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Items: 45

1.

Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections.

Dietz J, Spengler U, Müllhaupt B, Schulze Zur Wiesch J, Piecha F, Mauss S, Seegers B, Hinrichsen H, Antoni C, Wietzke-Braun P, Peiffer KH, Berger A, Matschenz K, Buggisch P, Backhus J, Zizer E, Boettler T, Neumann-Haefelin C, Semela D, Stauber R, Berg T, Berg C, Zeuzem S, Vermehren J, Sarrazin C; European HCV Resistance Study Group.

Clin Gastroenterol Hepatol. 2019 Nov 6. pii: S1542-3565(19)31260-1. doi: 10.1016/j.cgh.2019.10.051. [Epub ahead of print] No abstract available.

PMID:
31706062
2.

Follicular T helper cells shape the HCV-specific CD4 T cell repertoire after viral elimination.

Smits M, Zoldan K, Ishaque N, Gu Z, Jechow K, Wieland D, Conrad C, Eils R, Fauvelle C, Baumert TF, Emmerich F, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Boettler T.

J Clin Invest. 2019 Nov 7. pii: 129642. doi: 10.1172/JCI129642. [Epub ahead of print]

3.

Stereotactic Body Radiation Therapy as an Alternative Treatment for Patients with Hepatocellular Carcinoma Compared to Sorafenib: A Propensity Score Analysis.

Bettinger D, Pinato DJ, Schultheiss M, Sharma R, Rimassa L, Pressiani T, Burlone ME, Pirisi M, Kudo M, Park JW, Buettner N, Neumann-Haefelin C, Boettler T, Abbasi-Senger N, Alheit H, Baus W, Blanck O, Gerum S, Guckenberger M, Habermehl D, Ostheimer C, Riesterer O, Tamihardja J, Grosu AL, Thimme R, Brunner TB, Gkika E.

Liver Cancer. 2019 Jul;8(4):281-294. doi: 10.1159/000490260. Epub 2018 Jul 12. Erratum in: Liver Cancer. 2019 Jul;8(4):295.

4.

Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial.

Traussnigg S, Schattenberg JM, Demir M, Wiegand J, Geier A, Teuber G, Hofmann WP, Kremer AE, Spreda F, Kluwe J, Petersen J, Boettler T, Rainer F, Halilbasic E, Greinwald R, Pröls M, Manns MP, Fickert P, Trauner M; Austrian/German NAFLD-norUDCA study group.

Lancet Gastroenterol Hepatol. 2019 Oct;4(10):781-793. doi: 10.1016/S2468-1253(19)30184-0. Epub 2019 Jul 22.

PMID:
31345778
5.

HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.

Ackermann C, Smits M, Woost R, Eberhard JM, Peine S, Kummer S, Marget M, Kuntzen T, Kwok WW, Lohse AW, Jacobs T, Boettler T, Schulze Zur Wiesch J.

Sci Rep. 2019 Jul 23;9(1):10624. doi: 10.1038/s41598-019-47024-8.

6.

Acute pancreatitis and vasoplegic shock associated with leptospirosis - a case report and review of the literature.

Maier A, Kaeser R, Thimme R, Boettler T.

BMC Infect Dis. 2019 May 8;19(1):395. doi: 10.1186/s12879-019-4040-1. Review.

7.

[Hepatitis C: From Individual Cure to Worldwide Elimination?]

Boettler T, Lohmann V, Bartenschlager R.

Dtsch Med Wochenschr. 2019 Apr;144(8):535-542. doi: 10.1055/a-0837-2424. Epub 2019 Apr 15. Review. German.

PMID:
30986861
8.

OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection.

Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T.

J Hepatol. 2019 Jun;70(6):1103-1113. doi: 10.1016/j.jhep.2019.02.016. Epub 2019 Feb 28.

PMID:
30826436
9.

HCV-Specific T Cell Responses During and After Chronic HCV Infection.

Luxenburger H, Neumann-Haefelin C, Thimme R, Boettler T.

Viruses. 2018 Nov 17;10(11). pii: E645. doi: 10.3390/v10110645. Review.

10.

Treatment with proton pump inhibitors increases the risk for development of hepatic encephalopathy after implantation of transjugular intrahepatic portosystemic shunt (TIPS).

Sturm L, Bettinger D, Giesler M, Boettler T, Schmidt A, Buettner N, Thimme R, Schultheiss M.

United European Gastroenterol J. 2018 Nov;6(9):1380-1390. doi: 10.1177/2050640618795928. Epub 2018 Aug 15.

11.

NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M.

J Hepatol. 2019 Mar;70(3):351-360. doi: 10.1016/j.jhep.2018.10.006. Epub 2018 Oct 18.

12.

Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Adam L, Zoldan K, Hofmann M, Schultheiss M, Bettinger D, Neumann-Haefelin C, Thimme R, Böettler T.

Hepatol Commun. 2018 Sep 7;2(9):1051-1063. doi: 10.1002/hep4.1226. eCollection 2018 Sep.

