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Cost-effectiveness analysis on elderly pneumococcal vaccination in the Netherlands: Challenging the Dutch Health Council's advice.

Zeevat F, van der Schans J, Boersma WG, Boersma C, Postma MJ.

Vaccine. 2019 Sep 9. pii: S0264-410X(19)31125-9. doi: 10.1016/j.vaccine.2019.08.051. [Epub ahead of print]


Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis.

Chalmers JD, Boersma W, Lonergan M, Jayaram L, Crichton ML, Karalus N, Taylor SL, Martin ML, Burr LD, Wong C, Altenburg J.

Lancet Respir Med. 2019 Aug 9. pii: S2213-2600(19)30191-2. doi: 10.1016/S2213-2600(19)30191-2. [Epub ahead of print]


Plasma cytokine profile on admission related to aetiology in community-acquired pneumonia.

Burgmeijer EH, Duijkers R, Lutter R, Bonten MJM, Schweitzer VA, Boersma WG.

Clin Respir J. 2019 Jul 16. doi: 10.1111/crj.13062. [Epub ahead of print]


Aetiology and disease severity are among the determinants of quality of life in bronchiectasis.

Terpstra LC, Biesenbeek S, Altenburg J, Boersma WG.

Clin Respir J. 2019 Aug;13(8):521-529. doi: 10.1111/crj.13054. Epub 2019 Jul 24.


CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions.

Prins HJ, Duijkers R, van der Valk P, Schoorl M, Daniels JMA, van der Werf TS, Boersma WG.

Eur Respir J. 2019 May 23;53(5). pii: 1802014. doi: 10.1183/13993003.02014-2018. Print 2019 May.


Serum levels of hyaluronic acid are associated with COPD severity and predict survival.

Papakonstantinou E, Bonovolias I, Roth M, Tamm M, Schumann D, Baty F, Louis R, Milenkovic B, Boersma W, Stieltjes B, Kostikas K, Blasi F, Aerts JG, Rohde GGU, Lacoma A, Torres A, Welte T, Stolz D.

Eur Respir J. 2019 Mar 7;53(3). pii: 1801183. doi: 10.1183/13993003.01183-2018. Print 2019 Mar.


Feasibility of a quantitative polymerase chain reaction assay for diagnosing pneumococcal pneumonia using oropharyngeal swabs.

van Schaik ML, Duijkers R, Paternotte N, Jansen R, Rozemeijer W, van der Reijden WA, Boersma WG.

Mol Biol Rep. 2019 Feb;46(1):1013-1021. doi: 10.1007/s11033-018-4558-0. Epub 2018 Dec 19.


Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease.

Schumann DM, Leeming D, Papakonstantinou E, Blasi F, Kostikas K, Boersma W, Louis R, Milenkovic B, Aerts J, Sand JMB, Wouters EFM, Rohde G, Prat C, Torres A, Welte T, Tamm M, Karsdal M, Stolz D.

Chest. 2018 Oct;154(4):798-807. doi: 10.1016/j.chest.2018.06.028. Epub 2018 Jun 30.


IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

Egli A, Mandal J, Schumann DM, Roth M, Thomas B, Lorne Tyrrell D, Blasi F, Kostikas K, Boersma W, Milenkovic B, Lacoma A, Rentsch K, Rohde GGU, Louis R, Aerts JG, Welte T, Torres A, Tamm M, Stolz D.

BMC Pulm Med. 2018 Mar 21;18(1):51. doi: 10.1186/s12890-018-0616-6.


Management of community-acquired pneumonia in adults: 2016 guideline update from the Dutch Working Party on Antibiotic Policy (SWAB) and Dutch Association of Chest Physicians (NVALT).

Wiersinga WJ, Bonten MJ, Boersma WG, Jonkers RE, Aleva RM, Kullberg BJ, Schouten JA, Degener JE, van de Garde EMW, Verheij TJ, Sachs APE, Prins JM.

Neth J Med. 2018 Jan;76(1):4-13.


Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.


Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD.

