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Items: 1 to 50 of 69

1.

Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective.

Butler LD, Guzzie-Peck P, Hartke J, Bogdanffy MS, Will Y, Diaz D, Mortimer-Cassen E, Derzi M, Greene N, DeGeorge JJ.

Regul Toxicol Pharmacol. 2017 Jul 31;87 Suppl 3:S1-S15. doi: 10.1016/j.yrtph.2017.05.009. Epub 2017 May 5.

PMID:
28483710
2.

Evaluation of Therapeutics for Advanced-Stage Heart Failure and Other Severely-Debilitating or Life-Threatening Diseases.

Prescott JS, Andrews PA, Baker RW, Bogdanffy MS, Fields FO, Keller DA, Lapadula DM, Mahoney NM, Paul DE, Platz SJ, Reese DM, Stoch SA, DeGeorge JJ.

Clin Pharmacol Ther. 2017 Aug;102(2):219-227. doi: 10.1002/cpt.730. Epub 2017 Jun 21. Review.

PMID:
28474798
3.

Nonclinical safety of the sodium-glucose cotransporter 2 inhibitor empagliflozin.

Bogdanffy MS, Stachlewitz RF, van Tongeren S, Knight B, Sharp DE, Ku W, Hart SE, Blanchard K.

Int J Toxicol. 2014 Nov-Dec;33(6):436-49. doi: 10.1177/1091581814551648. Epub 2014 Sep 26.

PMID:
25260362
4.

A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry.

Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM.

Inhal Toxicol. 2008 Feb;20(4):375-90. doi: 10.1080/08958370801903750 .

PMID:
18302046
5.

Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.

Pottenger LH, Malley LA, Bogdanffy MS, Donner EM, Upton PB, Li Y, Walker VE, Harkema JR, Banton MI, Swenberg JA.

Toxicol Sci. 2007 Jun;97(2):336-47. Epub 2007 Mar 6.

PMID:
17341482
6.

Vinyl acetate induces intracellular acidification in mouse oral buccal epithelial cells.

Nakamoto T, Wagner M, Melvin JE, Bogdanffy MS.

Toxicol Lett. 2005 Aug 14;158(2):116-21. Epub 2005 Apr 7.

PMID:
16039400
7.

Interspecies dose extrapolation for inhaled dimethyl sulfate: a PBPK model-based analysis using nasal cavity N7-methylguanine adducts.

Sarangapani R, Teeguarden JG, Gentry PR, Clewell HJ 3rd, Barton HA, Bogdanffy MS.

Inhal Toxicol. 2004 Aug;16(9):593-605.

PMID:
16036752
8.
9.

Validation of human physiologically based pharmacokinetic model for vinyl acetate against human nasal dosimetry data.

Hinderliter PM, Thrall KD, Corley RA, Bloemen LJ, Bogdanffy MS.

Toxicol Sci. 2005 May;85(1):460-7. Epub 2005 Jan 19.

PMID:
15659566
10.

Dose-dependent transitions in mechanisms of toxicity: case studies.

Slikker W Jr, Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K.

Toxicol Appl Pharmacol. 2004 Dec 15;201(3):226-94. Review.

PMID:
15582646
11.

Dose-dependent transitions in mechanisms of toxicity.

Slikker W Jr, Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K.

Toxicol Appl Pharmacol. 2004 Dec 15;201(3):203-25. Review.

PMID:
15582645
12.

Vinyl acetate decreases intracellular pH in rat nasal epithelial cells.

Lantz RC, Orozco J, Bogdanffy MS.

Toxicol Sci. 2003 Oct;75(2):423-31. Epub 2003 Jul 25.

PMID:
12883081
13.

Workshop overview: use of genomic data in risk assessment.

Cunningham ML, Bogdanffy MS, Zacharewski TR, Hines RN.

Toxicol Sci. 2003 Jun;73(2):209-15. Epub 2003 Apr 15.

PMID:
12700425
14.
15.

Physiologically-based kinetic modeling of vapours toxic to the respiratory tract.

Bogdanffy MS, Sarangapani R.

Toxicol Lett. 2003 Feb 18;138(1-2):103-17. Review.

PMID:
12559695
17.

Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate.

Hengstler JG, Bogdanffy MS, Bolt HM, Oesch F.

Annu Rev Pharmacol Toxicol. 2003;43:485-520. Epub 2002 Jan 10. Review.

PMID:
12415124
18.

Histochemical localisation of carboxylesterase activity in rat and mouse oral cavity mucosa.

Robinson DA, Bogdanffy MS, Reed CJ.

Toxicology. 2002 Dec 2;180(3):209-20.

PMID:
12393291
19.

Time- and concentration-dependent increases in cell proliferation in rats and mice administered vinyl acetate in drinking water.

Valentine R, Bamberger JR, Szostek B, Frame SR, Hansen JF, Bogdanffy MS.

Toxicol Sci. 2002 Jun;67(2):190-7.

PMID:
12011478
20.
21.

Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats.

Moghaddam MF, Bogdanffy MS, Brown A, Ford K, Shalaby L.

Drug Metab Dispos. 2002 Jan;30(1):47-54.

PMID:
11744611
22.

Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk.

Bogdanffy MS, Plowchalk DR, Sarangapani R, Starr TB, Andersen ME.

Inhal Toxicol. 2001 May;13(5):377-96. Review.

PMID:
11295869
23.

Harmonization of cancer and noncancer risk assessment: proceedings of a consensus-building workshop.

Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J, Vu V.

Toxicol Sci. 2001 May;61(1):18-31. Review.

PMID:
11294970
24.

