wågsäter D.

PLoS One. 2017 Jun 1;12(6):e0178729. doi: 10.1371/journal.pone.0178729. eCollection 2017.


Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet.

Woods A, Williams JR, Muckett PJ, Mayer FV, Liljevald M, Bohlooly-Y M, Carling D.

Cell Rep. 2017 Mar 28;18(13):3043-3051. doi: 10.1016/j.celrep.2017.03.011.


Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.

Kviklyte S, Vertommen D, Yerna X, Andersén H, Xu X, Gailly P, Bohlooly-Y M, Oscarsson J, Rider MH.

Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E48-E62. doi: 10.1152/ajpendo.00304.2016. Epub 2017 Mar 21.


Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation.

Bjursell M, Ryberg E, Wu T, Greasley PJ, Bohlooly-Y M, Hjorth S.

PLoS One. 2016 Dec 12;11(12):e0167965. doi: 10.1371/journal.pone.0167965. eCollection 2016.


Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.


Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.

Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E.

Toxicol Pathol. 2016 Apr;44(3):346-57. doi: 10.1177/0192623315609688. Epub 2015 Oct 27. Review.


Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.

Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F.

Peptides. 2016 Mar;77:16-20. doi: 10.1016/j.peptides.2015.06.012. Epub 2015 Jul 2.


The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120.

Bjursell M, Xu X, Admyre T, Böttcher G, Lundin S, Nilsson R, Stone VM, Morgan NG, Lam YY, Storlien LH, Lindén D, Smith DM, Bohlooly-Y M, Oscarsson J.

PLoS One. 2014 Dec 26;9(12):e114942. doi: 10.1371/journal.pone.0114942. eCollection 2014.


Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle.

Plaideau C, Lai YC, Kviklyte S, Zanou N, Löfgren L, Andersén H, Vertommen D, Gailly P, Hue L, Bohlooly-Y M, Hallén S, Rider MH.

Chem Biol. 2014 Nov 20;21(11):1497-1510. doi: 10.1016/j.chembiol.2014.09.013.


Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

Lelliott CJ, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, Patterson L, Mumphrey MB, Bjursell M, Gorman T, Bohlooly-Y M, Buchanan A, Harrison P, Vaughan T, Berthoud HR, Lindén D.

PLoS One. 2014 Nov 26;9(11):e112109. doi: 10.1371/journal.pone.0112109. eCollection 2014.


Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.

Lindgren A, Levin M, Rodrigo Blomqvist S, Wikström J, Ahnmark A, Mogensen C, Böttcher G, Bohlooly-Y M, Borén J, Gan LM, Lindén D.

PLoS One. 2013 Nov 12;8(11):e80330. doi: 10.1371/journal.pone.0080330. eCollection 2013.


11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.

Harno E, Cottrell EC, Yu A, DeSchoolmeester J, Gutierrez PM, Denn M, Swales JG, Goldberg FW, Bohlooly-Y M, Andersén H, Wild MJ, Turnbull AV, Leighton B, White A.

Endocrinology. 2013 Dec;154(12):4580-93. doi: 10.1210/en.2013-1613. Epub 2013 Oct 29.


Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.

Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6.


Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice.

Bogazzi F, Raggi F, Russo D, Bohlooly-Y M, Sardella C, Urbani C, Lombardi M, Manetti L, Lupi I, Tornell J, Martino E.

Endocrinology. 2013 Nov;154(11):4226-36. doi: 10.1210/en.2013-1220. Epub 2013 Aug 2.


11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male mice.

Harno E, Cottrell EC, Keevil BG, DeSchoolmeester J, Bohlooly-Y M, Andersén H, Turnbull AV, Leighton B, White A.

Endocrinology. 2013 Oct;154(10):3599-609. doi: 10.1210/en.2013-1362. Epub 2013 Jul 5.


The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.

Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS.

Science. 2013 Aug 2;341(6145):569-73. doi: 10.1126/science.1241165. Epub 2013 Jul 4.


Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH.

Bjursell M, Wedin M, Admyre T, Hermansson M, Böttcher G, Göransson M, Lindén D, Bamberg K, Oscarsson J, Bohlooly-Y M.

PLoS One. 2013 May 20;8(5):e64721. doi: 10.1371/journal.pone.0064721. Print 2013.


Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.

Chen L, Yang G, Xu X, Grant G, Lawson JA, Bohlooly-Y M, FitzGerald GA.

Circulation. 2013 Jan 15;127(2):233-43. doi: 10.1161/CIRCULATIONAHA.112.119479. Epub 2012 Nov 30.


Local overexpression of GH and GH/IGF1 effects in the adult mouse hippocampus.

Walser M, Samà MT, Wickelgren R, Aberg M, Bohlooly-Y M, Olsson B, Törnell J, Isgaard J, Aberg ND.

J Endocrinol. 2012 Nov;215(2):257-68. doi: 10.1530/JOE-12-0077. Epub 2012 Aug 23.


Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice.

Frank E, Wu Y, Piyaratna N, Body WJ, Snikeris P, South T, Gerdin AK, Bjursell M, Bohlooly-Y M, Storlien L, Huang XF.

PLoS One. 2012;7(8):e42395. doi: 10.1371/journal.pone.0042395. Epub 2012 Aug 7.


Over-expression of Adamts1 in mice alters bone mineral density.