Mandal J, Roth M, Papakonstantinou E, Sun Q, Costa L, Boeck L, Scherr A, Rakic J, Louis R, Milenkovic B, Boersma W, Kostikas K, Blasi F, Aerts J, Rohde G, Lacoma A, Torres A, Welte T, Tamm M, Stolz D.

Pulm Pharmacol Ther. 2018 Feb;48:111-116. doi: 10.1016/j.pupt.2017.10.011. Epub 2017 Oct 21.


Corticosteroids in Patients Hospitalized With Community-Acquired Pneumonia: Systematic Review and Individual Patient Data Metaanalysis.

Briel M, Spoorenberg SMC, Snijders D, Torres A, Fernandez-Serrano S, Meduri GU, Gabarrús A, Blum CA, Confalonieri M, Kasenda B, Siemieniuk RAC, Boersma W, Bos WJW, Christ-Crain M; Ovidius Study Group; Capisce Study Group; STEP Study Group.

Clin Infect Dis. 2018 Jan 18;66(3):346-354. doi: 10.1093/cid/cix801.


Blood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPD.

Prins HJ, Duijkers R, Lutter R, Daniels JM, van der Valk P, Schoorl M, Kerstjens HA, van der Werf TS, Boersma WG.

Respir Med. 2017 Oct;131:118-124. doi: 10.1016/j.rmed.2017.07.064. Epub 2017 Aug 1.


Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial.

Rafiq R, Prins HJ, Boersma WG, Daniels JM, den Heijer M, Lips P, de Jongh RT.

Int J Chron Obstruct Pulmon Dis. 2017 Aug 28;12:2583-2592. doi: 10.2147/COPD.S132117. eCollection 2017.


Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research.

Hill AT, Haworth CS, Aliberti S, Barker A, Blasi F, Boersma W, Chalmers JD, De Soyza A, Dimakou K, Elborn JS, Feldman C, Flume P, Goeminne PC, Loebinger MR, Menendez R, Morgan L, Murris M, Polverino E, Quittner A, Ringshausen FC, Tino G, Torres A, Vendrell M, Welte T, Wilson R, Wong C, O'Donnell A, Aksamit T; EMBARC/BRR definitions working group.

Eur Respir J. 2017 Jun 8;49(6). pii: 1700051. doi: 10.1183/13993003.00051-2017. Print 2017 Jun.


Diagnosing ANCA-associated vasculitis in ANCA positive patients: A retrospective analysis on the role of clinical symptoms and the ANCA titre.

Houben E, Bax WA, van Dam B, Slieker WA, Verhave G, Frerichs FC, van Eijk IC, Boersma WG, de Kuyper GT, Penne EL.

Medicine (Baltimore). 2016 Oct;95(40):e5096.


The EMBARC European Bronchiectasis Registry: protocol for an international observational study.

Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, Dimakou K, Clifton I, van der Eerden M, Rohde G, Murris-Espin M, Masefield S, Gerada E, Shteinberg M, Ringshausen F, Haworth C, Boersma W, Rademacher J, Hill AT, Aksamit T, O'Donnell A, Morgan L, Milenkovic B, Tramma L, Neves J, Menendez R, Paggiaro P, Botnaru V, Skrgat S, Wilson R, Goeminne P, De Soyza A, Welte T, Torres A, Elborn JS, Blasi F.

ERJ Open Res. 2016 Jan 20;2(1). pii: 00081-2015. eCollection 2016 Jan.


Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD.

Stolz D, Leeming DJ, Kristensen JHE, Karsdal MA, Boersma W, Louis R, Milenkovic B, Kostikas K, Blasi F, Aerts J, Sand JMB, Wouters EFM, Rohde G, Prat C, Torres A, Welte T, Roth M, Papakonstantinou E, Tamm M.

Chest. 2017 Jan;151(1):47-59. doi: 10.1016/j.chest.2016.08.1440. Epub 2016 Aug 26.


Atypical aetiology in patients hospitalised with community-acquired pneumonia is associated with age, gender and season; a data-analysis on four Dutch cohorts.

Raeven VM, Spoorenberg SM, Boersma WG, van de Garde EM, Cannegieter SC, Voorn GP, Bos WJ, van Steenbergen JE; Alkmaar study group; Ovidius study group.

