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Items: 1 to 50 of 64

1.

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury.

Yakulov TA, Todkar AP, Slanchev K, Wiegel J, Bona A, Groß M, Scholz A, Hess I, Wurditsch A, Grahammer F, Huber TB, Lecaudey V, Bork T, Hochrein J, Boerries M, Leenders J, de Tullio P, Jouret F, Kramer-Zucker A, Walz G.

Nat Commun. 2018 Sep 10;9(1):3660. doi: 10.1038/s41467-018-06094-4.

2.

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin.

Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C.

Nat Commun. 2018 Aug 30;9(1):3524. doi: 10.1038/s41467-018-05850-w.

3.

MIRACUM: Medical Informatics in Research and Care in University Medicine.

Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, Daumke P, Ganslandt T, Hesser J, Höning G, Neumaier M, Marquardt K, Renz H, Rothkötter HJ, Schade-Brittinger C, Schmücker P, Schüttler J, Sedlmayr M, Serve H, Sohrabi K, Storf H.

Methods Inf Med. 2018 Jul;57(S 01):e82-e91. doi: 10.3414/ME17-02-0025. Epub 2018 Jul 17.

4.

Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development.

Koszinowski S, La Padula V, Edlich F, Krieglstein K, Busch H, Boerries M.

Front Physiol. 2018 Jun 29;9:797. doi: 10.3389/fphys.2018.00797. eCollection 2018.

5.

Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.

Dvornikov D, Schneider MA, Ohse S, Szczygieł M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H, Thomas M, Timmer J, Schilling M, Busch H, Boerries M, Meister M, Klingmüller U.

Sci Rep. 2018 Jun 22;8(1):9517. doi: 10.1038/s41598-018-27912-1.

6.

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.

Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW.

EMBO J. 2018 Aug 1;37(15). pii: e98615. doi: 10.15252/embj.201798615. Epub 2018 Jun 19.

7.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

8.

Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.

Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich CM, Michels KB, Busch H, Boerries M.

Epigenetics. 2018;13(4):386-397. doi: 10.1080/15592294.2018.1460034. Epub 2018 May 3.

9.

Implementing Pharmacogenomic Clinical Decision Support into German Hospitals.

Hinderer M, Boerries M, Boeker M, Neumaier M, Loubal FP, Acker T, Brunner M, Prokosch HU, Christoph J.

Stud Health Technol Inform. 2018;247:870-874.

PMID:
29678085
10.

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma.

Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Küsters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M.

Front Genet. 2018 Apr 5;9:108. doi: 10.3389/fgene.2018.00108. eCollection 2018.

11.

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.

Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB.

Sci Rep. 2018 Apr 4;8(1):5649. doi: 10.1038/s41598-018-23957-4.

12.

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaam7729. doi: 10.1126/scitranslmed.aam7729.

PMID:
29467301
13.

Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling.

Schmidt N, Haydn T, Schneider I, Busch H, Boerries M, Fulda S.

Cancer Lett. 2018 May 1;421:170-185. doi: 10.1016/j.canlet.2018.01.082. Epub 2018 Feb 5.

PMID:
29421152
14.

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.

Herr R, Halbach S, Heizmann M, Busch H, Boerries M, Brummer T.

Oncogene. 2018 Mar;37(12):1576-1593. doi: 10.1038/s41388-017-0063-5. Epub 2018 Jan 12.

PMID:
29326440
15.

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.

Nat Commun. 2017 Dec 19;8(1):2126. doi: 10.1038/s41467-017-02177-w.

16.

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.

Pastor VB, Sahoo SS, Boklan J, Schwabe GC, Saribeyoglu E, Strahm B, Lebrecht D, Voss M, Bryceson YT, Erlacher M, Ehninger G, Niewisch M, Schlegelberger B, Baumann I, Achermann JC, Shimamura A, Hochrein J, Tedgård U, Nilsson L, Hasle H, Boerries M, Busch H, Niemeyer CM, Wlodarski MW.

Haematologica. 2018 Mar;103(3):427-437. doi: 10.3324/haematol.2017.180778. Epub 2017 Dec 7.

17.

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.

