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Items: 1 to 50 of 254

1.

Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum.

Szumska J, Batool Z, Al-Hashimi A, Venugopalan V, Skripnik V, Schaschke N, Bogyo M, Brix K.

Biochimie. 2019 Jul 11. pii: S0300-9084(19)30201-9. doi: 10.1016/j.biochi.2019.07.010. [Epub ahead of print]

PMID:
31302164
Free Article
2.

Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis.

Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J.

Biochimie. 2019 Jun 15. pii: S0300-9084(19)30175-0. doi: 10.1016/j.biochi.2019.06.010. [Epub ahead of print]

PMID:
31212040
3.

Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

de Vries LE, Sanchez MI, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, Deu E.

FEBS J. 2019 Jun 8. doi: 10.1111/febs.14953. [Epub ahead of print]

PMID:
31177613
4.

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.

Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA.

PLoS Pathog. 2019 Jun 6;15(6):e1007722. doi: 10.1371/journal.ppat.1007722. eCollection 2019 Jun.

5.

Molecular imaging and validation of margins in surgically excised nonmelanoma skin cancer specimens.

Liu Y, Walker E, Iyer SR, Biro M, Kim I, Zhou B, Straight B, Bogyo M, Basilion JP, Popkin DL, Wilson DL.

J Med Imaging (Bellingham). 2019 Jan;6(1):016001. doi: 10.1117/1.JMI.6.1.016001. Epub 2019 Mar 18.

PMID:
30915384
6.

Fluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus.

Chen L, Keller LJ, Cordasco E, Bogyo M, Lentz CS.

Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5643-5647. doi: 10.1002/anie.201900511. Epub 2019 Mar 22.

PMID:
30768830
7.

Correction: Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope.

Shrivastav M, Gounaris E, Khan MW, Ko J, Ryu SH, Bogyo M, Larson A, Barrett TA, Bentrem DJ.

PLoS One. 2019 Jan 7;14(1):e0210677. doi: 10.1371/journal.pone.0210677. eCollection 2019.

8.

Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence.

Garland M, Babin BM, Miyashita SI, Loscher S, Shen Y, Dong M, Bogyo M.

ACS Chem Biol. 2019 Jan 18;14(1):76-87. doi: 10.1021/acschembio.8b00937. Epub 2019 Jan 8.

PMID:
30571080
9.

Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases.

Amara N, Foe IT, Onguka O, Garland M, Bogyo M.

Cell Chem Biol. 2019 Jan 17;26(1):35-47.e7. doi: 10.1016/j.chembiol.2018.10.005. Epub 2018 Nov 1.

PMID:
30393067
10.

Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope.

Shrivastav M, Gounaris E, Khan MW, Ko J, Ryu SH, Bogyo M, Larson A, Barret TA, Bentrem DJ.

PLoS One. 2018 Nov 2;13(11):e0206568. doi: 10.1371/journal.pone.0206568. eCollection 2018. Erratum in: PLoS One. 2019 Jan 7;14(1):e0210677.

11.

Catalytic linkage between caspase activity and proteostasis in Archaea.

Seth-Pasricha M, Senn S, Sanman LE, Bogyo M, Nanda V, Bidle KA, Bidle KD.

Environ Microbiol. 2019 Jan;21(1):286-298. doi: 10.1111/1462-2920.14456. Epub 2019 Jan 8.

PMID:
30370585
12.

The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture.

Foe IT, Onguka O, Amberg-Johnson K, Garner RM, Amara N, Beatty W, Yeh E, Bogyo M.

mSphere. 2018 Sep 19;3(5). pii: e00393-18. doi: 10.1128/mSphere.00393-18.

13.

Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models.

Amara N, Tholen M, Bogyo M.

ACS Chem Biol. 2018 Sep 21;13(9):2645-2654. doi: 10.1021/acschembio.8b00562. Epub 2018 Sep 11.

PMID:
30160940
14.

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

Yoo E, Stokes BH, de Jong H, Vanaerschot M, Kumar T, Lawrence N, Njoroge M, Garcia A, Van der Westhuyzen R, Momper JD, Ng CL, Fidock DA, Bogyo M.