BMC Infect Dis. 2016 Jun 17;16:299. doi: 10.1186/s12879-016-1641-9.


Prognostic assessment in COPD without lung function: the B-AE-D indices.

Boeck L, Soriano JB, Brusse-Keizer M, Blasi F, Kostikas K, Boersma W, Milenkovic B, Louis R, Lacoma A, Djamin R, Aerts J, Torres A, Rohde G, Welte T, Martinez-Camblor P, Rakic J, Scherr A, Koller M, van der Palen J, Marin JM, Alfageme I, Almagro P, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Miravitlles M, Celli BR, Tamm M, Stolz D.

Eur Respir J. 2016 Jun;47(6):1635-44. doi: 10.1183/13993003.01485-2015. Epub 2016 Apr 21.


Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD.

Baumeler L, Papakonstantinou E, Milenkovic B, Lacoma A, Louis R, Aerts JG, Welte T, Kostikas K, Blasi F, Boersma W, Torres A, Rohde GG, Boeck L, Rakic J, Scherr A, Tamm M, Stolz D.

Respirology. 2016 Jul;21(5):883-90. doi: 10.1111/resp.12758. Epub 2016 Mar 11.


Pneumococcal urinary antigen test: diagnostic yield and impact on antibiotic treatment.

Laijen W, Snijders D, Boersma WG.

Clin Respir J. 2017 Nov;11(6):999-1005. doi: 10.1111/crj.12453. Epub 2016 Feb 19.


Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.

Mandal J, Malla B, Steffensen R, Costa L, Egli A, Trendelenburg M, Blasi F, Kostikas K, Welte T, Torres A, Louis R, Boersma W, Milenkovic B, Aerts J, Rohde GG, Lacoma A, Rentsch K, Roth M, Tamm M, Stolz D.

Respir Res. 2015 Dec 18;16:150. doi: 10.1186/s12931-015-0306-3.


Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial.

Prins HJ, Daniels JM, Lindeman JH, Lutter R, Boersma WG.

Respir Med. 2016 Jan;110:46-52. doi: 10.1016/j.rmed.2015.10.009. Epub 2015 Oct 30.


Non-cystic fibrosis bronchiectasis: clinical presentation, diagnosis and treatment, illustrated by data from a Dutch Teaching Hospital.

Altenburg J, Wortel K, van der Werf TS, Boersma WG.

Neth J Med. 2015 May;73(4):147-54. Review.


Adrenomedullin optimises mortality prediction in COPD patients.

Brusse-Keizer M, Zuur-Telgen M, van der Palen J, VanderValk P, Kerstjens H, Boersma W, Blasi F, Kostikas K, Milenkovic B, Tamm M, Stolz D.

Respir Med. 2015 Jun;109(6):734-42. doi: 10.1016/j.rmed.2015.02.013. Epub 2015 Mar 6.


Antibiotic treatment strategies for community-acquired pneumonia in adults.

Postma DF, van Werkhoven CH, van Elden LJ, Thijsen SF, Hoepelman AI, Kluytmans JA, Boersma WG, Compaijen CJ, van der Wall E, Prins JM, Oosterheert JJ, Bonten MJ; CAP-START Study Group.

N Engl J Med. 2015 Apr 2;372(14):1312-23. doi: 10.1056/NEJMoa1406330.


Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials.

Barker AF, O'Donnell AE, Flume P, Thompson PJ, Ruzi JD, de Gracia J, Boersma WG, De Soyza A, Shao L, Zhang J, Haas L, Lewis SA, Leitzinger S, Montgomery AB, McKevitt MT, Gossage D, Quittner AL, O'Riordan TG.

Lancet Respir Med. 2014 Sep;2(9):738-49. doi: 10.1016/S2213-2600(14)70165-1. Epub 2014 Aug 18.


Validation of a visual analogue score (LRTI-VAS) in non-CF bronchiectasis.

Altenburg J, Wortel K, de Graaff CS, van der Werf TS, Boersma WG.