Jägle S, Busch H, Freihen V, Beyes S, Schrempp M, Boerries M, Hecht A.

PLoS Genet. 2017 Nov 20;13(11):e1007109. doi: 10.1371/journal.pgen.1007109. eCollection 2017 Nov.

18.

Specific role of RhoC in tumor invasion and metastasis.

Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G.

Oncotarget. 2017 Sep 16;8(50):87364-87378. doi: 10.18632/oncotarget.20957. eCollection 2017 Oct 20.

19.

KDM4 Inhibition Targets Breast Cancer Stem-like Cells.

Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford JA, Kanouni T, Maurer J, Schüle R.

Cancer Res. 2017 Nov 1;77(21):5900-5912. doi: 10.1158/0008-5472.CAN-17-1754. Epub 2017 Sep 7.

PMID:
28883001
20.

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.

Barrow TM, Klett H, Toth R, Böhm J, Gigic B, Habermann N, Scherer D, Schrotz-King P, Skender S, Abbenhardt-Martin C, Zielske L, Schneider M, Ulrich A, Schirmacher P, Herpel E, Brenner H, Busch H, Boerries M, Ulrich CM, Michels KB.

J Pathol. 2017 Nov;243(3):366-375. doi: 10.1002/path.4955. Epub 2017 Sep 29.

PMID:
28791728
21.

Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents.

Hettmer S, Andrieux G, Hochrein J, Kurz P, Rössler J, Lassmann S, Werner M, von Bubnoff N, Peters C, Koscielniak E, Sparber-Sauer M, Niemeyer C, Mentzel T, Busch H, Boerries M.

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26675. Epub 2017 Jun 9. Review.

PMID:
28598585
22.

Supporting Molecular Tumor Boards in Molecular-Guided Decision-Making - The Current Status of Five German University Hospitals.

Hinderer M, Boerries M, Haller F, Wagner S, Sollfrank S, Acker T, Prokosch HU, Christoph J.

Stud Health Technol Inform. 2017;236:48-54.

PMID:
28508778
23.

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression.

Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Rao Mittapalli V, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R.

Oncotarget. 2017 Jun 27;8(26):42901-42916. doi: 10.18632/oncotarget.17160.

24.

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.

Krebs AM, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton VG, Pilarsky C, Winkler TH, Brabletz S, Stemmler MP, Brabletz T.

Nat Cell Biol. 2017 May;19(5):518-529. doi: 10.1038/ncb3513. Epub 2017 Apr 17.

PMID:
28414315
25.

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.

Strotbek M, Schmid S, Sánchez-González I, Boerries M, Busch H, Olayioye MA.

Int J Cancer. 2017 May 15;140(10):2310-2320. doi: 10.1002/ijc.30661. Epub 2017 Mar 11.

26.

Understanding the mTOR signaling pathway via mathematical modeling.

Sulaimanov N, Klose M, Busch H, Boerries M.

Wiley Interdiscip Rev Syst Biol Med. 2017 Jul;9(4). doi: 10.1002/wsbm.1379. Epub 2017 Feb 10. Review.

27.

Absence of the Integrin α3 Subunit Induces an Activated Phenotype in Human Keratinocytes.

Pazzagli C, He Y, Busch H, Esser P, Kiritsi D, Gache Y, Bruckner-Tuderman L, Boerries M, Has C.

J Invest Dermatol. 2017 Jun;137(6):1387-1391. doi: 10.1016/j.jid.2017.01.018. Epub 2017 Feb 3. No abstract available.

28.

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.

Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U.

Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258.

29.

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility.

He Y, Maier K, Leppert J, Hausser I, Schwieger-Briel A, Weibel L, Theiler M, Kiritsi D, Busch H, Boerries M, Hannula-Jouppi K, Heikkilä H, Tasanen K, Castiglia D, Zambruno G, Has C.

Am J Hum Genet. 2016 Dec 1;99(6):1395-1404. doi: 10.1016/j.ajhg.2016.11.005. Epub 2016 Nov 23.

30.

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.

Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J.

Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.

31.

HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.

La Padula V, Staszewski O, Nestel S, Busch H, Boerries M, Roussa E, Prinz M, Krieglstein K.