Hu L, Jonsson KB, Andersén H, Edenro A, Bohlooly-Y M, Melhus H, Lind T.

J Bone Miner Metab. 2012 May;30(3):304-11. doi: 10.1007/s00774-011-0322-4. Epub 2011 Oct 15.


SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor.

Vinolo MA, Ferguson GJ, Kulkarni S, Damoulakis G, Anderson K, Bohlooly-Y M, Stephens L, Hawkins PT, Curi R.

PLoS One. 2011;6(6):e21205. doi: 10.1371/journal.pone.0021205. Epub 2011 Jun 15.


Cardiac extrinsic apoptotic pathway is silent in young but activated in elder mice overexpressing bovine GH: interplay with the intrinsic pathway.

Bogazzi F, Russo D, Raggi F, Bohlooly-Y M, Tornell J, Sardella C, Lombardi M, Urbani C, Manetti L, Brogioni S, Martino E.

J Endocrinol. 2011 Aug;210(2):231-8. doi: 10.1530/JOE-10-0402. Epub 2011 May 12.


Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet.

Bjursell M, Admyre T, Göransson M, Marley AE, Smith DM, Oscarsson J, Bohlooly-Y M.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E211-20. doi: 10.1152/ajpendo.00229.2010. Epub 2010 Oct 19.


Ghrelin increases intake of rewarding food in rodents.

Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL.

Addict Biol. 2010 Jul;15(3):304-11. doi: 10.1111/j.1369-1600.2010.00216.x. Epub 2010 May 6.


Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.

Egecioglu E, Ploj K, Xu X, Bjursell M, Salomé N, Andersson N, Ohlsson C, Taube M, Hansson C, Bohlooly-Y M, Morgan DG, Dickson SL.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E708-16. doi: 10.1152/ajpendo.91022.2008. Epub 2009 Jul 7.


The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice.

Yazdi M, Ahnmark A, William-Olsson L, Snaith M, Turner N, Osla F, Wedin M, Asztély AK, Elmgren A, Bohlooly-Y M, Schreyer S, Lindén D.

Biochem Biophys Res Commun. 2008 May 16;369(4):1065-70. doi: 10.1016/j.bbrc.2008.02.156. Epub 2008 Mar 11.


Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice.

Bjursell M, Gerdin AK, Lelliott CJ, Egecioglu E, Elmgren A, Törnell J, Oscarsson J, Bohlooly-Y M.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E251-60. Epub 2007 Nov 20.


GPR10 deficiency in mice results in altered energy expenditure and obesity.

Bjursell M, Lennerås M, Göransson M, Elmgren A, Bohlooly-Y M.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):633-8. Epub 2007 Sep 18.


Opposing effects of adiponectin receptors 1 and 2 on energy metabolism.

Bjursell M, Ahnmark A, Bohlooly-Y M, William-Olsson L, Rhedin M, Peng XR, Ploj K, Gerdin AK, Arnerup G, Elmgren A, Berg AL, Oscarsson J, Lindén D.

Diabetes. 2007 Mar;56(3):583-93.


Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function.

Egecioglu E, Andersson IJ, Bollano E, Palsdottir V, Gabrielsson BG, Kopchick JJ, Skott O, Bie P, Isgaard J, Bohlooly-Y M, Bergström G, Wickman A.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1418-25. Epub 2007 Jan 23.


Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.


Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.

Gerdin AK, Surve VV, Jönsson M, Bjursell M, Björkman M, Edenro A, Schuelke M, Saad A, Bjurström S, Lundgren EJ, Snaith M, Fransson-Steen R, Törnell J, Berg AL, Bohlooly-Y M.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):825-32. Epub 2006 Aug 24.


G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice.

Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, Törnell J, Bohlooly-Y M.

Biochem Biophys Res Commun. 2006 Sep 22;348(2):359-66. Epub 2006 Jul 28.


Mice with experimental colitis show an altered metabolism with decreased metabolic rate.

Melgar S, Bjursell M, Gerdin AK, Svensson L, Michaëlsson E, Bohlooly-Y M.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G165-72. Epub 2006 Jul 13.


The program for phenotyping of genetically modified animals at AstraZeneca.

Berg AL, Bohlooly-Y M.

Exp Toxicol Pathol. 2006 Jul;57(5-6):383-4. Epub 2006 May 18.


Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight.

Bjursell M, Gerdin AK, Ploj K, Svensson D, Svensson L, Oscarsson J, Snaith M, Törnell J, Bohlooly-Y M.

Diabetes. 2006 Mar;55(3):725-33.


Endothelial dysfunction in growth hormone transgenic mice.

Andersson IJ, Johansson ME, Wickman A, Bohlooly-Y M, Klintland N, Caidahl K, Gustafsson M, Borén J, Gan LM, Bergström G.

Clin Sci (Lond). 2006 Feb;110(2):217-25.


Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice.

Egecioglu E, Bjursell M, Ljungberg A, Dickson SL, Kopchick JJ, Bergström G, Svensson L, Oscarsson J, Törnell J, Bohlooly-Y M.

Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E317-25. Epub 2005 Sep 20.


Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.

Nilsson L, Binart N, Bohlooly-Y M, Bramnert M, Egecioglu E, Kindblom J, Kelly PA, Kopchick JJ, Ormandy CJ, Ling C, Billig H.

Biochem Biophys Res Commun. 2005 Jun 17;331(4):1120-6.


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