Clin Respir J. 2016 Mar;10(2):168-75. doi: 10.1111/crj.12198. Epub 2014 Sep 4.


Predicting pneumococcal community-acquired pneumonia in the emergency department: evaluation of clinical parameters.

Huijts SM, Boersma WG, Grobbee DE, Gruber WC, Jansen KU, Kluytmans JA, Kuipers BA, Palmen F, Pride MW, Webber C, Bonten MJ; CAP Diagnostics investigators.

Clin Microbiol Infect. 2014 Dec;20(12):1316-22. doi: 10.1111/1469-0691.12740. Epub 2014 Dec 12.


Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.

Stolz D, Boersma W, Blasi F, Louis R, Milenkovic B, Kostikas K, Aerts JG, Rohde G, Lacoma A, Rakic J, Boeck L, Castellotti P, Scherr A, Marin A, Hertel S, Giersdorf S, Torres A, Welte T, Tamm M.

Chest. 2014 Aug;146(2):328-338. doi: 10.1378/chest.13-1967.


Cerebral adenosine A₁ receptors are upregulated in rodent encephalitis.

Paul S, Khanapur S, Boersma W, Sijbesma JW, Ishiwata K, Elsinga PH, Meerlo P, Doorduin J, Dierckx RA, van Waarde A.

Neuroimage. 2014 May 15;92:83-9. doi: 10.1016/j.neuroimage.2014.01.054. Epub 2014 Feb 7.


Guideline adherence for empirical treatment of pneumonia and patient outcome. Treating pneumonia in the Netherlands.

Huijts SM, van Werkhoven CH, Boersma WG, Buijs J, Buunk G, Compaijen CJ, van Elde LJ, Gisolf JE, van der Kam R, Kluytmans JA, Kuipers BA, Mager JJ, Oppedijk B, Palmen F, Prins JM, van Reemst B, Silbermann MH, van Tiel FH, van der Wall E, van der Werf TS, Bonten MJ.

Neth J Med. 2013 Dec;71(10):502-7. Review.


Single versus combination antibiotic therapy in adults hospitalised with community-acquired pneumonia.

van der Eerden MM, Boersma WG.

Thorax. 2013 Nov;68(11):1068. doi: 10.1136/thoraxjnl-2013-203994. Epub 2013 Aug 1. No abstract available.


Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index.

Stolz D, Kostikas K, Blasi F, Boersma W, Milenkovic B, Lacoma A, Louis R, Aerts JG, Welte T, Torres A, Rohde GG, Boeck L, Rakic J, Scherr A, Hertel S, Giersdorf S, Tamm M.

Eur Respir J. 2014 Feb;43(2):397-408. doi: 10.1183/09031936.00058713. Epub 2013 Jun 21. Erratum in: Eur Respir J. 2014 Dec;44(6):1718.


Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques.

Said MA, Johnson HL, Nonyane BA, Deloria-Knoll M, O'Brien KL; AGEDD Adult Pneumococcal Burden Study Team, Andreo F, Beovic B, Blanco S, Boersma WG, Boulware DR, Butler JC, Carratalà J, Chang FY, Charles PG, Diaz AA, Domínguez J, Ehara N, Endeman H, Falcó V, Falguera M, Fukushima K, Garcia-Vidal C, Genne D, Guchev IA, Gutierrez F, Hernes SS, Hoepelman AI, Hohenthal U, Johansson N, Kolek V, Kozlov RS, Lauderdale TL, Mareković I, Masiá M, Matta MA, Miró Ò, Murdoch DR, Nuermberger E, Paolini R, Perelló R, Snijders D, Plečko V, Sordé R, Strålin K, van der Eerden MM, Vila-Corcoles A, Watt JP.

PLoS One. 2013;8(4):e60273. doi: 10.1371/journal.pone.0060273. Epub 2013 Apr 2. Review.


Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial.

Altenburg J, de Graaff CS, Stienstra Y, Sloos JH, van Haren EH, Koppers RJ, van der Werf TS, Boersma WG.

JAMA. 2013 Mar 27;309(12):1251-9. doi: 10.1001/jama.2013.1937.