Exp Neurol. 2016 Dec;286:40-49. doi: 10.1016/j.expneurol.2016.08.014. Epub 2016 Aug 24.

32.

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer.

Hillebrand LE, Bengsch F, Hochrein J, Hülsdünker J, Bender J, Follo M, Busch H, Boerries M, Reinheckel T.

Oncotarget. 2016 Sep 6;7(36):58244-58260. doi: 10.18632/oncotarget.11309.

33.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: e86177.

34.

S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling.

Lerchenmüller C, Heißenberg J, Damilano F, Bezzeridis VJ, Krämer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M, Most P.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1854-67. doi: 10.1161/ATVBAHA.115.306415. Epub 2016 Jul 7.

35.

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Fluhr S, Boerries M, Busch H, Symeonidi A, Witte T, Lipka DB, Mücke O, Nöllke P, Krombholz CF, Niemeyer CM, Plass C, Flotho C.

Clin Epigenetics. 2016 May 5;8:50. doi: 10.1186/s13148-016-0216-3. eCollection 2016.

36.

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation.

Offermann B, Knauer S, Singh A, Fernández-Cachón ML, Klose M, Kowar S, Busch H, Boerries M.

Front Genet. 2016 Apr 14;7:44. doi: 10.3389/fgene.2016.00044. eCollection 2016.

37.

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines.

Boerries M, Herr R, Brummer T, Busch H.

Genom Data. 2015 Apr 28;4:158-61. doi: 10.1016/j.gdata.2015.04.015. eCollection 2015 Jun.

38.

Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine.

Ahrens TD, Timme S, Hoeppner J, Ostendorp J, Hembach S, Follo M, Hopt UT, Werner M, Busch H, Boerries M, Lassmann S.

Epigenetics. 2015;10(5):431-45. doi: 10.1080/15592294.2015.1039216.

39.

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors.

Kalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F.

Aging (Albany NY). 2015 Feb;7(2):110-22.

40.

RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion.

Koszinowski S, Boerries M, Busch H, Krieglstein K.

Dev Neurobiol. 2015 Nov;75(11):1204-18. doi: 10.1002/dneu.22278. Epub 2015 Jun 12.

41.

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K.

Aging (Albany NY). 2014 Oct;6(10):856-78.

42.

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells.

Herr R, Köhler M, Andrlová H, Weinberg F, Möller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T.

Cancer Res. 2015 Jan 1;75(1):216-29. doi: 10.1158/0008-5472.CAN-13-3686. Epub 2014 Nov 7.

43.

miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion.

Bischoff A, Huck B, Keller B, Strotbek M, Schmid S, Boerries M, Busch H, Müller D, Olayioye MA.

Cancer Res. 2014 Sep 15;74(18):5256-65. doi: 10.1158/0008-5472.CAN-13-3319. Epub 2014 Jul 17.

44.

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.

Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2817-26. doi: 10.1073/pnas.1402352111. Epub 2014 Jun 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6826. Sander, Lukas [corrected to Sandner, Lukas].

45.

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.

Rohde D, Schön C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Völkers M, Herzog N, Mähler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P.

EMBO Mol Med. 2014 Jun;6(6):778-94. doi: 10.15252/emmm.201303498. Epub 2014 Apr 6.

46.

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F.

Exp Gerontol. 2014 Aug;56:59-68. doi: 10.1016/j.exger.2014.03.017. Epub 2014 Mar 31.

PMID:
24699405
47.

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract.

Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-Y-Sy S, Nascimento JM, Boerries M, Schmidt G, Brandner JM, Merfort I.

PLoS One. 2014 Jan 22;9(1):e86147. doi: 10.1371/journal.pone.0086147. eCollection 2014.

48.

In silico approaches and the role of ontologies in aging research.

Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D.

Rejuvenation Res. 2013 Dec;16(6):540-6. doi: 10.1089/rej.2013.1517.

49.

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints.

Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M.

Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521. Epub 2013 Oct 21.

50.

STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.

Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S.

Oncogene. 2014 Jun 19;33(25):3256-66. doi: 10.1038/onc.2013.298. Epub 2013 Aug 5.

PMID:
23912451

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