13.

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis.

Strnad P, Buch S, Hamesch K, Fischer J, Rosendahl J, Schmelz R, Brueckner S, Brosch M, Heimes CV, Woditsch V, Scholten D, Nischalke HD, Janciauskiene S, Mandorfer M, Trauner M, Way MJ, McQuillin A, Reichert MC, Krawczyk M, Casper M, Lammert F, Braun F, von Schönfels W, Hinz S, Burmeister G, Hellerbrand C, Teufel A, Feldman A, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Ridinger M, Wodarz N, Soyka M, Rietschel M, Kiefer F, Weber T, Marhenke S, Vogel A, Hinrichsen H, Canbay A, Schlattjan M, Sosnowsky K, Sarrazin C, von Felden J, Geier A, Deltenre P, Sipos B, Schafmayer C, Nothnagel M, Aigner E, Datz C, Stickel F, Morgan MY, Hampe J, Berg T, Trautwein C.

Gut. 2019 Jun;68(6):1099-1107. doi: 10.1136/gutjnl-2018-316228. Epub 2018 Aug 1.

PMID:
30068662
14.

Editorial: is proton pump inhibitor use associated with worse outcomes in patients with liver abscesses? Authors' reply.

Bettinger D, Thimme R, Boettler T.

Aliment Pharmacol Ther. 2018 Apr;47(8):1228-1229. doi: 10.1111/apt.14591. No abstract available.

15.

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.

Krawczyk M, Bantel H, Rau M, Schattenberg JM, Grünhage F, Pathil A, Demir M, Kluwe J, Boettler T, Weber SN, Geier A, Lammert F; NAFLD Clinical Study Group (NAFLD CSG).

J Hum Genet. 2018 May;63(5):621-626. doi: 10.1038/s10038-018-0420-4. Epub 2018 Feb 26.

PMID:
29483677
16.

Lost in Inflammation: The Functional Conversion of Regulatory T Cells in Acute Hepatitis A Virus Infection.

Boettler T, Thimme R.

Gastroenterology. 2018 Mar;154(4):798-800. doi: 10.1053/j.gastro.2018.02.003. Epub 2018 Feb 7. No abstract available.

PMID:
29427580
17.

Differential virus-specific CD8+ T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4.

Luxenburger H, Graß F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C.

J Viral Hepat. 2018 Jul;25(7):779-790. doi: 10.1111/jvh.12874. Epub 2018 Feb 27.

PMID:
29397015
18.

Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess.

Bettinger D, Martin D, Rieg S, Schultheiss M, Buettner N, Thimme R, Boettler T.

Aliment Pharmacol Ther. 2018 Mar;47(6):801-808. doi: 10.1111/apt.14512. Epub 2018 Jan 12.

19.

Survival benefit of transarterial chemoembolization in patients with metastatic hepatocellular carcinoma: a single center experience.

Bettinger D, Spode R, Glaser N, Buettner N, Boettler T, Neumann-Haefelin C, Brunner TB, Gkika E, Maruschke L, Thimme R, Schultheiss M.

BMC Gastroenterol. 2017 Aug 10;17(1):98. doi: 10.1186/s12876-017-0656-z.

20.

The ABCB4 p.T175A variant as potential modulator of hepatic fibrosis in patients with chronic liver diseases: Looking beyond the cholestatic realm.

Krawczyk M, Rau M, Grünhage F, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Geier A, Lammert F; NAFLD Clinical Study Group (NAFLD CSG).

Hepatology. 2017 Aug;66(2):666-667. doi: 10.1002/hep.29100. Epub 2017 Jul 4. No abstract available.

PMID:
28176361
21.

[Cholestatic liver disease].

Pichler C, Boettler T, Thimme R.

Dtsch Med Wochenschr. 2016 Nov;141(23):1683-1687. Epub 2016 Nov 17. Review. German.

PMID:
27855457
22.

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.

Krawczyk M, Rau M, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Lammert F, Geier A; NAFLD Clinical Study Group.

J Lipid Res. 2017 Jan;58(1):247-255. doi: 10.1194/jlr.P067454. Epub 2016 Nov 11.

23.

Procedural and shunt-related complications and mortality of the transjugular intrahepatic portosystemic shunt (TIPSS).

Bettinger D, Schultheiss M, Boettler T, Muljono M, Thimme R, Rössle M.

Aliment Pharmacol Ther. 2016 Nov;44(10):1051-1061. doi: 10.1111/apt.13809. Epub 2016 Sep 27.

24.

A rare cause of upper GI bleeding in a critically ill patient.

Walker C, Huber-Schumacher S, Boettler T, Thimme R, Fischer A.

Gut. 2016 Sep;65(9):1438. doi: 10.1136/gutjnl-2015-310564. Epub 2015 Dec 30. No abstract available.

PMID:
26719301
25.

Virus-Specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-Helper Cells in Patients With Acute and Chronic HCV Infections.

Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T.

Gastroenterology. 2016 Mar;150(3):696-706.e3. doi: 10.1053/j.gastro.2015.11.005. Epub 2015 Nov 14.

PMID:
26584604
26.

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.

Boettler T, Schneider D, Cheng Y, Kadoya K, Brandon EP, Martinson L, von Herrath M.

Cell Transplant. 2016;25(3):609-14. doi: 10.3727/096368915X688939. Epub 2015 Aug 21.

PMID:
26300527
27.

[Cure of chronic Hepatitis B and C: vision versus reality].

Boettler T, Thimme R, Neumann-Haefelin C.

Dtsch Med Wochenschr. 2015 Jul;140(14):1056-62. doi: 10.1055/s-0041-102928. Epub 2015 Jul 16. German.

PMID:
26182254
28.

Antiviral Therapy in Hepatitis B Virus-Associated Liver Cirrhosis.

Boettler T, Thimme R.

Dig Dis. 2015;33(4):608-12. doi: 10.1159/000375357. Epub 2015 Jul 6.

PMID:
26159281
29.

An uncommon presentation of a common pathogen.

Boettler T, Lutz L, Schmidt N, Thimme R, Neumann-Haefelin C.

Gut. 2015 Sep;64(9):1411, 1453. doi: 10.1136/gutjnl-2014-308851. Epub 2015 Jan 6. No abstract available.

PMID:
25564406
30.

Bridging basic science and clinical research: the EASL Monothematic Conference on Translational Research in Viral Hepatitis.

Boettler T, Moradpour D, Thimme R, Zoulim F.

J Hepatol. 2014 Sep;61(3):696-705. doi: 10.1016/j.jhep.2014.05.016. Epub 2014 May 15.

PMID:
24845610
31.

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M.

J Immunol. 2013 Nov 15;191(10):5026-35. doi: 10.4049/jimmunol.1300013. Epub 2013 Oct 7.

32.

The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes.

Boettler T, Pagni PP, Jaffe R, Cheng Y, Zerhouni P, von Herrath M.

J Autoimmun. 2013 Aug;44:40-8. doi: 10.1016/j.jaut.2013.05.002. Epub 2013 Jun 13.

33.

OX40 facilitates control of a persistent virus infection.

Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG.

PLoS Pathog. 2012 Sep;8(9):e1002913. doi: 10.1371/journal.ppat.1002913. Epub 2012 Sep 6.

34.

IL-7 receptor α blockade, an off-switch for autoreactive T cells.

Boettler T, von Herrath M.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12270-1. doi: 10.1073/pnas.1209749109. Epub 2012 Jul 23. No abstract available.

35.

TGF-β blockade does not improve control of an established persistent viral infection.

Boettler T, Cheng Y, Ehrhardt K, von Herrath M.

Viral Immunol. 2012 Jun;25(3):232-8. doi: 10.1089/vim.2011.0079. Epub 2012 May 23.

36.

Can an immune-regulatory vaccine prevent HIV infection?

Boettler T, Cunha-Neto E, Kalil J, von Herrath M.

Expert Rev Anti Infect Ther. 2012 Mar;10(3):299-305. doi: 10.1586/eri.11.178.

37.

Virus infections in type 1 diabetes.

Coppieters KT, Boettler T, von Herrath M.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a007682. doi: 10.1101/cshperspect.a007682. Review.

38.

Protection against or triggering of Type 1 diabetes? Different roles for viral infections.

Boettler T, von Herrath M.

Expert Rev Clin Immunol. 2011 Jan;7(1):45-53. doi: 10.1586/eci.10.91. Review.

39.

Type 1 diabetes vaccine development: animal models vs. humans.

Boettler T, von Herrath M.

Hum Vaccin. 2011 Jan 1;7(1):19-26. Epub 2011 Jan 1. Review.

PMID:
21157185
40.

Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D.

Boettler T, von Herrath M.

Int Immunopharmacol. 2010 Dec;10(12):1491-5. doi: 10.1016/j.intimp.2010.07.008. Epub 2010 Jul 25. Review.

PMID:
20667487
41.

Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma.

Thimme R, Neagu M, Boettler T, Neumann-Haefelin C, Kersting N, Geissler M, Makowiec F, Obermaier R, Hopt UT, Blum HE, Spangenberg HC.

Hepatology. 2008 Dec;48(6):1821-33. doi: 10.1002/hep.22535.

PMID:
19003875
42.

Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine.

Thimme R, Neumann-Haefelin C, Boettler T, Blum HE.

Biol Chem. 2008 May;389(5):457-67. Review.

PMID:
18953713
43.

[Systems biology].

Boettler T, Schultheiss M, Blum HE.

Dtsch Med Wochenschr. 2007 Dec;132(50):2702-5. Review. German. No abstract available.

PMID:
18058662
45.

T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsäcker F, Thimme R.

J Virol. 2005 Jun;79(12):7860-7.

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