Chronic toxicity and oncogenicity bioassay in rats with the chloro-s-triazine herbicide cyanazine.

Bogdanffy MS, O'Connor JC, Hansen JF, Gaddamidi V, Van Pelt CS, Green JW, Cook JC.

J Toxicol Environ Health A. 2000 Aug 25;60(8):567-86.

PMID:
10983523
25.

Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride.

Holt S, Roy G, Mitra S, Upton PB, Bogdanffy MS, Swenberg JA.

Mutat Res. 2000 Jul 25;460(2):105-15.

PMID:
10882851
26.

Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species.

Boivin-Angèle S, Lefrançois L, Froment O, Spiethoff A, Bogdanffy MS, Wegener K, Wesch H, Barbin A, Bancel B, Trépo C, Bartsch H, Swenberg J, Marion MJ.

Int J Cancer. 2000 Jan 15;85(2):223-7.

27.

Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis.

Swenberg JA, Bogdanffy MS, Ham A, Holt S, Kim A, Morinello EJ, Ranasinghe A, Scheller N, Upton PB.

IARC Sci Publ. 1999;(150):29-43. Review.

PMID:
10626206
28.

High-affinity nasal extraction of vinyl acetate vapor is carboxylesterase dependent.

Bogdanffy MS, Manning LA, Sarangapani R.

Inhal Toxicol. 1999 Oct;11(10):927-41.

PMID:
10509027
29.

A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity.

Bogdanffy MS, Sarangapani R, Plowchalk DR, Jarabek A, Andersen ME.

Toxicol Sci. 1999 Sep;51(1):19-35.

PMID:
10496674
30.

Determining modes of action for biologically based risk assessments.

Schlosser PM, Bogdanffy MS.

Regul Toxicol Pharmacol. 1999 Aug;30(1):75-9. No abstract available.

PMID:
10464048
31.

A comprehensive approach for integration of toxicity and cancer risk assessments.

Butterworth BE, Bogdanffy MS.

Regul Toxicol Pharmacol. 1999 Feb;29(1):23-36. Review.

PMID:
10051416
32.

Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique.

Bogdanffy MS, Sarangapani R, Kimbell JS, Frame SR, Plowchalk DR.

Toxicol Sci. 1998 Dec;46(2):235-46.

PMID:
10048126
33.

Mitogenic responses of rat nasal epithelium to hexamethylphosphoramide inhalation exposure.

Harman AE, Voigt JM, Frame SR, Bogdanffy MS.

Mutat Res. 1997 Oct 31;380(1-2):155-65.

PMID:
9385396
34.

Critical factors in assessing risk from exposure to nasal carcinogens.

Bogdanffy MS, Mathison BH, Kuykendall JR, Harman AE.

Mutat Res. 1997 Oct 31;380(1-2):125-41. Review.

PMID:
9385394
35.

DNA damage in the nasal passageway: a literature review.

Mathison BH, Harman AE, Bogdanffy MS.

Mutat Res. 1997 Oct 31;380(1-2):77-96. Review.

PMID:
9385391
36.

Mechanisms of chemical toxicity to the nasal cavity.

Bogdanffy MS.

Mutat Res. 1997 Oct 31;380(1-2):1-2. No abstract available.

PMID:
9385383
37.

Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity.

Plowchalk DR, Andersen ME, Bogdanffy MS.

Toxicol Appl Pharmacol. 1997 Feb;142(2):386-400.

PMID:
9070362
38.

Dimethyl sulfate uptake and methylation of DNA in rat respiratory tissues following acute inhalation.

Mathison BH, Taylor ML, Bogdanffy MS.

Fundam Appl Toxicol. 1995 Dec;28(2):255-63.

PMID:
8835235
39.
40.

Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats.

Eldridge SR, Bogdanffy MS, Jokinen MP, Andrews LS.

Fundam Appl Toxicol. 1995 Aug;27(1):25-32.

PMID:
7589926
41.
42.

Inhalation oncogenicity bioassay in rats and mice with vinyl fluoride.

Bogdanffy MS, Makovec GT, Frame SR.

Fundam Appl Toxicol. 1995 Jul;26(2):223-38.

PMID:
7589911
43.
44.

Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse.

Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, Feron VJ, Cascieri TC, Tyler TR, Vinegar MB, Rickard RW.

Fundam Appl Toxicol. 1994 Aug;23(2):215-29.

PMID:
7982530
45.

Chronic toxicity and oncogenicity study with vinyl acetate in the rat: in utero exposure in drinking water.

Bogdanffy MS, Tyler TR, Vinegar MB, Rickard RW, Carpanini FM, Cascieri TC.

Fundam Appl Toxicol. 1994 Aug;23(2):206-14.

PMID:
7982529
46.

Cytotoxicity and DNA-protein crosslink formation in rat nasal tissues exposed to vinyl acetate are carboxylesterase-mediated.

Kuykendall JR, Taylor ML, Bogdanffy MS.

Toxicol Appl Pharmacol. 1993 Dec;123(2):283-92.

PMID:
8248935
47.

Kinetics of nasal carboxylesterase-mediated metabolism of vinyl acetate.

Bogdanffy MS, Taylor ML.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1107-11.

PMID:
7905391
48.

Investigation of the effects of benomyl on rat nasal mucosa.

Hurtt ME, Mebus CA, Bogdanffy MS.

Fundam Appl Toxicol. 1993 Aug;21(2):253-5.

PMID:
8405789
50.

Reaction kinetics of DNA-histone crosslinking by vinyl acetate and acetaldehyde.

Kuykendall JR, Bogdanffy MS.

Carcinogenesis. 1992 Nov;13(11):2095-100.

PMID:
1423881

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