J Am Chem Soc. 2018 Sep 12;140(36):11424-11437. doi: 10.1021/jacs.8b06656. Epub 2018 Aug 29.

PMID:
30107725
15.

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S.

Immunity. 2018 Aug 21;49(2):247-263.e7. doi: 10.1016/j.immuni.2018.05.006. Epub 2018 Jul 24.

PMID:
30054205
16.

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.

Nat Chem Biol. 2018 Jun;14(6):609-617. doi: 10.1038/s41589-018-0060-1. Epub 2018 May 16.

17.

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, Flygare J, Bogyo M, Wertz IE.

Nat Commun. 2018 Mar 21;9(1):1162. doi: 10.1038/s41467-018-03511-6.

18.

TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development.

Flanagan-Steet H, Christian C, Lu PN, Aarnio-Peterson M, Sanman L, Archer-Hartmann S, Azadi P, Bogyo M, Steet RA.

Cell Rep. 2018 Mar 13;22(11):2964-2977. doi: 10.1016/j.celrep.2018.02.066.

19.

New Blood Test SEEKs To Detect and Localize Cancer before It's Too Late.

Bogyo M, Yim JJ, Rosenthal EL.

Biochemistry. 2018 Mar 13;57(10):1561-1562. doi: 10.1021/acs.biochem.8b00179. Epub 2018 Feb 28. No abstract available.

PMID:
29489339
20.

Development of an activity-based probe for acyl-protein thioesterases.

Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M.

PLoS One. 2018 Jan 24;13(1):e0190255. doi: 10.1371/journal.pone.0190255. eCollection 2018.

21.

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.

ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.

22.

Optimization of a Protease Activated Probe for Optical Surgical Navigation.

Yim JJ, Tholen M, Klaassen A, Sorger J, Bogyo M.

Mol Pharm. 2018 Mar 5;15(3):750-758. doi: 10.1021/acs.molpharmaceut.7b00822. Epub 2017 Dec 14.

PMID:
29172524
23.

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ.

Science. 2017 Dec 15;358(6369):1448-1453. doi: 10.1126/science.aao4165. Epub 2017 Nov 16.

PMID:
29146868
24.

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.

Duivenvoorden HM, Rautela J, Edgington-Mitchell LE, Spurling A, Greening DW, Nowell CJ, Molloy TJ, Robbins E, Brockwell NK, Lee CS, Chen M, Holliday A, Selinger CI, Hu M, Britt KL, Stroud DA, Bogyo M, Möller A, Polyak K, Sloane BF, O'Toole SA, Parker BS.

J Pathol. 2017 Dec;243(4):496-509. doi: 10.1002/path.4990. Epub 2017 Oct 31.

PMID:
29086922
25.

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P.

PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586. eCollection 2017 Sep.

26.

The lysosomal protein cathepsin L is a progranulin protease.

Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L.

Mol Neurodegener. 2017 Jul 25;12(1):55. doi: 10.1186/s13024-017-0196-6.

27.

Protein Degradation Systems as Antimalarial Therapeutic Targets.

Ng CL, Fidock DA, Bogyo M.

Trends Parasitol. 2017 Sep;33(9):731-743. doi: 10.1016/j.pt.2017.05.009. Epub 2017 Jul 5. Review.

28.

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.

Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB.

Nat Microbiol. 2017 Jun 19;2:17096. doi: 10.1038/nmicrobiol.2017.96.

29.

Introduction to the Special Issue on Proteases and Proteolysis in Health and Disease.

Bogyo M.

FEBS J. 2017 May;284(10):1392-1393. doi: 10.1111/febs.14089.

30.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.

31.

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M.

MBio. 2017 Feb 28;8(1). pii: e02189-16. doi: 10.1128/mBio.02189-16.

32.

Chemical Strategies To Target Bacterial Virulence.

Garland M, Loscher S, Bogyo M.

Chem Rev. 2017 Mar 8;117(5):4422-4461. doi: 10.1021/acs.chemrev.6b00676. Epub 2017 Feb 24. Review.

