Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 246


Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases.

Amara N, Foe IT, Onguka O, Garland M, Bogyo M.

Cell Chem Biol. 2018 Oct 22. pii: S2451-9456(18)30338-6. doi: 10.1016/j.chembiol.2018.10.005. [Epub ahead of print]


Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope.

Shrivastav M, Gounaris E, Khan MW, Ko J, Ryu SH, Bogyo M, Larson A, Barret TA, Bentrem DJ.

PLoS One. 2018 Nov 2;13(11):e0206568. doi: 10.1371/journal.pone.0206568. eCollection 2018.


Catalytic linkage between caspase activity and proteostasis in Archaea.

Seth-Pasricha M, Senn S, Sanman LE, Bogyo M, Nanda V, Bidle KA, Bidle KD.

Environ Microbiol. 2018 Oct 28. doi: 10.1111/1462-2920.14456. [Epub ahead of print]


The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture.

Foe IT, Onguka O, Amberg-Johnson K, Garner RM, Amara N, Beatty W, Yeh E, Bogyo M.

mSphere. 2018 Sep 19;3(5). pii: e00393-18. doi: 10.1128/mSphere.00393-18.


Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models.

Amara N, Tholen M, Bogyo M.

ACS Chem Biol. 2018 Sep 21;13(9):2645-2654. doi: 10.1021/acschembio.8b00562. Epub 2018 Sep 11.


Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

Yoo E, Stokes BH, de Jong H, Vanaerschot M, Kumar T, Lawrence N, Njoroge M, Garcia A, Van der Westhuyzen R, Momper JD, Ng CL, Fidock DA, Bogyo M.

J Am Chem Soc. 2018 Sep 12;140(36):11424-11437. doi: 10.1021/jacs.8b06656. Epub 2018 Aug 29.


PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S.

Immunity. 2018 Aug 21;49(2):247-263.e7. doi: 10.1016/j.immuni.2018.05.006. Epub 2018 Jul 24.


Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.

Nat Chem Biol. 2018 Jun;14(6):609-617. doi: 10.1038/s41589-018-0060-1. Epub 2018 May 16.


Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, Flygare J, Bogyo M, Wertz IE.

Nat Commun. 2018 Mar 21;9(1):1162. doi: 10.1038/s41467-018-03511-6.


TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development.

Flanagan-Steet H, Christian C, Lu PN, Aarnio-Peterson M, Sanman L, Archer-Hartmann S, Azadi P, Bogyo M, Steet RA.

Cell Rep. 2018 Mar 13;22(11):2964-2977. doi: 10.1016/j.celrep.2018.02.066.


New Blood Test SEEKs To Detect and Localize Cancer before It's Too Late.

Bogyo M, Yim JJ, Rosenthal EL.

Biochemistry. 2018 Mar 13;57(10):1561-1562. doi: 10.1021/acs.biochem.8b00179. Epub 2018 Feb 28. No abstract available.


Development of an activity-based probe for acyl-protein thioesterases.

Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M.

PLoS One. 2018 Jan 24;13(1):e0190255. doi: 10.1371/journal.pone.0190255. eCollection 2018.


Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.

ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.


Optimization of a Protease Activated Probe for Optical Surgical Navigation.

Yim JJ, Tholen M, Klaassen A, Sorger J, Bogyo M.

Mol Pharm. 2018 Mar 5;15(3):750-758. doi: 10.1021/acs.molpharmaceut.7b00822. Epub 2017 Dec 14.


Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ.

Science. 2017 Dec 15;358(6369):1448-1453. doi: 10.1126/science.aao4165. Epub 2017 Nov 16.


Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.

Duivenvoorden HM, Rautela J, Edgington-Mitchell LE, Spurling A, Greening DW, Nowell CJ, Molloy TJ, Robbins E, Brockwell NK, Lee CS, Chen M, Holliday A, Selinger CI, Hu M, Britt KL, Stroud DA, Bogyo M, Möller A, Polyak K, Sloane BF, O'Toole SA, Parker BS.

J Pathol. 2017 Dec;243(4):496-509. doi: 10.1002/path.4990. Epub 2017 Oct 31.


Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P.

PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586. eCollection 2017 Sep.


The lysosomal protein cathepsin L is a progranulin protease.

Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L.

Mol Neurodegener. 2017 Jul 25;12(1):55. doi: 10.1186/s13024-017-0196-6.


Protein Degradation Systems as Antimalarial Therapeutic Targets.

Ng CL, Fidock DA, Bogyo M.

Trends Parasitol. 2017 Sep;33(9):731-743. doi: 10.1016/ Epub 2017 Jul 5. Review.


Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.

Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB.

Nat Microbiol. 2017 Jun 19;2:17096. doi: 10.1038/nmicrobiol.2017.96.


Introduction to the Special Issue on Proteases and Proteolysis in Health and Disease.

Bogyo M.

FEBS J. 2017 May;284(10):1392-1393. doi: 10.1111/febs.14089.


Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.


Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M.

MBio. 2017 Feb 28;8(1). pii: e02189-16. doi: 10.1128/mBio.02189-16.


Chemical Strategies To Target Bacterial Virulence.

Garland M, Loscher S, Bogyo M.

Chem Rev. 2017 Mar 8;117(5):4422-4461. doi: 10.1021/acs.chemrev.6b00676. Epub 2017 Feb 24. Review.


Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

Hewings DS, Flygare JA, Bogyo M, Wertz IE.