Diagnostic accuracy of a serotype-specific antigen test in community-acquired pneumonia.

Huijts SM, Pride MW, Vos JM, Jansen KU, Webber C, Gruber W, Boersma WG, Snijders D, Kluytmans JA, van der Lee I, Kuipers BA, van der Ende A, Bonten MJ.

Eur Respir J. 2013 Nov;42(5):1283-90. doi: 10.1183/09031936.00137412. Epub 2013 Feb 8.


Transient impairment of reticulocyte hemoglobin content and hepcidin-25 induction in patients with community-acquired pneumonia.

Schoorl M, Snijders D, Schoorl M, Boersma WG, Bartels PC.

Scand J Clin Lab Invest. 2013 Feb;73(1):54-60. doi: 10.3109/00365513.2012.735694. Epub 2012 Oct 25.


Antibiotics in acute exacerbations of COPD: the good, the bad and the ugly.

Boersma WG.

Eur Respir J. 2012 Jul;40(1):1-3. doi: 10.1183/09031936.00211911. No abstract available.


D-dimer levels in assessing severity and clinical outcome in patients with community-acquired pneumonia. A secondary analysis of a randomised clinical trial.

Snijders D, Schoorl M, Schoorl M, Bartels PC, van der Werf TS, Boersma WG.

Eur J Intern Med. 2012 Jul;23(5):436-41. doi: 10.1016/j.ejim.2011.10.019. Epub 2011 Nov 21.


SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults.

Wiersinga WJ, Bonten MJ, Boersma WG, Jonkers RE, Aleva RM, Kullberg BJ, Schouten JA, Degener JE, Janknegt R, Verheij TJ, Sachs AP, Prins JM; Dutch Working Party on Antibiotic Policy; Dutch Association of Chest Physicians.

Neth J Med. 2012 Mar;70(2):90-101.


Temporary impairment of reticulocyte haemoglobin content in subjects with community-acquired pneumonia.

Schoorl M, Snijders D, Schoorl M, Boersma WG, Bartels PC.

Int J Lab Hematol. 2012 Aug;34(4):390-5. doi: 10.1111/j.1751-553X.2012.01408.x. Epub 2012 Mar 12.


Evaluation of a new procalcitonin assay for the Siemens ADVIA Centaur with the established method on the B.R.A.H.M.S Kryptor.

Sanders RJ, Schoorl M, Dekker E, Snijders D, Boersma WG, Ten Boekel E.

Clin Lab. 2011;57(5-6):415-20.


CURB-65 pneumonia severity assessment adapted for electronic decision support.

Jones BE, Jones J, Bewick T, Lim WS, Aronsky D, Brown SM, Boersma WG, van der Eerden MM, Dean NC.

Chest. 2011 Jul;140(1):156-163. doi: 10.1378/chest.10-1296. Epub 2010 Dec 16.


Treatment of haemothorax.

Boersma WG, Stigt JA, Smit HJ.

Respir Med. 2010 Nov;104(11):1583-7. doi: 10.1016/j.rmed.2010.08.006. Review.


Effect of Eimeria acervulina infection history on the immune response and transmission in broilers.

Velkers FC, Swinkels WJ, Rebel JM, Bouma A, Daemen AJ, Klinkenberg D, Boersma WJ, Stegeman JA, de Jong MC, Heesterbeek JA.

Vet Parasitol. 2010 Oct 29;173(3-4):184-92. doi: 10.1016/j.vetpar.2010.07.005. Epub 2010 Jul 22.


Immunomodulatory effects of macrolide antibiotics - part 2: advantages and disadvantages of long-term, low-dose macrolide therapy.

Altenburg J, de Graaff CS, van der Werf TS, Boersma WG.

Respiration. 2011;81(1):75-87. doi: 10.1159/000320320. Epub 2010 Aug 21. Review.


Immunomodulatory effects of macrolide antibiotics - part 1: biological mechanisms.

Altenburg J, de Graaff CS, van der Werf TS, Boersma WG.

Respiration. 2011;81(1):67-74. doi: 10.1159/000320319. Epub 2010 Aug 21. Review.

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