PMID:
28234447
33.

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

Hewings DS, Flygare JA, Bogyo M, Wertz IE.

FEBS J. 2017 May;284(10):1555-1576. doi: 10.1111/febs.14039. Epub 2017 Mar 10. Review.

34.

Fluorescence Imaging for Cancer Screening and Surveillance.

Tipirneni KE, Rosenthal EL, Moore LS, Haskins AD, Udayakumar N, Jani AH, Carroll WR, Morlandt AB, Bogyo M, Rao J, Warram JM.

Mol Imaging Biol. 2017 Oct;19(5):645-655. doi: 10.1007/s11307-017-1050-5. Review.

PMID:
28155079
35.

Activity-based probes for the multicatalytic proteasome.

Hewings DS, Flygare JA, Wertz IE, Bogyo M.

FEBS J. 2017 May;284(10):1540-1554. doi: 10.1111/febs.14016. Epub 2017 Feb 7. Review.

36.

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.

Orlowski GM, Sharma S, Colbert JD, Bogyo M, Robertson SA, Kataoka H, Chan FK, Rock KL.

J Leukoc Biol. 2017 Jul;102(1):7-17. doi: 10.1189/jlb.3HI0316-152R. Epub 2017 Jan 13.

37.

Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Bender KO, Garland M, Bogyo M.

Sci Transl Med. 2016 Dec 21;8(370):370tr2. doi: 10.1126/scitranslmed.aaf3410.

PMID:
28003551
38.

Rapid visualization of nonmelanoma skin cancer.

Walker E, Mann M, Honda K, Vidimos A, Schluchter MD, Straight B, Bogyo M, Popkin D, Basilion JP.

J Am Acad Dermatol. 2017 Feb;76(2):209-216.e9. doi: 10.1016/j.jaad.2016.09.008. Epub 2016 Nov 19.

39.

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ.

Mol Microbiol. 2017 Feb;103(4):618-634. doi: 10.1111/mmi.13577. Epub 2016 Dec 23.

40.

A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer.

Sensarn S, Zavaleta CL, Segal E, Rogalla S, Lee W, Gambhir SS, Bogyo M, Contag CH.

Mol Imaging Biol. 2016 Dec;18(6):820-829.

41.

Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe.

Edgington-Mitchell LE, Bogyo M, Verdoes M.

Methods Mol Biol. 2017;1491:145-159.

PMID:
27778287
42.

Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.

Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M.

ACS Infect Dis. 2016 Nov 11;2(11):807-815. Epub 2016 Jul 15.

43.

An in vivo multiplexed small-molecule screening platform.

Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM.

Nat Methods. 2016 Oct;13(10):883-889. doi: 10.1038/nmeth.3992. Epub 2016 Sep 12.

44.

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV, Blum G.

PLoS One. 2016 Aug 17;11(8):e0160522. doi: 10.1371/journal.pone.0160522. eCollection 2016.

45.

Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.

46.

Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection.

Sanman LE, van der Linden WA, Verdoes M, Bogyo M.

Cell Chem Biol. 2016 Jul 21;23(7):793-804. doi: 10.1016/j.chembiol.2016.05.019. Epub 2016 Jul 14.

47.

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.

van der Linden WA, Schulze CJ, Herbert AS, Krause TB, Wirchnianski AA, Dye JM, Chandran K, Bogyo M.

ACS Infect Dis. 2016 Mar 11;2(3):173-179. Epub 2016 Jan 20.

48.

The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.

Li H, Bogyo M, da Fonseca PC.

FEBS J. 2016 Dec;283(23):4238-4243. doi: 10.1111/febs.13780. Epub 2016 Jul 2. Review.

49.

Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation.

Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV, Bogyo M.

J Nucl Med. 2016 Oct;57(10):1583-1590. Epub 2016 May 19.

50.

Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes.

Edgington-Mitchell LE, Bogyo M.

Methods Mol Biol. 2016;1419:27-39. doi: 10.1007/978-1-4939-3581-9_3.

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