FEBS J. 2017 May;284(10):1555-1576. doi: 10.1111/febs.14039. Epub 2017 Mar 10. Review.


Fluorescence Imaging for Cancer Screening and Surveillance.

Tipirneni KE, Rosenthal EL, Moore LS, Haskins AD, Udayakumar N, Jani AH, Carroll WR, Morlandt AB, Bogyo M, Rao J, Warram JM.

Mol Imaging Biol. 2017 Oct;19(5):645-655. doi: 10.1007/s11307-017-1050-5. Review.


Activity-based probes for the multicatalytic proteasome.

Hewings DS, Flygare JA, Wertz IE, Bogyo M.

FEBS J. 2017 May;284(10):1540-1554. doi: 10.1111/febs.14016. Epub 2017 Feb 7. Review.


Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.

Orlowski GM, Sharma S, Colbert JD, Bogyo M, Robertson SA, Kataoka H, Chan FK, Rock KL.

J Leukoc Biol. 2017 Jul;102(1):7-17. doi: 10.1189/jlb.3HI0316-152R. Epub 2017 Jan 13.


Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Bender KO, Garland M, Bogyo M.

Sci Transl Med. 2016 Dec 21;8(370):370tr2. doi: 10.1126/scitranslmed.aaf3410.


Rapid visualization of nonmelanoma skin cancer.

Walker E, Mann M, Honda K, Vidimos A, Schluchter MD, Straight B, Bogyo M, Popkin D, Basilion JP.

J Am Acad Dermatol. 2017 Feb;76(2):209-216.e9. doi: 10.1016/j.jaad.2016.09.008. Epub 2016 Nov 19.


Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ.

Mol Microbiol. 2017 Feb;103(4):618-634. doi: 10.1111/mmi.13577. Epub 2016 Dec 23.


A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer.

Sensarn S, Zavaleta CL, Segal E, Rogalla S, Lee W, Gambhir SS, Bogyo M, Contag CH.

Mol Imaging Biol. 2016 Dec;18(6):820-829.


Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe.

Edgington-Mitchell LE, Bogyo M, Verdoes M.

Methods Mol Biol. 2017;1491:145-159.


Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.

Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M.

ACS Infect Dis. 2016 Nov 11;2(11):807-815. Epub 2016 Jul 15.


An in vivo multiplexed small-molecule screening platform.

Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM.

Nat Methods. 2016 Oct;13(10):883-889. doi: 10.1038/nmeth.3992. Epub 2016 Sep 12.


Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV, Blum G.

PLoS One. 2016 Aug 17;11(8):e0160522. doi: 10.1371/journal.pone.0160522. eCollection 2016.


Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.


Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection.

Sanman LE, van der Linden WA, Verdoes M, Bogyo M.

Cell Chem Biol. 2016 Jul 21;23(7):793-804. doi: 10.1016/j.chembiol.2016.05.019. Epub 2016 Jul 14.


Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.

van der Linden WA, Schulze CJ, Herbert AS, Krause TB, Wirchnianski AA, Dye JM, Chandran K, Bogyo M.

ACS Infect Dis. 2016 Mar 11;2(3):173-179. Epub 2016 Jan 20.


The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.

Li H, Bogyo M, da Fonseca PC.

FEBS J. 2016 Dec;283(23):4238-4243. doi: 10.1111/febs.13780. Epub 2016 Jul 2. Review.


Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation.

Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV, Bogyo M.

J Nucl Med. 2016 Oct;57(10):1583-1590. Epub 2016 May 19.


Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes.

Edgington-Mitchell LE, Bogyo M.

Methods Mol Biol. 2016;1419:27-39. doi: 10.1007/978-1-4939-3581-9_3.


Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.

Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M.

Elife. 2016 Mar 24;5:e13663. doi: 10.7554/eLife.13663.


A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application.

Garland M, Yim JJ, Bogyo M.

Cell Chem Biol. 2016 Jan 21;23(1):122-136. doi: 10.1016/j.chembiol.2015.12.003. Review.


Structure- and function-based design of Plasmodium-selective proteasome inhibitors.

Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M.

Nature. 2016 Feb 11;530(7589):233-6. doi: 10.1038/nature16936.


Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes.

Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, Wolters PJ, Rosen GD, Collard HR, Zhu Z, Cheng Z, Bogyo M.

Sci Rep. 2016 Jan 22;6:19755. doi: 10.1038/srep19755.


Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes.

Withana NP, Garland M, Verdoes M, Ofori LO, Segal E, Bogyo M.

Nat Protoc. 2016 Jan;11(1):184-91. doi: 10.1038/nprot.2016.004. Epub 2015 Dec 30.


Correction: Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation.

Orlowski GM, Colbert JD, Sharma S, Bogyo M, Robertson SA, Rock KL.

J Immunol. 2016 Jan 1;196(1):503. doi: 10.4049/jimmunol.1502363. No abstract available.


Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR.

ACS Med Chem Lett. 2015 Oct 2;6(11):1145-9. doi: 10.1021/acsmedchemlett.5b00296. eCollection 2015 Nov 12.


Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.

Foe IT, Child MA, Majmudar JD, Krishnamurthy S, van der Linden WA, Ward GE, Martin BR, Bogyo M.

Cell Host Microbe. 2015 Oct 14;18(4):501-11. doi: 10.1016/j.chom.2015.09.006.

Supplemental Content

Support Center